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Article Open Access

Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts

Corrigendum in: /10.3892/ijmm.2019.4095
  • Authors:
    • Chanchan Chen
    • Jianying Zhang
    • Junqi Ling
    • Yu Du
    • Yuluan Hou
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R. China, Department of Operative Dentistry and Endodontics, Xiangya School of Stomatology, Xiangya Stomatological Hospital, Central South University, Changsha, Hu'nan 410083, P.R. China, Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Research Institute of Stomatology, Guangdong Province Key Laboratory of Stomatology, Sun Yat‑sen University, Guangzhou, Guangdong 510055, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2403-2414
    |
    Published online on: August 14, 2018
       https://doi.org/10.3892/ijmm.2018.3822
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Abstract

Dental follicle stem/progenitor cells have the potential to undergo osteogenesis. naked cuticle homolog 2 (Nkd2) is a signal‑inducible feedback antagonist of the canonical Wnt signaling pathway. The purpose of the present study was to investigate the function of Nkd2 in the differentiation of dental follicle stem/progenitor cells (DFSCs) into osteoblasts. Immunohistochemistry, reverse transcription‑quantitative polymerase chain reaction and western blotting were employed to detect Nkd2 expression in rat DFSCs. In addition, rat DFSCs (rDFSCs) were transfected with small interfering RNAs to examine the effect of Nkd2 on the differentiation of these cells into osteoblasts. Furthermore, the function of Nkd2 in the Wnt/β‑catenin pathway in rDFSCs was investigated using β‑catenin/T‑cell factor luciferase activity assays and western blotting. It was revealed that the expression of Nkd2 was upregulated during the differentiation of rDFSCs into osteoblasts. Furthermore, osteoblast differentiation ability and Wnt/β‑catenin pathway activity were significantly decreased in Nkd2‑silenced rDFSCs compared with the si‑NC group (P<0.05 and P<0.001, respectively). The results suggest that Nkd2 promotes the differentiation of rDFSCs into osteoblasts through Wnt/β‑catenin signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Chen C, Zhang J, Ling J, Du Y and Hou Y: Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095. Int J Mol Med 42: 2403-2414, 2018.
APA
Chen, C., Zhang, J., Ling, J., Du, Y., & Hou, Y. (2018). Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095. International Journal of Molecular Medicine, 42, 2403-2414. https://doi.org/10.3892/ijmm.2018.3822
MLA
Chen, C., Zhang, J., Ling, J., Du, Y., Hou, Y."Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095". International Journal of Molecular Medicine 42.5 (2018): 2403-2414.
Chicago
Chen, C., Zhang, J., Ling, J., Du, Y., Hou, Y."Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095". International Journal of Molecular Medicine 42, no. 5 (2018): 2403-2414. https://doi.org/10.3892/ijmm.2018.3822
Copy and paste a formatted citation
x
Spandidos Publications style
Chen C, Zhang J, Ling J, Du Y and Hou Y: Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095. Int J Mol Med 42: 2403-2414, 2018.
APA
Chen, C., Zhang, J., Ling, J., Du, Y., & Hou, Y. (2018). Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095. International Journal of Molecular Medicine, 42, 2403-2414. https://doi.org/10.3892/ijmm.2018.3822
MLA
Chen, C., Zhang, J., Ling, J., Du, Y., Hou, Y."Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095". International Journal of Molecular Medicine 42.5 (2018): 2403-2414.
Chicago
Chen, C., Zhang, J., Ling, J., Du, Y., Hou, Y."Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095". International Journal of Molecular Medicine 42, no. 5 (2018): 2403-2414. https://doi.org/10.3892/ijmm.2018.3822
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