Epigenetic mechanisms and implications in tendon inflammation (Review)
- Authors:
- Finosh G. Thankam
- Chandra S. Boosani
- Matthew F. Dilisio
- Devendra K. Agrawal
-
Affiliations: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA, Department of Orthopedic Surgery, Creighton University School of Medicine, Omaha, NE 68178, USA - Published online on: October 29, 2018 https://doi.org/10.3892/ijmm.2018.3961
- Pages: 3-14
-
Copyright: © Thankam et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
 |
 |
 |
|
Thankam FG, Dilisio MF, Dougherty KA, Dietz NE and Agrawal DK: Triggering receptor expressed on myeloid cells and 5'adenosine monophosphate-activated protein kinase in the inflammatory response: A potential therapeutic target. Expert Rev Clin Immunol. 12:1239–1249. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Thankam FG, Dilisio MF and Agrawal DK: Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. Mol Cell Biochem. 417:17–33. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Page P: Shoulder muscle imbalance and subacromial impingement syndrome in overhead athletes. Int J Sports Phys Ther. 6:51–58. 2011.PubMed/NCBI | |
|
Waddington CH: Towards a theoretical biology. Nature. 218:525–527. 1968. View Article : Google Scholar : PubMed/NCBI | |
|
Kornberg RD: Chromatin structure: A repeating unit of histones and DNA. Science. 184:868–871. 1974. View Article : Google Scholar : PubMed/NCBI | |
|
Weintraub H and Groudine M: Chromosomal subunits in active genes have an altered conformation. Science. 193:848–856. 1976. View Article : Google Scholar : PubMed/NCBI | |
|
Narlikar GJ, Fan HY and Kingston RE: Cooperation between complexes that regulate chromatin structure and transcription. Cell. 108:475–487. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Felsenfeld G and Groudine M: Controlling the double helix. Nature. 421:448–453. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Surani MA, Hayashi K and Hajkova P: Genetic and epigenetic regulators of pluripotency. Cell. 128:747–762. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Human Genome Structural Variation Working Group; Eichler EE, Nickerson DA, Altshuler D, Bowcock AM, Brooks LD, Carter NP, Church DM, Felsenfeld A, Guyer M, et al: Completing the map of human genetic variation. Nature. 447:161–165. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Sebat J: Major changes in our DNA lead to major changes in our thinking. Nat Genet. 39(Suppl 7): S3–S5. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Jin B, Li Y and Robertson KD: DNA Methylation: Superior or subordinate in the epigenetic hierarchy. Genes Cancer. 2:607–617. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Herman JG and Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 349:2042–2054. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Voelter-Mahlknecht S: Epigenetic associations in relation to cardiovascular prevention and therapeutics. Clin Epigenetics. 8:42016. View Article : Google Scholar : PubMed/NCBI | |
|
Shea JM, Serra RW, Carone BR, Shulha HP, Kucukural A, Ziller MJ, Vallaster MP, Gu H, Tapper AR, Gardner PD, et al: Genetic and epigenetic variation, but not diet, shape the sperm methylome. Dev Cell. 35:750–758. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lachner M and Jenuwein T: The many faces of histone lysine methylation. Curr Opin Cell Biol. 14:286–298. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Pradhan S, Bacolla A, Wells RD and Roberts RJ: Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem. 274:33002–33010. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Leonhardt H, Page AW, Weier HU and Bestor TH: A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell. 71:865–873. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Okano M, Bell DW, Haber DA and Li E: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 99:247–257. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Borgel J, Guibert S, Li Y, Chiba H, Schübeler D, Sasaki H, Forné T and Weber M: Targets and dynamics of promoter DNA methylation during early mouse development. Nat Genet. 42:1093–1100. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, Li E, Zhang Y and Sun YE: Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science. 329:444–448. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ooi SK, Qiu C, Bernstein E, Li K, Jia D, Yang Z, Erdjument-Bromage H, Tempst P, Lin SP, Allis CD, et al: DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 448:714–717. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ramsahoye BH, Biniszkiewicz D, Lyko F, Clark V, Bird AP and Jaenisch R: Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci USA. 97:5237–5242. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Pinney S: Mammalian Non-CpG methylation: Stem cells and beyond. Biology (Basel). 3. pp. 739–751. 2014 | |
