Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2015 Volume 36 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2015 Volume 36 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods

  • Authors:
    • Jiaxuan He
    • Rongliang Xue
    • Siyuan Li
    • Jianrui Lv
    • Yong Zhang
    • Liying Fan
    • Yunpeng Teng
    • Haidong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
  • Pages: 1593-1600
    |
    Published online on: October 22, 2015
       https://doi.org/10.3892/ijmm.2015.2389
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to explore potential molecular targets and gain further insights into the mechanism of intervertebral disc degeneration (IDD) progression. Microarray datasets of GSE19943, GSE15227 and GSE34095 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in 3 IDD specimens compared with 3 controls in GSE34095, DEGs in 7 grade III and 3 grade IV samples compared with 5 grade II samples in GSE19943, and differentially expressed miRNAs in 3 degenerated samples compared with 3 controls in GSE15227 were screened. Grade III‑ and IV‑specific networks were constructed and grade‑specific genes were extracted. The network features were analyzed, followed by Gene Ontology (GO) enrichment analysis and pathway enrichment analysis of grade‑specific genes and DEGs identified in GSE34095. Furthermore, miRNA‑pathway interactions were analyzed using Fisher's exact test. Tumor protein p53 (TP53) was a hub gene in the grade III‑specific network and ubiquitin C (UBC) was identified to be a hub gene in the grade IV‑specific network. Six significant features were identified by grade‑specific network topology analysis. Grade‑specific genes and DEGs were involved in different GO terms and pathways. Differentially expressed miRNAs were identified to participate in 35 pathways, among which 6 pathways were significantly enriched by DEGs, including apoptosis. The present study identified that key genes (TP53 and UBC) and miR‑129‑5p may participate in the mechanism of IDD progression. Thus, they may be potential therapeutic targets for IDD.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Hadjipavlou AG, Tzermiadianos MN, Bogduk N and Zindrick MR: The pathophysiology of disc degeneration: A critical review. J Bone Joint Surg Br. 90:1261–1270. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Wang SZ, Rui YF, Tan Q and Wang C: Enhancing intervertebral disc repair and regeneration through biology: Platelet-rich plasma as an alternative strategy. Arthritis Res Ther. 15:2202013. View Article : Google Scholar : PubMed/NCBI

3 

Yorimitsu E, Chiba K, Toyama Y and Hirabayashi K: Long-term outcomes of standard discectomy for lumbar disc herniation: A follow-up study of more than 10 years. Spine. 26:652–657. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Karasek M and Bogduk N: Twelve-month follow-up of a controlled trial of intradiscal thermal anuloplasty for back pain due to internal disc disruption. Spine. 25:2601–2607. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Anderson PA and Rouleau JP: Intervertebral disc arthroplasty. Spine. 29:2779–2786. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Shimer AL, Chadderdon RC, Gilbertson LG and Kang JD: Gene therapy approaches for intervertebral disc degeneration. Spine. 29:2770–2778. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Choi YS: Pathophysiology of degenerative disc disease. Asian Spine J. 3:39–44. 2009. View Article : Google Scholar

8 

Tang Y, Wang S, Liu Y and Wang X: Microarray analysis of genes and gene functions in disc degeneration. Exp Ther Med. 7:343–348. 2014.PubMed/NCBI

9 

Antoniou J, Epure LM, Michalek AJ, Grant MP, Iatridis JC and Mwale F: Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration. J Magn Reson Imaging. 38:1402–1414. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IK and Bishop PB: Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine. 15:411–415. 1990. View Article : Google Scholar : PubMed/NCBI

11 

Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J and Boos N: Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 26:1873–1878. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Adams MA and Roughley PJ: What is intervertebral disc degeneration, and what causes it? Spine. 31:2151–2161. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Bachmeier BE, Nerlich A, Mittermaier N, Weiler C, Lumenta C, Wuertz K and Boos N: Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration. Eur Spine J. 18:1573–1586. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Takahashi M, Haro H, Wakabayashi Y, Kawauchi T, Komori H and Shinomiya K: The association of degeneration of the inter-vertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. J Bone Joint Surg Br. 83:491–495. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Pratsinis H and Kletsas D: PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways. Eur Spine J. 16:1858–1866. 2007. View Article : Google Scholar : PubMed/NCBI

16 

van Rooij E and Kauppinen S: Development of microRNA therapeutics is coming of age. EMBO Mol Med. 6:851–864. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Yu X, Li Z, Shen J, Wu WK, Liang J, Weng X and Qiu G: MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PLoS One. 8:e830802013. View Article : Google Scholar :

18 

Chen Y, Chen K, Li M, Li C, Ma H, Bai YS, Zhu XD and Fu Q: Genes associated with disc degeneration identified using microarray gene expression profiling and bioinformatics analysis. Genet Mol Res. 12:1431–1439. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Wang HQ, Yu XD, Liu ZH, Cheng X, Samartzis D, Jia LT, Wu SX, Huang J, Chen J and Luo ZJ: Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. J Pathol. 225:232–242. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Gruber HE, Hoelscher G, Loeffler B, Chow Y, Ingram JA, Halligan W and Hanley EN Jr: Prostaglandin E1 and misoprostol increase epidermal growth factor production in 3D-cultured human annulus cells. Spine J. 9:760–766. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Tsai TT, Lai PL, Liao JC, Fu TS, Niu CC, Chen LH, Lee MS, Chen WJ, Fang HC, Ho NY, et al: Increased periostin gene expression in degenerative intervertebral disc cells. Spine J. 13:289–298. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S: Bioinformatics and computational biology solutions using R and Bioconductor. Springer; 2005, View Article : Google Scholar

23 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc B. 57:289–300. 1995.

