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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November-2018 Volume 42 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article Open Access

Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway

  • Authors:
    • Aonan Li
    • Ke Gu
    • Qi Wang
    • Xiyan Chen
    • Xucheng Fu
    • Ying Wang
    • Yong Wen

  • View Affiliations / Copyright

    Affiliations: Department of Implantology, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Implantology, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2615-2627
    |
    Published online on: August 9, 2018
       https://doi.org/10.3892/ijmm.2018.3818
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Abstract

The purpose of the present study was to investigate the mechanism by which epigallocatechin‑3‑gallate (EGCG) inhibits the biological behaviors of the tongue squamous cell carcinoma (TSCC) through the Hippo‑tafazzin (TAZ) signaling pathway and to provide insights into molecular targeted therapy in TSCC. CAL27 and SCC15 cells were treated with different concentrations of EGCG for 24 h. Cell proliferation was determined using Cell‑Counting Kit‑8 and EdU assays. Cell apoptosis was evaluated by flow cytometry. Cell migration and invasion were measured using scratch and Transwell assays, respectively. Furthermore, protein levels of associated target genes were detected using a western blot assay. It was demonstrated that EGCG affected biological behaviors of CAL27 and SCC15 cells in concentration‑ and time‑dependent manners. In addition, EGCG decreased the protein levels of TAZ, LATS1, MOB1 and JNK. Overexpression of TAZ alleviated the effect of EGCG on CAL27 cells. Furthermore, the combination of EGCG and simvastatin inhibited the proliferation, migration and invasion, and promoted apoptosis significantly compared with single treatment in CAL27 cells. The results of the present study suggested that EGCG affects proliferation, apoptosis, migration and invasion of TSCC through the Hippo‑TAZ signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Li A, Gu K, Wang Q, Chen X, Fu X, Wang Y and Wen Y: Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway. Int J Mol Med 42: 2615-2627, 2018.
APA
Li, A., Gu, K., Wang, Q., Chen, X., Fu, X., Wang, Y., & Wen, Y. (2018). Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway. International Journal of Molecular Medicine, 42, 2615-2627. https://doi.org/10.3892/ijmm.2018.3818
MLA
Li, A., Gu, K., Wang, Q., Chen, X., Fu, X., Wang, Y., Wen, Y."Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway". International Journal of Molecular Medicine 42.5 (2018): 2615-2627.
Chicago
Li, A., Gu, K., Wang, Q., Chen, X., Fu, X., Wang, Y., Wen, Y."Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway". International Journal of Molecular Medicine 42, no. 5 (2018): 2615-2627. https://doi.org/10.3892/ijmm.2018.3818
Copy and paste a formatted citation
x
Spandidos Publications style
Li A, Gu K, Wang Q, Chen X, Fu X, Wang Y and Wen Y: Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway. Int J Mol Med 42: 2615-2627, 2018.
APA
Li, A., Gu, K., Wang, Q., Chen, X., Fu, X., Wang, Y., & Wen, Y. (2018). Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway. International Journal of Molecular Medicine, 42, 2615-2627. https://doi.org/10.3892/ijmm.2018.3818
MLA
Li, A., Gu, K., Wang, Q., Chen, X., Fu, X., Wang, Y., Wen, Y."Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway". International Journal of Molecular Medicine 42.5 (2018): 2615-2627.
Chicago
Li, A., Gu, K., Wang, Q., Chen, X., Fu, X., Wang, Y., Wen, Y."Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway". International Journal of Molecular Medicine 42, no. 5 (2018): 2615-2627. https://doi.org/10.3892/ijmm.2018.3818
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