Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June-2016 Volume 37 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2016 Volume 37 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer

  • Authors:
    • Chen Chen
    • Hong Shen
    • Li-Guo Zhang
    • Jian Liu
    • Xiao-Ge Cao
    • An-Liang Yao
    • Shao-San Kang
    • Wei-Xing Gao
    • Hui Han
    • Feng-Hong Cao
    • Zhi-Guo Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China, Department of Modern Technology and Education Center, North China University of Science and Technology and International Science and Technology Cooperation Base of Geriatric Medicine, Tangshan, Hebei 063000, P.R. China, Tianjin Binhai New Area Hangu No. 1 High School, Tianjin 300480, P.R. China, Medical Research Center, North China University of Science and Technology and International Science and Technology Cooperation Base of Geriatric Medicine, Tangshan, Hebei 063000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1576-1586
    |
    Published online on: April 26, 2016
       https://doi.org/10.3892/ijmm.2016.2577
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Currently, using human prostate cancer (PCa) tissue samples to conduct proteomics research has generated a large amount of data; however, only a very small amount has been thoroughly investigated. In this study, we manually carried out the mining of the full text of proteomics literature that involved comparisons between PCa and normal or benign tissue and identified 41 differentially expressed proteins verified or reported more than 2 times from different research studies. We regarded these proteins as seed proteins to construct a protein-protein interaction (PPI) network. The extended network included one giant network, which consisted of 1,264 nodes connected via 1,744 edges, and 3 small separate components. The backbone network was then constructed, which was derived from key nodes and the subnetwork consisting of the shortest path between seed proteins. Topological analyses of these networks were conducted to identify proteins essential for the genesis of PCa. Solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4) had the highest closeness centrality located in the center of each network, and the highest betweenness centrality and largest degree in the backbone network. Tubulin, beta 2C (TUBB2C) had the largest degree in the giant network and subnetwork. In addition, using module analysis of the whole PPI network, we obtained a densely connected region. Functional annotation indicated that the Ras protein signal transduction biological process, mitogen-activated protein kinase (MAPK), neurotrophin and the gonadotropin-releasing hormone (GnRH) signaling pathway may play an important role in the genesis and development of PCa. Further investigation of the SLC2A4, TUBB2C proteins, and these biological processes and pathways may therefore provide a potential target for the diagnosis and treatment of PCa.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Smith RA, Manassaram-Baptiste D, Brooks D, Doroshenk M, Fedewa S, Saslow D, Brawley OW and Wender R: Cancer screening in the United States, 2015: A review of current American cancer society guidelines and current issues in cancer screening. CA Cancer J Clin. 65:30–54. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Davalieva K, Kiprijanovska S, Komina S, Petrusevska G, Zografska NC and Polenakovic M: Proteomics analysis of urine reveals acute phase response proteins as candidate diagnostic biomarkers for prostate cancer. Proteome Sci. 13(2)2015. View Article : Google Scholar : PubMed/NCBI

4 

Dihazi GH and Dihazi H: Protein-protein interaction networks improve the proteomics data interpretation in induced apoptosis. Expert Rev Proteomics. 7:177–180. 2010. View Article : Google Scholar : PubMed/NCBI

5 

von Mering C, Krause R, Snel B, Cornell M, Oliver SG, Fields S and Bork P: Comparative assessment of large-scale data sets of protein-protein interactions. Nature. 417:399–403. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Xin-Yu Y and Zheng-Ping X: An introduction to protein-protein interaction database and its application. Chin J Biochem Mol Biol. 24:189–196. 2008.