|
Suzuki MM and Bird A: DNA methylation landscapes: Provocative insights from epigenomics. Nat Rev Genet. 9:465–476. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Ehrlich M, Gama-Sosa MA, Huang LH, Midgett RM, Kuo KC, McCune RA and Gehrke C: Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 10:2709–2721. 1982. View Article : Google Scholar : PubMed/NCBI | |
|
Reik W, Dean W and Walter J: Epigenetic reprogramming in mammalian development. Science. 293:1089–1093. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA and Issa JP: Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 3:2023–2036. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Henderson IR and Jacobsen SE: Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading. Genes Dev. 22:1597–1606. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lienert F, Wirbelauer C, Som I, Dean A, Mohn F and Schübeler D: Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet. 43:1091–1097. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, et al: Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 454:766–770. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Smith ZD, Chan MM, Mikkelsen TS, Gu H, Gnirke A, Regev A and Meissner A: A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature. 484:339–344. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Aran D, Sabato S and Hellman A: DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes. Genome Biol. 14:R212013. View Article : Google Scholar : PubMed/NCBI | |
|
Sharif O and Knapp S: From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology. 213:701–713. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Jones PA: Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nat Rev Genet. 13:484–492. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, et al: Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature. 466:253–257. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Laurent L, Wong E, Li G, Huynh T, Tsirigos A, Ong CT, Low HM, Kin Sung KW, Rigoutsos I, Loring J and Wei CL: Dynamic changes in the human methylome during differentiation. Genome Res. 20:320–331. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Mayer W, Niveleau A, Walter J, Fundele R and Haaf T: Demethylation of the zygotic paternal genome. Nature. 403:501–502. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Inoue A and Zhang Y: Replication-dependent loss of 5- hydroxymethylcytosine in mouse preimplantation embryos. Science. 334:1942011. View Article : Google Scholar | |
|
Guo JU, Su Y, Zhong C, Ming GL and Song H: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 145:423–434. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Yang H, Lin H, Xu H, Zhang L, Cheng L, Wen B, Shou J, Guan K, Xiong Y and Ye D: TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Res. 24:1017–1020. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H and Zhang Y: Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 25:2436–2452. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Kouzarides T: Chromatin modifications and their function. Cell. 128:693–705. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Gill G: SUMO and ubiquitin in the nucleus: Different functions, similar mechanisms. Genes Dev. 18:2046–2059. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Tsankova N, Renthal W, Kumar A and Nestler EJ: Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci. 8:355–367. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ragunathan K, Jih G and Moazed D: Epigenetic inheritance uncoupled from sequence-specific recruitment. Science. 348:12586992015. View Article : Google Scholar : | |
|
Covic M, Hassa PO, Saccani S, Buerki C, Meier NI, Lombardi C, Imhof R, Bedford MT, Natoli G and Hottiger MO: Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 24:85–96. 2005. View Article : Google Scholar | |
|
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H and Shinkai Y: G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16:1779–1791. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J and Mer G: Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 127:1361–1373. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Techima M: Inquiring for new approach to nursing education. III. A case in clinical practicum (2). Kango Kenkyu. 24:366–372. 1991.In Japanese. | |
|
