|
1
|
Shan L, Liu RH, Shen YH, Zhang WD, Zhang
C, Wu DZ, Min L, Su J and Xu XK: Gastroprotective effect of a
traditional Chinese herbal drug ‘Baishouwu’ on experimental gastric
lesions in rats. J Ethnopharmacol. 107:389–394. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Li Y, Zhang J, Gu X, Peng Y, Huang W and
Qian S: Two new cytotoxic pregnane glycosides from Cynanchum
auriculatum. Planta Med. 74:551–554. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wang DY, Hua X, Ye JL, Li JJ, Li Q and Yan
HS: Antitumor effect of C21 steroidal glycosides in Radix Cynanchi
bungei on Heps rats and its influence on hematopoiesis. J Clin Med
Pract. 18:6–8. 2014.
|
|
4
|
Peng YR, Li YB, Liu XD, Zhang JF and Duan
JA: Antitumor activity of C-21 steroidal glycosides fro. Cynanchum
auriculatum Royle ex Wight Phytomedicine. 15:1016–1020. 2008.
|
|
5
|
Zhang RS, Ye YP and Liu XL: Studies on in
vitro antitumor activity of total steroidal glycoside from the root
of Cynanchum auriculatum. Chin Tradit Herbal Drugs. 31:599–601.
2000.
|
|
6
|
Zhang RS, Ye YP, Shen YM and Liang HL: Two
new cytotoxic C-21 steroidal glycosides from the root of Cynanchum
auriculatum. Tetrahedron. 56:3875–3879. 2000. View Article : Google Scholar
|
|
7
|
Wang YQ, Zhang SJ, Lu H, Yang B, Ye LF and
Zhang RS: A C21-steroidal glycoside isolated from the roots of
Cynanchum auriculatum induces cell cycle arrest and apoptosis in
human gastric cancer SGC-7901 cells. Evid Based Complement Alternat
Med. 2013.180839:2013.
|
|
8
|
Wang DY, Zhang HQ and Li X: Apoptosis
induced by the C21 sterols in Baishouwu and its mechanism of action
in hepatoma. Yao Xue Xue Bao. 42:366–370. 2007.In Chinese.
PubMed/NCBI
|
|
9
|
Shan L, Zhang WD, Zhang C, Liu RH, Su J
and Zhou Y: Antitumor activity of crude extract and fractions from
root tuber of Cynanchum auriculatum Royle ex Wight. Phytother Res.
19:259–261. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Peng YR, Li YB, Liu XD, Zhang JF and Duan
JA: Apoptosis induced by caudatin in human hepatoma cell line
SMMC7721. Chin J Nat Med. 6:210–213. 2008. View Article : Google Scholar
|
|
11
|
Peng YR, Ding YF, Wei YJ, Shu B, Li YB and
Liu XD: Caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside 1
induced apoptosis through caspase 3-dependent pathway in human
hepatoma cell line SMMC7721. Phytother Res. 25:631–637. 2011.
View Article : Google Scholar
|
|
12
|
Zhang SX, Li X, Yin JL, Chen LL and Zhang
HQ: Effect of C21 steroidal glycoside from root of Cynanchum
auriculatum on D-galactose induced aging model mice. Zhongguo Zhong
Yao Za Zhi. 32:2511–2514. 2007.In Chinese.
|
|
13
|
Song JM and Ding XL: Study on the
scavenging effect of Baishouwu on superoxide free radicals. Chin
Wild Plant Resources. 17:1–4. 1997.
|
|
14
|
Gu LG, Gong SS, Tao JD, Liu CH and Zhou Y:
Studies on the regulation effect of Baishouwu on the immunity of
mouse. Chin J Int Med. 7:37–41. 1987.
|
|
15
|
Ji CX, Li XY, Jia SB, Liu LL, Ge YC, Yang
QX and Zhang JJ: The antidepressant effect of Cynanchum auriculatum
in mice. Pharm Biol. 50:1067–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Yoon MY, Choi NH, Min BS, Choi GJ, Choi
YH, Jang KS, Han SS, Cha B and Kim JC: Potent in vivo antifungal
activity against powdery mildews of pregnane glycosides from the
roots of Cynanchum wilfordii. J Agric Food Chem. 59:12210–12216.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Lv W, Zhang A, Xu S and Zhang H: Effects
of general glycosides in Cynanchum auriculatum of Jiangsu province
on liver fibrosis of rats. Zhongguo Zhong Yao Za Zhi. 34:2508–2511.