7 

Rakshit H, Rathi N and Roy D: Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease. PLoS One. 9:e1030472014. View Article : Google Scholar : PubMed/NCBI

8 

Sun J and Zhao Z: A comparative study of cancer proteins in the human protein-protein interaction network. BMC Genomics. 11(Suppl 3): S52010. View Article : Google Scholar

9 

Lee SA, Tsao TT, Yang KC, Lin H, Kuo YL, Hsu CH, Lee WK, Huang KC and Kao CY: Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression. BMC Bioinformatics. 12(Suppl 13): S202011. View Article : Google Scholar

10 

Ran J, Li H, Fu J, Liu L, Xing Y, Li X, Shen H, Chen Y, Jiang X, Li Y, et al: Construction and analysis of the protein-protein interaction network related to essential hypertension. BMC Syst Biol. 7(32)2013. View Article : Google Scholar : PubMed/NCBI

11 

Davalieva K, Kostovska IM, Kiprijanovska S, Markoska K, Kubelka-Sabit K, Filipovski V, Stavridis S, Stankov O, Komina S, Petrusevska G and Polenakovic M: Proteomics analysis of malignant and benign prostate tissue by 2D DIGE/MS reveals new insights into proteins involved in prostate cancer. Prostate. 75:1586–1600. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Wu CH, Yeh LS, Huang H, Arminski L, Castro-Alvear J, Chen Y, Hu Z, Kourtesis P, Ledley RS, Suzek BE, et al: The Protein Information Resource. Nucleic Acids Res. 31:345–347. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Sardiu ME and Washburn MP: Building protein-protein interaction networks with proteomics and informatics tools. J Biol Chem. 286:23645–23651. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Lee S-A, Chan C-H, Chen T-C, Yang CY, Huang KC, Tsai CH, Lai JM, Wang FS, Kao CY and Huang CY: POINeT: Protein interactome with sub-network analysis and hub prioritization. BMC Bioinformatics. 10(114)2009. View Article : Google Scholar

15 

Saito R, Smoot ME, Ono K, Ruscheinski J, Wang PL, Lotia S, Pico AR, Bader GD and Ideker T: A travel guide to Cytoscape plugins. Nat Methods. 9:1069–1076. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Jeanquartier F, Jean-Quartier C and Holzinger A: Integrated web visualizations for protein-protein interaction databases. BMC Bioinformatics. 16(195)2015. View Article : Google Scholar : PubMed/NCBI

17 

Raman K: Construction and analysis of protein-protein interaction networks. Autom Exp. 2(2)2010. View Article : Google Scholar : PubMed/NCBI

18 

Xie W, Sun J and Wu J: Construction and analysis of a protein-protein interaction network related to self-renewal of mouse spermatogonial stem cells. Mol Biosyst. 11:835–843. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Scardoni G, Petterlini M and Laudanna C: Analyzing biological network parameters with CentiScaPe. Bioinformatics. 25:2857–2859. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Rhrissorrakrai K and Gunsalus KC: MINE: Module identification in networks. BMC Bioinformatics. 12(192)2011. View Article : Google Scholar : PubMed/NCBI

21 

Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC and Lempicki RA: DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol. 4:P32003. View Article : Google Scholar : PubMed/NCBI

22 

Lima-Mendez G and van Helden J: The powerful law of the power law and other myths in network biology. Mol Biosyst. 5:1482–1493. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Xia J, Benner MJ and Hancock RE: NetworkAnalyst - integrative approaches for protein-protein interaction network analysis and visual exploration. Nucleic Acids Res. 42:W167–W174. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Sanz-Pamplona R, Berenguer A, Sole X, Cordero D, Crous-Bou M, Serra-Musach J, Guinó E, Pujana MÁ and Moreno V: Tools for protein-protein interaction network analysis in cancer research. Clin Transl Oncol. 14:3–14. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Jonsson PF and Bates PA: Global topological features of cancer proteins in the human interactome. Bioinformatics. 22:2291–2297. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Xu J and Li Y: Discovering disease-genes by topological features in human protein-protein interaction network. Bioinformatics. 22:2800–2805. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Sanz-Pamplona R, Aragüés R, Driouch K, Martín B, Oliva B, Gil M, Boluda S, Fernández PL, Martínez A, Moreno V, et al: Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2− primary breast tumors. Am J Pathol. 179:564–579. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, et al: Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 39:1338–1349. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Sugita Y, Nakamura Y, Yamamoto M, Oda E, Tokunaga O and Shigemori M: Expression of tubulin beta II in neuroepithelial tumors: Reflection of architectural changes in the developing human brain. Acta Neuropathol. 110:127–134. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Ranganathan S, Salazar H, Benetatos CA and Hudes GR: Immunohistochemical analysis of beta-tubulin isotypes in human prostate carcinoma and benign prostatic hypertrophy. Prostate. 30:263–268. 1997. View Article : Google Scholar : PubMed/NCBI

