|
1
|
Solt LA, Griffin PR and Burris TP: Ligand
regulation of retinoic acid receptor-related orphan receptors:
implications for development of novel therapeutics. Curr Opin
Lipidol. 21:204–211. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Becker-André M, André E and DeLamarter JF:
Identification of nuclear receptor mRNAs by RT-PCR amplification of
conserved zinc-finger motif sequences. Biochem Biophys Res Commun.
194:1371–1379. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Carlberg C, Hooft van Huijsduijnen R,
Staple JK, DeLamarter JF and Becker-André M: RZRs, a new family of
retinoid-related orphan receptors that function as both monomers
and homodimers. Mol Endocrinol. 8:757–770. 1994.PubMed/NCBI
|
|
4
|
Jetten AM and Ueda E: Retinoid-related
orphan receptors (RORs): roles in cell survival, differentiation
and disease. Cell Death Differ. 9:1167–1171. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Jetten AM, Kurebayashi S and Ueda E: The
ROR nuclear orphan receptor subfamily: critical regulators of
multiple biological processes. Prog Nucleic Acid Res Mol Biol.
69:205–247. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Giguère V: Orphan nuclear receptors: from
gene to function. Endocr Rev. 20:689–725. 1999.PubMed/NCBI
|
|
7
|
Gawlas K and Stunnenberg HG: Differential
transcription of the orphan receptor RORbeta in nuclear extracts
derived from Neuro2A and HeLa cells. Nucleic Acids Res.
29:3424–3432. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Gawlas K and Stunnenberg HG: Differential
binding and transcriptional behaviour of two highly related orphan
receptors, ROR alpha(4) and ROR beta(1). Biochim Biophys Acta.
1494:236–241. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Stehlin C, Wurtz JM, Steinmetz A, et al:
X-ray structure of the orphan nuclear receptor RORbeta
ligand-binding domain in the active conformation. EMBO J.
20:5822–5831. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Sullivan AA and Thummel CS: Temporal
profiles of nuclear receptor gene expression reveal coordinate
transcriptional responses during Drosophila development. Mol
Endocrinol. 17:2125–2137. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Palli SR, Ladd TR and Retnakaran A:
Cloning and characterization of a new isoform of Choristoneura
hormone receptor 3 from the spruce budworm. Arch Insect Biochem
Physiol. 35:33–44. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Hiruma K and Riddiford LM: Differential
control of MHR3 promoter activity by isoforms of the ecdysone
receptor and inhibitory effects of E75A and MHR3. Dev Biol.
272:510–521. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Flores MV, Hall C, Jury A, Crosier K and
Crosier P: The zebrafish retinoid-related orphan receptor (ror)
gene family. Gene Expr Patterns. 7:535–543. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Jetten AM: Recent advances in the
mechanisms of action and physiological functions of the
retinoid-related orphan receptors (RORs). Curr Drug Targets Inflamm
Allergy. 3:395–412. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Solt LA, Kojetin DJ and Burris TP: The
REV-ERBs and RORs: molecular links between circadian rhythms and
lipid homeostasis. Future Med Chem. 3:623–638. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Tosini G, Davidson AJ, Fukuhara C,
Kasamatsu M and Castanon-Cervantes O: Localization of a circadian
clock in mammalian photoreceptors. FASEB J. 21:3866–3871. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Vogel MW, Sinclair M, Qiu D and Fan H:
Purkinje cell fate in staggerer mutants: agenesis versus cell
death. J Neurobiol. 42:323–337. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Ino H: Immunohistochemical
characterization of the orphan nuclear receptor ROR alpha in the
mouse nervous system. J Histochem Cytochem. 52:311–323. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Kang HS, Angers M, Beak JY, et al: Gene
expression profiling reveals a regulatory role for ROR alpha and
ROR gamma in phase I and phase II metabolism. Physiol Genomics.
31:281–294. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
André E, Gawlas K and Becker-André M: A
novel isoform of the orphan nuclear receptor RORbeta is
specifically expressed in pineal gland and retina. Gene.
216:277–283. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chow L, Levine EM and Reh TA: The nuclear
receptor transcription factor, retinoid-related orphan receptor
beta, regulates retinal progenitor proliferation. Mech Dev.
77:149–164. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Baler R, Coon S and Klein DC: Orphan
nuclear receptor RZRbeta: cyclic AMP regulates expression in the
pineal gland. Biochem Biophys Res Commun. 220:975–978. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Mühlbauer E, Bazwinsky-Wutschke I, Wolgast
S, Labucay K and Peschke E: Differential and day-time dependent
expression of nuclear receptors RORalpha, RORbeta, RORgamma and
RXRalpha in the rodent pancreas and islet. Mol Cell Endocrinol.
365:129–138. 2013. View Article : Google Scholar
|
|
24
|
André E, Conquet F, Steinmayr M, Stratton
SC, Porciatti V and Becker-André M: Disruption of retinoid-related
orphan receptor beta changes circadian behavior, causes retinal
degeneration and leads to vacillans phenotype in mice. EMBO J.
