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Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia

  • Authors:
    • Yoshiji Yamada
    • Kimihiko Kato
    • Mitsutoshi Oguri
    • Hideki Horibe
    • Tetsuo Fujimaki
    • Yoshiki Yasukochi
    • Ichiro Takeuchi
    • Jun Sakuma
  • View Affiliations / Copyright

    Affiliations: Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu, Mie 514‑8507, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507‑8522, Japan, Department of Cardiovascular Medicine, Northern Mie Medical Center Inabe General Hospital, Inabe, Mie 511‑0428, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332‑0012, Japan
    Copyright: © Yamada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 57-82
    |
    Published online on: October 19, 2018
       https://doi.org/10.3892/ijmm.2018.3943
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Abstract

The circulating concentrations of triglycerides, high density lipoprotein (HDL)‑cholesterol, and low density lipoprotein (LDL)‑cholesterol have a substantial genetic component, and the heritability of early‑onset dyslipidemia might be expected to be higher compared with late‑onset forms. In the present study, exome‑wide association studies (EWASs) were performed for early‑onset hypertriglyceridemia, hypo‑HDL‑cholesterolemia, and hyper‑LDL‑cholesterolemia, with the aim to identify genetic variants that confer susceptibility to these conditions in the Japanese population. A total of 8,073 individuals aged ≤65 years were enrolled in the study. The EWASs for hypertriglyceridemia (2,664 cases and 5,294 controls), hypo‑HDL‑cholesterolemia (974 cases and 7,085 controls), and hyper‑LDL‑cholesterolemia (2,911 cases and 5,111 controls) were performed with Illumina Human Exome‑12 v1.2 DNA Analysis BeadChip or Infinium Exome‑24 v1.0 BeadChip arrays. The association of allele frequencies for 31,198, 31,133, or 31,175 single nucleotide polymorphisms (SNPs) to hypertriglyceridemia, hypo‑HDL‑cholesterolemia, or hyper‑LDL‑cholesterolemia, respectively, was examined with Fisher's exact test. To compensate for multiple comparisons of genotypes with each of the three conditions, Bonferroni's correction was applied for statistical significance of association. The results demonstrated that 25, 28 and 65 SNPs were significantly associated with hypertriglyceridemia, hypo‑HDL‑cholesterolemia and hyper‑LDL‑cholesterolemia, respectively. Multivariable logistic regression analysis with adjustment for age and sex revealed that all 25, 28 and 65 of these SNPs were significantly associated with hypertriglyceridemia, hypo‑HDL‑cholesterolemia and hyper‑LDL‑cholesterolemia, respectively. Following examination of the association of the identified SNPs to serum concentrations of triglycerides, HDL‑cholesterol, or LDL‑cholesterol, linkage disequilibrium of the SNPs, and results of previous genome‑wide association studies, we newly identified chromosomal region 19p12 as a susceptibility locus for hypertriglyceridemia, eight loci (MOB3C‑TMOD4, LPGAT1, EHD3, COL6A3, ZNF860‑CACNA1D, COL6A5, DCLRE1C, ZNF77) for hypo‑HDL‑cholesterolemia, and three loci (KIAA0319‑FAM65B, UBD, LOC105375015) for hyper‑LDL‑cholesterolemia. The present study thus identified 12 novel loci that may confer susceptibility to early‑onset dyslipidemia. Determination of genotypes for the SNPs at these loci may prove informative for assessment of genetic risk for hypertriglyceridemia, hypo‑HDL‑cholesterolemia, or hyper‑LDL‑cholesterolemia in the Japanese population.
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View References

1 

Durrington P: Dyslipidaemia. Lancet. 362:717–731. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Paththinige CS, Sirisena ND and Dissanayake V: Genetic determinants of inherited susceptibility to hypercholesterolemia-a comprehensive literature review. Lipids Health Dis. 16:1032017. View Article : Google Scholar

3 

Dron JS and Hegele RA: Genetics of triglycerides and the risk of atherosclerosis. Curr Atheroscler Rep. 19:312017. View Article : Google Scholar : PubMed/NCBI

4 

Soutar AK and Naoumova RP: Mechanism of disease: Genetic causes of familial hypercholesterolemia. Nat Clin Pract Cardiovasc Med. 4:214–225. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Heller DA, DeFaire U, Pedersen N, Dahlén G and McClearn GE: Genetic and environmental influences on serum lipid levels in twins. N Engl J Med. 328:1150–1156. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Abney M, McPeek MS and Ober C: Broad and narrow herita-bilities of quantitative traits in a founder population. Am J Hum Genet. 68:1302–1307. 2001. View Article : Google Scholar : PubMed/NCBI

7 

van Dongen J, Willemsen G, Chen WM, de Geus EJ and Boomsma DI: Heritability of metabolic syndrome traits in a large population-based sample. J Lipid Res. 54:2914–2923. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Woo JG, Morrison JA, Stroop DM, Aronson Friedman L and Martin LJ: Genetic architecture of lipid traits changes over time and differs by race: Princeton Lipid Follow-up Study. J Lipid Res. 55:1515–1524. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al: Heart disease and stroke statistics-2018 update: A report from the American Heart Association. Circulation. 137:e67–e492. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Law MR, Wald NJ and Rudnicka AR: Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: Systematic review and meta-analysis. Br Med J. 326:14232003. View Article : Google Scholar

11 

Agnoli C, Grioni S, Sieri S, Sacerdote C, Vineis P, Tumino R, Giurdanella MC, Pala V, Mattiello A, Chiodini P, et al: Colorectal cancer risk and dyslipidemia: A case-cohort study nested in an Italian multicentre cohort. Cancer Epidemiol. 38:144–151. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Yao X and Tian Z: Dyslipidemia and colorectal cancer risk: A meta-analysis of prospective studies. Cancer Causes Control. 26:257–268. 2015. View Article : Google Scholar

