|
1
|
Rabinowitz YS: Keratoconus. Surv
Ophthalmol. 42:297–319. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Katsoulos C, Karageorgiadis L, Vasileiou
N, Mousafeiropoulos T and Asimellis G: Customized hydrogel contact
lenses for kera-toconus incorporating correction for vertical coma
aberration. Ophthalmic Physiol Opt. 29:321–329. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Abu-Amero KK, Al-Muammar AM and Kondkar
AA: Genetics of keratoconus: Where do we stand? J Ophthalmol.
2014:6417082014.PubMed/NCBI
|
|
4
|
Nielsen K, Hjortdal J, Pihlmann M and
Corydon TJ: Update on the keratoconus genetics. Acta Ophthalmol.
91:106–113. 2013. View Article : Google Scholar
|
|
5
|
Kenney MC, Chwa M, Atilano SR, Tran A,
Carballo M, Saghizadeh M, Vasiliou V, Adachi W and Brown DJ:
Increased levels of catalase and cathepsin V/l2 but decreased
TIMP-1 in keratoconus corneas: Evidence that oxidative stress plays
a role in this disorder. Investig Ophthalmol Vis Sci. 46:823–832.
2005. View Article : Google Scholar
|
|
6
|
Chwa M, Atilano SR, Hertzog D, Zheng H,
Langberg J, Kim DW and Kenney MC: Hypersensitive response to
oxidative stress in keratoconus corneal fibroblasts. Investig
Ophthalmol Vis Sci. 49:4361–4369. 2008. View Article : Google Scholar
|
|
7
|
Buddi R, Lin B, Atilano SR, Zorapapel NC,
Kenney MC and Brown DJ: Evidence of oxidative stress in human
corneal diseases. J Histochem Cytochem. 50:341–351. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Chwa M, Atilano SR, Reddy V, Jordan N, Kim
DW and Kenney MC: Increased stress-induced generation of reactive
oxygen species and apoptosis in human keratoconus fibroblasts.
Investig Ophthalmol Vis Sci. 47:1902–1910. 2006. View Article : Google Scholar
|
|
9
|
Jeong WS, Jun M and Kong AN: Nrf2: A
potential molecular target for cancer chemoprevention by natural
compounds. Antioxid Redox Signal. 8:99–106. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Siow RC, Ishii T and Mann GE: Modulation
of antioxidant gene expression by 4-hydroxynonenal:
Atheroprotective role of the Nrf2/ARE transcription pathway. Redox
Rep. 12:11–15. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Itoh K, Chiba T, Takahashi S, Ishii T,
Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, et
al: An Nrf2/small maf heterodimer mediates the induction of phase
II detoxifying enzyme genes through antioxidant response elements.
Biochem Biophys Res Commun. 236:313–322. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Cheng X, Siow RCM and Mann GE: Impaired
redox signaling and antioxidant gene expression in endothelial
cells in diabetes: A role for mitochondria and the nuclear
factor-E2-related factor 2-Kelch-like ECH-associated protein 1
defense pathway. Antioxid Redox Signal. 14:469–487. 2011.
View Article : Google Scholar
|
|
13
|
Zhang Y, Talalay P, Cho CG and Posner GH:
A major inducer of anticarcinogenic protective enzymes from
broccoli: Isolation and elucidation of structure. Proc Natl Acad
Sci USA. 89:2399–2403. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zhao J, Kobori N, Aronowski J and Dash PK:
Sulforaphane reduces infarct volume following focal cerebral
ischemia in rodents. Neurosci Lett. 393:108–112. 2006. View Article : Google Scholar
|
|
15
|
Danilov CA, Chandrasekaran K, Racz J,
Soane L, Zielke C and Fiskum G: Sulforaphane protects astrocytes
against oxidative stress and delayed death caused by oxygen and
glucose deprivation. Glia. 57:645–656. 2009. View Article : Google Scholar :
|
|
16
|
Tarozzi A, Morroni F, Merlicco A, Hrelia
S, Angeloni C, Cantelli-Forti G and Hrelia P: Sulforaphane as an
inducer of glutathione prevents oxidative stress-induced cell death
in a dopaminergic-like neuroblastoma cell line. J Neurochem.
111:1161–1171. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Piao CS, Gao S, Lee GH, Kim DS, Park BH,
Chae SW, Chae HJ and Kim SH: Sulforaphane protects ischemic injury
of hearts through antioxidant pathway and mitochondrial K(ATP)
channels. Pharmacol Res. 61:342–348. 2010. View Article : Google Scholar
|
|
18
|
Cheung IMY, Mcghee CN and Sherwin T:
Beneficial effect of the antioxidant riboflavin on gene expression
of extracellular matrix elements, antioxidants and oxidases in
keratoconic stromal cells. Clin Exp Optom. 97:349–355.
