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Article

Loss of ancestral N-glycosylation sites in conserved proteins during human evolution

  • Authors:
    • Dong Seon Kim
    • Dongjin Choi
    • Yoonsoo Hahn
  • View Affiliations / Copyright

    Affiliations: Department of Life Science, Research Center for Biomolecules and Biosystems, Chung-Ang University, Seoul 156-756, Republic of Korea
  • Pages: 1685-1692
    |
    Published online on: October 7, 2015
       https://doi.org/10.3892/ijmm.2015.2362
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Abstract

N-linked protein glycosylation is involved in various biological processes, such as protein quality control and adhesion or signaling among cells. The loss of ancestrally conserved N-glycosylation sites may result in the evolution of protein structure and function. In the present study, a mouse glycoproteome dataset and mammalian proteome data were assessed to identify 40 ancestral N-glycosylation sites in 37 proteins that disappeared during human evolution since the last common ancestor of the Euarchonta (primates and treeshrews). The results showed that each of the human proteins, CELSR1, ST3GAL5 and VSIG10, lost an ancestrally conserved N-glycosylation site following human-chimpanzee divergence. Notably, CELSR1 and ST3GAL5 are crucial for normal development and function of the mammalian nervous system, suggesting an association with the evolution of human cognitive function. Thus, the lost ancestrally conserved N-glycosylation sites identified in the present study may be useful targets for functional analyses to identify molecular changes linked with the evolution of human phenotypes.
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Copy and paste a formatted citation
Spandidos Publications style
Kim DS, Choi D and Hahn Y: Loss of ancestral N-glycosylation sites in conserved proteins during human evolution. Int J Mol Med 36: 1685-1692, 2015.
APA
Kim, D.S., Choi, D., & Hahn, Y. (2015). Loss of ancestral N-glycosylation sites in conserved proteins during human evolution. International Journal of Molecular Medicine, 36, 1685-1692. https://doi.org/10.3892/ijmm.2015.2362
MLA
Kim, D. S., Choi, D., Hahn, Y."Loss of ancestral N-glycosylation sites in conserved proteins during human evolution". International Journal of Molecular Medicine 36.6 (2015): 1685-1692.
Chicago
Kim, D. S., Choi, D., Hahn, Y."Loss of ancestral N-glycosylation sites in conserved proteins during human evolution". International Journal of Molecular Medicine 36, no. 6 (2015): 1685-1692. https://doi.org/10.3892/ijmm.2015.2362
Copy and paste a formatted citation
x
Spandidos Publications style
Kim DS, Choi D and Hahn Y: Loss of ancestral N-glycosylation sites in conserved proteins during human evolution. Int J Mol Med 36: 1685-1692, 2015.
APA
Kim, D.S., Choi, D., & Hahn, Y. (2015). Loss of ancestral N-glycosylation sites in conserved proteins during human evolution. International Journal of Molecular Medicine, 36, 1685-1692. https://doi.org/10.3892/ijmm.2015.2362
MLA
Kim, D. S., Choi, D., Hahn, Y."Loss of ancestral N-glycosylation sites in conserved proteins during human evolution". International Journal of Molecular Medicine 36.6 (2015): 1685-1692.
Chicago
Kim, D. S., Choi, D., Hahn, Y."Loss of ancestral N-glycosylation sites in conserved proteins during human evolution". International Journal of Molecular Medicine 36, no. 6 (2015): 1685-1692. https://doi.org/10.3892/ijmm.2015.2362
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