Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics

  • Authors:
    • Ying Zhou
    • Ling Li
    • Jun Qian
    • Haoyuan Jia
    • Yubao Cui
  • View Affiliations

  • Published online on: September 13, 2018     https://doi.org/10.3892/ijmm.2018.3877
  • Pages: 3551-3561
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Aquaporins (AQPs), or water channel proteins, are highly conserved across species. These transmembrane proteins promote water and solute transport across cell membranes. No AQP‑related proteins have been identified in mites to date. The present study used transcriptomics (RNA‑sequencing) to identify potential AQPs in the mite species Blomia tropicalis. Molecular cloning techniques were then used to obtain the full‑length gene sequences encoding these AQP family members, and bioinformatics analyses were used to categorize them based on similarity to AQPs in other species. This approach led to the identification of 5 putative AQP‑coding sequences, known as BlotAQP1‑5 (GenBank accession numbers: KX655540, KX655541, KX655542, KX655543 and KX655544, respectively), which were indexed into all three subgroups, i.e., AQPs, aquaglyceroporins and superAQPs. To the best of our knowledge, these represent the first known AQPs in any mite species. Further studies are required to investigate their functional roles in water transport and their potential as drug targets.
View Figures
View References

Related Articles

Journal Cover

December-2018
Volume 42 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Y, Li L, Qian J, Jia H and Cui Y: Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics. Int J Mol Med 42: 3551-3561, 2018
APA
Zhou, Y., Li, L., Qian, J., Jia, H., & Cui, Y. (2018). Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics. International Journal of Molecular Medicine, 42, 3551-3561. https://doi.org/10.3892/ijmm.2018.3877
MLA
Zhou, Y., Li, L., Qian, J., Jia, H., Cui, Y."Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics". International Journal of Molecular Medicine 42.6 (2018): 3551-3561.
Chicago
Zhou, Y., Li, L., Qian, J., Jia, H., Cui, Y."Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics". International Journal of Molecular Medicine 42, no. 6 (2018): 3551-3561. https://doi.org/10.3892/ijmm.2018.3877