Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
July-2016 Volume 38 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 38 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

  • Authors:
    • Baoxia Dong
    • Ally-Khan Somani
    • Paul E. Love
    • Xuan Zheng
    • Xiequn Chen
    • Jinyi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Haematology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Lunenfeld‑Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada, The Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 45-56
    |
    Published online on: May 17, 2016
       https://doi.org/10.3892/ijmm.2016.2592
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The CD5 transmembrane glycoprotein functions as a co-receptor in the signaling pathway linking T-cell antigen receptor (TCR) engagement to activation and differentiation. Although CD5 effects on TCR signaling have been shown to be primarily inhibitory, the underlying mechanisms remain unclear. In view of recent data revealing the ability of CD5 to associate with the SHP-1 tyrosine phosphatase, a protein that also downregulates TCR signaling, we examined the role of SHP-1 in modulating CD5 function using thymocytes from SHP-1‑deficient viable motheaten (mev) mice. The results revealed the association of SHP-1 with CD5 to be markedly increased following TCR stimulation and indicated that this interaction was enhanced by and was dependent on CD5 tyrosine phosphorylation. However, there was no difference of the tyrosine phosphorylation status of CD5 between resting and TCR-stimulated cells in SHP-1‑deficient compared to wild-type thymocytes. Lack of SHP-1 activity did not affect the levels of CD5 surface expression, CD5 co-immunoprecipitable tyrosine phosphatase activity and intracellular calcium increase following co-crosslinking of the TCR and CD5. Similarly, an analysis of T‑cell thymocyte populations in mev mice expressing an H-Y transgene as well as a construct mediating T‑cell restricted CD5 overexpression, revealed that the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency. CD5 is not a SHP-1 substrate and SHP-1 is not required for and possibly not involved in the CD5-mediated modulation of TCR signaling.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Martínez VG, Moestrup SK, Holmskov U, Mollenhauer J and Lozano F: The conserved scavenger receptor cysteine-rich super-family in therapy and diagnosis. Pharmacol Rev. 63:967–1000. 2011. View Article : Google Scholar

2 

Mandl JN, Monteiro JP, Vrisekoop N and Germain RN: T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity. 38:263–274. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Azzam HS, Grinberg A, Lui K, Shen H, Shores EW and Love PE: CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J Exp Med. 188:2301–2311. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Stamou P, de Jersey J, Carmignac D, Mamalaki C, Kioussis D and Stockinger B: Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells. J Immunol. 171:1278–1284. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Raman C: CD5, an important regulator of lymphocyte selection and immune tolerance. Immunol Res. 26:255–263. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Klinker MW and Lundy SK: Multiple mechanisms of immune suppression by B lymphocytes. Mol Med. 18:123–137. 2012. View Article : Google Scholar :

7 

Mage RG and Pospisil R: CD5 and other superantigens may select and maintain rabbit self-renewing B-lymphocytes and human B-CLL cells. Curr Top Microbiol Immunol. 252:87–96. 2000.PubMed/NCBI

8 

Mamonkin M, Rouce RH, Tashiro H and Brenner MK: A T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies. Blood. 126:983–992. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Sheng JR, Quan S and Soliven B: CD1d(hi)CD5+ B cells expanded by GM-CSF in vivo suppress experimental autoimmune myasthenia gravis. J Immunol. 193:2669–2677. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Beaudette-Zlatanova BC, Le PT, Knight KL, Zhang S, Zakrzewski S, Parthasarathy M and Stiff PJ: A potential role for B cells in suppressed immune responses in cord blood transplant recipients. Bone Marrow Transplant. 48:85–93. 2013. View Article : Google Scholar

11 

Spertini F, Stohl W, Ramesh N, Moody C and Geha RS: Induction of human T cell proliferation by a monoclonal antibody to CD5. J Immunol. 146:47–52. 1991.PubMed/NCBI

12 

Alberola-Ila J, Places L, Cantrell DA, Vives J and Lozano F: Intracellular events involved in CD5-induced human T cell activation and proliferation. J Immunol. 148:1287–1293. 1992.PubMed/NCBI

13 

Ochi H and Watanabe T: Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity. Int Immunol. 12:1417–1423. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, Alberola-Ila J, et al: Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses. PLoS One. 9:e848952014. View Article : Google Scholar : PubMed/NCBI

