MicroRNAs regulate vascular smooth muscle cell functions in atherosclerosis (Review)
- Authors:
- Xin Yu
- Zheng Li
-
Affiliations: Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, P.R. China - Published online on: July 15, 2014 https://doi.org/10.3892/ijmm.2014.1853
- Pages: 923-933
This article is mentioned in:
Abstract
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|
Lusis AJ: Atherosclerosis. Nature. 407:233–241. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Gittenberger-de Groot AC, DeRuiter MC, Bergwerff M and Poelmann RE: Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol. 19:1589–1594. 1999.PubMed/NCBI | |
|
Frid MG, Dempsey EC, Durmowicz AG and Stenmark KR: Smooth muscle cell heterogeneity in pulmonary and systemic vessels. Importance in vascular disease. Arterioscler Thromb Vasc Biol. 17:1203–1209. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Schachter M: Vascular smooth muscle cell migration, atherosclerosis, and calcium channel blockers. Int J Cardiol. 62(Suppl 2): S85–S90. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Libby P, Sukhova G, Lee RT and Liao JK: Molecular biology of atherosclerosis. Int J Cardiol. 62(Suppl 2): S23–S29. 1997. View Article : Google Scholar | |
|
Schwartz SM: Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest. 100(Suppl): S87–S89. 1997.PubMed/NCBI | |
|
Doran AC, Meller N and McNamara CA: Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol. 28:812–819. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Huntzinger E and Izaurralde E: Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet. 12:99–110. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cho WC: OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer. 6:602007. View Article : Google Scholar : PubMed/NCBI | |
|
Small EM and Olson EN: Pervasive roles of microRNAs in cardiovascular biology. Nature. 469:336–342. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Song Z and Li G: Role of specific microRNAs in regulation of vascular smooth muscle cell differentiation and the response to injury. J Cardiovasc Transl Res. 3:246–250. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zernecke A: MicroRNAs in the regulation of immune cell functions-implications for atherosclerotic vascular disease. Thromb Haemost. 107:626–633. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Aghabozorg Afjeh SS and Ghaderian SM: The role of microRNAs in cardiovascular disease. Int J Mol Cell Med. 2:50–57. 2013.PubMed/NCBI | |
|
Robinson HC and Baker AH: How do microRNAs affect vascular smooth muscle cell biology? Curr Opin Lipidol. 23:405–411. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Owens GK, Kumar MS and Wamhoff BR: Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 84:767–801. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Stegemann JP, Hong H and Nerem RM: Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype. J Appl Physiol (1985). 98:2321–2327. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Y, Yang X, Friesel RE, Vary CP and Liaw L: Mechanisms of TGF-β-induced differentiation in human vascular smooth muscle cells. J Vasc Res. 48:485–494. 2011. | |
|
Millette E, Rauch BH, Kenagy RD, Daum G and Clowes AW: Platelet-derived growth factor-BB transactivates the fibroblast growth factor receptor to induce proliferation in human smooth muscle cells. Trends Cardiovasc Med. 16:25–28. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Raines EW: PDGF and cardiovascular disease. Cytokine Growth Factor Rev. 15:237–254. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ross R: The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:801–809. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Yin H, Jiang Y, et al: Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. Arterioscler Thromb Vasc Biol. 31:368–375. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Xie C, Huang H, Sun X, et al: MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4. Stem Cells Dev. 20:205–210. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang Y, Yin H and Zheng XL: MicroRNA-1 inhibits myocardin-induced contractility of human vascular smooth muscle cells. J Cell Physiol. 225:506–511. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Suzuki T, Aizawa K, Matsumura T and Nagai R: Vascular implications of the Kruppel-like family of transcription factors. Arterioscler Thromb Vasc Biol. 25:1135–1141. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH and Owens GK: Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J Biol Chem. 280:9719–9727. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Yoshida T, Kaestner KH and Owens GK: Conditional deletion of Kruppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res. 102:1548–1557. 2008. View Article : Google Scholar | |
|
