Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2019 Volume 43 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 43 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages

  • Authors:
    • Ji Hye Hwang
    • Jun Nan Ma
    • Jong Hun Park
    • Hyo Won Jung
    • Yong‑Ki Park
  • View Affiliations / Copyright

    Affiliations: Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea, Department of Herbology, College of Korean Medicine, Dongguk University, Gyeongju, North Gyeongsang 38066, Republic of Korea
    Copyright: © Hwang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 26-36
    |
    Published online on: October 16, 2018
       https://doi.org/10.3892/ijmm.2018.3937
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MOK, a pharmacopuncture medicine consisting of 10 herbs, has a long history as treatment for various inflammatory conditions. To investigate the mechanisms of action of MOK, its anti‑inflammatory and antioxidative effects were assessed in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS). RAW 264.7 cells were treated with different concentrations of MOK extract for 30 min prior to stimulation with or without LPS for the indicated times. Nitric oxide (NO) production was measured using Griess reagent, while the mRNA levels of inflammatory cytokines, tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL‑6 and the antioxidant enzymes Mn superoxide dismutase and heme oxygenase‑1, were determined using reverse transcription‑polymerase chain reaction analysis. Western blotting was used to determine the protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)‑2, superoxide dismutase (SOD)2, catalase (CAT) and heme oxygenase‑1 (HO‑1), and the phosphorylation of mitogen‑activated protein kinases (MAPKs), including ERK1/2, JNK and p38. Western blotting and immunocytochemistry were used to observe the nuclear expression of nuclear factor (NF)‑κB p65. Additionally, reactive oxygen species (ROS) and prostaglandin (PG)E2 production were determined using the ROS assay and an enzyme immunoassay. With MOK treatment, there was a notable decrease in NO and PGE2 production induced by LPS in RAW 264.7 cells by downregulation of iNOS and COX‑2 mRNA and protein expression. Furthermore, with MOK treatment, there was a decrease in the mRNA expression levels of TNF‑α, IL‑1β and IL‑6, as well as in the phosphorylation of ERK, JNK and p38 MAPK, by blocking the nuclear translocation of NF‑κB p65 in LPS‑stimulated cells. In addition, MOK treatment led to an increase in the antioxidant enzymes SOD, CAT and HO‑1 in LPS‑stimulated cells, with a concomitant decrease in ROS generation. These results indicate that the inflammatory responses in activated macrophages are inhibited by MOK through downregulation of the transcription levels of inflammatory mediators and inhibition of the MAPK/NF‑κB pathway. Moreover, MOK protects against oxidative damage by upregulating the expression of antioxidant enzymes and generating ROS scavengers.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Liu Z, Tang L, Zou P, Zhang Y, Wang Z, Fang Q, Jiang L, Chen G, Xu Z, Zhang H and Liang G: Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents. Eur J Med Chem. 74:671–682. 2014. View Article : Google Scholar

2 

Mittal M, Siddiqui MR, Tran K, Reddy SP and Malik AB: Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 20:1126–1167. 2014. View Article : Google Scholar :

3 

Zhang L and Wang CC: Inflammatory response of macrophages in infection. Hepastobiliary Pancreat Dis Int. 13:138–152. 2014. View Article : Google Scholar

4 

Cho SY, Yang SB, Shin HS, Lee SH, Koh JS, Kwon S, Jung WS, Moon SK, Park JM, Ko CN and Park SU: Anti-inflammatory and immune regulatory effects of acupuncture after craniotomy: Study protocol for a parallel-group randomized controlled trial. Trials. 18:4812017. View Article : Google Scholar

5 

Zijlstra FJ, van den Berg-de Lange I, Huygen FJ and Klein J: Anti-inflammatory actions of acupuncture. Mediators Inflamm. 12:59–69. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Lisboa MR, Gondim DV, Ervolino E, Vale ML, Frota NP, Nunes NL, Mariguela VC, Taba M Jr, Messora MR and Furlaneto FA: Effects of electroacupuncture on experimental periodontitis in rats. J Periodontol. 86:801–811. 2015. View Article : Google Scholar : PubMed/NCBI

7 

McDonald JL, Cripps AW, Smith PK, Smith CA, Xue CC and Golianu B: The anti-inflammatory effects of acupuncture and their relevance to allergic rhinitis: A narrative review and proposed model. Evid Based Complement Alternat Med. 2013.591796:2013.

8 

Song Q, Hu S, Wang H, Lv Y, Shi X, Sheng Z and Sheng W: Electroacupuncturing at Zusanli point (ST36) attenuates pro-inflammatory cytokine release and organ dysfunction by activating cholinergic anti-inflammatory pathway in rat with endotoxin challenge. Afr J Tradit Complement Altern Med. 11:469–474. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wei Y, Dong M, Zhang H, Lv Y, Liu J, Wei K, Luo Q, Sun J, Liu F, Xu F and Dong J: Acupuncture attenuated inflammation and inhibited Th17 and treg activity in experimental asthma. Evid Based Complement Alternat Med. 2015.340126:2015.

