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Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells

  • Authors:
    • Yanjie Guo
    • Xiya Ma
    • Weini Wu
    • Mingyan Shi
    • Junlong Ma
    • Yaping Zhang
    • Erkang Zhao
    • Xueyi Yang
  • View Affiliations / Copyright

    Affiliations: Life Science College, Luoyang Normal University, Luoyang, Henan 471934, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 877-887
    |
    Published online on: December 1, 2017
       https://doi.org/10.3892/ijmm.2017.3304
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Abstract

Skin epidermal stem cells (SESCs), which share a single origin with corneal epithelial cells (CECs), are considered to be one of the most ideal seed cells for the construction of tissue engineered corneas. However, the mechanism underlying the transdifferentiation of SESCs to CECs has not been fully elucidated. In the present study, to identify critical microRNAs (miRNAs/miRs) and genes that regulate the transdifferentiation of SESCs to CECs, SESCs and CECs were collected from sheep and used for small RNA sequencing and mRNA microarray analyses. Among the differentially expressed miRNAs and genes, 36 miRNAs were downregulated and 123 genes were upregulated in the CECs compared with those in the SESCs. miR‑10b exhibited the largest change in expression between the cell types. Target genes of the 36 downregulated miRNAs were predicted and a computational approach demonstrated that these target genes may be involved in several signaling pathways, including the ‘PI3K signaling pathway’, the ‘Wnt signaling pathway’ and the ‘MAPK signaling pathway’, as well as in ‘focal adhesion’. Comparison of these target genes to the 123 upregulated genes identified 43 intersection genes. A regulatory network of these 43 intersection genes and its correlative miRNAs were constructed, and three genes (dedicator of cytokinesis 9, neuronal differentiation 1 and activated leukocyte cell adhesion molecule) were found to have high interaction frequencies. The expression levels of 7 randomly selected miRNAs and the 3 intersection genes were further validated by reverse transcription-quantitative polymerase chain reaction. It was found that miR‑10b, the Wnt signaling pathway and the 3 intersection genes may act together and serve a critical role in the transdifferentiation process. This study identified miRNAs and genes that were expressed in SESCs and CECs that may assist in uncovering its underlying molecular mechanism, as well as promote corneal tissue engineering using epidermal stem cells for clinical applications.
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View References

1 

Pellegrini G, Traverso CE, Franzi AT, Zingirian M, Cancedda R and De Luca M: Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet. 349:990–993. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, et al: WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature. 511:358–361. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Li W, Chen YT, Hayashida Y, Blanco G, Kheirkah A, He H, Chen SY, Liu CY and Tseng SC: Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases. J Pathol. 214:114–122. 2008. View Article : Google Scholar

4 

Lamm V, Hara H, Mammen A, Dhaliwal D and Cooper DK: Corneal blindness and xenotransplantation. Xenotransplantation. 21:99–114. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Yang X, Moldovan I, Zhao Q, Mi S, Zhou Z, Chen D, Gao Z, Tong D and Dou Z: Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells. Mol Vis. 14:1064–1070. 2008.PubMed/NCBI

6 

Shortt AJ, Secker GA, Notara MD, Limb GA, Khaw PT, Tuft SJ and Daniels JT: Transplantation of ex vivo cultured limbal epithelial stem cells: A review of techniques and clinical results. Surv Ophthalmol. 52:483–502. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Tseng SC, Prabhasawat P, Barton K, Gray T and Meller D: Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol. 116:431–441. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Nakamura T and Kinoshita S: Ocular surface reconstruction using cultivated mucosal epithelial stem cells. Cornea. 22(Suppl 7): S75–S80. 2003. View Article : Google Scholar

9 

Utheim TP, Utheim OA, Khan QE and Sehic A: Culture of oral mucosal epithelial cells for the purpose of treating limbal stem cell deficiency. J Funct Biomater. 7:52016. View Article : Google Scholar

10 

Nishida K, Yamato M, Hayashida Y, Watanabe K, Yamamoto K, Adachi E, Nagai S, Kikuchi A, Maeda N, Watanabe H, et al: Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium. N Engl J Med. 351:1187–1196. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Katikireddy KR, Dana R and Jurkunas UV: Differentiation potential of limbal fibroblasts and bone marrow mesenchymal stem cells to corneal epithelial cells. Stem Cells. 32:717–729. 2014. View Article : Google Scholar