King KE, Iyemere VP, Weissberg PL and Shanahan CM: Kruppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. J Biol Chem. 278:11661–11669. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Han M, Zhao XM and Wen JK: Kruppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid. J Biochem. 144:313–321. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Katakami N, Kaneto H, Hao H, et al: Role of pim-1 in smooth muscle cell proliferation. J Biol Chem. 279:54742–54749. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Yan CH, Li Y, et al: MicroRNA-31 controls phenotypic modulation of human vascular smooth muscle cells by regulating its target gene cellular repressor of E1A-stimulated genes. Exp Cell Res. 319:1165–1175. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Han Y, Deng J, Guo L, et al: CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. Cardiovasc Res. 78:597–604. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Torella D, Iaconetti C, Catalucci D, et al: MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo. Circ Res. 109:880–893. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Fichtlscherer S, De Rosa S, Fox H, et al: Circulating microRNAs in patients with coronary artery disease. Circ Res. 107:677–684. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Miano JM: Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol. 35:577–593. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Madsen CS, Hershey JC, Hautmann MB, White SL and Owens GK: Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements. J Biol Chem. 272:6332–6340. 1997. View Article : Google Scholar | |
|
Deaton RA, Gan Q and Owens GK: Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle. Am J Physiol Heart Circ Physiol. 296:H1027–H1037. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Cordes KR, Sheehy NT, White MP, et al: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 460:705–710. 2009.PubMed/NCBI | |
|
Raitoharju E, Lyytikäinen LP, Levula M, et al: miR-21, miR-210, miR-34a, and miR-146a/b are upregulated in human atherosclerotic plaques in the Tampere Vascular Study. Atherosclerosis. 219:211–217. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hergenreider E, Heydt S, Tréguer K, et al: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol. 14:249–256. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lovren F, Pan Y, Quan A, et al: MicroRNA-145 targeted therapy reduces atherosclerosis. Circulation. 126(Suppl 1): S81–S90. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Boettger T, Beetz N, Kostin S, et al: Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest. 119:2634–2647. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Rangrez AY, Massy ZA, Metzinger-Le Meuth V and Metzinger L: miR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells. Circ Cardiovasc Genet. 4:197–205. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Chan MC, Hilyard AC, Wu C, et al: Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 29:559–573. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Chan MC, Nguyen PH, Davis BN, et al: A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 27:5776–5789. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Leeper NJ, Raiesdana A, Kojima Y, et al: MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J Cell Physiol. 226:1035–1043. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Cheng Y, Zhang S, Lin Y, Yang J and Zhang C: A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res. 104:476–487. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Davis BN, Hilyard AC, Nguyen PH, Lagna G and Hata A: Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 284:3728–3738. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Cheng Y, Yang J, Xu L and Zhang C: Cell-specific effects of miR-221/222 in vessels: molecular mechanism and therapeutic application. J Mol Cell Cardiol. 52:245–255. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Tanner FC, Yang ZY, Duckers E, Gordon D, Nabel GJ and Nabel EG: Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ Res. 82:396–403. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Stewart MC, Kadlcek RM, Robbins PD, MacLeod JN and Ballock RT: Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation. J Bone Miner Res. 19:123–132. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ashman LK: The biology of stem cell factor and its receptor c-kit. Int J Biochem Cell Biol. 31:1037–1051. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Yang G, Pei Y, Cao Q and Wang R: MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells. J Cell Physiol. 227:3192–3200. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ji R, Cheng Y, Yue J, et al: MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation. Circ Res. 100:1579–1588. 2007. View Article : Google Scholar | |
|
Davis BN, Hilyard AC, Lagna G and Hata A: SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 454:56–61. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ozpolat B, Akar U, Steiner M, et al: Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res. 5:95–108. 2007. View Article : Google Scholar | |
|
Cash AC and Andrews J: Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals programmed cell death 4 promotes the differentiation of female germline stem cells. BMC Dev Biol. 12:42012. | |
|
Curcio A, Torella D and Indolfi C: Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy. Circ J. 75:1287–1296. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Cheng Y, Chen X, Yang J, Xu L and Zhang C: MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2. J Biol Chem. 286:42371–42380. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
An Y, Kang Q, Zhao Y, Hu X and Li N: Lats2 modulates adipocyte proliferation and differentiation via hippo signaling. PloS One. 8:e720422013. View Article : Google Scholar : PubMed/NCBI | |
|
