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Article

Characterization of microRNA expression in serous ovarian carcinoma

  • Authors:
    • Yanhong Li
    • Li Yao
    • Fei Liu
    • Jia Hong
    • Lin Chen
    • Beilei Zhang
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, The Helmholtz Sino‑German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
  • Pages: 491-498
    |
    Published online on: June 17, 2014
       https://doi.org/10.3892/ijmm.2014.1813
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Abstract

Serous ovarian cancer is a major gynecologic malignancy with a poor 5‑year survival rate. However, little is known regarding the behavior and genetics of ovarian tumorigenesis. MicroRNAs (miRNAs) have been shown to be dysregulated in ovarian carcinomas. To assess the miRNA expression profiles in serous ovarian cancer, we defined the patterns of miRNA expression in 100 formalin‑fixed, paraffin‑embedded ovarian cancer tissues blocks as well as 50 corresponding normal oviduct tissues using miRNA microarray. MiRNA expression profiling showed that 63 miRNAs were downregulated and 43 miRNAs were upregulated in serous ovarian cancer tissues compared with control tissues. The expression of five dysregulated miRNAs was validated using quantitative polymerase chain reaction (RT‑qPCR). GO term and pathway analysis revealed that the biological process of the cell cycle was significantly enriched and the MAPK signaling pathway was highly involved in the progression of ovarian cancer. The results suggested that the aberrant expression of miRNAs is involved in ovarian carcinogenesis and thus these miRNAs may function as diagnostic and prognostic biomarkers.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Yao L, Liu F, Hong J, Chen L, Zhang B and Zhang W: Characterization of microRNA expression in serous ovarian carcinoma. Int J Mol Med 34: 491-498, 2014.
APA
Li, Y., Yao, L., Liu, F., Hong, J., Chen, L., Zhang, B., & Zhang, W. (2014). Characterization of microRNA expression in serous ovarian carcinoma. International Journal of Molecular Medicine, 34, 491-498. https://doi.org/10.3892/ijmm.2014.1813
MLA
Li, Y., Yao, L., Liu, F., Hong, J., Chen, L., Zhang, B., Zhang, W."Characterization of microRNA expression in serous ovarian carcinoma". International Journal of Molecular Medicine 34.2 (2014): 491-498.
Chicago
Li, Y., Yao, L., Liu, F., Hong, J., Chen, L., Zhang, B., Zhang, W."Characterization of microRNA expression in serous ovarian carcinoma". International Journal of Molecular Medicine 34, no. 2 (2014): 491-498. https://doi.org/10.3892/ijmm.2014.1813
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Yao L, Liu F, Hong J, Chen L, Zhang B and Zhang W: Characterization of microRNA expression in serous ovarian carcinoma. Int J Mol Med 34: 491-498, 2014.
APA
Li, Y., Yao, L., Liu, F., Hong, J., Chen, L., Zhang, B., & Zhang, W. (2014). Characterization of microRNA expression in serous ovarian carcinoma. International Journal of Molecular Medicine, 34, 491-498. https://doi.org/10.3892/ijmm.2014.1813
MLA
Li, Y., Yao, L., Liu, F., Hong, J., Chen, L., Zhang, B., Zhang, W."Characterization of microRNA expression in serous ovarian carcinoma". International Journal of Molecular Medicine 34.2 (2014): 491-498.
Chicago
Li, Y., Yao, L., Liu, F., Hong, J., Chen, L., Zhang, B., Zhang, W."Characterization of microRNA expression in serous ovarian carcinoma". International Journal of Molecular Medicine 34, no. 2 (2014): 491-498. https://doi.org/10.3892/ijmm.2014.1813
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