Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature

  • Authors:
    • Dominika Labochka
    • Barbara Moszczuk
    • Wojciech Kukwa
    • Cezary Szczylik
    • Anna M. Czarnecka
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  • Published online on: October 17, 2016     https://doi.org/10.3892/ijmm.2016.2776
  • Pages: 1887-1894
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Abstract

Renal cell carcinoma (RCC) comprises 2‑3% of all malignant tumors in adults. Many studies have established the key roles of smoking, hypertension and other components of metabolic syndrome in the occurrence of RCC. Diabetes mellitus (DM), one of the main consequences of metabolic syndrome, appears much more often in patients with RCC. The prognosis for patients suffering from both diabetes and RCC is worse than for those with kidney cancer only. Diabetes is linked to higher rate of recurrence and a greater number of distant metastases. These factors contribute to a reduction in overall survival (OS) and cause‑specific survival (CSS). Diabetes can also occur as a paraneoplastic syndrome. Tyrosine kinase inhibitors (TKIs), which are agents used in the therapy of metastatic RCC, may have unexpected effects when administered to patients with diabetes. Studies and case reports have shown that they influence blood glucose levels (BGLs) in diabetic patients, sometimes causing dangerous episodes of hypoglycemia. Hyperinsulinemia and hyperglycemia can be considered independent carcinogenic factors, as they increase the amount of pro‑inflammatory cytokines, reactive oxygen species and lipid peroxidation. TKIs have yet to be re‑evaluated as to their safety of use in patients with diabetes.
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December-2016
Volume 38 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Labochka D, Moszczuk B, Kukwa W, Szczylik C and Czarnecka AM: Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature. Int J Mol Med 38: 1887-1894, 2016
APA
Labochka, D., Moszczuk, B., Kukwa, W., Szczylik, C., & Czarnecka, A.M. (2016). Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature. International Journal of Molecular Medicine, 38, 1887-1894. https://doi.org/10.3892/ijmm.2016.2776
MLA
Labochka, D., Moszczuk, B., Kukwa, W., Szczylik, C., Czarnecka, A. M."Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature". International Journal of Molecular Medicine 38.6 (2016): 1887-1894.
Chicago
Labochka, D., Moszczuk, B., Kukwa, W., Szczylik, C., Czarnecka, A. M."Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature". International Journal of Molecular Medicine 38, no. 6 (2016): 1887-1894. https://doi.org/10.3892/ijmm.2016.2776