Open Access

Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review)

  • Authors:
    • Shuo Cai
    • Jun Cai
    • Wen G. Jiang
    • Lin Ye
  • View Affiliations

  • Published online on: August 9, 2017     https://doi.org/10.3892/ijmm.2017.3093
  • Pages: 965-971
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The mechanistic complexes of kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) bind and integrate a variety of cellular cues to mediate neuronal activities such as neuronal differentiation, survival, and cytoskeleton remodelling by interacting with a variety of binding partners. Accumulated evidence has also indicated its role in the regulation of vascular development. Mice with Kidins220 knockdown phenotypically present with cardiovascular abnormalities. Kidins220 also contributes to immunomodulation in combination with B cells and T cells. Moreover, emerging evidence has revealed that this protein regulates many crucial cellular processes and thus has been implicated in an increasing number of malignancies. Here, we review recent advances in our understanding of Kidins220 and its role in cancer development. Further investigation is warranted to shed light on the role played by Kidins220 in the dynamic arrangement of the cytoskeleton and epithelial–mesenchymal transition, and its implication in tumourigenesis and cancer progression.
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October-2017
Volume 40 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Cai S, Cai J, Jiang WG and Ye L: Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). Int J Mol Med 40: 965-971, 2017
APA
Cai, S., Cai, J., Jiang, W.G., & Ye, L. (2017). Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). International Journal of Molecular Medicine, 40, 965-971. https://doi.org/10.3892/ijmm.2017.3093
MLA
Cai, S., Cai, J., Jiang, W. G., Ye, L."Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review)". International Journal of Molecular Medicine 40.4 (2017): 965-971.
Chicago
Cai, S., Cai, J., Jiang, W. G., Ye, L."Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review)". International Journal of Molecular Medicine 40, no. 4 (2017): 965-971. https://doi.org/10.3892/ijmm.2017.3093