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Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension

  • Authors:
    • Jia Liu
    • Jiamei Liu
    • Linying Shi
    • Fan Zhang
    • Liping Yu
    • Xinchun Yang
    • Jun Cai
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1835-1844
    |
    Published online on: January 23, 2018
       https://doi.org/10.3892/ijmm.2018.3420
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Abstract

The present study aimed to explore microRNA-126 (miR-126) as a novel therapeutic target for primary hypertension. The lentiviral vector containing human immunodeficiency virus 1 (HIV‑1), the miR‑126 gene knockdown viral vector (lenti-miR-126-KD), and control lentiviral vector (lenti‑scramble‑miR) were constructed. Spontaneously hypertensive rats were randomly divided into 4 groups, which received a high dose of lenti‑miR‑126‑KD (1x108, n=5), low dose of lenti‑miR‑126‑KD (1x107, n=6), scramble‑miR (5x107, n=6), and PBS (n=6). Lentiviral vectors were injected into the tail vein. Data on the systolic blood pressure, diastolic pressure, mean arterial pressure, and heart rate were collected weekly. After 8 weeks of virus administration, the distribution of lentiviral vectors in different tissues was observed by fluorescence microscopy. Picric acid Sirius red and H&E staining were used to observe the target organ damage, and the ELISA kit was used to determine the serum nitric oxide (NO) content. The lentiviral vector was found to be constructed successfully. Eight weeks after the lentiviral vector injection, green fluorescent protein was observed in different tissues in each group. The blood pressure and heart rate were not significantly altered after lentiviral vector injection (P>0.05). No significant differences in the heart‑to‑body weight ratio among the four groups were observed (P=0.23). Picric acid Sirius red and H&E staining revealed that there was no significant difference in morphology among the four groups. No significant difference in the serum NO level among the four groups was noted (P=0.23). The miR‑126 gene knockdown lentiviral vector was constructed successfully. No significant antihypertensive effect was observed by the knockdown of miR‑126 for the treatment of primary hypertension. The target organs were not protected significantly after the treatment. The increased level of miR‑126 expression in hypertensive patients may be due to a compensatory mechanism.
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1 

Liu LS; Writing Group of 2010 Chinese Guidelines for the Management of Hypertension: 2010 Chinese guidelines for the management of hypertension. Zhonghua Xin Xue Guan Bing Za Zhi. 39:579–615. 2011.In Chinese. PubMed/NCBI

2 

Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Zhao Y, Samal E and Srivastava D: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature. 436:214–220. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Alvarez-Garcia I and Miska EA: MicroRNA functions in animal development and human disease. Development. 132:4653–4662. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Denli AM, Tops BB, Plasterk RH, Ketting RF and Hannon GJ: Processing of primary microRNAs by the Microprocessor complex. Nature. 432:231–235. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N and Shiekhattar R: The microprocessor complex mediates the genesis of microRNAs. Nature. 432:235–240. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S and Kim VN: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Pillai RS, Bhattacharyya SN and Filipowicz W: Repression of protein synthesis by miRNAs: How many mechanisms. Trends Cell Biol. 17:118–126. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W and Tuschl T: Identification of tissue-specific microRNAs from mouse. Curr Biol. 12:735–739. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R and Olson EN: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 15:261–271. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY and Srivastava D: miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 15:272–284. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Köppel T, Jahantigh MN, Lutgens E, et al: Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2:ra812009. View Article : Google Scholar : PubMed/NCBI

15 

Harris TA, Yamakuchi M, Ferlito M, Mendell JT and Lowenstein CJ: MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA. 105:1516–1521. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Stumpf C, John S, Jukic J, Yilmaz A, Raaz D, Schmieder RE, Daniel WG and Garlichs CD: Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertension. J Hypertens. 23:995–1000. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Cai J, Yi FF, Yang L, Shen DF, Yang Q, Li A, Ghosh AK, Bian ZY, Yan L, Tang QZ, et al: Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling. Hypertension. 53:539–548. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Cai J, Yi FF, Bian ZY, Shen DF, Yang L, Yan L, Tang QZ, Yang XC and Li H: Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway. J Cell Mol Med. 13:909–925. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science. 303:83–86. 2004. View Article : Google Scholar