12 

Gu S, Xing C, Han J, Tso MO and Hong J: Differentiation of rabbit bone marrow mesenchymal stem cells into corneal epithelial cells in vivo and ex vivo. Mol Vis. 15:99–107. 2009.PubMed/NCBI

13 

Ahmad S, Stewart R, Yung S, Kolli S, Armstrong L, Stojkovic M, Figueiredo F and Lako M: Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche. Stem Cells. 25:1145–1155. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Gomes JA, Geraldes Monteiro B, Melo GB, Smith RL, Cavenaghi Pereira da Silva M, Lizier NF, Kerkis A, Cerruti H and Kerkis I: Corneal reconstruction with tissue-engineered cell sheets composed of human immature dental pulp stem cells. Invest Ophthalmol Vis Sci. 51:1408–1414. 2010. View Article : Google Scholar

15 

Toma JG, Akhavan M, Fernandes KJ, Barnabé-Heider F, Sadikot A, Kaplan DR and Miller FD: Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol. 3:778–784. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Dyce PW, Wen L and Li J: In vitro germline potential of stem cells derived from fetal porcine skin. Nat Cell Biol. 8:384–390. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Chee KY, Kicic A and Wiffen SJ: Limbal stem cells: The search for a marker. Clin Experiment Ophthalmol. 34:64–73. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Lavker RM and Sun TT: Epidermal stem cells: Properties, markers, and location. Proc Natl Acad Sci USA. 97:13473–13475. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Bose A, Teh MT, Mackenzie IC and Waseem A: Keratin k15 as a biomarker of epidermal stem cells. Int J Mol Sci. 14:19385–19398. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Forni MF, Trombetta-Lima M and Sogayar MC: Stem cells in embryonic skin development. Biol Res. 45:215–222. 2012. View Article : Google Scholar

21 

Ghadially R: 25 years of epidermal stem cell research. J Invest Dermatol. 132:797–810. 2012. View Article : Google Scholar

22 

Blazejewska EA, Schlötzer-Schrehardt U, Zenkel M, Bachmann B, Chankiewitz E, Jacobi C and Kruse FE: Corneal limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial-like cells. Stem Cells. 27:642–652. 2009. View Article : Google Scholar :

23 

Saichanma S, Bunyaratvej A and Sila-Asna M: In vitro trans-differentiation of corneal epithelial-like cells from human skin-derived precursor cells. Int J Ophthalmol. 5:158–163. 2012.

24 

Araki K, Ohashi Y, Sasabe T, Kinoshita S, Hayashi K, Yang XZ, Hosaka Y, Aizawa S and Handa H: Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector. Invest Ophthalmol Vis Sci. 34:2665–2671. 1993.PubMed/NCBI

25 

Yang X, Qu L, Wang X, Zhao M, Li W, Hua J, Shi M, Moldovan N, Wang H and Dou Z: Plasticity of epidermal adult stem cells derived from adult goat ear skin. Mol Reprod Dev. 74:386–396. 2007. View Article : Google Scholar

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

27 

Shukla GC, Singh J and Barik S: MicroRNAs: Processing, maturation, target recognition and regulatory functions. Mol Cell Pharmacol. 3:83–92. 2011.PubMed/NCBI

28 

Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, et al: MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol. 219:214–221. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449:682–688. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C and Croce CM: MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA. 297:1901–1908. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Tian Y, Luo A, Cai Y, Su Q, Ding F, Chen H and Liu Z: MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. J Biol Chem. 285:7986–7994. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Ciafrè SA, Galardi S, Mangiola A, Ferracin M, Liu CG, Sabatino G, Negrini M, Maira G, Croce CM and Farace MG: Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun. 334:1351–1358. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Ma L, Reinhardt F, Pan E, Soutschek J, Bhat B, Marcusson EG, Teruya-Feldstein J, Bell GW and Weinberg RA: Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol. 28:341–347. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Chai G, Liu N, Ma J, Li H, Oblinger JL, Prahalad AK, Gong M, Chang LS, Wallace M, Muir D, et al: MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1. Cancer Sci. 101:1997–2004. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Lin J, Teo S, Lam DH, Jeyaseelan K and Wang S: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis. 3:e3982012. View Article : Google Scholar : PubMed/NCBI