2014.PubMed/NCBI
|
|
19
|
Clark JE, Foresti R, Green CJ and
Motterlini R: Dynamics of haem oxygenase-1 expression and bilirubin
production in cellular protection against oxidative stress. Biochem
J. 348(Pt 3): 615–619. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Qiao J, Li H, Tang Y, Song W, Rong B, Yang
S, Wu Y and Yan X: A rabbit model of corneal Ectasia generated by
treatment with collagenase type II. BMC Ophthalmol. 18:942018.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zheng H, Whitman SA, Wu W, Wondrak GT,
Wong PK, Fang D and Zhang DD: Therapeutic potential of Nrf2
activators in streptozotocin-induced diabetic nephropathy.
Diabetes. 60:3055–3066. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Park J, Kang JW and Lee SM: Activation of
the cholinergic anti-inflammatory pathway by nicotine attenuates
hepatic ischemia/reperfusion injury via heme oxygenase-1 induction.
Eur J Pharmacol. 707:61–70. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wang W, Wang F, Shi L, Jia X and Lin L:
Role of heme oxygenase-1/carbon monoxide system in pulmonary
ischemia-reperfusion injury. Interact Cardiovasc Thorac Surg.
9:159–162. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
He M, Pan H, Xiao C and Pu M: Roles for
redox signaling by NADPH oxidase in hyperglycemia-induced heme
oxygenase-1 expression in the diabetic retina. Investig
Opthalmology Vis Sci. 54:4092–4101. 2013. View Article : Google Scholar
|
|
25
|
Fleige S, Walf V, Huch S, Prgomet C, Sehm
J and Pfaffl MW: Comparison of relative mRNA quantification models
and the impact of RNA integrity in quantitative real-time RT-PCR.
Biotechnol Lett. 28:1601–1613. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
27
|
O'Brien WJ, Heimann T and Rizvi F: NADPH
oxidase expression and production of superoxide by human corneal
stromal cells. Mol Vis. 15:2535–2543. 2009.PubMed/NCBI
|
|
28
|
Kermer P, Ankerhold R, Klöcker N,
Krajewski S, Reed JC and Bähr M: Caspase-9: Involvement in
secondary death of axotomized rat retinal ganglion cells in vivo.
Brain Res Mol Brain Res. 85:144–150. 2000. View Article : Google Scholar
|
|
29
|
Itoh K, Wakabayashi N, Katoh Y, Ishii T,
Igarashi K, Engel JD and Yamamoto M: Keap1 represses nuclear
activation of antioxidant responsive elements by Nrf2 through
binding to the aminoterminal Neh2 domain. Genes Dev. 13:76–86.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hong CW, Sinha-Roy A, Schoenfield L,
Mcmahon JT and Dupps WJ Jr: Collagenase-mediated tissue modeling of
corneal ectasia and collagen cross-linking treatments. Investig
Ophthalmol Vis Sci. 53:2321–2327. 2012. View Article : Google Scholar
|
|
31
|
Wang X, Huang Y, Jastaneiah S, Majumdar S,
Kang JU, Yiu SC, Stark W and Elisseeff JH: Protective effects of
soluble collagen during ultraviolet-A crosslinking on
enzyme-mediated corneal ectatic models. PLoS One. 10:e01369992015.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Egeblad M and Werb Z: New functions for
the matrix metalloproteinases in cancer progression. Nat Rev
Cancer. 2:161–174. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
33
|
Davidson AE, Hayes S, Hardcastle AJ and
Tuft SJ: The pathogenesis of keratoconus. Eye (Lond). 28:189–195.
2014. View Article : Google Scholar
|
|
34
|
Meek KM and Knupp C: Corneal structure and
transparency. Prog Retin Eye Res. 49:1–16. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Elsheikh A, Ross S, Alhasso D and Rama P:
Numerical study of the effect of corneal layered structure on
ocular biomechanics. Curr Eye Res. 34:26–35. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Jester JV, Moller-Pedersen T, Huang J, Sax
CM, Kays WT, Cavangh HD, Petroll WM and Piatigorsky J: The cellular
basis of corneal transparency: Evidence for 'corneal crystallins'.
J Cell Sci. 112:613–622. 1999.PubMed/NCBI
|
|
37
|
Karamichos D, Hutcheon a EK, Rich CB,
Trinkaus-Randall V, Asara JM and Zieske JD: In vitro model suggests
oxidative stress involved in keratoconus disease. Sci Rep.
4:46082014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Arnal E, Peris-Martínez C, Menezo JL,
Johnsen-Soriano S and Romero FJ: Oxidative stress in keratoconus?
Invest Ophthalmol Vis Sci. 52:8592–8597. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Gondhowiardjo TD and van Haeringen NJ:
Corneal aldehyde dehydrogenase, glutathione reductase, and
glutathione S-transferase in pathologic corneas. Cornea.
