Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
February-2018 Volume 41 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 41 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome

  • Authors:
    • Ying‑Ming Tsai
    • Kuo‑Hwa Chiang
    • Jen‑Yu Hung
    • Wei‑An Chang
    • Hui‑Ping Lin
    • Jiunn‑Min Shieh
    • Inn‑Wen Chong
    • Ya‑Ling Hsu
  • View Affiliations / Copyright

    Affiliations: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C., Department of Internal Medicine, Chi Mei Medical Center, Tainan 710, Taiwan, R.O.C., Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C., Department of Respiratory Care, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan, R.O.C.
    Copyright: © Tsai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 757-764
    |
    Published online on: December 5, 2017
       https://doi.org/10.3892/ijmm.2017.3310
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Damage to the bronchial epithelium leads to persistent inflammation and airway remodelling in various respiratory diseases, such as asthma and chronic obstructive pulmonary disease. To date, the mechanisms underlying bronchial epithelial cell damage and death by common allergens remain largely unknown. The aim of the present study was to investigate Der f1, an allergen of Dermatophagoides farinae, which may result in the death of human bronchial epithelial cells (HBECs). Der f1 induces BECs to undergo the inflammatory cell death referred to as pyroptosis, induced by increasing lactate dehydrogenase release and propidium iodide penetration. Stimulation by Der f1 enhances interleukin (IL)‑1β cleavage and release, which is associated with caspase‑1 activation. In addition, the NOD‑like receptor family pyrin domain‑containing 3 (NLRP3), is required for the activation of caspase‑1 through increasing the formation of the inflammasome complex. Consistent with these findings, pre‑treatment of HBECs with a caspase‑1 inhibitor, or silencing of NLRP3 by siRNA transfection, reduced Der f1‑mediated IL‑1β and pyroptosis. Therefore, the common allergen Der f1 was not only found to induce allergy, but also led to pyroptosis and IL‑1β secretion via the NLRP3‑caspase‑1 inflammasome in HBECs. This newly identified connection of the Der f1 allergen with BEC damage and inflammation may play an important role in the pathogenesis of asthma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bel EH: Clinical Practice. Mild asthma. N Engl J Med. 369:549–557. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Lambrecht BN and Hammad H: The airway epithelium in asthma. Nat Med. 18:684–692. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Holgate ST, Roberts G, Arshad HS, Howarth PH and Davies DE: The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proc Am Thorac Soc. 6:655–659. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Lloyd CM and Saglani S: Asthma and allergy: The emerging epithelium. Nat Med. 16:273–274. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Martínez-Girón R and van Woerden HC: Disruption of airway epithelium in asthma pathogenesis: Are protozoa responsible. Proc Am Thorac So. 7:161author reply 161. 2010.

6 

Chanez P: Severe asthma is an epithelial disease. Eur Respir J. 25:945–946. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Holgate ST: The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev. 242:205–219. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Holgate ST: Epithelial damage and response. Clin Exp Allerg. 30(Suppl 1): 37–41. 2000. View Article : Google Scholar

9 

Davies DE: The role of the epithelium in airway remodeling in asthma. Proc Am Thorac Soc. 6:678–682. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Bergsbaken T, Fink SL and Cookson BT: Pyroptosis: Host cell death and inflammation. Nat Rev Microbiol. 7:99–109. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Yeretssian G, Labbé K and Saleh M: Molecular regulation of inflammation and cell death. Cytokine. 43:380–390. 2008. View Article : Google Scholar : PubMed/NCBI

12 

LaRock CN and Cookson BT: Burning down the house: Cellular actions during pyroptosis. PLoS Pathog. 9:pp. e10037932013, View Article : Google Scholar : PubMed/NCBI

13 

Tanaka H, Miyazaki N, Oashi K, Teramoto S, Shiratori M, Hashimoto M, Ohmichi M and Abe S: IL-18 might reflect disease activity in mild and moderate asthma exacerbation. J Allergy Clin Immunol. 107:331–336. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H and Iwamoto I: Role of IgE in Th2 cell-mediated allergic airway inflammation. Int Arch Allergy Immuno. 131(Suppl 1): pp. 2–6. 2003, View Article : Google Scholar

15 

Jacquet A: Innate immune responses in house dust mite allergy. ISRN Allergy. 735031:2013. View Article : Google Scholar : PubMed/NCBI