15 

Tarakhovsky A, Kanner SB, Hombach J, Ledbetter JA, Müller W, Killeen N and Rajewsky K: A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science. 269:535–537. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Peña-Rossi C, Zuckerman LA, Strong J, Kwan J, Ferris W, Chan S, Tarakhovsky A, Beyers AD and Killeen N: Negative regulation of CD4 lineage development and responses by CD5. J Immunol. 163:6494–6501. 1999.PubMed/NCBI

17 

Dennehy KM, Ferris WF, Veenstra H, Zuckerman LA, Killeen N and Beyers AD: Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5. Int Immunol. 13:149–156. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Iwai LK, Benoist C, Mathis D and White FM: Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res. 9:3135–3145. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Beyers AD, Spruyt LL and Williams AF: Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Acad Sci USA. 89:2945–2949. 1992. View Article : Google Scholar : PubMed/NCBI

20 

Unkeless JC and Jin J: Inhibitory receptors, ITIM sequences and phosphatases. Curr Opin Immunol. 9:338–343. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, Aruffo AA and Kanner SB: CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: Involvement of SH2-containing phosphotyrosine phosphatase SHP-1. Mol Cell Biol. 19:2903–2912. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Carmo AM, Castro MA and Arosa FA: CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells. J Immunol. 163:4238–4245. 1999.PubMed/NCBI

23 

Tibaldi E, Brunati AM, Zonta F, Frezzato F, Gattazzo C, Zambello R, Gringeri E, Semenzato G, Pagano MA and Trentin L: Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells. Leukemia. 25:1768–1781. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Kisielow P, Blüthmann H, Staerz UD, Steinmetz M and von Boehmer H: Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature. 333:742–746. 1988. View Article : Google Scholar : PubMed/NCBI

25 

Love PE, Shores EW, Lee EJ, Grinberg A, Munitz TI, Westphal H and Singer A: Differential effects of zeta and eta transgenes on early alpha/beta T cell development. J Exp Med. 179:1485–1494. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Zhang J, Somani AK, Yuen D, Yang Y, Love PE and Siminovitch KA: Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection. J Immunol. 163:3012–3021. 1999.PubMed/NCBI

27 

Kozlowski M, Mlinaric-Rascan I, Feng GS, Shen R, Pawson T and Siminovitch KA: Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med. 178:2157–2163. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Pani G, Fischer KD, Mlinaric-Rascan I and Siminovitch KA: Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med. 184:839–852. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Bikah G, Carey J, Ciallella JR, Tarakhovsky A and Bondada S: CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science. 274:1906–1909. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Sen G, Bikah G, Venkataraman C and Bondada S: Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells. Eur J Immunol. 29:3319–3328. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Gary-Gouy H, Bruhns P, Schmitt C, Dalloul A, Daëron M and Bismuth G: The pseudo-immunoreceptor tyrosine-based activation motif of CD5 mediates its inhibitory action on B-cell receptor signaling. J Biol Chem. 275:548–556. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Dennehy KM, Broszeit R, Ferris WF and Beyers AD: Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5. Eur J Immunol. 28:1617–1625. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Weiss A, Dazin PF, Shields R, Fu SM and Lanier LL: Functional competency of T cell antigen receptors in human thymus. J Immunol. 139:3245–3250. 1987.PubMed/NCBI

34 

Johnson KG, LeRoy FG, Borysiewicz LK and Matthews RJ: TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. J Immunol. 162:3802–3813. 1999.PubMed/NCBI

35 

Imboden JB, Weiss A and Stobo JD: The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. J Immunol. 134:663–665. 1985.PubMed/NCBI

36 

Imboden JB and Stobo JD: Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med. 161:446–456. 1985. View Article : Google Scholar : PubMed/NCBI

37 

Ledbetter JA, June CH, Martin PJ, Spooner CE, Hansen JA and Meier KE: Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: Distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation. J Immunol. 136:3945–3952. 1986.PubMed/NCBI

38 

Altman A, Coggeshall KM and Mustelin T: Molecular events mediating T cell activation. Adv Immunol. 48:227–360. 1990. View Article : Google Scholar : PubMed/NCBI

39 

Hardy RR and Hayakawa K: Development and physiology of Ly-1 B and its human homolog, Leu-1 B. Immunol Rev. 93:53–79. 1986. View Article : Google Scholar : PubMed/NCBI

40 

June CH, Rabinovitch PS and Ledbetter JA: CD5 antibodies increase intracellular ionized calcium concentration in T cells. J Immunol. 138:2782–2792. 1987.PubMed/NCBI

41 

Gupta S: Mechanisms of transmembrane signalling in human T cell activation. Mol Cell Biochem. 91:45–50. 1989. View Article : Google Scholar : PubMed/NCBI