10 

Jung C, Jung JH and Lee MS: A Clinical Study of Immune Pharmacopuncturology. Kyungrak Medical Publishing Co.; Chungnam: 2011, In Korean.

11 

Hwang JH: A case report of Hwa-byeong with MOK herbal acupuncture therapy. J Immuno-Pharmacopuncture. 2:43–55. 2013.In Korean.

12 

Ha TD and Jung C: A case report on severe tension-type headache treated with pharmacopuncture (Yakchim). J Immuno-Pharmacopuncture. 5:37–45. 2016.In Korean.

13 

Kim MJ, Kim SK, Ko SJ and Park JW: A case study of MOK and V Yakchim on functional dyspepsia. J Immuno-Pharmacopuncture. 3:41–49. 2014.In Korean.

14 

Kim HJ, Gwan R, Han JW, Jung C and Park KH: Analysis of physioactivities on MOK Yakchim. J Immuno-Pharmacopuncture. 2:17–25. 2013.In Korean.

15 

Hwang JH, Kang SY, Kang AN, Jung HW, Jung C, Jeong JH and Park YK: MOK, a pharmacopuncture medicine, regulates thyroid dysfunction in L-thyroxin-induced hyperthyroidism in rats through the regulation of oxidation and the TRPV1 ion channel. BMC Complement Altern Med. 17:5352017. View Article : Google Scholar : PubMed/NCBI

16 

Hwang JH, Jung HW, Kang SY, Kang AN, Ma JN, Meng XL, Hwang MS and Park YK: Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats. Exp Ther Med. 16:310–320. 2018.PubMed/NCBI

17 

Hwang JH, Hwang MS and Park YK: MOK, a pharmacopuncture medicine, reduces inflammatory response through inhibiting the proinflammatory cytokine production in LPS-stimulated mouse peritoneal macrophages. J Acupunct Res. 34:11–21. 2017. View Article : Google Scholar

18 

Raschke WC, Baird S, RalpH P and Nakoinz I: Functional macrophage cell lines transformed by Abelson leukemia virus. Cell. 15:261–267. 1978. View Article : Google Scholar : PubMed/NCBI

19 

Zhang X, Xiong H and Liu L: Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol. 141:206–211. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Choi HS, Seo HS, Kim SR, Choi YK, Shin YC and Ko SG: Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells. Mol Med Rep. 9:1569–1574. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Li T, Gao D, Du M, Cheng X and Mao X: Casein glycomacropeptide hydrolysates inhibit PGE2 production and COX2 expression in LPS-stimulated RAW264.7 macrophage cells via Akt mediated NF-κB and MAPK pathways. Food Funct. 9:2524–2532. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Yang X, Kang MC, Li Y, Kim EA, Kang SM and Jeon YJ: Anti-inflammatory activity of questinol isolated from marine-derived fungus Eurotium amstelodami in lipopoly-saccharide-stimulated RAW 264.7 macrophages. J Microbiol Biotechnol. 24:1346–1353. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Kim HJ, Tsoyi K, Heo JM, Kang YJ, Park MK, Lee YS, Lee JH, Seo HG, Choi HS and Chang KC: Regulation of lipopolysaccha-ride-induced inducible nitric-oxide synthase expression through the nuclear factor-κB pathway and interferon-β/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (THI 53), a new synthetic isoquino-line alkaloid. J Pharmacol Exp Ther. 320:782–789. 2007. View Article : Google Scholar

24 

Gong HM, Jun SA, Lee HJ and Kim JS: A case report of Herpes zoster patient treated with additional CS, V pharmacopuncture. J Immuno-Pharmacopuncture. 1:27–36. 2016.

25 

De D, Datta Chakraborty P, Mitra J, Sharma K, Mandal S, Das A, Chakrabarti S and Bhattacharyya D: Ubiquitin-like protein from human placental extract exhibits collagenase activity. PLoS One. 8:e595852013. View Article : Google Scholar : PubMed/NCBI

26 

Feng Y, Siu K, Wang N, Ng KM, Tsao SW, Nagamatsu T and Tong Y: Bear bile: Dilemma of traditional medicinal use and animal protection. J Ethnobiol Ethnomed. 5:22009. View Article : Google Scholar : PubMed/NCBI

27 

Jang SY, Park JW, Bu Y, Kang JO and Kim J: Protective effects of hominis placenta hydrolysates on radiation enteropathy in mice. Nat Prod Res. 25:1988–1992. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Li X, Xu Y, Zhang C, Deng L, Chang M, Yu Z and Liu D: Protective effect of calculus bovis sativus on dextran sulphate sodium-induced uicerative colitis in mice. Evid Based Complement Alternat Med. 2015.469506:2015.

29 

The National College of Oriental Medicine Herbology Classroom: Herbology: Youngrimsa, Seoul. 2016.In Korean.