17:3867–3877. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Masana MI, Sumaya IC, Becker-André M and
Dubocovich ML: Behavioral characterization and modulation of
circadian rhythms by light and melatonin in C3H/HeN mice homozygous
for the RORbeta knockout. Am J Physiol Regul Integr Comp Physiol.
292:R2357–R2367. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Stehlin-Gaon C, Willmann D, Zeyer D, et
al: All-trans retinoic acid is a ligand for the orphan nuclear
receptor ROR beta. Nat Struct Biol. 10:820–825. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wärnmark A, Treuter E, Wright AP and
Gustafsson JA: Activation functions 1 and 2 of nuclear receptors:
molecular strategies for transcriptional activation. Mol
Endocrinol. 17:1901–1909. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Watanabe M, Yanagisawa J, Kitagawa H, et
al: A subfamily of RNA-binding DEAD-box proteins acts as an
estrogen receptor alpha coactivator through the N-terminal
activation domain (AF-1) with an RNA coactivator, SRA. EMBO J.
20:1341–1352. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Nishihara E, O’Malley BW and Xu J: Nuclear
receptor coregulators are new players in nervous system development
and function. Mol Neurobiol. 30:307–325. 2004. View Article : Google Scholar
|
|
30
|
Kurebayashi S, Nakajima T, Kim SC, et al:
Selective LXXLL peptides antagonize transcriptional activation by
the retinoid-related orphan receptor RORgamma. Biochem Biophys Res
Commun. 315:919–927. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Greiner EF, Kirfel J, Greschik H, et al:
Differential ligand-dependent protein-protein interactions between
nuclear receptors and a neuronal-specific cofactor. Proc Natl Acad
Sci USA. 97:7160–7165. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Heery DM, Hoare S, Hussain S, Parker MG
and Sheppard H: Core LXXLL motif sequences in CREB-binding protein,
SRC1, and RIP140 define affinity and selectivity for steroid and
retinoid receptors. J Biol Chem. 276:6695–6702. 2001. View Article : Google Scholar
|
|
33
|
Torchia J, Rose DW, Inostroza J, et al:
The transcriptional co-activator p/CIP binds CBP and mediates
nuclear-receptor function. Nature. 387:677–684. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Glass CK, Rose DW and Rosenfeld MG:
Nuclear receptor coactivators. Curr Opin Cell Biol. 9:222–232.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Gabriely G, Kama R, Gelin-Licht R and
Gerst JE: Different domains of the UBL-UBA ubiquitin receptor,
Ddi1/Vsm1, are involved in its multiple cellular roles. Mol Biol
Cell. 19:3625–3637. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Akashi M and Takumi T: The orphan nuclear
receptor RORalpha regulates circadian transcription of the
mammalian core-clock Bmal1. Nat Struct Mol Biol. 12:441–448. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Eberl G, Marmon S, Sunshine MJ, Rennert
PD, Choi Y and Littman DR: An essential function for the nuclear
receptor RORgamma(t) in the generation of fetal lymphoid tissue
inducer cells. Nat Immunol. 5:64–73. 2004. View Article : Google Scholar
|
|
38
|
Liu H, Kim SY, Fu Y, et al: An isoform of
retinoid-related orphan receptor beta directs differentiation of
retinal amacrine and horizontal interneurons. Nat Commun.
4:18132013. View Article : Google Scholar
|
|
39
|
Roforth MM, Khosla S and Monroe DG:
Identification of Rorβ targets in cultured osteoblasts and in human
bone. Biochem Biophys Res Commun. 440:768–773. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Davidson B, Abeler VM, Forsund M, et al:
Gene expression signatures of primary and metastatic uterine
leiomyosarcoma. Hum Pathol. 45:691–700. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Jetten AM: Retinoid-related orphan
receptors (RORs): critical roles in development, immunity,
circadian rhythm, and cellular metabolism. Nucl Recept Signal.
7:e0032009.PubMed/NCBI
|
|
42
|
Oh EC, Khan N, Novelli E, Khanna H,
Strettoi E and Swaroop A: Transformation of cone precursors to
functional rod photoreceptors by bZIP transcription factor NRL.
Proc Natl Acad Sci USA. 104:1679–1684. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Jia L, Oh EC, Ng L, et al:
Retinoid-related orphan nuclear receptor RORbeta is an early-acting
factor in rod photoreceptor development. Proc Natl Acad Sci USA.
106:17534–17539. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Roforth MM, Liu G, Khosla S and Monroe DG:
Examination of nuclear receptor expression in osteoblasts reveals
Rorbeta as an important regulator of osteogenesis. J Bone Miner
Res. 27:891–901. 2012. View Article : Google Scholar
|
|
45
|
Komori T, Yagi H, Nomura S, et al:
Targeted disruption of Cbfa1 results in a complete lack of bone
formation owing to maturational arrest of osteoblasts. Cell.
89:755–764. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Munger JS, Harpel JG, Gleizes PE, Mazzieri
R, Nunes I and Rifkin DB: Latent transforming growth factor-beta:
structural features and mechanisms of activation. Kidney Int.