24 

Xiao F, Zuo Z, Cai G, Kang S, Gao X and Li T: miRecords: An integrated resource for microRNA-target interactions. Nucleic Acids Res. 37:D105–D110. 2009. View Article : Google Scholar

25 

Hsu SD, Lin FM, Wu WY, Liang C, Huang WC, Chan WL, Tsai WT, Chen GZ, Lee CJ, Chiu CM, et al: miRTarBase: A database curates experimentally validated microRNA-target interactions. Nucleic Acids Res. 39:D163–D169. 2011. View Article : Google Scholar

26 

Vergoulis T, Vlachos IS, Alexiou P, Georgakilas G, Maragkakis M, Reczko M, Gerangelos S, Koziris N, Dalamagas T and Hatzigeorgiou AG: TarBase 6.0: Capturing the exponential growth of miRNA targets with experimental support. Nucleic Acids Res. 40:D222–D229. 2012. View Article : Google Scholar :

27 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar

28 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar :

29 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C, et al: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:D808–D815. 2013. View Article : Google Scholar :

30 

Assenov Y, Ramírez F, Schelhorn S-E, Lengauer T and Albrecht M: Computing topological parameters of biological networks. Bioinformatics. 24:282–284. 2008. View Article : Google Scholar

31 

Huang Y, Pepe MS and Feng Z: Logistic regression analysis with standardized markers. Ann Appl Stat. 7:72013. View Article : Google Scholar

32 

Sherman BT, Huang da W, Tan Q, Guo Y, Bour S, Liu D, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID Knowledgebase: A gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinformatics. 8:4262007. View Article : Google Scholar : PubMed/NCBI

33 

Blevins L and McDonald C: Fisher's Exact Test: an easy-to-use statistical test for comparing outcomes. MD Comput. 2:151985.PubMed/NCBI

34 

Estrada E and Higham DJ: Network properties revealed through matrix functions. SIAM Rev. 52:696–714. 2010. View Article : Google Scholar

35 

Estrada E: Virtual identification of essential proteins within the protein interaction network of yeast. Proteomics. 6:35–40. 2006. View Article : Google Scholar

36 

Tailor A, Jurkovic D, Bourne TH, Collins WP and Campbell S: Sonographic prediction of malignancy in adnexal masses using multivariate logistic regression analysis. Ultrasound Obstet Gynecol. 10:41–47. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Dumont P, Leu JI, Della Pietra AC III, George DL and Murphy M: The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet. 33:357–365. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Vaghefi H and Neet KE: Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. Oncogene. 23:8078–8087. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Richardson SM, Doyle P, Minogue BM, Gnanalingham K and Hoyland JA: Increased expression of matrix metallopro-teinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther. 11:R1262009. View Article : Google Scholar

40 

Liu XW, Kang J, Fan XD and Sun LF: Expression and significance of VEGF and p53 in rat degenerated intervertebral disc tissues. Asian Pac J Trop Med. 6:404–406. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Marinovic AC, Zheng B, Mitch WE and Price SR: Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. J Biol Chem. 277:16673–16681. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Yew PR: Ubiquitin-mediated proteolysis of vertebrate G1- and S-phase regulators. J Cell Physiol. 187:1–10. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Gruber HE, Ingram JA, Norton HJ and Hanley EN Jr: Senescence in cells of the aging and degenerating intervertebral disc: Immunolocalization of senescence-associated β-galactosidase in human and sand rat discs. Spine. 32:321–327. 2007. View Article : Google Scholar

44 

Kohyama K, Saura R, Doita M and Mizuno K: Intervertebral disc cell apoptosis by nitric oxide: Biological understanding of inter-vertebral disc degeneration. Kobe J Med Sci. 46:283–295. 2000.

45 

Li M, Tian L, Wang L, Yao H, Zhang J, Lu J, Sun Y, Gao X, Xiao H and Liu M: Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC. PLoS One. 8:e778292013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He J, Xue R, Li S, Lv J, Zhang Y, Fan L, Teng Y and Wei H: Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods. Int J Mol Med 36: 1593-1600, 2015.
APA
He, J., Xue, R., Li, S., Lv, J., Zhang, Y., Fan, L. ... Wei, H. (2015). Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods. International Journal of Molecular Medicine, 36, 1593-1600. https://doi.org/10.3892/ijmm.2015.2389
MLA
He, J., Xue, R., Li, S., Lv, J., Zhang, Y., Fan, L., Teng, Y., Wei, H."Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods". International Journal of Molecular Medicine 36.6 (2015): 1593-1600.
Chicago
He, J., Xue, R., Li, S., Lv, J., Zhang, Y., Fan, L., Teng, Y., Wei, H."Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods". International Journal of Molecular Medicine 36, no. 6 (2015): 1593-1600. https://doi.org/10.3892/ijmm.2015.2389
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Xue R, Li S, Lv J, Zhang Y, Fan L, Teng Y and Wei H: Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods. Int J Mol Med 36: 1593-1600, 2015.
APA
He, J., Xue, R., Li, S., Lv, J., Zhang, Y., Fan, L. ... Wei, H. (2015). Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods. International Journal of Molecular Medicine, 36, 1593-1600. https://doi.org/10.3892/ijmm.2015.2389
MLA
He, J., Xue, R., Li, S., Lv, J., Zhang, Y., Fan, L., Teng, Y., Wei, H."Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods". International Journal of Molecular Medicine 36.6 (2015): 1593-1600.
Chicago
He, J., Xue, R., Li, S., Lv, J., Zhang, Y., Fan, L., Teng, Y., Wei, H."Identification of the potential molecular targets for human intervertebral disc degeneration based on bioinformatic methods". International Journal of Molecular Medicine 36, no. 6 (2015): 1593-1600. https://doi.org/10.3892/ijmm.2015.2389
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team