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International Journal of Molecular Medicine
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August-2014 Volume 34 Issue 2

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Article

Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination

  • Authors:
    • Yazhou Wang
    • Xingjun Wu
    • Yueping Zhong
    • Jianhong  Shen
    • Xinhua Wu
    • Shaoqing Ju
    • Xiaofei Wang
  • View Affiliations / Copyright

    Affiliations: Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurology, Xuhui Central Hospital, Xuhui, Shanghai 200031, P.R. China, Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 599-605
    |
    Published online on: June 2, 2014
       https://doi.org/10.3892/ijmm.2014.1792
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Abstract

Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, has been shown to have neuroprotective, neurotrophic and anti-inflammatory properties in both animal and cellular models of neurodegenerative disorders. In a previous study of ours, we demonstrated that TSA inhibited the proliferation and increased the differentiation of neuronal precursor cells (NPCs). However, the effects of TSA on Schwann cells (SCs) have not yet been fully elucidated. Thus, in the present study, using SCs derived from adult rat sciatic nerves, we investigated the effects of TSA on the survival, proliferation, migration and myelination of SCs. We found that TSA significantly induced SC death when used at high concentrations. We also observed that TSA promoted the proliferation of SCs in a time-dependent manner. In addition, TSA inhibited the migration of SCs. Moreover, RT-PCR revealed that TSA increased the mRNA expression of several neurotrophic factors and inhibited the expression of genes associated with myelination, including myelin basic protein (MBP) and myelin protein zero (MPZ). Taken together, our results suggest that TSA plays an important role in regulating the growth and biological function of SCs. These data may contribute to our understanding of TSA-based treatment of neurodegenerative diseases.
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1 

Sobani ZA, Quadr SA and Enam SA: Stem cells for spinal cord regeneration: current status. Surg Neurol Int. 1:932010. View Article : Google Scholar : PubMed/NCBI

2 

Garbossa D, Boido M, Fontanella M, et al: Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells. Neurosurg Rev. 35:293–311. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Hill CE, Hurtado A, Blits B, et al: Early necrosis and apoptosis of Schwann cells transplanted into the injured rat spinal cord. Eur J Neurosci. 26:1433–1445. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Lavdas AA, Papastefanaki F, Thomaidou D and Matsas R: Schwann cell transplantation for CNS repair. Curr Med Chem. 15:151–160. 2008. View Article : Google Scholar

5 

Takami T, Oudega M, Bates ML, et al: Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord. J Neurosci. 22:6670–6681. 2002.PubMed/NCBI

6 

Ide C, Nakai Y, Nakano N, et al: Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat. Brain Res. 1332:32–47. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Schaal SM, Kitay BM, Cho KS, et al: Schwann cell transplantation improves reticulospinal axon growth and forelimb strength after severe cervical spinal cord contusion. Cell Transplant. 16:207–228. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Kocsis JD and Waxman SG: Schwann cells and their precursors for repair of central nervous system myelin. Brain. 130:1978–1980. 2007. View Article : Google Scholar

9 

Patel V, Joseph G, Patel A, et al: Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord. J Neurotrauma. 27:789–801. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Redell JB, Moore AN, Ward NH III, Hergenroeder GW and Dash PK: Human traumatic brain injury alters plasma microRNA levels. J Neurotrauma. 27:2147–2156. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Yu IT, Park JY, Kim SH, et al: Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation. Neuropharmacology. 56:473–480. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Feng HL, Leng Y, Ma CH, et al: Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience. 155:567–572. 2008. View Article : Google Scholar

13 

Tsai LK, Tsai MS, Ting CH, Wang SH and Li H: Restoring Bcl-x(L) levels benefits a mouse model of spinal muscular atrophy. Neurobiol Dis. 31:361–367. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Ferrante RJ, Kubilus JK, Lee J, et al: Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington,’s disease mice. J Neurosci. 23:9418–9427. 2003.PubMed/NCBI

15 

Langley B, D’Annibale MA, Suh K, et al: Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21 (waf1/cip1) in cell cycle-independent neuroprotection. J Neurosci. 28:163–176. 2008. View Article : Google Scholar

16 

Chuang DM, Leng Y, Marinova Z, Kim HJ and Chiu CT: Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci. 32:591–601. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Wang Z, Zang C, Cui K, et al: Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell. 138:1019–1031. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Liu H, Wu H, Wang Y, et al: Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells. Acta Neurobiol Exp (Wars). 72:365–376. 2012.PubMed/NCBI