51:1376–1382. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Risinger JI, Allard J, Chandran U, et al:
Gene expression analysis of early stage endometrial cancers reveals
unique transcripts associated with grade and histology but not
depth of invasion. Front Oncol. 3:1392013. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Matijevic T and Pavelic J: The dual role
of TLR3 in metastatic cell line. Clin Exp Metastasis. 28:701–712.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Kimmel AR: An orphan nuclear receptor
finds a home. Mol Cell. 37:155–157. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
McDonald SL and Silver A: The opposing
roles of Wnt-5a in cancer. Br J Cancer. 101:209–214. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Lee JM, Kim IS, Kim H, et al: RORalpha
attenuates Wnt/beta-catenin signaling by PKCalpha-dependent
phosphorylation in colon cancer. Mol Cell. 37:183–195. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Gery S and Koeffler HP: The role of
circadian regulation in cancer. Cold Spring Harb Symp Quant Biol.
72:459–464. 2007. View Article : Google Scholar
|
|
53
|
Kettner NM, Katchy CA and Fu L: Circadian
gene variants in cancer. Ann Med. 46:208–220. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Fu L and Kettner NM: The circadian clock
in cancer development and therapy. Prog Mol Biol Transl Sci.
119:221–282. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Ueda HR, Hayashi S, Chen W, et al:
System-level identification of transcriptional circuits underlying
mammalian circadian clocks. Nat Genet. 37:187–192. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Shearman LP, Sriram S, Weaver DR, et al:
Interacting molecular loops in the mammalian circadian clock.
Science. 288:1013–1019. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Reick M, Garcia JA, Dudley C and McKnight
SL: NPAS2: an analog of clock operative in the mammalian forebrain.
Science. 293:506–509. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Nakahata Y, Kaluzova M, Grimaldi B, et al:
The NAD+-dependent deacetylase SIRT1 modulates
CLOCK-mediated chromatin remodeling and circadian control. Cell.
134:329–340. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Asher G, Gatfield D, Stratmann M, et al:
SIRT1 regulates circadian clock gene expression through PER2
deacetylation. Cell. 134:317–328. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Rana S and Mahmood S: Circadian rhythm and
its role in malignancy. J Circadian Rhythms. 8:32010. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Pukkala E, Aspholm R, Auvinen A, et al:
Cancer incidence among 10,211 airline pilots: a Nordic study. Aviat
Space Environ Med. 74:699–706. 2003.PubMed/NCBI
|
|
62
|
Viswanathan AN, Hankinson SE and
Schernhammer ES: Night shift work and the risk of endometrial
cancer. Cancer Res. 67:10618–10622. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Koppes LL, Geuskens GA, Pronk A, Vermeulen
RC and de Vroome EM: Night work and breast cancer risk in a general
population prospective cohort study in The Netherlands. Eur J
Epidemiol. 29:577–584. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Schernhammer ES, Laden F, Speizer FE, et
al: Night-shift work and risk of colorectal cancer in the nurses’
health study. J Natl Cancer Inst. 95:825–828. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Keith LG, Oleszczuk JJ and Laguens M:
Circadian rhythm chaos: a new breast cancer marker. Int J Fertil
Womens Med. 46:238–247. 2001.PubMed/NCBI
|
|
66
|
Zhu Y, Stevens RG, Hoffman AE, et al:
Epigenetic impact of long-term shiftwork: pilot evidence from
circadian genes and whole-genome methylation analysis. Chronobiol
Int. 28:852–861. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Shih MC, Yeh KT, Tang KP, Chen JC and
Chang JG: Promoter methylation in circadian genes of endometrial
cancers detected by methylation-specific PCR. Mol Carcinog.
45:732–740. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Hwang-Verslues WW, Chang PH, Jeng YM, et
al: Loss of core-pressor PER2 under hypoxia up-regulates
OCT1-mediated EMT gene expression and enhances tumor malignancy.
Proc Natl Acad Sci USA. 110:12331–12336. 2013. View Article : Google Scholar
|
|
69
|
Yang X, Wood PA, Oh EY, Du-Quiton J,
Ansell CM and Hrushesky WJ: Down regulation of circadian clock gene
Period 2 accelerates breast cancer growth by altering its daily
growth rhythm. Breast Cancer Res Treat. 117:423–431. 2009.
View Article : Google Scholar
|
|
70
|
Gery S, Virk RK, Chumakov K, Yu A and
Koeffler HP: The clock gene Per2 links the circadian system to the
estrogen receptor. Oncogene. 26:7916–7920. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Filipski E and Levi F: Circadian
disruption in experimental cancer processes. Integr Cancer Ther.
8:298–302. 2009. View Article : Google Scholar
|
|
72
|
Kumaki Y, Ukai-Tadenuma M, Uno KD, et al:
Analysis and synthesis of high-amplitude Cis-elements in the
mammalian circadian clock. Proc Natl Acad Sci USA. 105:14946–14951.
2008. View Article : Google Scholar : PubMed/NCBI
|