2009.In Chinese.
|
|
18
|
Jaeschke H: Reactive oxygen and mechanisms
of inflammatory liver injury: Present concepts. J Gastroenterol
Hepatol. 26(Suppl 1): S173–S179. 2011. View Article : Google Scholar
|
|
19
|
Miller AM, Wang H, Park O, Horiguchi N,
Lafdil F, Mukhopadhyay P, Moh A, Fu XY, Kunos G, Pacher P and Gao
B: Anti-inflammatory and anti-apoptotic roles of endothelial cell
STAT3 in alcoholic liver injury. Alcohol Clin Exp Res. 34:719–725.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Dey A and Cederbaum AI: Alcohol and
oxidative liver injury. Hepatology. 43(Suppl 1): S63–S74. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Sies H, Berndt C and Jones DP: Oxidative
stress. Annu Rev Biochem. 86:715–748. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Weng D, Lu Y, Wei Y, Liu Y and Shen P: The
role of ROS in microcystin-LR-induced hepatocyte apoptosis and
liver injury in mice. Toxicology. 232:15–23. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Tsukiyama-Kohara K: Role of oxidative
stress in hepatocarcinogenesis induced by hepatitis C virus. Int J
Mol Sci. 13:15271–15278. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Das S, Maras JS, Hussain MS, Sharma S,
David P, Sukriti S, Shasthry SM, Maiwall R, Trehanpati N, Singh TP
and Sarin SK: Hyperoxidized albumin modulates neutrophils to induce
oxidative stress and inflammation in severe alcoholic hepatitis.
Hepatology. 65:631–646. 2017. View Article : Google Scholar
|
|
25
|
Chen G, Ni Y, Nagata N, Xu L and Ota T:
Micronutrient antioxidants and nonalcoholic fatty liver disease.
Int J Mol Sci. 17:pii: E13792016. View Article : Google Scholar
|
|
26
|
Wang M, Ma HL, Liu B, Wang HB, Xie H, Li
RD and Wang JF: Pinus massoniana bark extract protects against
oxidative damage in L-02 hepatic cells and mice. Am J Chin Med.
38:909–919. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sies H: Hydrogen peroxide as a central
redox signaling molecule in physiological oxidative stress:
Oxidative eustress. Redox Biol. 11:613–619. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Hseu YC, Wu FY, Wu JJ, Chen JY, Chang WH,
Lu FJ, Lai YC and Yang HL: Anti-inflammatory potential of Antrodia
Camphorata through inhibition of iNOS, COX-2 and cytokines via the
NF-kappaB pathway. Int Immunopharmacol. 5:1914–1925. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Lee D, Park S, Bae S, Jeong D, Park M,
Kang C, Yoo W, Samad MA, Ke Q, Khang G and Kang PM: Hydrogen
peroxide-activatable antioxidant prodrug as a targeted therapeutic
agent for ischemia-reperfusion injury. Sci Rep. 5:165922015.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Li W and Kong AN: Molecular mechanisms of
Nrf2-mediated antioxidant response. Mol Carcinog. 48:91–104. 2009.
View Article : Google Scholar :
|
|
31
|
Yu J, Zhu X, Qi X, Che J and Cao B:
Paeoniflorin protects human EA.hy926 endothelial cells against
gamma-radiation induced oxidative injury by activating the
NF-E2-related factor 2/heme oxygenase-1 pathway. Toxicol Lett.
218:224–234. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Shin SM, Yang JH and Ki SH: Role of the
Nrf2-ARE pathway in liver diseases. Oxid Med Cell Longev.
2013.763257:2013.
|
|
33
|
Huo X, Liu C, Gao L, Xu X, Zhu N and Cao
L: Hepatoprotective effect of aqueous extract from the seeds of
orychophragmus violaceus against liver injury in mice and HepG2
cells. Int J Mol Sci. 18:pii: E11972017. View Article : Google Scholar
|
|
34
|
Conde de la Rosa L, Schoemaker MH, Vrenken
TE, Buist-Homan M, Havinga R, Jansen PL and Moshage H: Superoxide
anions and hydrogen peroxide induce hepatocyte death by different
mechanisms: Involvement of JNK and ERK MAP kinases. J Hepatol.
44:918–929. 2006. View Article : Google Scholar
|
|
35
|
Vaziri ND: Oxidative stress in uremia:
Nature, mechanisms, and potential consequences. Semin Nephrol.
24:469–473. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Kim D, Kim H, Kim K and Roh S: The
protective effect of indole-3-acetic acid (IAA) on H2O2-damaged
human dental pulp stem cells is mediated by the AKT pathway and
involves increased expression of the transcription factor nuclear
factor-erythroid 2-related factor 2 (Nrf2) and its downstream
target heme oxygenase 1 (HO-1). Oxid Med Cell Longev.
