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Article Open Access

Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells

Retraction in: /10.3892/ijmm.2023.5224
  • Authors:
    • Yunshan Wang
    • Xiaoyan Liu
    • Hui Zheng
    • Qin Wang
    • Li An
    • Guangwei Wei
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Key Laboratory of Experimental Teratology, Ministry of Education, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Science and Education, Taian Maternal and Child Health-Care Hospital, Taian, Shandong 271000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1114-1124
    |
    Published online on: September 1, 2017
       https://doi.org/10.3892/ijmm.2017.3118
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Abstract

Transforming growth factor-β1 (TGF-β1) plays a vital role in the process of epithelial-to-mesenchymal transition (EMT) in breast cancer and the cullin 4A (CUL4A) gene is overexpressed in primary breast cancer. However, whether TGF-β1 signaling can induce CUL4A expression has not been investigated to date, at least to the best of our knowledge. In this study, using breast cancer cell lines, we found that the CUL4A expression level was increased following EMT induced by TGF-β1. Silencing CUL4A expression or CUL4A inhibition by thalidomide suppressed the EMT process induced by TGF-β1. We also found that CUL4A was associated with the expression of zinc finger E-box-binding homeobox 1 (ZEB1) which was induced by TGF-β1. These results suggest that CUL4A is upregulated in TGF-β1-induced EMT, and has a regulatory function in this process. The identification of CUL4A as a downstream target of TGF-β1 represents a critical pro-survival mechanism in breast cancer progression and provides another point for therapeutic intervention in breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Liu X, Zheng H, Wang Q, An L and Wei G: Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224. Int J Mol Med 40: 1114-1124, 2017.
APA
Wang, Y., Liu, X., Zheng, H., Wang, Q., An, L., & Wei, G. (2017). Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224. International Journal of Molecular Medicine, 40, 1114-1124. https://doi.org/10.3892/ijmm.2017.3118
MLA
Wang, Y., Liu, X., Zheng, H., Wang, Q., An, L., Wei, G."Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224". International Journal of Molecular Medicine 40.4 (2017): 1114-1124.
Chicago
Wang, Y., Liu, X., Zheng, H., Wang, Q., An, L., Wei, G."Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224". International Journal of Molecular Medicine 40, no. 4 (2017): 1114-1124. https://doi.org/10.3892/ijmm.2017.3118
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Liu X, Zheng H, Wang Q, An L and Wei G: Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224. Int J Mol Med 40: 1114-1124, 2017.
APA
Wang, Y., Liu, X., Zheng, H., Wang, Q., An, L., & Wei, G. (2017). Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224. International Journal of Molecular Medicine, 40, 1114-1124. https://doi.org/10.3892/ijmm.2017.3118
MLA
Wang, Y., Liu, X., Zheng, H., Wang, Q., An, L., Wei, G."Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224". International Journal of Molecular Medicine 40.4 (2017): 1114-1124.
Chicago
Wang, Y., Liu, X., Zheng, H., Wang, Q., An, L., Wei, G."Suppression of CUL4A attenuates TGF-β1-induced epithelial-to-mesenchymal transition in breast cancer cells Retraction in /10.3892/ijmm.2023.5224". International Journal of Molecular Medicine 40, no. 4 (2017): 1114-1124. https://doi.org/10.3892/ijmm.2017.3118
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