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Article

Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells

  • Authors:
    • Estelle R. Simo-Cheyou
    • George Vardatsikos
    • Ashok K. Srivastava
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cellular Signaling, Montreal Diabetes Research Center, Research Center - University of Montreal Hospital Center, Montreal, QC H2X 0A9, Canada
  • Pages: 1879-1886
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    Published online on: October 6, 2016
       https://doi.org/10.3892/ijmm.2016.2767
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Abstract

We have previously demonstrated that the non-receptor protein tyrosine kinase (NR-PTK) c-Src is an upstream regulator of endothelin-1 (ET-1) and angiotensin II-induced activation of protein kinase B (PKB) signaling in vascular smooth muscle cells (VSMCs). We have also demonstrated that ET-1 potently induces the expression of the early growth response protein-1 (Egr-1), a zinc finger transcription factor that is overexpressed in models of vascular diseases, such as atherosclerosis. However, the involvement of c-Src in ET-1‑induced Egr-1 expression has not yet been investigated and its role in mitogen-activated protein kinase (MAPK) signaling remains controversial. Therefore, the aim of the present study was to examine the role of c-Src in the ET-1-induced phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and p38 MAPK, 3 key members of the MAPK family and in the regulation of Egr-1 expression in rat aortic A10 VSMCs. ET-1 rapidly induced the phosphorylation of MAPKs, as well as the expression of Egr-1; however, treatment of the VSMCs with PP2, a specific pharmacological inhibitor of c-Src, dose-dependently reduced the phosphorylation of the 3 MAPKs and the expression of Egr-1 induced by ET-1. Furthermore, in mouse embryonic fibroblasts (MEFs) deficient in c-Src (SYF), the ET-1-induced Egr-1 expression and MAPK phosphorylation were significantly suppressed, as compared to MEFs expressing normal Src levels. These results suggest that c-Src plays a critical role in mediating ET-1-induced MAPK phosphorylation and Egr-1 expression in VSMCs.
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1 

Schwartz SM: Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest. 100(Suppl 11): S87–S89. 1997.PubMed/NCBI

2 

Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN and Srivastava D: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 460:705–710. 2009.PubMed/NCBI

3 

Iglarz M and Schiffrin EL: Role of endothelin-1 in hypertension. Curr Hypertens Rep. 5:144–148. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Touyz RM and Schiffrin EL: Role of endothelin in human hypertension. Can J Physiol Pharmacol. 81:533–541. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Arai H, Hori S, Aramori I, Ohkubo H and Nakanishi S: Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 348:730–732. 1990. View Article : Google Scholar : PubMed/NCBI

6 

Bouallegue A, Daou GB and Srivastava AK: Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr Vasc Pharmacol. 5:45–52. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Seger R and Krebs EG: The MAPK signaling cascade. FASEB J. 9:726–735. 1995.PubMed/NCBI

8 

Kyosseva SV: Mitogen-activated protein kinase signaling. Int Rev Neurobiol. 59:201–220. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Daou GB and Srivastava AK: Reactive oxygen species mediate endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells. Free Radic Biol Med. 37:208–215. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Touyz RM, Yao G, Viel E, Amiri F and Schiffrin EL: Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. J Hypertens. 22:1141–1149. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Daigle C, Martens FM, Girardot D, Dao HH, Touyz RM and Moreau P: Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo. BMC Cardiovasc Disord. 4:62004. View Article : Google Scholar : PubMed/NCBI

12 

Bouallegue A, Daou GB and Srivastava AK: Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway. Am J Physiol Heart Circ Physiol. 293:H2072–H2079. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Wang TR, Yang G and Liu GN: DNA enzyme ED5 depletes egr-1 and inhibits neointimal hyperplasia in rats. Cardiology. 125:192–200. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Cheyou ER, Youreva V and Srivastava AK: Involvement of the early growth response protein 1 in vascular pathophysiology: an overview. Indian J Biochem Biophys. 51:457–466. 2014.