2017.8639485:2017.
|
|
37
|
Cao YJ, Zhang YM, Qi JP, Liu R, Zhang H
and He LC: Ferulic acid inhibits H2O2-induced oxidative stress and
inflammation in rat vascular smooth muscle cells via inhibition of
the NADPH oxidase and NF-κB pathway. Int Immunopharmacol.
28:1018–1025. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Tian Y, Li Z, Shen B, Zhang Q and Feng H:
Protective effects of morin on
lipopolysaccharide/d-galactosamine-induced acute liver injury by
inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways.
Int Immunopharmacol. 45:148–155. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Tan ZW, Xie S, Hu SY, Liao T, Liu P, Peng
KH, Yang XZ, He ZL, Tang HY, Cui Y, et al: Caudatin targets
TNFAIP1/NF-κB and cytochrome c/caspase signaling to suppress tumor
progression in human uterine cancer. Int J Oncol. 49:1638–1650.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Gu XJ, Yao N, Qian SH, Li YB and Li P:
Four new C21 steroidal glycosides from the root of Cynanchum
auriculatum. Helvetica Chimica Acat. 92:88–97. 2009. View Article : Google Scholar
|
|
41
|
Wang XJ, Li ZL, Lv XH, Zuo QY, Zhao YM,
Ding YF, Pu SB, Qian SH and Peng YR: Antitumor evaluation and
multiple analysis on different extracted fractions of the root of
Cynanchum auriculatum Royle ex Wight. J Sep Sci. 40:3054–3063.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Zhao YN, Wang ZL, Dai JG, Chen L and Huang
YF: Preparation and quality assessment of high-purity ginseng total
saponins by ion exchange resin combined with macroporous adsorption
resin separation. Chin J Nat Med. 12:382–392. 2014.PubMed/NCBI
|
|
43
|
Hu X, Yang T, Li C, Zhang L, Li M, Huang W
and Zhou P: Human fetal hepatocyte line, L-02, exhibits good liver
function in vitro and in an acute liver failure model. Transplant
Proc. 45:695–700. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Myhre O, Andersen JM, Aarnes H and Fonnum
F: Evaluation of the probes 2′,7′-dichlorofluorescin diacetate,
luminol, and lucigenin as indicators of reactive species formation.
Biochem Pharmacol. 65:1575–1582. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ding YF, Wu ZH, Wei YJ, Shu L and Peng YR:
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular
carcinoma induced by diethylnitrosamine. J Cancer Res Clin Oncol.
143:821–834. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
47
|
Wei Y, Chen K, Whaley-Connell AT, Stump
CS, Ibdah JA and Sowers JR: Skeletal muscle insulin resistance:
Role of inflammatory cytokines and reactive oxygen species. Am J
Physiol Regul Integr Comp Physiol. 294:R673–R680. 2008. View Article : Google Scholar
|
|
48
|
Sid B, Verrax J and Calderon PB: Role of
oxidative stress in the pathogenesis of alcohol-induced liver
disease. Free Radic Res. 47:894–904. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Dong J, Peng X, Li L, Lu S, Zhou L and Qiu
M: C21 steroidal glycosides with cytotoxic activities from
Cynanchum otophyllum. Bioorg Med Chem Lett. 28:1520–1524. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Wang YQ, Yang B, Zhang RS and Wei EQ:
Inhibitive effect of C-21 steroidal glycosides of Cynanchum
auriculatum on rat glioma cells in vitro. Zhejiang Da Xue Xue Bao
Yi Xue Ban. 40:402–407. 2011.In Chinese. PubMed/NCBI
|
|
51
|
Wang YB, Su SS, Chen SF, Tang MX, Chen G,
Zhao D, Sang XN, Si YY, Wang HF and Pei YH: C 21 steroidal
glycosides with cytotoxic activity from Cynanchum taihangense.
Phytochem Lett. 20:218–223. 2017. View Article : Google Scholar
|
|
52
|
Kim CS, Ju YO, Sang UC and Lee KR:
Chemical constituents from the roots of Cynanchum paniculatum, and
their cytotoxic activity. Carbohydr Res. 381:1–5. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Wang DY and Zhang HQ: The current
situation and progress of Baishouwu planted in Jiangsu. Chin Wild
Plant Resources. 24:13–15. 2005.
|
|
54
|
Fu XY, Zhang S, Wang K, Yang MF, Fan CD
and Sun BL: Caudatin inhibits human glioma cells growth through
triggering DNA damage-mediated cell cycle arrest. Cell Mol
Neurobiol. 35:953–959. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Su M, Yu T, Zhang H, Wu Y, Wang X and Li
G: The antiapoptosis effect of glycyrrhizate on HepG2 cells induced
by hydrogen peroxide. Oxid Med Cell Longev. 2016.6849758:2016.
|
|
56
|
Zhao L, Chen J, Su J, Li L, Hu S, Li B,
Zhang X, Xu Z and Chen T: In vitro antioxidant and
antiproliferative activities of 5-hydroxymethylfurfural. J Agric
Food Chem. 61:10604–10611. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Herken H, Uz E, Ozyurt H, Söğüt S, Virit O
and Akyol O: Evidence that the activities of erythrocyte free
radical scavenging enzymes and the products of lipid peroxidation
are increased in different forms of schizophrenia. Mol Psychiatry.