12:310–314. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
McKay TB, Sarker-Nag A, Lyon D, Asara JM
and Karamichos D: Quercetin modulates keratoconus metabolism in
vitro. Cell Biochem Funct. 33:341–350. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
McKay TB, Lyon D, Sarker-Nag A,
Priyadarsini S, Asara JM and Karamichos D: Quercetin attenuates
lactate production and extracellular matrix secretion in
keratoconus. Sci Rep. 5:90032015. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Fahey JW, Holtzclaw WD, Wehage SL, Wade
KL, Stephenson KK and Talalay P: Sulforaphane bioavailability from
glucoraphanin-rich broccoli: Control by active endogenous
myrosinase. PLoS One. 10:e01409632015. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zhao HD, Zhang F, Shen G, Li YB, Li YH,
Jing HR, Ma LF, Yao JH and Tian XF: Sulforaphane protects liver
injury induced by intestinal ischemia reperfusion through Nrf2-ARE
pathway. World J Gastroenterol. 16:3002–3010. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Ping Z, Liu W, Kang Z, Cai J, Wang Q,
Cheng N, Wang S, Wang S, Zhang JH and Sun X: Sulforaphane protects
brains against hypoxic-ischemic injury through induction of
Nrf2-dependent phase 2 enzyme. Brain Res. 1343:178–185. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Yoon HY, Kang NI, Lee HK, Jang KY, Park JW
and Park BH: Sulforaphane protects kidneys against
ischemia-reperfusion injury through induction of the Nrf2-dependent
phase 2 enzyme. Biochem Pharmacol. 75:2214–2223. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Ziaei A, Schmedt T, Chen Y and Jurkunas
UV: Sulforaphane decreases endothelial cell apoptosis in Fuchs
endothelial corneal dystrophy: A novel treatment. Investig
Ophthalmol Vis Sci. 54:6724–6734. 2013. View Article : Google Scholar
|
|
47
|
Tanito M, Masutani H, Kim YC, Nishikawa M,
Ohira A and Yodoi J: Sulforaphane induces thioredoxin through the
antioxidant-responsive element and attenuates retinal light damage
in mice. Investig Ophthalmol Vis Sci. 46:979–987. 2005. View Article : Google Scholar
|
|
48
|
Kong L, Tanito M, Huang Z, Li F, Zhou X,
Zaharia A, Yodoi J, McGinnis JF and Cao W: Delay of photoreceptor
degeneration in tubby mouse by sulforaphane. J Neurochem.
101:1041–1052. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Lambeth JD: NOX enzymes and the biology of
reactive oxygen. Nat Rev Immunol. 4:181–189. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Kensler TW, Wakabayashi N and Biswal S:
Cell survival responses to environmental stresses via the
Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 47:89–116.
2007. View Article : Google Scholar
|
|
51
|
Kobayashi M and Yamamoto M: Molecular
mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene
regulation. Antioxid Redox Signal. 7:385–394. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Kang KW, Lee SJ and Kim SG: Molecular
mechanism of nrf2 activation by oxidative stress. Antioxid Redox
Signal. 7:1664–1673. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Ishii T, Itoh K, Ruiz E, Leake DS, Unoki
H, Yamamoto M and Mann GE: Role of Nrf2 in the regulation of CD36
and stress protein expression in murine macrophages: Activation by
oxidatively modified LDL and 4-hydroxynonenal. Circ Res.
94:609–616. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wakabayashi N, Slocum SL, Skoko JJ, Shin S
and Kensler TW: When NRF2 talks, who's listening? Antioxid Redox
Signal. 13:1649–1663. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Ryter SW, Alam J and Choi AMK: Heme
oxygenase-1/carbon monoxide : From basic science to therapeutic
applications. Physiol Rev. 86:583–650. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hu C, Eggler AL, Mesecar AD and Van
Breemen RB: Modification of Keap1 cysteine residues by
sulforaphane. Chem Res Toxicol. 24:515–521. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Kizilgun M, Poyrazoglu Y, Oztas Y, Yaman
H, Cakir E, Cayci T, Akgul OE, Kurt YG, Yaren H, Kunak ZI, et al:
Beneficial effects of N-acetylcysteine and ebselen on renal
ischemia/reperfusion injury. Ren Fail. 33:512–517. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Rosani U, Tarricone E, Venier P and Brun
P, Deligianni V, Zuin M, Martines E, Leonardi A and Brun P:
Atmospheric-pressure cold plasma induces transcriptional changes in
ex vivo human corneas. PLoS One. 10:e01331732015. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Yalçin E, Altin F, Cinhüseyinoglue F and
Arslan MO: N-acetylcysteine in chronic blepharitis. Cornea.
21:164–168. 2002. View Article : Google Scholar
|
|
60
|
Schmidl D, Werkmeister R, Kaya S,
Unterhuber A, Witkowska KJ, Baumgartner R, Höller S, O'Rourke M,
Peterson W, Wolter A, et al: A controlled, randomized double-blind
study to evaluate the safety and efficacy of
chitosan-N-acetylcysteine for the treatment of dry eye syndrome. J
Ocul Pharmacol Ther. 33:375–382. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Ishii T, Miyazawa M, Onouchi H, Yasuda K,
Hartman PS and Ishii N: Model animals for the study of oxidative
stress from complex II. Biochim Biophys Acta. 1827:588–597. 2013.
View Article : Google Scholar
|