13 

Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, et al: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 40:189–197. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, et al: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 41:56–65. 2009. View Article : Google Scholar

15 

Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, et al: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 41:47–55. 2009. View Article : Google Scholar :

16 

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466:707–713. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, et al: Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet. 91:823–838. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, et al: Discovery and refinement of loci associated with lipid levels. Nat Genet. 45:1274–1283. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M, et al: Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 94:223–232. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Surakka I, Horikoshi M, Mägi R, Sarin AP, Mahajan A, Lagou V, Marullo L, Ferreira T, Miraglio B, Timonen S, et al: The impact of low-frequency and rare variants on lipid levels. Nat Genet. 47:589–597. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, et al: Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 94:233–245. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Helgadottir A, Gretarsdottir S, Thorleifsson G, Hjartarson E, Sigurdsson A, Magnusdottir A, Jonasdottir A, Kristjansson H, Sulem P, Oddsson A, et al: Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. Nat Genet. 48:634–639. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, et al: Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet. 49:1758–1766. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, et al: A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet. 50:401–413. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Peloso Lu X, Liu GM, Wu DJ, Zhang Y, Zhou H, Li W, Tang J, Dorajoo CS, Li RH, et al: Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat Genet. 49:1722–1730. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, Long J, Wu Y, Wang YX, Takeuchi F, et al: Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 26:1770–1784. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Kurano M, Tsukamoto K, Kamitsuji S, Kamatani N, Hara M, Ishikawa T, Kim BJ, Moon S, Jin Kim Y and Teramoto T: Genome-wide association study of serum lipids confirms previously reported associations as well as new associations of common SNPs within PCSK7 gene with triglyceride. J Hum Genet. 61:427–433. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki T, Horibe H, Muramatsu M, Sawabe M, et al: Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies. Oncotarget. 8:38950–38961. 2017.PubMed/NCBI

29 

Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. Int J Mol Med. 35:1189–1198. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples LA, Fornage M, et al: Best practices and joint calling of the HumanExome BeadChip: The CHARGE Consortium. PLoS One. 8:e680952013. View Article : Google Scholar : PubMed/NCBI

31 

Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP and Zondervan KT: Data quality control in genetic case-control association studies. Nat Protoc. 5:1564–1573. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA and Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 38:904–909. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Leslie R, O’Donnell CJ and Johnson AD: GRASP: Analysis of genotype-phenotype results from 1,390 genome-wide association studies and corresponding open access database. Bioinformatics. 30:i185-i1942014. View Article : Google Scholar

34 

Eicher JD, Landowski C, Stackhouse B, Sloan A, Chen W, Jensen N, Lien JP, Leslie R and Johnson AD: GRASP v2.0: An update on the genome-wide repository of associations between SNPs and phenotypes. Nucleic Acids Res. 43(Database Issue): D799–D804. 2015. View Article : Google Scholar :

35 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38:W214–W220. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Montojo J, Zuberi K, Rodriguez H, Kazi F, Wright G, Donaldson SL, Morris Q and Bader GD: GeneMANIA cytoscape plugin: Fast gene function predictions on the desktop. Bioinformatics. 26:2927–2928. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Montojo J, Zuberi K, Rodriguez H, Bader GD and Morris Q: GeneMANIA: Fast gene network construction and function prediction for Cytoscape. F1000Res. 3:1532014.PubMed/NCBI

38 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Piñero J, Queralt-Rosinach N, Bravo À, Deu-Pons J, Bauer-Mehren A, Baron M, Sanz F and Furlong LI: DisGeNET: A discovery platform for the dynamical exploration of human diseases and their genes. Database (Oxford) 2015. bav0282015. View Article : Google Scholar

40 

Piñero J, Bravo À, Queralt-Rosinach N, Gutiérrez-Sacristán A, Deu-Pons J, Centeno E, García-García J, Sanz F and Furlong LI: DisGeNET: A comprehensive platform integrating information on human disease-associated genes and variants. Nucleic Acids Res. 45:D833–D839. 2017. View Article : Google Scholar :

41 

Lempiäinen H, Brænne I, Michoel T, Tragante V, Vilne B, Webb TR, Kyriakou T, Eichner J, Zeng L, Willenborg C, et al: Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets. Sci Rep. 8:34342018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yamada Y, Kato K, Oguri M, Horibe H, Fujimaki T, Yasukochi Y, Takeuchi I and Sakuma J: Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia. Int J Mol Med 43: 57-82, 2019.
APA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y. ... Sakuma, J. (2019). Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia. International Journal of Molecular Medicine, 43, 57-82. https://doi.org/10.3892/ijmm.2018.3943
MLA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia". International Journal of Molecular Medicine 43.1 (2019): 57-82.
Chicago
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia". International Journal of Molecular Medicine 43, no. 1 (2019): 57-82. https://doi.org/10.3892/ijmm.2018.3943
Copy and paste a formatted citation
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Spandidos Publications style
Yamada Y, Kato K, Oguri M, Horibe H, Fujimaki T, Yasukochi Y, Takeuchi I and Sakuma J: Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia. Int J Mol Med 43: 57-82, 2019.
APA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y. ... Sakuma, J. (2019). Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia. International Journal of Molecular Medicine, 43, 57-82. https://doi.org/10.3892/ijmm.2018.3943
MLA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia". International Journal of Molecular Medicine 43.1 (2019): 57-82.
Chicago
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 12 novel loci that confer susceptibility to early-onset dyslipidemia". International Journal of Molecular Medicine 43, no. 1 (2019): 57-82. https://doi.org/10.3892/ijmm.2018.3943
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