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Review

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)

  • Authors:
    • Thomas Mbimba
    • Nazar J. Hussein
    • Ayesha Najeed
    • Fayez F. Safadi
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA
  • Pages: 2991-2997
    |
    Published online on: September 21, 2018
       https://doi.org/10.3892/ijmm.2018.3889
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Abstract

Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), which has been reported to be important in the trafficking of cargo from the endoplasmic reticulum (ER) to the Golgi, and in intra‑Golgi and endosome‑to‑Golgi transport in yeast cells. In mammalian cells, TRAPPII has been shown to be important in Golgi vesicle tethering and intra‑Golgi transport. TRAPPC9 is considered to be a novel molecule capable of modulating the activation of nuclear factor‑κB (NF‑κB). Mutations in TRAPPC9 have been linked to a rare consanguineous hereditary form of mental retardation, as part of the NF‑κB pathways. In addition, TRAPPC9 has been reported to be involved in breast and colon cancer and liver diseases. The present review highlights the most recent publications on the structure, expression and function of TRAPPC9, and its association with various human diseases.
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1 

Kim JJ, Lipatova Z and Segev N: TRAPP complexes in secretion and autophagy. Front Cell Dev Biol. 4:202016. View Article : Google Scholar : PubMed/NCBI

2 

Yip CK, Berscheminski J and Walz T: Molecular architecture of the TRAPPII complex and implications for vesicle tethering. Nat Struct Mol Biol. 17:1298–1304. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Zong M, Satoh A, Yu MK, Siu KY, Ng WY, Chan HC, Tanner JA and Yu S: TRAPPC9 mediates the interaction between p150 and COPII vesicles at the target membrane. PLoS One. 7:e299952012. View Article : Google Scholar : PubMed/NCBI

4 

Mohamoud HS, Ahmed S, Jelani M, Alrayes N, Childs K, Vadgama N, Almramhi MM, Al-Aama JY, Goodbourn S and Nasir J: A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features. Sci Rep. 8:20532018. View Article : Google Scholar : PubMed/NCBI

5 

Mir A, Kaufman L, Noor A, Motazacker MM, Jamil T, Azam M, Kahrizi K, Rafiq MA, Weksberg R, Nasr T, et al: Identification of mutations in TRAPPC9, which encodes the NIK- and IKK-beta-binding protein, in nonsyndromic autosomal-recessive mental retardation. Am J Hum Genet. 85:909–915. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Schou KB, Morthorst SK, Christensen ST and Pedersen LB: Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8. Cilia. 3:62014. View Article : Google Scholar : PubMed/NCBI

7 

Zeytuni N and Zarivach R: Structural and functional discussion of the tetra-trico-peptide repeat, a protein interaction module. Structure. 20:397–405. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Clairfeuille T, Norwood SJ, Qi X, Teasdale RD and Collins BM: Structure and membrane binding properties of the endosomal tetratricopeptide repeat (TPR) domain-containing sorting nexins SNX20 and SNX21. J Biol Chem. 290:14504–14517. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Hwang JY, Ahn SJ, Kwon MG, Seo JS, Hwang SD and Son MH: Interferon-induced protein 56 (IFI56) is induced by VHSV infection but not by bacterial infection in olive flounder (paralichthys olivaceus). Fish Shellfish Immunol. 66:382–389. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Ponting CP: A novel domain suggests a ciliary function for ASPM, a brain size determining gene. Bioinformatics. 22:1031–1035. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Zhang Y, Bitner D, Pontes Filho AA, Li F, Liu S, Wang H, Yang F, Adhikari S, Gordon J, Srinivasan S and Hu W: Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system. Neurogastroenterol Motil. 26:77–97. 2014. View Article : Google Scholar :

