Open Access

Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review)

  • Authors:
    • Xin Wang
    • Guoli Huai
    • Hailian Wang
    • Yuande Liu
    • Ping Qi
    • Wei Shi
    • Jie Peng
    • Hongji Yang
    • Shaoping Deng
    • Yi Wang
  • View Affiliations

  • Published online on: December 29, 2017     https://doi.org/10.3892/ijmm.2017.3352
  • Pages: 1201-1212
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glaucoma is the leading cause of irreversible blindness worldwide and there is no effective treatment thus far. The trabecular meshwork has been identified as the major pathological area involved. Certain signaling pathways in the trabecular meshwork, including the Wnt, lysophosphatidic acid and transforming growth factor‑β pathways, have been identified as novel therapeutic targets in glaucoma treatment. Meanwhile, it has been reported that key proteins in these pathways, particularly the primary transcription regulator Yes‑associated protein (YAP) and transcriptional co‑activator with PDZ‑binding motif (TAZ), exhibit interactions with the Hippo pathway. The Hippo pathway, which was first identified in Drosophila, has drawn great focus with regard to various aspects of studies in recent years. One role of the Hippo pathway in the regulation of organ size was indicated by more recent evidence. Defining the relevant physiological function of the Hippo pathway has proven to be extremely complicated. Studies have ascribed a role for the Hippo pathway in an overwhelming number of processes, including cell proliferation, cell death and cell differentiation. Therefore, the present review aimed to unravel the roles of YAP and TAZ in the Hippo pathway and the pathogenesis of glaucoma. Furthermore, a new and creative study for the treatment of glaucoma is provided.
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March 2018
Volume 41 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Wang, X., Huai, G., Wang, H., Liu, Y., Qi, P., Shi, W. ... Wang, Y. (2018). Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review). International Journal of Molecular Medicine, 41, 1201-1212. https://doi.org/10.3892/ijmm.2017.3352
MLA
Wang, X., Huai, G., Wang, H., Liu, Y., Qi, P., Shi, W., Peng, J., Yang, H., Deng, S., Wang, Y."Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review)". International Journal of Molecular Medicine 41.3 (2018): 1201-1212.
Chicago
Wang, X., Huai, G., Wang, H., Liu, Y., Qi, P., Shi, W., Peng, J., Yang, H., Deng, S., Wang, Y."Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review)". International Journal of Molecular Medicine 41, no. 3 (2018): 1201-1212. https://doi.org/10.3892/ijmm.2017.3352