Wu WH, Hu CP, Chen XP, et al: MicroRNA-130a mediates proliferation of vascular smooth muscle cells in hypertension. Am J Hypertens. 24:1087–1093. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Weir L, Chen D, Pastore C, Isner JM and Walsh K: Expression of gax, a growth arrest homeobox gene, is rapidly downregulated in the rat carotid artery during the proliferative response to balloon injury. J Biol Chem. 270:5457–5461. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Xia S, Tai X, Wang Y, et al: Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells. Am J Respir Cell Mol Biol. 44:66–73. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Saito T, Itoh H, Yamashita J, et al: Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK). Regul Pept. 127:159–167. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Gorski DH, LePage DF, Patel CV, Copeland NG, Jenkins NA and Walsh K: Molecular cloning of a diverged homeobox gene that is rapidly downregulated during the G0/G1 transition in vascular smooth muscle cells. Mol Cell Biol. 13:3722–3733. 1993.PubMed/NCBI | |
|
Yamashita J, Itoh H, Ogawa Y, et al: Opposite regulation of Gax homeobox expression by angiotensin II and C-type natriuretic peptide. Hypertension. 29:381–387. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Witzenbichler B, Kureishi Y, Luo Z, Le Roux A, Branellec D and Walsh K: Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor. J Clin Invest. 104:1469–1480. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Wassmann S, Wassmann K, Jung A, et al: Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. J Mol Cell Cardiol. 43:301–307. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Sun SG, Zheng B, Han M, et al: miR-146a and Krüppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation. EMBO Rep. 12:56–62. 2011. | |
|
Zhang Y, Wang Y, Wang X, et al: Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated downregulation of p21. J Hypertens. 29:1560–1568. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng X, Li A, Zhao L, et al: Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. Biochem Biophys Res Commun. 437:625–631. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng Y, Liu X, Yang J, et al: MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res. 105:158–166. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Quintavalle M, Elia L, Condorelli G and Courtneidge SA: MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol. 189:13–22. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wang YS, Chou WW, Chen KC, Cheng HY, Lin RT and Juo SH: MicroRNA-152 mediates DNMT1-regulated DNA methylation in the estrogen receptor α gene. PloS One. 7:e306352012.PubMed/NCBI | |
|
Li E, Bestor TH and Jaenisch R: Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 69:915–926. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Huang RS, Hu GQ, Lin B, Lin ZY and Sun CC: MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized low-density lipoprotein-stimulated human THP-1 macrophages. J Investig Med. 58:961–967. 2010.PubMed/NCBI | |
|
Ma X, Ma C and Zheng X: MicroRNA-155 in the pathogenesis of atherosclerosis: a conflicting role? Heart Lung Circ. 22:811–818. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Remus EW, Lyle AN, Weiss D, et al: miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells. Atherosclerosis. 228:168–174. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang YS, Wang HY, Liao YC, et al: MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation. Cardiovasc Res. 95:517–526. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ammit AJ and Panettieri RA Jr: Invited review: the circle of life: cell cycle regulation in airway smooth muscle. J Appl Physiol (1985). 91:1431–1437. 2001.PubMed/NCBI | |
|
Chotani MA, Touhalisky K and Chiu IM: The small GTPases Ras, Rac, and Cdc42 transcriptionally regulate expression of human fibroblast growth factor 1. J Biol Chem. 275:30432–30438. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Lindner V and Reidy MA: Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci USA. 88:3739–3743. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Hanna AK, Fox JC, Neschis DG, Safford SD, Swain JL and Golden MA: Antisense basic fibroblast growth factor gene transfer reduces neointimal thickening after arterial injury. J Vasc Surg. 25:320–325. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Merlet E, Atassi F, Motiani RK, et al: miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat. Cardiovasc Res. 98:458–468. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Q, Fu H, Sun F, et al: miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic acids Res. 36:5391–5404. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sahoo SK, Kim T, Kang GB, Lee JG, Eom SH and Kim do H: Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum. J Biol Chem. 284:31109–31121. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Y, Chen D, Cao L, et al: miR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A. Cardiovasc Res. 100:272–279. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Li P, Liu Y, Yi B, et al: MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1. Cardiovasc Res. 99:185–193. 2013. View Article : Google Scholar | |
|
