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Article Open Access

NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells

  • Authors:
    • Hongyan Zhang
    • Liqun Li
    • Yifan Wang
    • Fengyun Dong
    • Xiaocui Chen
    • Fuhong Liu
    • Dongmei Xu
    • Fan Yi
    • Carolyn M. Kapron
    • Ju Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Xintai City People's Hospital, Xintai Hospital Affiliated to Taishan Medical University, Xintai, Shandong 271200, P.R. China, Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Weifang Medical College, Weifang, Shandong 261031, P.R. China, Department of Nephrology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Pharmacology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Department of Biology, Trent University, Peterborough, ON K9L 0G2, Canada
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 417-422
    |
    Published online on: June 14, 2016
       https://doi.org/10.3892/ijmm.2016.2640
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Abstract

The kidney is one of the primary organs targeted by cadmium (Cd), a widely distributed environmental pollutant. The glomerular endothelium is the major component of the glomerular filtration barrier. However, the effects of Cd on glomerular endothelial cells remain largely unknown. For this purpose, we aimed to determine the effects of low dose Cd on the survival of human renal glomerular endothelial cells (HRGECs). Cultured HRGECs were exposed to 4 µM cadmium chloride (CdCl2) and examined at different time-points. We found that Cd activates the nuclear factor-κB (NF-κB) pathway without inducing the apoptosis of HRGECs. Pre-treating the cells with pyrrolidine dithiocarbamate (PDTC), a potent NF-κB inhibitor, prior to Cd exposure triggered extensive cell death (73.5%). In addition, Cd activates the c-Jun N-terminal kinase (JNK) pathway, and inhibition of the NF-κB pathway significantly elevates Cd-induced JNK phosphorylation in HRGECs (p<0.01). The combination treatment of PDTC and SP600125, a JNK pathway inhibitor, increased the survival of Cd-stimulated HRGECs compared with those cells treated with PDTC alone (p<0.05). Taken together, these findings demonstrate that the NF-κB pathway plays an essential role in maintaining the survival of Cd-exposed HRGECs.
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1 

Järup L, Berglund M, Elinder CG, Nordberg G and Vahter M: Health effects of cadmium exposure - a review of the literature and a risk estimate. Scand J Work Environ Health. 24(Suppl 1): 1–51. 1998.

2 

Thévenod F and Lee WK: Toxicology of cadmium and its damage to mammalian organs. Met Ions Life Sci. 11:415–490. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Prozialeck WC and Edwards JR: Early biomarkers of cadmium exposure and nephrotoxicity. Biometals. 23:793–809. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Chakraborty PK, Lee WK, Molitor M, Wolff NA and Thévenod F: Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells. Mol Cancer. 9:1022010. View Article : Google Scholar : PubMed/NCBI

5 

Prozialeck WC, Edwards JR and Woods JM: The vascular endothelium as a target of cadmium toxicity. Life Sci. 79:1493–1506. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Dong F, Guo F, Li L, Guo L, Hou Y, Hao E, Yan S, Allen TD and Liu J: Cadmium induces vascular permeability via activation of the p38 MAPK pathway. Biochem Biophys Res Commun. 450:447–452. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Liu J and Kapron CM: Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells. Reprod Toxicol. 29:286–291. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Yuan Y, Jiang C, Hu F, Wang Q, Zhang K, Wang Y, Gu J, Liu X, Bian J and Liu Z: The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway. J Trace Elem Med Biol. 29:275–283. 2015. View Article : Google Scholar

9 

Green DR and Llambi F: Cell Death Signaling. Cold Spring Harb Perspect Biol. 7:72015. View Article : Google Scholar

10 

Wyllie AH, Kerr JF and Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol. 68:251–306. 1980. View Article : Google Scholar : PubMed/NCBI

11 

Kucharczak J, Simmons MJ, Fan Y and Gélinas C: To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene. 22:8961–8982. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Wajant H, Pfizenmaier K and Scheurich P: Tumor necrosis factor signaling. Cell Death Differ. 10:45–65. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Ashkenazi A and Salvesen G: Regulated cell death: signaling and mechanisms. Annu Rev Cell Dev Biol. 30:337–356. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Dutta J, Fan Y, Gupta N, Fan G and Gélinas C: Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene. 25:6800–6816. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Huxford T, Huang DB, Malek S and Ghosh G: The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell. 95:759–770. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Karin M and Ben-Neriah Y: Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 18:621–663. 2000. View Article : Google Scholar

17 

Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schröter M, Burns K, Mattmann C, et al: Inhibition of death receptor signals by cellular FLIP. Nature. 388:190–195. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH and Ballard DW: Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci USA. 94:10057–10062. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M and Lin A: Inhibition of JNK activation through NF-kappaB target genes. Nature. 414:313–317. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Chen YR and Tan TH: The c-Jun N-terminal kinase pathway and apoptotic signaling (Review). Int J Oncol. 16:651–662. 2000.PubMed/NCBI

