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International Journal of Molecular Medicine
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Article

Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation

  • Authors:
    • Bo-Kyung Kim
    • Minhwa Park
    • Ji-Yon Kim
    • Kyung-Ho Lee
    • So-Youn Woo
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea, Department of Dermatology, College of Medicine, The Catholic University of Korea, Bucheon, Gyeonggi 420-727, Republic of Korea
  • Pages: 650-658
    |
    Published online on: June 7, 2016
       https://doi.org/10.3892/ijmm.2016.2627
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Abstract

The pathogenesis of inflammatory skin diseases involves interactions between immune cells and keratinocytes, including the T helper 17 (Th17)-mediated immune response. Several chemokines [chemokine (C-X-C motif) ligand (CXCL)1, CXCL5 and CXCL8] and antimicrobial peptides [β-defensin 1 (BD1), LL-37, S100A8 and S100A9] were transcriptionally upregulated in the keratinocyte cell line HaCaT upon stimulation with interleukin (IL)-17. Balneotherapy, the treatment of disease by bathing, is an alternative therapy that has frequently been used for the treatment of inflammatory skin diseases. Immersion in pools of thermal mineral water is often considered to have chemical, thermal, mechanical and immunomodulatory benefits. We examined the effect of thermal treatment on IL-17-mediated inflammation in a model of skin disease. As Act1 is required for IL-17 signaling and is a client protein of heat shock protein 90 (HSP90), we evaluated the effect of HSP90 inhibition on IL-17-mediated cytokine and antimicrobial peptide expression in keratinocytes following heat treatment. We found that after thermal stimulation, Act1 binding to HSP90α was significantly increased in the presence of IL-17 (100 ng/ml) and 17-N-allylamino-17-demethoxygeldanamycin (17-AAG, 1 µM). Antimicrobial peptide and chemokine expression generally increased after heat treatment; Act1 knockdown and 17‑AAG reversed this effect. These observations demonstrate the possible immunomodulatory effect of heat on keratinocytes during the progression of IL-17-mediated inflammatory skin diseases.
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1 

Cho KA, Suh JW, Lee KH, Kang JL and Woo SY: IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway. Int Immunol. 24:147–158. 2012. View Article : Google Scholar

2 

Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, Liu C, Herjan T, Misra S, Carman JA, et al: The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 14:72–81. 2013. View Article : Google Scholar

3 

Edwards MJ, Marks R, Dykes PJ, Merrett VR, Morgan HE and O'Donovan MR: Heat shock proteins in cultured human keratinocytes and fibroblasts. J Invest Dermatol. 96:392–396. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Wilson N, McArdle A, Guerin D, Tasker H, Wareing P, Foster CS, Jackson MJ and Rhodes LE: Hyperthermia to normal human skin in vivo upregulates heat shock proteins 27, 60, 72i and 90. J Cutan Pathol. 27:176–182. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Dickel H, Gambichler T, Kamphowe J, Altmeyer P and Skrygan M: Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-α and IL-8/CXCL8 mRNA: new insights into the involvement of 'alarmins'. Contact Dermat. 63:215–222. 2010. View Article : Google Scholar

6 

Kakeda M, Arock M, Schlapbach C and Yawalkar N: Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis. J Am Acad Dermatol. 70:683–690.e1. 2014. View Article : Google Scholar

7 

Halevy S and Sukenik S: Different modalities of spa therapy for skin diseases at the Dead Sea area. Arch Dermatol. 134:1416–1420. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Choi YJ, Lee HJ, Lee H, Woo SY, Lee KH, Yun ST, Kim JM, Kim HJ and Kim JW: Therapeutic effects and immunomodulation of Suanbo mineral water therapy in a murine model of atopic dermatitis. Ann Dermatol. 25:462–470. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Matz H, Orion E and Wolf R: Balneotherapy in dermatology. Dermatol Ther (Heidelb). 16:132–140. 2003. View Article : Google Scholar

10 

Vidal Magalhães W, Gouveia Nogueira MF and Kaneko TM: Heat shock proteins (HSP): dermatological implications and perspectives. Eur J Dermatol. 22:8–13. 2012.PubMed/NCBI