Bonta PI, Pols TW and de Vries CJ: NR4A nuclear receptors in atherosclerosis and vein-graft disease. Trends Cardiovasc Med. 17:105–111. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Yu ML, Wang JF, Wang GK, et al: Vascular smooth muscle cell proliferation is influenced by let-7d microRNA and its interaction with KRAS. Circ J. 75:703–709. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Doe Z, Fukumoto Y, Takaki A, et al: Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ J. 73:1731–1739. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou YC and Waxman DJ: Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated by stat5b. J Biol Chem. 274:2672–2681. 1999. | |
|
Chen KC, Hsieh IC, Hsi E, et al: Negative feedback regulation between microRNA let-7g and the oxLDL receptor LOX-1. J Cell Sci. 124:4115–4124. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Mehta JL, Chen J, Hermonat PL, Romeo F and Novelli G: Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc Res. 69:36–45. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Mehta JL and Li DY: Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells. Biochem Biophys Res Commun. 248:511–514. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Tan KS, Armugam A, Sepramaniam S, et al: Expression profile of MicroRNAs in young stroke patients. PloS One. 4:e76892009. View Article : Google Scholar : PubMed/NCBI | |
|
Urbich C, Kuehbacher A and Dimmeler S: Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 79:581–588. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Chen KC, Wang YS, Hu CY, et al: OxLDL upregulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases. FASEB J. 25:1718–1728. 2011. View Article : Google Scholar | |
|
Aoyagi M, Yamamoto M, Azuma H, et al: Immunolocalization of matrix metalloproteinases in rabbit carotid arteries after balloon denudation. Histochem Cell Biol. 109:97–102. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Gimona M, Kaverina I, Resch GP, Vignal E and Burgstaller G: Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells. Mol Biol Cell. 14:2482–2491. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Linder S and Aepfelbacher M: Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol. 13:376–385. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Kunugi S, Iwabuchi S, Matsuyama D, Okajima T and Kawahara K: Negative-feedback regulation of ATP release: ATP release from cardiomyocytes is strictly regulated during ischemia. Biochem Biophys Res Commun. 416:409–415. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bennett MR: Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture. Cardiovasc Res. 41:361–368. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Fuster V: Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation. 90:2126–2146. 1994.PubMed/NCBI | |
|
Davies MJ, Richardson PD, Woolf N, Katz DR and Mann J: Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J. 69:377–381. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Geng YJ and Libby P: Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am J Pathol. 147:251–266. 1995.PubMed/NCBI | |
|
Sedding DG, Widmer-Teske R, Mueller A, et al: Role of the phosphatase PTEN in early vascular remodeling. PloS One. 8:e554452013. View Article : Google Scholar : PubMed/NCBI | |
|
Geng YJ: Molecular signal transduction in vascular cell apoptosis. Cell Res. 11:253–264. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Clowes AW, Clowes MM, Fingerle J and Reidy MA: Regulation of smooth muscle cell growth in injured artery. J Cardiovasc Pharmacol. 14(Suppl 6): S12–S15. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Liu G, Chou IN and Kagan HM: Hydrogen peroxide-mediated, lysyl oxidase-dependent chemotaxis of vascular smooth muscle cells. J Cell Biochem. 78:550–557. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Lazarus HM, Cruikshank WW, Narasimhan N, Kagan HM and Center DM: Induction of human monocyte motility by lysyl oxidase. Matrix Biol. 14:727–731. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Kothapalli D, Liu SL, Bae YH, et al: Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep. 2:1259–1271. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Iyemere VP, Proudfoot D, Weissberg PL and Shanahan CM: Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification. J Intern Med. 260:192–210. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Du Y, Gao C, Liu Z, et al: Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification. Arterioscler Thromb Vasc Biol. 32:2580–2588. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zheng J, Bai X, et al: ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries. Circ Res. 104:688–698. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Liu CJ, Kong W, Ilalov K, et al: ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. FASEB J. 20:988–990. 2006. View Article : Google Scholar | |
|
Du Y, Wang Y, Wang L, et al: Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2. Circ Res. 108:917–928. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Villeneuve LM, Kato M, Reddy MA, Wang M, Lanting L and Natarajan R: Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes. 59:2904–2915. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Goettsch C, Rauner M, Pacyna N, Hempel U, Bornstein SR and Hofbauer LC: miR-125b regulates calcification of vascular smooth muscle cells. Ame J Pathol. 179:1594–1600. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu F, Friedman MS, Luo W, Woolf P and Hankenson KD: The transcription factor osterix (SP7) regulates BMP6-induced human osteoblast differentiation. J Cell Physiol. 227:2677–2685. 2012. View Article : Google Scholar : PubMed/NCBI |