15 

Lowe HC, Fahmy RG, Kavurma MM, Baker A, Chesterman CN and Khachigian LM: Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis. Circ Res. 89:670–677. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Blaschke F, Bruemmer D and Law RE: Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis. Rev Endocr Metab Disord. 5:249–254. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Khachigian LM: Early growth response-1 in cardiovascular pathobiology. Circ Res. 98:186–191. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Bouallegue A, Simo Cheyou ER, Anand-Srivastava MB and Srivastava AK: ET-1-induced growth promoting responses involving ERK1/2 and PKB signaling and Egr-1 expression are mediated by Ca2+/CaM-dependent protein kinase-II in vascular smooth muscle cells. Cell Calcium. 54:428–435. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Bouallegue A, Vardatsikos G and Srivastava AK: Role of insulin-like growth factor 1 receptor and c-Src in endothelin-1- and angiotensin II-induced PKB phosphorylation, and hypertrophic and proliferative responses in vascular smooth muscle cells. Can J Physiol Pharmacol. 87:1009–1018. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Youreva V and Srivastava AK: Early growth response protein-1 expression by insulin-like growth factor-1 requires ROS-dependent activation of ERK1/2 and PKB pathways in vascular smooth muscle cells. J Cell Biochem. 117:152–162. 2016. View Article : Google Scholar

21 

Huang RP and Adamson ED: The phosphorylated forms of the transcription factor, Egr-1, bind to DNA more efficiently than non-phosphorylated. Biochem Biophys Res Commun. 200:1271–1276. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Yogi A, Callera GE, Montezano AC, Aranha AB, Tostes RC, Schiffrin EL and Touyz RM: Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 27:1960–1967. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Mugabe BE, Yaghini FA, Song CY, Buharalioglu CK, Waters CM and Malik KU: Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation. J Pharmacol Exp Ther. 332:116–124. 2010. View Article : Google Scholar

24 

Lowe HC, Chesterman CN and Khachigian LM: Catalytic antisense DNA molecules targeting Egr-1 inhibit neointima formation following permanent ligation of rat common carotid arteries. Thromb Haemost. 87:134–140. 2002.PubMed/NCBI

25 

Harja E, Bucciarelli LG, Lu Y, Stern DM, Zou YS, Schmidt AM and Yan SF: Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation. Circ Res. 94:333–339. 2004. View Article : Google Scholar

26 

Khachigian LM, Lindner V, Williams AJ and Collins T: Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science. 271:1427–1431. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Klinghoffer RA, Sachsenmaier C, Cooper JA and Soriano P: Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18:2459–2471. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Roskoski R Jr: Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun. 324:1155–1164. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Hasan RN and Schafer AI: Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB. Circ Res. 102:42–50. 2008. View Article : Google Scholar

30 

Thiel G, Mayer SI, Müller I, Stefano L and Rössler OG: Egr-1-A Ca(2+)-regulated transcription factor. Cell Calcium. 47:397–403. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Cui MZ, Laag E, Sun L, Tan M, Zhao G and Xu X: Lysophosphatidic acid induces early growth response gene 1 expression in vascular smooth muscle cells: CRE and SRE mediate the transcription. Arterioscler Thromb Vasc Biol. 26:1029–1035. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Ni J, Waldman A and Khachigian LM: c-Jun regulates shear-and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins. J Biol Chem. 285:4038–4048. 2010. View Article : Google Scholar

33 

Hodge C, Liao J, Stofega M, Guan K, Carter-Su C and Schwartz J: Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem. 273:31327–31336. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Molnar P, Perrault R, Louis S and Zahradka P: The cyclic AMP response element-binding protein (CREB) mediates smooth muscle cell proliferation in response to angiotensin II. J Cell Commun Signal. 8:29–37. 2014. View Article : Google Scholar :

35 

Mayer SI and Thiel G: Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB. Eur J Cell Biol. 88:19–33. 2009. View Article : Google Scholar

36 

Lieskovska J, Ling Y, Badley-Clarke J and Clemmons DR: The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. J Biol Chem. 281:25041–25053. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F and Duarte J: Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation. Atherosclerosis. 212:78–85. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Mehdi MZ, Pandey NR, Pandey SK and Srivastava AK: H2O2-induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin receptor and c-Src. Antioxid Redox Signal. 7:1014–1020. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Bou Daou G, Li Y and Anand-Srivastava MB: Enhanced expression of Giα proteins contributes to the hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats via MAP kinase- and PI3 kinase-independent pathways. Can J Physiol Pharmacol. 94:49–58. 2016. View Article : Google Scholar