11 

Zaba LC, Cardinale I, Gilleaudeau P, Sullivan-Whalen M, Suárez-Fariñas M, Fuentes-Duculan J, Novitskaya I, Khatcherian A, Bluth MJ, Lowes MA and Krueger JG: Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med. 204:3183–3194. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Miyoshi S, Yamazaki S, Uchiumi A and Katagata Y: The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes. FEBS Open Bio. 2:47–50. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Garcia-Carbonero R, Carnero A and Paz-Ares L: Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol. 14:e358–e369. 2013. View Article : Google Scholar : PubMed/NCBI

14 

An WG, Schulte TW and Neckers LM: The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome. Cell Growth Differ. 11:355–360. 2000.PubMed/NCBI

15 

Mimnaugh EG, Chavany C and Neckers L: Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin. J Biol Chem. 271:22796–22801. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Sauvageot CM, Weatherbee JL, Kesari S, Winters SE, Barnes J, Dellagatta J, Ramakrishna NR, Stiles CD, Kung AL, Kieran MW and Wen PY: Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol. 11:109–121. 2009. View Article : Google Scholar :

17 

Nimmanapalli R, O'Bryan E and Bhalla K: Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. Cancer Res. 61:1799–1804. 2001.PubMed/NCBI

18 

Shimp SK III, Chafin CB, Regna NL, Hammond SE, Read MA, Caudell DL, Rylander M and Reilly CM: Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. Cell Mol Immunol. 9:255–266. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, Antonova G, Snead C, Cannon J, Venema RC and Catravas JD: Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med. 176:667–675. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Prakken BJ, Wendling U, van der Zee R, Rutten VP, Kuis W and van Eden W: Induction of IL-10 and inhibition of experimental arthritis are specific features of microbial heat shock proteins that are absent for other evolutionarily conserved immunodominant proteins. J Immunol. 167:4147–4153. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Poulaki V, Iliaki E, Mitsiades N, Mitsiades CS, Paulus YN, Bula DV, Gragoudas ES and Miller JW: Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. FASEB J. 21:2113–2123. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Dello Russo C, Polak PE, Mercado PR, Spagnolo A, Sharp A, Murphy P, Kamal A, Burrows FJ, Fritz LC and Feinstein DL: The heat-shock protein 90 inhibitor 17-allylamino-17-deme-thoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J Neurochem. 99:1351–1362. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P and de Zoeten EF: Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 6:960–971. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Reinholz M, Ruzicka T and Schauber J: Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. Ann Dermatol. 24:126–135. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Di Cesare A, Di Meglio P and Nestle FO: The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 129:1339–1350. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Park CC, Kim KJ, Woo SY, Chun JH and Lee KH: Comparison of the expression profile of JunB, c-Jun, and S100A8 (calgranulin A) in psoriasis vulgaris and guttate psoriasis. Ann Dermatol. 21:35–38. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim B, Park M, Kim J, Lee K and Woo S: Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation. Int J Mol Med 38: 650-658, 2016.
APA
Kim, B., Park, M., Kim, J., Lee, K., & Woo, S. (2016). Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation. International Journal of Molecular Medicine, 38, 650-658. https://doi.org/10.3892/ijmm.2016.2627
MLA
Kim, B., Park, M., Kim, J., Lee, K., Woo, S."Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation". International Journal of Molecular Medicine 38.2 (2016): 650-658.
Chicago
Kim, B., Park, M., Kim, J., Lee, K., Woo, S."Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation". International Journal of Molecular Medicine 38, no. 2 (2016): 650-658. https://doi.org/10.3892/ijmm.2016.2627
Copy and paste a formatted citation
x
Spandidos Publications style
Kim B, Park M, Kim J, Lee K and Woo S: Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation. Int J Mol Med 38: 650-658, 2016.
APA
Kim, B., Park, M., Kim, J., Lee, K., & Woo, S. (2016). Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation. International Journal of Molecular Medicine, 38, 650-658. https://doi.org/10.3892/ijmm.2016.2627
MLA
Kim, B., Park, M., Kim, J., Lee, K., Woo, S."Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation". International Journal of Molecular Medicine 38.2 (2016): 650-658.
Chicago
Kim, B., Park, M., Kim, J., Lee, K., Woo, S."Heat shock protein 90 is involved in IL-17-mediated skin inflammation following thermal stimulation". International Journal of Molecular Medicine 38, no. 2 (2016): 650-658. https://doi.org/10.3892/ijmm.2016.2627
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