19 

Morrissey TK, Kleitman N and Bunge RP: Isolation and functional characterization of Schwann cells derived from adult peripheral nerve. J Neurosci. 11:2433–2442. 1991.PubMed/NCBI

20 

Xu XM, Guénard V, Kleitman N, Aebischer P and Bunge MB: A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp Neurol. 134:261–272. 1995. View Article : Google Scholar

21 

Xu XM, Guénard VV, Kleitman N and Bunge MB: Axonal regeneration into Schwann cell-seeded guidance channels grafted into transected adult rat spinal cord. J Comp Neurol. 351:145–160. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Wang X, Fu S, Wang Y, et al: Interleukin-1beta mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway. Mol Cell Neurosci. 36:343–354. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Jeong MR, Hashimoto R, Senatorov VV, et al: Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition. FEBS Lett. 542:74–78. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Forgione N and Tropepe V: Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons. Mol Cell Neurosci. 48:117–128. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Mi S, Lee X, Shao Z, et al: LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci. 7:221–228. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Di Daniel E, Mudge AW and Maycox PR: Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons. Bipolar Disord. 7:33–41. 2005.PubMed/NCBI

27 

Hao Y, Creson T, Zhang L, et al: Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci. 24:6590–6599. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Michaelis M, Suhan T, Michaelis UR, et al: Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells. Cell Death Differ. 13:446–453. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Chen PS, Peng GS, Li G, et al: Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol Psychiatry. 11:1116–1125. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Castro LM, Gallant M and Niles LP: Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells. J Neurochem. 95:1227–1236. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Otsuka S, Adamson C, Sankar V, et al: Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth. J Neurotrauma. 28:1063–1076. 2011. View Article : Google Scholar

32 

Ananthakrishnan R and Ehrlicher A: The forces behind cell movement. Int J Biol Sci. 3:303–317. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Heermann S and Schwab MH: Molecular control of Schwann cell migration along peripheral axons: keep moving! Cell Adh Migr. 7:18–22. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Ishida-Yamamoto A, Yamauchi T, Tanaka H, et al: Electron microscopic in situ DNA nick end-labeling in combination with immunoelectron microscopy. J Histochem Cytochem. 47:711–717. 1999. View Article : Google Scholar : PubMed/NCBI

35 

Cornejo M, Nambi D, Walheim C, et al: Effect of NRG1, GDNF, EGF and NGF in the migration of a Schwann cell precursor line. Neurochem Res. 35:1643–1651. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Heermann S, Spittau B, Zajzon K, Schwab MH and Krieglstein K: Schwann cells migrate along axons in the absence of GDNF signaling. BMC Neurosci. 13:922012. View Article : Google Scholar : PubMed/NCBI

37 

Jacob C, Christen CN, Pereira JA, et al: HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells. Nat Neurosci. 14:429–436. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wu X, Zhong Y, Shen J, Wu X, Ju S and Wang X: Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. Int J Mol Med 34: 599-605, 2014.
APA
Wang, Y., Wu, X., Zhong, Y., Shen, J., Wu, X., Ju, S., & Wang, X. (2014). Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. International Journal of Molecular Medicine, 34, 599-605. https://doi.org/10.3892/ijmm.2014.1792
MLA
Wang, Y., Wu, X., Zhong, Y., Shen, J., Wu, X., Ju, S., Wang, X."Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination". International Journal of Molecular Medicine 34.2 (2014): 599-605.
Chicago
Wang, Y., Wu, X., Zhong, Y., Shen, J., Wu, X., Ju, S., Wang, X."Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination". International Journal of Molecular Medicine 34, no. 2 (2014): 599-605. https://doi.org/10.3892/ijmm.2014.1792
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wu X, Zhong Y, Shen J, Wu X, Ju S and Wang X: Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. Int J Mol Med 34: 599-605, 2014.
APA
Wang, Y., Wu, X., Zhong, Y., Shen, J., Wu, X., Ju, S., & Wang, X. (2014). Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. International Journal of Molecular Medicine, 34, 599-605. https://doi.org/10.3892/ijmm.2014.1792
MLA
Wang, Y., Wu, X., Zhong, Y., Shen, J., Wu, X., Ju, S., Wang, X."Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination". International Journal of Molecular Medicine 34.2 (2014): 599-605.
Chicago
Wang, Y., Wu, X., Zhong, Y., Shen, J., Wu, X., Ju, S., Wang, X."Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination". International Journal of Molecular Medicine 34, no. 2 (2014): 599-605. https://doi.org/10.3892/ijmm.2014.1792
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