36 

Widelitz RB: Wnt signaling in skin organogenesis. Organogenesis. 4:123–133. 2008. View Article : Google Scholar

37 

Lim X and Nusse R: Wnt signaling in skin development, homeostasis, and disease. Cold Spring Harb Perspect Biol. 5:52013. View Article : Google Scholar

38 

Pearton DJ, Yang Y and Dhouailly D: Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals. Proc Natl Acad Sci USA. 102:3714–3719. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Mukhopadhyay M, Gorivodsky M, Shtrom S, Grinberg A, Niehrs C, Morasso MI and Westphal H: Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium. Development. 133:2149–2154. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Kwofie MA and Skowronski J: Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. J Biol Chem. 283:3088–3096. 2008. View Article : Google Scholar

41 

Czugala M, Karolak JA, Nowak DM, Polakowski P, Pitarque J, Molinari A, Rydzanicz M, Bejjani BA, Yue BY, Szaflik JP, et al: Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus. Eur J Hum Genet. 20:389–397. 2012. View Article : Google Scholar :

42 

Caspi E and Rosin-Arbesfeld R: A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling. Mol Biol Cell. 19:4660–4674. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Poulin G, Turgeon B and Drouin J: NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol Cell Biol. 17:6673–6682. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Marsich E, Vetere A, Di Piazza M, Tell G and Paoletti S: The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2. Biochem J. 376:707–715. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Fujiwara K, Ohuchida K, Sada M, Horioka K, Ulrich CD III, Shindo K, Ohtsuka T, Takahata S, Mizumoto K, Oda Y, et al: CD166/ALCAM expression is characteristic of tumorigenicity and invasive and migratory activities of pancreatic cancer cells. PLoS One. 9:e1072472014. View Article : Google Scholar : PubMed/NCBI

46 

Park GB, Kim D, Kim YS, Kim S, Lee HK, Yang JW and Hur DY: The Epstein-Barr virus causes epithelial-mesenchymal transition in human corneal epithelial cells via Syk/src and Akt/Erk signaling pathways. Invest Ophthalmol Vis Sci. 55:1770–1779. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo Y, Ma X, Wu W, Shi M, Ma J, Zhang Y, Zhao E and Yang X: Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells. Int J Mol Med 41: 877-887, 2018.
APA
Guo, Y., Ma, X., Wu, W., Shi, M., Ma, J., Zhang, Y. ... Yang, X. (2018). Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells. International Journal of Molecular Medicine, 41, 877-887. https://doi.org/10.3892/ijmm.2017.3304
MLA
Guo, Y., Ma, X., Wu, W., Shi, M., Ma, J., Zhang, Y., Zhao, E., Yang, X."Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells". International Journal of Molecular Medicine 41.2 (2018): 877-887.
Chicago
Guo, Y., Ma, X., Wu, W., Shi, M., Ma, J., Zhang, Y., Zhao, E., Yang, X."Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells". International Journal of Molecular Medicine 41, no. 2 (2018): 877-887. https://doi.org/10.3892/ijmm.2017.3304
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Y, Ma X, Wu W, Shi M, Ma J, Zhang Y, Zhao E and Yang X: Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells. Int J Mol Med 41: 877-887, 2018.
APA
Guo, Y., Ma, X., Wu, W., Shi, M., Ma, J., Zhang, Y. ... Yang, X. (2018). Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells. International Journal of Molecular Medicine, 41, 877-887. https://doi.org/10.3892/ijmm.2017.3304
MLA
Guo, Y., Ma, X., Wu, W., Shi, M., Ma, J., Zhang, Y., Zhao, E., Yang, X."Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells". International Journal of Molecular Medicine 41.2 (2018): 877-887.
Chicago
Guo, Y., Ma, X., Wu, W., Shi, M., Ma, J., Zhang, Y., Zhao, E., Yang, X."Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells". International Journal of Molecular Medicine 41, no. 2 (2018): 877-887. https://doi.org/10.3892/ijmm.2017.3304
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