20 

Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:806–811. 1998. View Article : Google Scholar : PubMed/NCBI

21 

Caplen NJ: Gene therapy progress and prospects. Downregulating gene expression: The impact of RNA interference. Gene Ther. 11:1241–1248. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Wall NR and Shi Y: Small RNA: Can RNA interference be exploited for therapy. Lancet. 362:1401–1403. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Uchida H, Tanaka T, Sasaki K, Kato K, Dehari H, Ito Y, Kobune M, Miyagishi M, Taira K, Tahara H and Hamada H: Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther. 10:162–171. 2004. View Article : Google Scholar : PubMed/NCBI

24 

McCaffrey AP, Nakai H, Pandey K, Huang Z, Salazar FH, Xu H, Wieland SF, Marion PL and Kay MA: Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol. 21:639–644. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Randall G, Grakoui A and Rice CM: Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc Natl Acad Sci USA. 100:235–240. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Ding H, Schwarz DS, Keene A, Affar B, Fenton L, Xia X, Shi Y, Zamore PD and Xu Z: Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell. 2:209–217. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, et al: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 33:401–406. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Vázquez J, Correa de Adjounian MF, Sumners C, González A, Diez-Freire C and Raizada MK: Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference. Hypertension. 45:115–119. 2005. View Article : Google Scholar

29 

Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, et al: MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 20:368–376. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Zhang J, Zhang Z, Zhang DY, Zhu J, Zhang T and Wang C: MicroRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS One. 8:e832942013. View Article : Google Scholar : PubMed/NCBI

31 

Goerke SM, Kiefer LS, Stark GB, Simunovic F and Finkenzeller G: miR-126 modulates angiogenic growth parameters of peripheral blood endothelial progenitor cells. Biol Chem. 396:245–252. 2015. View Article : Google Scholar

32 

Chen Y, Chen H, Hoffmann A, Cool DR, Diz DI, Chappell MC, Chen AF and Morris M: Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain. Hypertension. 47:230–237. 2006. View Article : Google Scholar

33 

Fridman E, Dotan Z, Barshack I, David MB, Dov A, Tabak S, Zion O, Benjamin S, Benjamin H, Kuker H, et al: Accurate molecular classification of renal tumors using microRNA expression. J Mol Diagn. 12:687–696. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ and Ma D: The cell growth suppressor, mir-126, targets IRS-1. Biochem Biophys Res Commun. 377:136–140. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Wang F, Zheng Z, Guo J and Ding X: Correlation and quantitation of microRNA aberrant expression in tissues and sera from patients with breast tumor. Gynecol Oncol. 119:586–593. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Miko E, Czimmerer Z, Csánky E, Boros G, Buslig J, Dezso B and Scholtz B: Differentially expressed microRNAs in small cell lung cancer. Exp Lung Res. 35:646–664. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Li XM, Wang AM, Zhang J and Yi H: Downregulation of miR-126 expression in colorectal cancer and its clinical significance. Med Oncol. 28:1054–1057. 2011. View Article : Google Scholar

38 

Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL and Massagué J: Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 451:147–152. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Fulci V, Colombo T, Chiaretti S, Messina M, Citarella F, Tavolaro S, Guarini A, Foà R and Macino G: Characterization of B- and T-lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles. Genes Chromosomes Cancer. 48:1069–1082. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Cammarata G, Augugliaro L, Salemi D, Agueli C, La Rosa M, Dagnino L, Civiletto G, Messana F, Marfia A, Bica MG, et al: Differential expression of specific microRNA and their targets in acute myeloid leukemia. Am J Hematol. 85:331–339. 2010.PubMed/NCBI

41 

Lever AM, Strappe PM and Zhao J: Lentiviral vectors. J Biomed Sci. 11:439–449. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Lois C, Hong EJ, Pease S, Brown EJ and Baltimore D: Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science. 295:868–872. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Pfeifer A, Ikawa M, Dayn Y and Verma IM: Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc Natl Acad Sci USA. 99:2140–2145. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Lai Z and Brady RO: Gene transfer into the central nervous system in vivo using a recombinanat lentivirus vector. J Neurosci Res. 67:363–371. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L and Trono D: Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol. 72:9873–9880. 1998.PubMed/NCBI