42 

Vandenberghe P, Verwilghen J, Van Vaeck F and Ceuppens JL: Ligation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism. Immunology. 78:210–217. 1993.PubMed/NCBI

43 

Simarro M, Calvo J, Vilà JM, Places L, Padilla O, Alberola-Ila J, Vives J and Lozano F: Signaling through CD5 involves acidic sphingomyelinase, protein kinase C-zeta, mitogen-activated protein kinase kinase, and c-Jun NH2-terminal kinase. J Immunol. 162:5149–5155. 1999.PubMed/NCBI

44 

Osman N, Ley SC and Crumpton MJ: Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes. Eur J Immunol. 22:2995–3000. 1992. View Article : Google Scholar : PubMed/NCBI

45 

Page DM: Cutting edge: Thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation. J Immunol. 163:3577–3581. 1999.PubMed/NCBI

46 

Mageed RA, Garaud S, Taher TE, Parikh K, Pers JO, Jamin C, Renaudineau Y and Youinou P: CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmun Rev. 11:795–798. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Amantini C, Mosca M, Lucciarini R, Perfumi MC and Santoni G: Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. J Pharmacol Exp Ther. 327:215–225. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Dennehy KM, Broszeit R, Garnett D, Durrheim GA, Spruyt LL and Beyers AD: Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5. Eur J Immunol. 27:679–686. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Cuevas B, Lu Y, Watt S, Kumar R, Zhang J, Siminovitch KA and Mills GB: SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem. 274:27583–27589. 1999. View Article : Google Scholar : PubMed/NCBI

50 

Imani F, Rager KJ, Catipovic B and Marsh DG: Interleukin-4 (IL-4) induces phosphatidylinositol 3-kinase (p85) dephosphorylation. Implications for the role of SHP-1 in the IL-4-induced signals in human B cells. J Biol Chem. 272:7927–7931. 1997. View Article : Google Scholar : PubMed/NCBI

51 

Antony P, Petro JB, Carlesso G, Shinners NP, Lowe J and Khan WN: B cell receptor directs the activation of NFAT and NF-kappaB via distinct molecular mechanisms. Exp Cell Res. 291:11–24. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Kishimoto H and Sprent J: Several differenT cell surface molecules control negative selection of medullary thymocytes. J Exp Med. 190:65–73. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Sanjurjo L, Amézaga N, Aran G, Naranjo-Gómez M, Arias L, Armengol C, Borràs FE and Sarrias MR: The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses. Autophagy. 11:487–502. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Turner M, Mee PJ, Walters AE, Quinn ME, Mellor AL, Zamoyska R and Tybulewicz VL: A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 7:451–460. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Tanaka Y, So T, Lebedeva S, Croft M and Altman A: Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. Blood. 106:1286–1295. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dong B, Somani A, Love PE, Zheng X, Chen X and Zhang J: CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1. Int J Mol Med 38: 45-56, 2016.
APA
Dong, B., Somani, A., Love, P.E., Zheng, X., Chen, X., & Zhang, J. (2016). CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1. International Journal of Molecular Medicine, 38, 45-56. https://doi.org/10.3892/ijmm.2016.2592
MLA
Dong, B., Somani, A., Love, P. E., Zheng, X., Chen, X., Zhang, J."CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1". International Journal of Molecular Medicine 38.1 (2016): 45-56.
Chicago
Dong, B., Somani, A., Love, P. E., Zheng, X., Chen, X., Zhang, J."CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1". International Journal of Molecular Medicine 38, no. 1 (2016): 45-56. https://doi.org/10.3892/ijmm.2016.2592
Copy and paste a formatted citation
x
Spandidos Publications style
Dong B, Somani A, Love PE, Zheng X, Chen X and Zhang J: CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1. Int J Mol Med 38: 45-56, 2016.
APA
Dong, B., Somani, A., Love, P.E., Zheng, X., Chen, X., & Zhang, J. (2016). CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1. International Journal of Molecular Medicine, 38, 45-56. https://doi.org/10.3892/ijmm.2016.2592
MLA
Dong, B., Somani, A., Love, P. E., Zheng, X., Chen, X., Zhang, J."CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1". International Journal of Molecular Medicine 38.1 (2016): 45-56.
Chicago
Dong, B., Somani, A., Love, P. E., Zheng, X., Chen, X., Zhang, J."CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1". International Journal of Molecular Medicine 38, no. 1 (2016): 45-56. https://doi.org/10.3892/ijmm.2016.2592
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team