|
1
|
Siegel R, Ward E, Brawley O and Jemal A:
Cancer statistics, 2011: the impact of eliminating socioeconomic
and racial disparities on premature cancer deaths. CA Cancer J
Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Marquardt JU, Galle PR and Teufel A:
Molecular diagnosis and therapy of hepatocellular carcinoma (HCC):
an emerging field for advanced technologies. J Hepatol. 56:267–275.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wang YH, Dong YY, Wang WM, et al: Vascular
endothelial cells facilitated HCC invasion and metastasis through
the Akt and NF-κB pathways induced by paracrine cytokines. J Exp
Clin Cancer Res. 32:512013.PubMed/NCBI
|
|
4
|
Chen JS, Huang XH, Wang Q, et al: Sonic
hedgehog signaling pathway induces cell migration and invasion
through focal adhesion kinase/AKT signaling-mediated activation of
matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer.
Carcinogenesis. 34:10–19. 2013. View Article : Google Scholar
|
|
5
|
Liu L, Dai Y, Chen J, et al: Maelstrom
promotes hepatocellular carcinoma metastasis by inducing
epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail
signaling. Hepatology. 59:531–543. 2014.PubMed/NCBI
|
|
6
|
Bolós V, Grego-Bessa J and de la Pompa JL:
Notch signaling in development and cancer. Endocr Rev. 28:339–363.
2007.
|
|
7
|
Hu YY, Zheng MH, Zhang R, Liang YM and Han
H: Notch signaling pathway and cancer metastasis. Adv Exp Med Biol.
727:186–198. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Wang XQ, Zhang W, Lui EL, et al:
Notch1-Snail1-E-cadherin pathway in metastatic hepatocellular
carcinoma. Int J Cancer. 131:E163–E172. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Zhou L, Wang DS, Li QJ, Sun W, Zhang Y and
Dou KF: Downregulation of the Notch signaling pathway inhibits
hepatocellular carcinoma cell invasion by inactivation of matrix
metalloproteinase-2 and -9 and vascular endothelial growth factor.
Oncol Rep. 28:874–882. 2012.
|
|
10
|
Ahn S, Hyeon J and Park CK: Notchl and
Notch4 are markers for poor prognosis of hepatocellular carcinoma.
Hepatobiliary Pancreat Dis Int. 12:286–294. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Fox V, Gokhale PJ, Walsh JR, Matin M,
Jones M and Andrews PW: Cell-cell signaling through NOTCH regulates
human embryonic stem cell proliferation. Stem Cells. 26:715–723.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Singh G and Chan AM: Post-translational
modifications of PTEN and their potential therapeutic implications.
Curr Cancer Drug Targets. 11:536–547. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Golubovskaya VM: Focal adhesion kinase as
a cancer therapy target. Anticancer Agents Med Chem. 10:735–741.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zhang L, Yu Q, He J and Zha X: Study of
the PTEN gene expression and FAK phosphorylation in human
hepatocarcinoma tissues and cell lines. Mol Cell Biochem.
262:25–33. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Wong R, Frenette C and Gish R:
Hepatocellular carcinoma: locoregional and targeted therapies.
Gastroenterol Clin North Am. 40:599–610. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Silva A, Jotta PY, Silveira AB, et al:
Regulation of PTEN by CK2 and Notch1 in primary T-cell acute
lymphoblastic leukemia: rationale for combined use of CK2-and
γ-secretase inhibitors. Haematologica. 95:674–678. 2010.PubMed/NCBI
|
|
17
|
Palomero T, Sulis ML, Cortina M, et al:
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in
T-cell leukemia. Nat Med. 13:1203–1210. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Wang L, Wang WL, Zhang Y, Guo SP, Zhang J
and Li QL: Epigenetic and genetic alterations of PTEN in
hepatocellular carcinoma. Hepatol Res. 37:389–396. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chow LM and Baker SJ: PTEN function in
normal and neoplastic growth. Cancer Lett. 241:184–196. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Hu TH, Huang CC, Lin PR, et al: Expression
and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1
in hepatocellular carcinoma. Cancer. 97:1929–1940. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Dong-Dong L, Xi-Ran Z and Xiang-Rong C:
Expression and significance of new tumor suppressor gene PTEN in
primary liver cancer. J Cell Mol Med. 7:67–71. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Thanapprapasr D, Hu W, Sood AK and Coleman
RL: Moving beyond VEGF for anti-angiogenesis strategies in g
ynecologic cancer. Curr Pharm Des. 18:2713–2719. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Bai X, Wang J, Zhang L, et al:
Prostaglandin E2 receptor EP1-mediated phosphorylation
of focal adhesion kinase enhances cell adhesion and migration in
hepatocellular carcinoma cells. Int J Oncol. 42:1833–1841.
2013.
|
|
24
|
Zhang C, He H, Zhang H, et al: The
blockage of Ras/ERK pathway augments the sensitivity of SphK1
inhibitor SKI II in human hepatoma HepG2 cells. Biochem Biophys Res
Commun. 434:35–41. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Chen JS, Huang XH, Wang Q, et al: FAK is
involved in invasion and metastasis of hepatocellular carcinoma.
Clin Exp Metastasis. 27:71–82. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lau GM, Lau GM, Yu GL, et al: Expression
of Src and FAK in hepatocellular carcinoma and the effect of Src
inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci.
54:1465–1474. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Han S, Han L, Yao Y, Sun H, Zan X and Liu
Q: Activated hepatic stellate cells promote hepatocellular
carcinoma cell migration and invasion via the activation of
FAK-MMP9 signaling. Oncol Rep. 31:641–648. 2014.PubMed/NCBI
|
|
28
|
Ko BS, Jan YJ, Chang TC, et al:
Upregulation of focal adhesion kinase by 14-3-3ɛ via NFκB
activation in hepatocellular carcinoma. Anticancer Agents Med Chem.
13:555–562. 2013.PubMed/NCBI
|
|
29
|
Sheng SL, Liu JJ, Dai YH, Sun XG, Xiong XP
and Huang G: Knockdown of lactate dehydrogenase A suppresses tumor
growth and metastasis of human hepatocellular carcinoma. FEBS J.
279:3898–3910. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Xu HY, Qian AR, Shang P, et al: siRNA
targeted against HAb18G/CD147 inhibits MMP-2 secretion, actin and
FAK expression in hepatocellular carcinoma cell line via ERK1/2
pathway. Cancer Lett. 247:336–344. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chetram MA and Hinton CV: PTEN regulation
of ERK1/2 signaling in cancer. J Recept Signal Transduct Res.
32:190–195. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Tamura M, Gu J, Danen EHJ, et al: PTEN
interactions with focal adhesion kinase and suppression of the
extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt
cell survival pathway. J Biol Chem. 274:20693–20703. 1999.
View Article : Google Scholar : PubMed/NCBI
|