46 

Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI and Cheng L: Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 7:827–838. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Lifton RP, Gharavi AG and Geller DS: Molecular mechanisms of human hypertension. Cell. 104:545–556. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Wilson EM, Diwan A, Spinale FG and Mann DL: Duality of innate stress responses in cardiac injury, repair, and remodeling. J Mol Cell Cardiol. 37:801–811. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Fernandez-Real JM, Vayreda M, Richart C, Gutierrez C, Broch M, Vendrell J and Ricart W: Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab. 86:1154–1159. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Moon SK, Cha BY and Kim CH: ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway. J Cell Physiol. 198:417–427. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA and O'Donnell VB: Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. Am J Pathol. 171:315–325. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Davis JR, Giardina JB, Green GM, Alexander BT, Granger JP and Khalil RA: Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol. 282:R390–R399. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC and Smithies O: Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA. 93:13176–13181. 1996. View Article : Google Scholar : PubMed/NCBI

54 

Chin K, Kurashima Y, Ogura T, Tajiri H, Yoshida S and Esumi H: Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. Oncogene. 15:437–442. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Gélinas DS, Bernatchez PN, Rollin S, Bazan NG and Sirois MG: Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: Role of PI3K, PKC and PLC pathways. Br J Pharmacol. 137:1021–1030. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M and Horvitz HR: Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol. 5:R682004. View Article : Google Scholar : PubMed/NCBI

57 

Chivukula RR and Mendell JT: Circular reasoning: microRNAs and cell-cycle control. Trends Biochem Sci. 33:474–481. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Pan Q and Chegini N: MicroRNA signature and regulatory functions in the endometrium during normal and disease states. Semin Reprod Med. 26:479–493. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Fontana L, Sorrentino A, Condorelli G and Peschle C: Role of microRNAs in haemopoiesis, heart hypertrophy and cancer. Biochem Soc Trans. 36:1206–1210. 2008. View Article : Google Scholar : PubMed/NCBI

60 

Finnegan EJ and Matzke MA: The small RNA world. J Cell Sci. 116:4689–4693. 2003. View Article : Google Scholar : PubMed/NCBI

61 

Liu B, Peng XC, Zheng XL, Wang J and Qin YW: MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer. 66:169–175. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Liu J, Shi L, Zhang F, Yu L, Yang X and Cai J: Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension. Int J Mol Med 41: 1835-1844, 2018.
APA
Liu, J., Liu, J., Shi, L., Zhang, F., Yu, L., Yang, X., & Cai, J. (2018). Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension. International Journal of Molecular Medicine, 41, 1835-1844. https://doi.org/10.3892/ijmm.2018.3420
MLA
Liu, J., Liu, J., Shi, L., Zhang, F., Yu, L., Yang, X., Cai, J."Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension". International Journal of Molecular Medicine 41.4 (2018): 1835-1844.
Chicago
Liu, J., Liu, J., Shi, L., Zhang, F., Yu, L., Yang, X., Cai, J."Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension". International Journal of Molecular Medicine 41, no. 4 (2018): 1835-1844. https://doi.org/10.3892/ijmm.2018.3420
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Liu J, Shi L, Zhang F, Yu L, Yang X and Cai J: Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension. Int J Mol Med 41: 1835-1844, 2018.
APA
Liu, J., Liu, J., Shi, L., Zhang, F., Yu, L., Yang, X., & Cai, J. (2018). Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension. International Journal of Molecular Medicine, 41, 1835-1844. https://doi.org/10.3892/ijmm.2018.3420
MLA
Liu, J., Liu, J., Shi, L., Zhang, F., Yu, L., Yang, X., Cai, J."Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension". International Journal of Molecular Medicine 41.4 (2018): 1835-1844.
Chicago
Liu, J., Liu, J., Shi, L., Zhang, F., Yu, L., Yang, X., Cai, J."Preliminary study of microRNA-126 as a novel therapeutic target for primary hypertension". International Journal of Molecular Medicine 41, no. 4 (2018): 1835-1844. https://doi.org/10.3892/ijmm.2018.3420
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