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Review Open Access

Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)

  • Authors:
    • Jing‑Hua Pan
    • Hong Zhou
    • Xiao‑Xu Zhao
    • Hui Ding
    • Wei Li
    • Li Qin
    • Yun‑Long Pan
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Histology and Embryology, Medical School of Jinan University, Guangzhou, Guangdong 510632, P.R. China
    Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1809-1816
    |
    Published online on: January 11, 2018
       https://doi.org/10.3892/ijmm.2018.3383
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Abstract

Communication between hepatocellular carcinoma (HCC) cells and their environment is essential for the development and progression of HCC. Exosomes, which are microvesicles secreted by a number of cell types, are carriers of intercellular information and regulate the tumour microenvironment. Studies have demonstrated that exosomes are involved in the communication between HCC cells, endothelial cells and stem cells, and that they serve important roles in the metastasis and invasion, immune evasion and immunotherapy of HCC. In addition, the mechanism of HCC‑derived exosome‑mediated microRNA (miRNA) transfer is important in the environmental modulation of HCC growth and progression. As exosomes can be used for detecting and monitoring HCC, they can potentially serve as specific biomarkers for early‑stage tumours and the tumour metastasis of HCC. Moreover, mesenchymal stem cell‑derived exosomes can be transfected with miRNAs to inhibit HCC development. Therefore, as nucleic acid delivery vehicles, exosomes show a tremendous potential for effective treatment against HCC. In the present review, recent advances in our understanding of the source, composition and function of exosomes in HCC, and their potential value in the early diagnosis and treatment of HCC, are summarized.
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Copy and paste a formatted citation
Spandidos Publications style
Pan JH, Zhou H, Zhao XX, Ding H, Li W, Qin L and Pan YL: Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review). Int J Mol Med 41: 1809-1816, 2018.
APA
Pan, J., Zhou, H., Zhao, X., Ding, H., Li, W., Qin, L., & Pan, Y. (2018). Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review). International Journal of Molecular Medicine, 41, 1809-1816. https://doi.org/10.3892/ijmm.2018.3383
MLA
Pan, J., Zhou, H., Zhao, X., Ding, H., Li, W., Qin, L., Pan, Y."Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)". International Journal of Molecular Medicine 41.4 (2018): 1809-1816.
Chicago
Pan, J., Zhou, H., Zhao, X., Ding, H., Li, W., Qin, L., Pan, Y."Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)". International Journal of Molecular Medicine 41, no. 4 (2018): 1809-1816. https://doi.org/10.3892/ijmm.2018.3383
Copy and paste a formatted citation
x
Spandidos Publications style
Pan JH, Zhou H, Zhao XX, Ding H, Li W, Qin L and Pan YL: Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review). Int J Mol Med 41: 1809-1816, 2018.
APA
Pan, J., Zhou, H., Zhao, X., Ding, H., Li, W., Qin, L., & Pan, Y. (2018). Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review). International Journal of Molecular Medicine, 41, 1809-1816. https://doi.org/10.3892/ijmm.2018.3383
MLA
Pan, J., Zhou, H., Zhao, X., Ding, H., Li, W., Qin, L., Pan, Y."Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)". International Journal of Molecular Medicine 41.4 (2018): 1809-1816.
Chicago
Pan, J., Zhou, H., Zhao, X., Ding, H., Li, W., Qin, L., Pan, Y."Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)". International Journal of Molecular Medicine 41, no. 4 (2018): 1809-1816. https://doi.org/10.3892/ijmm.2018.3383
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