31 

He ZY, Wen H, Shi CB and Wang J: Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer. World J Gastroenterol. 16:4670–4676. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Chan CML, Wong SCC, Lam MYY, Hui EP, Chan JK, Lo ES, Cheuk W, Wong MC, Tsao SW and Chan AT: Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and β2-tubulin for nasopharyngeal carcinoma. Arch Pathol Lab Med. 132:675–683. 2008.PubMed/NCBI

33 

Sejima T, Iwamoto H, Masago T, Morizane S, Yao A, Isoyama T, Kadowaki H and Takenaka A: Low pre-operative levels of serum albumin predict lymph node metastases and ultimately correlate with a biochemical recurrence of prostate cancer in radical pros-tatectomy patients. Cent European J Urol. 66:126–132. 2013.

34 

Aparicio LM, Villaamil VM, Calvo MB, Rubira LV, Rois JM, Valladares-Ayerbes M, Campelo RG, Bolós MV and Pulido EG: Glucose transporter expression and the potential role of fructose in renal cell carcinoma: A correlation with pathological parameters. Mol Med Rep. 3:575–580. 2010. View Article : Google Scholar

35 

Ito T, Noguchi Y, Satoh S, Hayashi H, Inayama Y and Kitamura H: Expression of facilitative glucose transporter isoforms in lung carcinomas: Its relation to histologic type, differentiation grade, and tumor stage. Mod Pathol. 11:437–443. 1998.PubMed/NCBI

36 

Shibata K, Kajiyama H, Ino K, Nawa A, Nomura S, Mizutani S and Kikkawa F: P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling. BMC Cancer. 7(15)2007. View Article : Google Scholar

37 

Liu J, Wen D, Fang X, Wang X, Liu T and Zhu J: p38MAPK signaling enhances glycolysis through the up-regulation of the glucose transporter GLUT-4 in gastric cancer cells. Cell Physiol Biochem. 36:155–165. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Garrido P, Osorio FG, Morán J, Cabello E, Alonso A, Freije JM and González C: Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells. J Cell Physiol. 230:191–198. 2015. View Article : Google Scholar

39 

Won HJ, Ha TK, Kwon SJ, Cho HY, Hur SJ, Baik HH, Suh SI, Ha E and Kim YH: Differential effects of 5-fluorouracil on glucose transport and expressions of glucose transporter proteins in gastric cancer cells. Anticancer Drugs. 21:270–276. 2010. View Article : Google Scholar

40 

Gonzalez-Menendez P, Hevia D, Rodriguez-Garcia A, Mayo JC and Sainz RM: Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells. Endocrinology. 155:3238–3250. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Fortier AM, Asselin E and Cadrin M: Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem. 288:11555–11571. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Misra UK and Pizzo SV: Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. Cancer Biol Ther. 9:142–152. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Bakin RE, Gioeli D, Bissonette EA and Weber MJ: Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells. Cancer Res. 63:1975–1980. 2003.PubMed/NCBI

44 

Erlich S, Tal-Or P, Liebling R, Blum R, Karunagaran D, Kloog Y and Pinkas-Kramarski R: Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells. Biochem Pharmacol. 72:427–436. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Jia S, Gao X, Lee SH, Maira SM, Wu X, Stack EC, Signoretti S, Loda M, Zhao JJ and Roberts TM: Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov. 3:44–51. 2013. View Article : Google Scholar :

46 

Yin J, Pollock C, Tracy K, Chock M, Martin P, Oberst M and Kelly K: Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone. Mol Cell Biol. 27:7538–7550. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Mulholland DJ, Kobayashi N, Ruscetti M, Zhi A, Tran LM, Huang J, Gleave M and Wu H: Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res. 72:1878–1889. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Sun C, Song C, Ma Z, Xu K, Zhang Y, Jin H, Tong S, Ding W, Xia G and Ding Q: Periostin identified as a potential biomarker of prostate cancer by iTRAQ-proteomics analysis of prostate biopsy. Proteome Sci. 9(22)2011. View Article : Google Scholar