12 

Sacher M, Barrowman J, Schieltz D, Yates JR III and Ferro-Novick S: Identification and characterization of five new subunits of TRAPP. Eur J Cell Biol. 79:71–80. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Mochida GH, Mahajnah M, Hill AD, Basel-Vanagaite L, Gleason D, Hill RS, Bodell A, Crosier M, Straussberg R and Walsh CA: A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly. Am J Hum Genet. 85:897–902. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Sacher M, Jiang Y, Barrowman J, Scarpa A, Burston J, Zhang L, Schieltz D, Yates JR III, Abeliovich H and Ferro-Novick S: TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J. 17:2494–2503. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Cai H, Zhang Y, Pypaert M, Walker L and Ferro-Novick S: Mutants in trs120 disrupt traffic from the early endosome to the late golgi. J Cell Biol. 171:823–833. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Barrowman J, Sacher M and Ferro-Novick S: TRAPP stably associates with the golgi and is required for vesicle docking. EMBO J. 19:862–869. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Zahoor MA, Yamane D, Mohamed YM, Suda Y, Kobayashi K, Kato K, Tohya Y and Akashi H: Bovine viral diarrhea virus non-structural protein 5A interacts with NIK- and IKKbeta-binding protein. J Gen Virol. 91:1939–1948. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Yu S and Liang Y: A trapper keeper for TRAPP, its structures and functions. Cell Mol Life Sci. 69:3933–3944. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Sacher M, Barrowman J, Wang W, Horecka J, Zhang Y, Pypaert M and Ferro-Novick S: TRAPP I implicated in the specificity of tethering in ER-to-golgi transport. Mol Cell. 7:433–442. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Choi C, Davey M, Schluter C, Pandher P, Fang Y, Foster LJ and Conibear E: Organization and assembly of the TRAPPII complex. Traffic. 12:715–725. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Hu WH, Pendergast JS, Mo XM, Brambilla R, Bracchi-Ricard V, Li F, Walters WM, Blits B, He L, Schaal SM and Bethea JR: NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. J Biol Chem. 280:29233–29241. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Barrowman J, Bhandari D, Reinisch K and Ferro-Novick S: TRAPP complexes in membrane traffic: Convergence through a common rab. Nat Rev Mol Cell Biol. 11:759–763. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Delic M, Valli M, Graf AB, Pfeffer M, Mattanovich D and Gasser B: The secretory pathway: Exploring yeast diversity. FEMS Microbiol Rev. 37:872–914. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Zou S, Chen Y, Liu Y, Segev N, Yu S, Liu Y, Min G, Ye M, Zeng Y, Zhu X, et al: Trs130 participates in autophagy through GTPases Ypt31/32 in saccharomyces cerevisiae. Traffic. 14:233–246. 2013. View Article : Google Scholar :

25 

Montpetit B and Conibear E: Identification of the novel TRAPP associated protein Tca17. Traffic. 10:713–723. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Scrivens PJ, Shahrzad N, Moores A, Morin A, Brunet S and Sacher M: TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. Traffic. 10:724–736. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Yamasaki A, Menon S, Yu S, Barrowman J, Meerloo T, Oorschot V, Klumperman J, Satoh A and Ferro-Novick S: mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Mol Biol Cell. 20:4205–4215. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Israel LP, Benharoch D, Gopas J and Goldbart AD: A pro-inflammatory role for nuclear factor kappa B in childhood obstructive sleep apnea syndrome. Sleep. 36:1947–1955. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Brasier AR: The NF-kappaB regulatory network. Cardiovasc Toxicol. 6:111–130. 2006. View Article : Google Scholar

30 

Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell. 132:344–362. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Sun SC: The noncanonical NF-κB pathway. Immunol Rev. 246:125–140. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Sun SC: Non-canonical NF-kappaB signaling pathway. Cell Res. 21:71–85. 2011. View Article : Google Scholar

