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Article

Effects of caffeic acid on learning deficits in a model of Alzheimer's disease

  • Authors:
    • Yunliang Wang
    • Yutong Wang
    • Jinfeng Li
    • Linlin Hua
    • Bing Han
    • Yuzhen Zhang
    • Xiaopeng Yang
    • Zhilei Zeng
    • Hongying Bai
    • Honglei Yin
    • Jiyu Lou
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255300, P.R. China, Class of 2014 Graduate Students, Henan University School of Medicine, Kaifeng, Henan 475000, P.R. China, Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China
  • Pages: 869-875
    |
    Published online on: July 18, 2016
       https://doi.org/10.3892/ijmm.2016.2683
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Abstract

Caffeic acid is a type of phenolic acid and organic acid. It is found in food (such as tomatoes, carrots, strawberries, blueberries and wheat), beverages (such as wine, tea, coffee and apple juice) as well as Chinese herbal medicines. In the present study, we examined the effects of caffeic acid on learning deficits in a rat model of Alzheimer's disease (AD). The rats were randomly divided into three groups: i) control group, ii) AD model group and iii) caffeic acid group. Caffeic acid significantly rescued learning deficits and increased cognitive function in the rats with AD as demonstrated by the Morris water maze task. Furthermore, caffeic acid administration resulted in a significant decrease in acetylcholinesterase activity and nitrite generation in the rats with AD compared with the AD model group. Furthermore, caffeic acid suppressed oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression and caspase‑3 activity as well as regulating the protein expression of p53 and phosphorylated (p-)p38 MAPK expression in the rats with AD. These experimental results indicate that the beneficial effects of caffeic acid on learning deficits in a model of AD were due to the suppression of oxidative stress and inflammation through the p38 MAPK signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang Y, Li J, Hua L, Han B, Zhang Y, Yang X, Zeng Z, Bai H, Yin H, Yin H, et al: Effects of caffeic acid on learning deficits in a model of Alzheimer's disease. Int J Mol Med 38: 869-875, 2016.
APA
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y. ... Lou, J. (2016). Effects of caffeic acid on learning deficits in a model of Alzheimer's disease. International Journal of Molecular Medicine, 38, 869-875. https://doi.org/10.3892/ijmm.2016.2683
MLA
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., Lou, J."Effects of caffeic acid on learning deficits in a model of Alzheimer's disease". International Journal of Molecular Medicine 38.3 (2016): 869-875.
Chicago
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., Lou, J."Effects of caffeic acid on learning deficits in a model of Alzheimer's disease". International Journal of Molecular Medicine 38, no. 3 (2016): 869-875. https://doi.org/10.3892/ijmm.2016.2683
Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Wang Y, Li J, Hua L, Han B, Zhang Y, Yang X, Zeng Z, Bai H, Yin H, Yin H, et al: Effects of caffeic acid on learning deficits in a model of Alzheimer's disease. Int J Mol Med 38: 869-875, 2016.
APA
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y. ... Lou, J. (2016). Effects of caffeic acid on learning deficits in a model of Alzheimer's disease. International Journal of Molecular Medicine, 38, 869-875. https://doi.org/10.3892/ijmm.2016.2683
MLA
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., Lou, J."Effects of caffeic acid on learning deficits in a model of Alzheimer's disease". International Journal of Molecular Medicine 38.3 (2016): 869-875.
Chicago
Wang, Y., Wang, Y., Li, J., Hua, L., Han, B., Zhang, Y., Yang, X., Zeng, Z., Bai, H., Yin, H., Lou, J."Effects of caffeic acid on learning deficits in a model of Alzheimer's disease". International Journal of Molecular Medicine 38, no. 3 (2016): 869-875. https://doi.org/10.3892/ijmm.2016.2683
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