49 

Pang J, Liu W-P, Liu X-P, Li LY, Fang YQ, Sun QP, Liu SJ, Li MT, Su ZL and Gao X: Profiling protein markers associated with lymph node metastasis in prostate cancer by DIGE-based proteomics analysis. J Proteome Res. 9:216–226. 2010. View Article : Google Scholar

50 

Ummanni R, Junker H, Zimmermann U, Venz S, Teller S, Giebel J, Scharf C, Woenckhaus C, Dombrowski F and Walther R: Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. Cancer Lett. 266:171–185. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Alaiya AA, Al-Mohanna M, Aslam M, Shinwari Z, Al-Mansouri L, Al-Rodayan M, Al-Eid M, Ahmad I, Hanash K, Tulbah A, et al: Proteomics-based signature for human benign prostate hyperplasia and prostate adenocarcinoma. Int J Oncol. 38:1047–1057. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Geisler C, Gaisa NT, Pfister D, Fuessel S, Kristiansen G, Braunschweig T, Gostek S, Beine B, Diehl HC, Jackson AM, et al: Identification and validation of potential new biomarkers for prostate cancer diagnosis and prognosis using 2D-DIGE and MS. BioMed Res Int. 2015(454256)2015. View Article : Google Scholar : PubMed/NCBI

53 

Skvortsov S, Schäfer G, Stasyk T, Fuchsberger C, Bonn GK, Bartsch G, Klocker H and Huber LA: Proteomics profiling of microdissected low- and high-grade prostate tumors identifies Lamin A as a discriminatory biomarker. J Proteome Res. 10:259–268. 2011. View Article : Google Scholar

54 

Han ZD, Zhang YQ, He HC, Dai QS, Qin GQ, Chen JH, Cai C, Fu X, Bi XC, Zhu JG, et al: Identification of novel serological tumor markers for human prostate cancer using integrative transcriptome and proteome analysis. Med Oncol. 29:2877–2888. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen C, Shen H, Zhang L, Liu J, Cao X, Yao A, Kang S, Gao W, Han H, Cao F, Cao F, et al: Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer. Int J Mol Med 37: 1576-1586, 2016.
APA
Chen, C., Shen, H., Zhang, L., Liu, J., Cao, X., Yao, A. ... Li, Z. (2016). Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer. International Journal of Molecular Medicine, 37, 1576-1586. https://doi.org/10.3892/ijmm.2016.2577
MLA
Chen, C., Shen, H., Zhang, L., Liu, J., Cao, X., Yao, A., Kang, S., Gao, W., Han, H., Cao, F., Li, Z."Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer". International Journal of Molecular Medicine 37.6 (2016): 1576-1586.
Chicago
Chen, C., Shen, H., Zhang, L., Liu, J., Cao, X., Yao, A., Kang, S., Gao, W., Han, H., Cao, F., Li, Z."Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer". International Journal of Molecular Medicine 37, no. 6 (2016): 1576-1586. https://doi.org/10.3892/ijmm.2016.2577
Copy and paste a formatted citation
x
Spandidos Publications style
Chen C, Shen H, Zhang L, Liu J, Cao X, Yao A, Kang S, Gao W, Han H, Cao F, Cao F, et al: Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer. Int J Mol Med 37: 1576-1586, 2016.
APA
Chen, C., Shen, H., Zhang, L., Liu, J., Cao, X., Yao, A. ... Li, Z. (2016). Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer. International Journal of Molecular Medicine, 37, 1576-1586. https://doi.org/10.3892/ijmm.2016.2577
MLA
Chen, C., Shen, H., Zhang, L., Liu, J., Cao, X., Yao, A., Kang, S., Gao, W., Han, H., Cao, F., Li, Z."Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer". International Journal of Molecular Medicine 37.6 (2016): 1576-1586.
Chicago
Chen, C., Shen, H., Zhang, L., Liu, J., Cao, X., Yao, A., Kang, S., Gao, W., Han, H., Cao, F., Li, Z."Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer". International Journal of Molecular Medicine 37, no. 6 (2016): 1576-1586. https://doi.org/10.3892/ijmm.2016.2577
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team