21 

Davis RJ: Signal transduction by the JNK group of MAP kinases. Cell. 103:239–252. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Dhanasekaran DN and Johnson GL: MAPKs: function, regulation, role in cancer and therapeutic targeting. Oncogene. 26:3097–3099. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Fan M and Chambers TC: Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat. 4:253–267. 2001. View Article : Google Scholar

24 

Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA and Davis RJ: Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science. 288:870–874. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Lei K and Davis RJ: JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA. 100:2432–2437. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Chen LF and Greene WC: Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol. 5:392–401. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Jacobs MD and Harrison SC: Structure of an IkappaBalpha/NF-kappaB complex. Cell. 95:749–758. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J and Kitamura M: Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem. 283:4252–4260. 2008. View Article : Google Scholar

29 

Liu F, Wang B, Li L, Dong F, Chen X, Li Y, Dong X, Wada Y, Kapron CM and Liu J: Low-dose cadmium upregulates VEGF expression in lung adenocarcinoma cells. Int J Environ Res Public Health. 12:10508–10521. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Dong F, Zhou X, Li C, Yan S, Deng X, Cao Z, Li L, Tang B, Allen TD and Liu J: Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis. Cancer Biol Ther. 15:1479–1488. 2014. View Article : Google Scholar

31 

Javelaud D and Besançon F: NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B. Oncogene. 20:4365–4372. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Du L, Dong F, Guo L, Hou Y, Yi F, Liu J and Xu D: Interleukin-1β increases permeability and upregulates the expression of vascular endothelial-cadherin in human renal glomerular endothelial cells. Mol Med Rep. 11:3708–3714. 2015.PubMed/NCBI

33 

Li L, Dong F, Xu D, Du L, Yan S, Hu H, Lobe CG, Yi F, Kapron CM and Liu J: Short-term, low-dose cadmium exposure induces hyperpermeability in human renal glomerular endothelial cells. J Appl Toxicol. 36:257–265. 2016. View Article : Google Scholar

34 

Morales AI, Vicente-Sánchez C, Jerkic M, Santiago JM, Sánchez-González PD, Pérez-Barriocanal F and López-Novoa JM: Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicol Appl Pharmacol. 210:128–135. 2006. View Article : Google Scholar

35 

Bubici C, Papa S, Pham CG, Zazzeroni F and Franzoso G: NF-kappaB and JNK: an intricate affair. Cell Cycle. 3:1524–1529. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Beg AA and Baltimore D: An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science. 274:782–784. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Jeong EM, Moon CH, Kim CS, Lee SH, Baik EJ, Moon CK and Jung YS: Cadmium stimulates the expression of ICAM-1 via NF-kappaB activation in cerebrovascular endothelial cells. Biochem Biophys Res Commun. 320:887–892. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Chen DJ, Xu YM, Du JY, Huang DY and Lau AT: Cadmium induces cytotoxicity in human bronchial epithelial cells through upregulation of eIF5A1 and NF-kappaB. Biochem Biophys Res Commun. 445:95–99. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Huang TT, Wuerzberger-Davis SM, Wu ZH and Miyamoto S: Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell. 115:565–576. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin AS Jr: NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281:1680–1683. 1998. View Article : Google Scholar : PubMed/NCBI

41 

De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R and Franzoso G: Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature. 414:308–313. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Zong WX, Edelstein LC, Chen C, Bash J and Gélinas C: The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev. 13:382–387. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Li L, Wang Y, Dong F, Chen X, Liu F, Xu D, Yi F, Kapron CM, Liu J, Liu J, et al: NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. Int J Mol Med 38: 417-422, 2016.
APA
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F. ... Liu, J. (2016). NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. International Journal of Molecular Medicine, 38, 417-422. https://doi.org/10.3892/ijmm.2016.2640
MLA
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F., Xu, D., Yi, F., Kapron, C. M., Liu, J."NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells". International Journal of Molecular Medicine 38.2 (2016): 417-422.
Chicago
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F., Xu, D., Yi, F., Kapron, C. M., Liu, J."NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells". International Journal of Molecular Medicine 38, no. 2 (2016): 417-422. https://doi.org/10.3892/ijmm.2016.2640
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Li L, Wang Y, Dong F, Chen X, Liu F, Xu D, Yi F, Kapron CM, Liu J, Liu J, et al: NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. Int J Mol Med 38: 417-422, 2016.
APA
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F. ... Liu, J. (2016). NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. International Journal of Molecular Medicine, 38, 417-422. https://doi.org/10.3892/ijmm.2016.2640
MLA
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F., Xu, D., Yi, F., Kapron, C. M., Liu, J."NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells". International Journal of Molecular Medicine 38.2 (2016): 417-422.
Chicago
Zhang, H., Li, L., Wang, Y., Dong, F., Chen, X., Liu, F., Xu, D., Yi, F., Kapron, C. M., Liu, J."NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells". International Journal of Molecular Medicine 38, no. 2 (2016): 417-422. https://doi.org/10.3892/ijmm.2016.2640
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