40 

Gomez Sandoval YH and Anand-Srivastava MB: Enhanced levels of endogenous endothelin-1 contribute to the over expression of Giα protein in vascular smooth muscle cells from SHR: role of growth factor receptor activation. Cell Signal. 23:354–362. 2011. View Article : Google Scholar

41 

Li Y, Lévesque LO and Anand-Srivastava MB: Epidermal growth factor receptor transactivation by endogenous vasoactive peptides contributes to hyperproliferation of vascular smooth muscle cells of SHR. Am J Physiol Heart Circ Physiol. 299:H1959–H1967. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU and Chen YE: Egr-1 target genes in human endothelial cells identified by microarray analysis. Gene. 315:33–41. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Kaufmann K and Thiel G: Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells. J Neurol Sci. 189:83–91. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Houston P, Dickson MC, Ludbrook V, White B, Schwachtgen JL, McVey JH, Mackman N, Reese JM, Gorman DG, Campbell C and Braddock M: Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1. Arterioscler Thromb Vasc Biol. 19:281–289. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Yan SF, Lu J, Zou YS, Soh-Won J, Cohen DM, Buttrick PM, Cooper DR, Steinberg SF, Mackman N, Pinsky DJ and Stern DM: Hypoxia-associated induction of early growth response-1 gene expression. J Biol Chem. 274:15030–15040. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Youreva V, Kapakos G and Srivastava AK: Insulin-like growth-factor-1-induced PKB signaling and Egr-1 expression is inhibited by curcumin in A-10 vascular smooth muscle cells. Can J Physiol Pharmacol. 91:241–247. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Day FL, Rafty LA, Chesterman CN and Khachigian LM: Angiotensin II (ATII)-inducible platelet-derived growth factor A-chain gene expression is p42/44 extracellular signal-regulated kinase-1/2 and Egr-1-dependent and mediated via the ATII type 1 but not type 2 receptor. Induction by ATII antagonized by nitric oxide. J Biol Chem. 274:23726–23733. 1999. View Article : Google Scholar : PubMed/NCBI

48 

Morimoto M, Kume N, Miyamoto S, Ueno Y, Kataoka H, Minami M, Hayashida K, Hashimoto N and Kita T: Lysophosphatidylcholine induces early growth response factor-1 expression and activates the core promoter of PDGF-A chain in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 21:771–776. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Iyoda T, Zhang F, Sun L, Hao F, Schmitz-Peiffer C, Xu X and Cui MZ: Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cδ-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells. J Biol Chem. 287:22635–22642. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Simo-Cheyou ER, Vardatsikos G and Srivastava AK: Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells. Int J Mol Med 38: 1879-1886, 2016.
APA
Simo-Cheyou, E.R., Vardatsikos, G., & Srivastava, A.K. (2016). Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells. International Journal of Molecular Medicine, 38, 1879-1886. https://doi.org/10.3892/ijmm.2016.2767
MLA
Simo-Cheyou, E. R., Vardatsikos, G., Srivastava, A. K."Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells". International Journal of Molecular Medicine 38.6 (2016): 1879-1886.
Chicago
Simo-Cheyou, E. R., Vardatsikos, G., Srivastava, A. K."Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells". International Journal of Molecular Medicine 38, no. 6 (2016): 1879-1886. https://doi.org/10.3892/ijmm.2016.2767
Copy and paste a formatted citation
x
Spandidos Publications style
Simo-Cheyou ER, Vardatsikos G and Srivastava AK: Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells. Int J Mol Med 38: 1879-1886, 2016.
APA
Simo-Cheyou, E.R., Vardatsikos, G., & Srivastava, A.K. (2016). Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells. International Journal of Molecular Medicine, 38, 1879-1886. https://doi.org/10.3892/ijmm.2016.2767
MLA
Simo-Cheyou, E. R., Vardatsikos, G., Srivastava, A. K."Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells". International Journal of Molecular Medicine 38.6 (2016): 1879-1886.
Chicago
Simo-Cheyou, E. R., Vardatsikos, G., Srivastava, A. K."Src tyrosine kinase mediates endothelin-1-induced early growth response protein-1 expression via MAP kinase-dependent pathways in vascular smooth muscle cells". International Journal of Molecular Medicine 38, no. 6 (2016): 1879-1886. https://doi.org/10.3892/ijmm.2016.2767
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