33 

Abbasi AA, Blaesius K, Hu H, Latif Z, Picker-Minh S, Khan MN, Farooq S, Khan MA and Kaindl AM: Identification of a novel homozygous TRAPPC9 gene mutation causing non-syndromic intellectual disability, speech disorder, and secondary micro-cephaly. Am J Med Genet B Neuropsychiatr Genet. 174:839–845. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Najmabadi H, Motazacker MM, Garshasbi M, Kahrizi K, Tzschach A, Chen W, Behjati F, Hadavi V, Nieh SE, Abedini SS, et al: Homozygosity mapping in consanguineous families reveals extreme heterogeneity of non-syndromic autosomal recessive mental retardation and identifies 8 novel gene loci. Hum Genet. 121:43–48. 2007. View Article : Google Scholar

35 

Philippe O, Rio M, Carioux A, Plaza JM, Guigue P, Molinari F, Boddaert N, Bole-Feysot C, Nitschke P, Smahi A, et al: Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation. Am J Hum Genet. 85:903–908. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Kakar N, Goebel I, Daud S, Nürnberg G, Agha N, Ahmad A, Nürnberg P, Kubisch C, Ahmad J and Borck G: A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly. Eur J Med Genet. 55:727–731. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Marangi G, Leuzzi V, Manti F, Lattante S, Orteschi D, Pecile V, Neri G and Zollino M: TRAPPC9-related autosomal recessive intellectual disability: Report of a new mutation and clinical phenotype. Eur J Hum Genet. 21:229–232. 2013. View Article : Google Scholar :

38 

Wattacheril J, Lavine JE, Chalasani NP, Guo X, Kwon S, Schwimmer J, Molleston JP, Loomba R, Brunt EM, Chen YI, et al: Genome-wide associations related to hepatic histology in nonalcoholic fatty liver disease in hispanic boys. J Pediatr. 190:100–107.e102. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Zhang Y, Liu S, Wang H, Yang W, Li F, Yang F, Yu D, Ramsey FV, Tuszyski GP and Hu W: Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling. Oncotarget. 6:6160–6178. 2015.PubMed/NCBI

40 

Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A and Yu SS: COPI-TRAPPII activates Rab18 and regulates its lipid droplet association. EMBO J. 36:441–457. 2017. View Article : Google Scholar

41 

Salamat MK, Dron M, Chapuis J, Langevin C and Laude H: Prion propagation in cells expressing PrP glycosylation mutants. J Virol. 85:3077–3085. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Thellmann M, Rybak K, Thiele K, Wanner G and Assaad FF: Tethering factors required for cytokinesis in arabidopsis. Plant Physiol. 154:720–732. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mbimba T, Hussein NJ, Najeed A and Safadi FF: TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review). Int J Mol Med 42: 2991-2997, 2018.
APA
Mbimba, T., Hussein, N.J., Najeed, A., & Safadi, F.F. (2018). TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review). International Journal of Molecular Medicine, 42, 2991-2997. https://doi.org/10.3892/ijmm.2018.3889
MLA
Mbimba, T., Hussein, N. J., Najeed, A., Safadi, F. F."TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)". International Journal of Molecular Medicine 42.6 (2018): 2991-2997.
Chicago
Mbimba, T., Hussein, N. J., Najeed, A., Safadi, F. F."TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)". International Journal of Molecular Medicine 42, no. 6 (2018): 2991-2997. https://doi.org/10.3892/ijmm.2018.3889
Copy and paste a formatted citation
x
Spandidos Publications style
Mbimba T, Hussein NJ, Najeed A and Safadi FF: TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review). Int J Mol Med 42: 2991-2997, 2018.
APA
Mbimba, T., Hussein, N.J., Najeed, A., & Safadi, F.F. (2018). TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review). International Journal of Molecular Medicine, 42, 2991-2997. https://doi.org/10.3892/ijmm.2018.3889
MLA
Mbimba, T., Hussein, N. J., Najeed, A., Safadi, F. F."TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)". International Journal of Molecular Medicine 42.6 (2018): 2991-2997.
Chicago
Mbimba, T., Hussein, N. J., Najeed, A., Safadi, F. F."TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)". International Journal of Molecular Medicine 42, no. 6 (2018): 2991-2997. https://doi.org/10.3892/ijmm.2018.3889
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