16 

Baker SF, Yin Y, Runswick SK, Stewart GA, Thompson PJ, Garrod DR and Robinson C: Peptidase allergen Der 1initiates apoptosis of epithelial cells independently of tight junction proteolysis. Mol Membr Biol. 20:71–81. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Gandhi VD, Davidson C, Asaduzzaman M, Nahirney D and Vliagoftis H: House dust mite interactions with airway epithelium: Role in allergic airway inflammation. Curr Allergy Asthma Rep. 13:262–270. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Wang JY: The innate immune response in house dust mite-induced allergic inflammation. Allergy Asthma Immunol Res. 5:68–74. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Takai T, Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K and Ogawa H: Recombinant Der 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity. Biochem Biophys Res Commun. 328:944–952. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Holgate ST: Pathogenesis of asthma. Clin Exp Allergy. 38:872–897. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Holt PG and Sly PD: Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment. Nat Med. 18:726–735. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Fahy JV: Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Me. 164(Suppl 2): S46–S51. 2001. View Article : Google Scholar

23 

Reisetter AC, Stebounova LV, Baltrusaitis J, Powers L, gupta A, grassian VH and Monick MM: Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles. J Biol Chem. 286:21844–21852. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z, Lommatzsch SE, Huang MT, Ting JP and Koller BH: NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol. 189:2006–2016. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Denes A, Lopez-Castejon G and Brough D: Caspase-1: Is IL-1 just the tip of the ICEberg. Cell Death Di. 3:e3382012. View Article : Google Scholar

26 

Whelan R, Kim C, Chen M, Leiter J, Grunstein MM and Hakonarson H: Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle. Eur Respir. 24:559–567. 2004. View Article : Google Scholar

27 

Delaleu N and Bickel M: Interleukin-1 beta and interleukin-18: Regulation and activity in local inflammation. Periodontol. 35:42–52. 2004. View Article : Google Scholar

28 

Mariathasan S and Monack DM: Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation. Nat Rev Immunol. 7:31–40. 2007. View Article : Google Scholar

29 

Aachoui Y, Sagulenko V, Miao EA and Stacey KJ: Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. Curr Opin Microbiol. 16:319–326. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Miao EA, Rajan JV and Aderem A: Caspase-1-induced pyroptotic cell death. Immunol Rev. 243:206–214. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW and Hsu YL: Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome. Int J Mol Med 41: 757-764, 2018.
APA
Tsai, Y., Chiang, K., Hung, J., Chang, W., Lin, H., Shieh, J. ... Hsu, Y. (2018). Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome. International Journal of Molecular Medicine, 41, 757-764. https://doi.org/10.3892/ijmm.2017.3310
MLA
Tsai, Y., Chiang, K., Hung, J., Chang, W., Lin, H., Shieh, J., Chong, I., Hsu, Y."Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome". International Journal of Molecular Medicine 41.2 (2018): 757-764.
Chicago
Tsai, Y., Chiang, K., Hung, J., Chang, W., Lin, H., Shieh, J., Chong, I., Hsu, Y."Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome". International Journal of Molecular Medicine 41, no. 2 (2018): 757-764. https://doi.org/10.3892/ijmm.2017.3310
Copy and paste a formatted citation
x
Spandidos Publications style
Tsai YM, Chiang KH, Hung JY, Chang WA, Lin HP, Shieh JM, Chong IW and Hsu YL: Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome. Int J Mol Med 41: 757-764, 2018.
APA
Tsai, Y., Chiang, K., Hung, J., Chang, W., Lin, H., Shieh, J. ... Hsu, Y. (2018). Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome. International Journal of Molecular Medicine, 41, 757-764. https://doi.org/10.3892/ijmm.2017.3310
MLA
Tsai, Y., Chiang, K., Hung, J., Chang, W., Lin, H., Shieh, J., Chong, I., Hsu, Y."Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome". International Journal of Molecular Medicine 41.2 (2018): 757-764.
Chicago
Tsai, Y., Chiang, K., Hung, J., Chang, W., Lin, H., Shieh, J., Chong, I., Hsu, Y."Der f1 induces pyroptosis in human bronchial epithelia via the NLRP3 inflammasome". International Journal of Molecular Medicine 41, no. 2 (2018): 757-764. https://doi.org/10.3892/ijmm.2017.3310
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team