6:66–73. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Pan MH, Yang JR, Tsai ML, Sang S and Ho
CT: Anti-inflammatory effect of Momordica grosvenori, Swingle
extract through suppressed LPS-induced upregulation of iNOS and
COX-2 in murine macrophages. J Funct Foods. 1:145–152. 2009.
View Article : Google Scholar
|
|
59
|
Wang WW, Smith DL and Zucker SD: Bilirubin
inhibits iNOS expression and NO production in response to endotoxin
in rats. Hepatology. 40:424–433. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Li J, Zhang X and Huang H: Protective
effect of linalool against
lipopolysaccharide/D-galactosamine-induced liver injury in mice.
Int Immunopharmacol. 23:523–529. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Dai C, Li B, Zhou Y, Li D, Zhang S, Li H,
Xiao X and Tang S: Curcumin attenuates quinocetone induced
apoptosis and inflammation via the opposite modulation of Nrf2/HO-1
and NF-κB pathway in human hepatocyte L02 cells. Food Chem Toxicol.
95:52–63. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Arranz J, Soriano A, Garcia I, García I,
Concepción MT, Navarro J, Arteaga A, Filella X, Bravo P, Barrera M,
et al: Effect of proinflammatory cytokines (IL-6, TNF-alpha,
IL-1beta) on hemodynamic performance during orthotopic liver
transplantation. Transplant Proc. 35:1884–1887. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Ma Q: Role of nrf2 in oxidative stress and
toxicity. Annu Rev Pharmacol Toxicol. 53:401–426. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Kim HJ and Vaziri ND: Contribution of
impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in
chronic renal failure. Am J Physiol Renal Physiol. 298:F662–F671.
2010. View Article : Google Scholar
|
|
65
|
Fahey JW, Haristoy X, Dolan PM, Kensler
TW, Scholtus I, Stephenson KK, Talalay P and Lozniewski A:
Sulforaphane inhibits extracellular, intracellular, and
antibiotic-resistant strains of Helicobacter pylori and prevents
benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA.
99:7610–7615. 2002. View Article : Google Scholar
|
|
66
|
Kensler TW, Wakabayashi N and Biswal S:
Cell survival responses to environmental stresses via the
Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 47:89–116.
2007. View Article : Google Scholar
|
|
67
|
Covas G, Marinho HS, Cyrne L and Antunes
F: Activation of Nrf2 by H2O2: De novo
synthesis versus nuclear translocation. Methods Enzymol.
528:157–171. 2013. View Article : Google Scholar
|
|
68
|
Ma Z, Li C, Qiao Y, Lu C, Li J, Song W,
Sun J, Zhai X, Niu J, Ren Q and Wen A: Safflower yellow B
suppresses HepG2 cell injury induced by oxidative stress through
the AKT/Nrf2 pathway. Int J Mol Med. 37:603–612. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Chang Y, Li S, Guo W, Yang Y, Zhang W,
Zhang Q, He Y, Yi X, Cui T, An Y, et al: Simvastatin protects human
melanocytes from H2O2-induced oxidative
stress by activating Nrf2. J Invest Dermatol. 137:1286–1296. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Jian Z, Li K, Song P, Zhu G, Zhu L, Cui T,
Liu B, Tang L, Wang X, Wang G, et al: Impaired activation of the
Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress
response: A possible mechanism for melanocyte degeneration in
vitiligo. J Invest Dermatol. 134:2221–2230. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Mao J, Li Z, Lin R, Zhu X, Lin J, Peng J
and Chen L: Preconditioning with Gua Lou Gui Zhi decoction enhances
H2O2-induced Nrf2/HO-1 activation in PC12
cells. Exp Ther Med. 10:877–884. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Lee IT, Luo SF, Lee CW, Wang SW, Lin CC,
Chang CC, Chen YL, Chau LY and Yang CM: Overexpression of HO-1
protects against TNF-alpha-mediated airway inflammation by
down-regulation of TNFR1-dependent oxidative stress. Am J Pathol.
175:519–532. 2009. View Article : Google Scholar : PubMed/NCBI
|