30 

Park SY, Phark S, Lee M, Lim JY and Sul D: Anti-oxidative and anti-inflammatory activities of placental extracts in benzo[a] pyrene-exposed rats. Placenta. 31:873–879. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Park JY, Lee J, Jeong M, Min S, Kim SY, Lee H, Lim Y and Park HJ: Effect of Hominis Placenta on cutaneous wound healing in normal and diabetic mice. Nutr Res Pract. 8:404–409. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Thevis M, Schänzer W, Geyer H, Thieme D, Grosse J, Rautenberg C, Flenker U, Beuck S, Thomas A, Holland R and Dvorak J: Traditional Chinese medicine and sports drug testing: Identification of natural steroid administration in doping control urine samples resulting from musk (pod) extracts. Br J Sports Med. 47:109–114. 2013. View Article : Google Scholar

33 

Okin D and Medzhitov R: Evolution of inflammatory diseases. Curr Biol. 22:R733–R740. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Monaco C, Andreakos E, Kiriakidis S, Feldmann M and Paleolog E: T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases. Curr Drug Targets Inflamm Allergy. 3:35–42. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Yamamoto Y and Gaynor RB: IkappaB kinases: Key regulators of the NF-kappaB pathway. Trends Biochem Sci. 29:72–79. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Adib-Conquy M, Scott-Algara D, Cavaillon JM and Souza- Fonseca-Guimaraes F: TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals. Immunol Cell Biol. 92:256–262. 2014. View Article : Google Scholar

37 

Korhonen R, Lahti A, Kankaanranta H and Moilanen E: Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy. 4:471–479. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Sweet MJ and Hume DA: Endotoxin signal transduction in macrophages. J Leukoc Biol. 60:8–26. 1996. View Article : Google Scholar : PubMed/NCBI

39 

Davies KJ: Oxidative stress: The paradox of aerobic life. Biochem Soc Symp. 61:1–31. 1995. View Article : Google Scholar : PubMed/NCBI

40 

Thalhamer T, McGrath MA and Harnett MM: MAPKs and their relevance to arthritis and inflammation. Rheumatol (Oxford). 47:409–414. 2008. View Article : Google Scholar

41 

Chang LY, Wan HC, Lai YL, Chou IC, Chen YT and Hung SL: Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. Arch Oral Biol. 58:1523–1531. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Satoh M, Minami Y, Takahashi Y and Nakamura M: Immune modulation: Role of theinflammatory cytokine cascade in the failing human heart. Curr Heart Fail Rep. 5:69–74. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Wang L, Xu Ml, Liu J, Wang Y, Hu JH and Wang MH: Sonchus asper extract inhibits 7 macrophages. Nutr Res Pract. 9:579–585. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Jin Y, Yang J, Lin L, Lin Y and Zheng C: The attenuation of scutellariae radix extract on oxidative stress for colon injury in lipopolysaccharide-induced RAW264.7 Cell and 2,4,6-trinitro-benzene sulfonic acid-induced ulcerative colitis rats. Pharmacogn Mag. 12:153–159. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Broom OJ, Widjaya B, Troelsen J, Olsen J and Nielsen OH: Mitogen activated protein kinases: A role in inflammatory bowel disease. Clin Exp Immunol. 158:272–280. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Shan J, Fu J, Zhao Z, Kong X, Huang H, Luo L and Yin Z: Chlorogenic acid inhibits lipopolysaccharide-induced cyclo-oxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. Int Immunopharmacol. 9:1042–1048. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hwang JH, Ma JN, Park JH, Jung HW and Park YK: Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages. Int J Mol Med 43: 26-36, 2019.
APA
Hwang, J.H., Ma, J.N., Park, J.H., Jung, H.W., & Park, Y. (2019). Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages. International Journal of Molecular Medicine, 43, 26-36. https://doi.org/10.3892/ijmm.2018.3937
MLA
Hwang, J. H., Ma, J. N., Park, J. H., Jung, H. W., Park, Y."Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages". International Journal of Molecular Medicine 43.1 (2019): 26-36.
Chicago
Hwang, J. H., Ma, J. N., Park, J. H., Jung, H. W., Park, Y."Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages". International Journal of Molecular Medicine 43, no. 1 (2019): 26-36. https://doi.org/10.3892/ijmm.2018.3937
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang JH, Ma JN, Park JH, Jung HW and Park YK: Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages. Int J Mol Med 43: 26-36, 2019.
APA
Hwang, J.H., Ma, J.N., Park, J.H., Jung, H.W., & Park, Y. (2019). Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages. International Journal of Molecular Medicine, 43, 26-36. https://doi.org/10.3892/ijmm.2018.3937
MLA
Hwang, J. H., Ma, J. N., Park, J. H., Jung, H. W., Park, Y."Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages". International Journal of Molecular Medicine 43.1 (2019): 26-36.
Chicago
Hwang, J. H., Ma, J. N., Park, J. H., Jung, H. W., Park, Y."Anti-inflammatory and antioxidant effects of MOK, a polyherbal extract, on lipopolysaccharide‑stimulated RAW 264.7 macrophages". International Journal of Molecular Medicine 43, no. 1 (2019): 26-36. https://doi.org/10.3892/ijmm.2018.3937
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team