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Article

Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity

  • Authors:
    • Bo‑Mi Kim
    • Byoung Ok Cho
    • Seon Il Jang
  • View Affiliations / Copyright

    Affiliations: Department of Chemical Engineering, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea, Research Institute, Ato Q&A Co., Ltd., Jeonju, Jeonbuk 54840, Republic of Korea
  • Pages: 603-613
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    Published online on: October 18, 2018
       https://doi.org/10.3892/ijmm.2018.3941
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Abstract

Diospyros (D.) lotus has been demonstrated to have antioxidant and anti‑inflammatory properties. The purpose of the present study was to evaluate the effect of D. lotus leaf water extract (DLE) on high‑fat diet (HFD)‑induced obesity in C57BL/6 mice. The present study first investigated the effect of DLE on the lipid accumulation and triglyceride (TG) contents in 3T3‑L1 cells, and the results revealed that treatment with DLE suppressed the lipid accumulation and TG level. Subsequently, the anti‑obesity effects of DLE were investigated in vivo. Oral administration of DLE reduced the body weight gain, food efficiency ratio, and liver and visceral fat weight in mice fed with a HFD. DLE administration in these mice also reduced TG, total cholesterol, low‑density lipoprotein cholesterol, glucose, insulin and leptin levels, as well as the atherogenic index. Furthermore, DLE administration decreased hepatic steatosis, as well as serum aspartate transaminase, alanine transaminase and alkaline phosphatase levels in mice fed with HFD. It was further observed that treatment of the HFD‑fed mice with DLE prevented lipid peroxidation, while it recovered glutathione depletion and the activities of superoxide dismutase, catalase and glutathione peroxidase. In conclusion, the current study suggests that the anti‑obesity effect of DLE may provide positive insights as a potential functional food ingredient for the prevention of obesity.
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Copy and paste a formatted citation
Spandidos Publications style
Kim BM, Cho BO and Jang SI: Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity. Int J Mol Med 43: 603-613, 2019.
APA
Kim, B., Cho, B.O., & Jang, S.I. (2019). Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity. International Journal of Molecular Medicine, 43, 603-613. https://doi.org/10.3892/ijmm.2018.3941
MLA
Kim, B., Cho, B. O., Jang, S. I."Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity". International Journal of Molecular Medicine 43.1 (2019): 603-613.
Chicago
Kim, B., Cho, B. O., Jang, S. I."Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity". International Journal of Molecular Medicine 43, no. 1 (2019): 603-613. https://doi.org/10.3892/ijmm.2018.3941
Copy and paste a formatted citation
x
Spandidos Publications style
Kim BM, Cho BO and Jang SI: Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity. Int J Mol Med 43: 603-613, 2019.
APA
Kim, B., Cho, B.O., & Jang, S.I. (2019). Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity. International Journal of Molecular Medicine, 43, 603-613. https://doi.org/10.3892/ijmm.2018.3941
MLA
Kim, B., Cho, B. O., Jang, S. I."Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity". International Journal of Molecular Medicine 43.1 (2019): 603-613.
Chicago
Kim, B., Cho, B. O., Jang, S. I."Anti-obesity effects of Diospyros lotus leaf extract in mice with high-fat diet-induced obesity". International Journal of Molecular Medicine 43, no. 1 (2019): 603-613. https://doi.org/10.3892/ijmm.2018.3941
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