Fischle W, Tseng BS, Dormann HL, Ueberheide BM, Garcia BA, Shabanowitz J, Hunt DF, Funabiki H and Allis CD: Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature. 438:1116–1122. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Margueron R, Trojer P and Reinberg D: The key to development: Interpreting the histone code. Curr Opin Genet Dev. 15:163–176. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, et al: A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature. 442:86–90. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Andrews FH, Gatchalian J, Krajewski K, Strahl BD and Kutateladze TG: Regulation of methyllysine readers through phosphorylation. ACS Chem Biol. 11:547–553. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Couture JF, Collazo E and Trievel RC: Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol. 13:698–703. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Kadota S and Nagata K: pp32, an INHAT component, is a transcription machinery recruiter for maximal induction of IFN-stimulated genes. J Cell Sci. 124:892–899. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Shao Z, Raible F, Mollaaghababa R, Guyon JR, Wu CT, Bender W and Kingston RE: Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell. 98:37–46. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Chandrasekharan MB, Huang F and Sun ZW: Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc Natl Acad Sci USA. 106:16686–16691. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Canzonetta C, Vernarecci S, Iuliani M, Marracino C, Belloni C, Ballario P and Filetici P: SAGA DUB-Ubp8 deubiquitylates centromeric histone variant Cse4. G3 (Bethesda). 6:287–298. 2015. View Article : Google Scholar | |
|
Sun L, Johnston SA and Kodadek T: Physical association of the APIS complex and general transcription factors. Biochem Biophys Res Commun. 296:991–999. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Muratani M and Tansey WP: How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol. 4:192–201. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Sun ZW and Allis CD: Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature. 418:104–108. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, Shilatifard A, Osley MA and Berger SL: Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev. 17:2648–2663. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Gao C, Huang W, Kanasaki K and Xu Y: The role of ubiquitination and sumoylation in diabetic nephropathy. Biomed Res Int. 2014.160692:2014. | |
|
Collins P, Mitxitorena I and Carmody R: The ubiquitination of NF-κB subunits in the control of transcription. Cells. 5:pii: E232016. View Article : Google Scholar | |
|
Moazed D: Small RNAs in transcriptional gene silencing and genome defence. Nature. 457:413–420. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Cech TR and Steitz JA: The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 157:77–94. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC: Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans. Nature. 391:806–811. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Matzke M, Matzke AJ and Kooter JM: RNA: Guiding gene silencing. Science. 293:1080–1083. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Boosani C and Agrawal D: Epigenetic regulation of innate immunity by microRNAs. Antibodies. 5:82016. View Article : Google Scholar | |
|
Castel SE and Martienssen RA: RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet. 14:100–112. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kim VN, Han J and Siomi MC: Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 10:126–139. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Pak J and Fire A: Distinct populations of primary and secondary effectors during RNAi iC elegans. Science. 315:241–244. 2007. View Article : Google Scholar | |
|
Halic M and Moazed D: Dicer-independent primal RNAs trigger RNAi and heterochromatin formation. Cell. 140:504–516. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP and Moazed D: Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 119:789–802. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Bühler M, Verdel A and Moazed D: Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell. 125:873–886. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Holoch D and Moazed D: RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet. 16:71–84. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Bayne EH, White SA, Kagansky A, Bijos DA, Sanchez-Pulido L, Hoe KL, Kim DU, Park HO, Ponting CP, Rappsilber J and Allshire RC: Stc1: A critical link between RNAi and chromatin modification required for heterochromatin integrity. Cell. 140:666–677. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Gerace EL, Halic M and Moazed D: The methyltransferase activity of Clr4Suv39h triggers RNAi independently of histone H3K9 methylation. Mol Cell. 39:360–372. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Zaratiegui M, Castel SE, Irvine DV, Kloc A, Ren J, Li F, de Castro E, Marí L, Chang AY, Goto D, et al: RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature. 479:135–138. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Li F, Martienssen R and Cande WZ: Coordination of DNA replication and histone modification by the Rik1-Dos2 complex. Nature. 475:244–248. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Millar NL, Murrell GA and McInnes IB: Inflammatory mechanisms in tendinopathy-towards translation. Nat Rev Rheumatol. 13:110–122. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Campbell AL, Smith NC, Reilly JH, Kerr SC, Leach WJ, Fazzi UG, Rooney BP, Murrell GA and Millar NL: IL-21 receptor expression in human tendinopathy. Mediators Inflamm. 2014.481206:2014. | |
|
Legerlotz K, Jones ER, Screen HR and Riley GP: Increased expression of IL-6 family members in tendon pathology. Rheumatology (Oxford). 51:1161–1165. 2012. View Article : Google Scholar | |
|
Dean BJ, Gettings P, Dakin SG and Carr AJ: Are inflammatory cells increased in painful human tendinopathy? A systematic review. Br J Sports Med. 50:216–220. 2016. View Article : Google Scholar | |
|
Thankam FG, Dilisio MF, Dietz NE and Agrawal DK: TREM-1, HMGB1 and RAGE in the shoulder tendon: Dual mechanisms for inflammation based on the coincidence of glenohumeral arthritis. PLoS One. 11:e01654922016. View Article : Google Scholar : PubMed/NCBI | |
|
Guo J, Zhang JF, Li G and Chan KM: A Mini-review: MicroRNA in tendon injuries. J Stem Cell Res Ther. 5:3032015. | |
|
Millar NL, Gilchrist DS, Akbar M, Reilly JH, Kerr SC, Campbell AL, Murrell GA, Liew FY, Kurowska-Stolarska M and McInnes IB: MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nat Commun. 6:67742015. View Article : Google Scholar : PubMed/NCBI | |
|
Thankam FG, Boosani CS, Dilisio MF, Dietz NE and Agrawal DK: MicroRNAs associated with shoulder tendon matrisome disorganization in glenohumeral arthritis. PLoS One. 11:e01680772016. View Article : Google Scholar : PubMed/NCBI | |
|
Thankam FG, Boosani CS, Dilisio MF and Agrawal DK: MicroRNAs associated with inflammation in shoulder tendinopathy and glenohumeral arthritis. Mol Cell Biochem. 437:81–97. 2018. View Article : Google Scholar | |
|
Medzhitov R and Horng T: Transcriptional control of the inflammatory response. Nat Rev Immunol. 9:692–703. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Wierda RJ, Geutskens SB, Jukema JW, Quax PH and van den Elsen PJ: Epigenetics in atherosclerosis and inflammation. J Cell Mol Med. 14:1225–1240. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G and Natoli G: The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell. 130:1083–1094. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Hahn MA, Hahn T, Lee DH, Esworthy RS, Kim BW, Riggs AD, Chu FF and Pfeifer GP: Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res. 68:10280–10289. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, El Gazzar M, Yoza BK and McCall CE: The NF-kappaB Factor RelB and Histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem. 284:27857–27865. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Gazzar ME, Yoza BK, Chen X, Hu J, Hawkins GA and McCall CE: G9a and HP1 couple histone and DNA methylation to TNF transcription silencing during endotoxin tolerance. J Biol Chem. 283:32198–32208. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Villagra A, Sotomayor EM and Seto E: Histone deacetylases and the immunological network: Implications in cancer and inflammation. Oncogene. 29:157–173. 2010. View Article : Google Scholar | |
|
Bayarsaihan D: Epigenetic Mechanisms in Inflammation. J Dent Res. 90:9–17. 2011. View Article : Google Scholar : | |
|
Shuto T, Furuta T, Oba M, Xu H, Li JD, Cheung J, Gruenert DC, Uehara A, Suico MA, Okiyoneda T and Kai H: Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. FASEB J. 20:782–784. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Takahashi N: Microbial ecosystem in the oral cavity: Metabolic diversity in an ecological niche and its relationship with oral diseases. Int Congr Ser. 1284:103–112. 2005. View Article : Google Scholar | |
|
Brand RA: Surgical anatomy of the rotator cuff and the natural history of degenerative periarthritis. Clin Orthop Related Res. 466:543–551. 2008. View Article : Google Scholar | |
|
Claycombe KJ, Brissette CA and Ghribi O: Epigenetics of inflammation, maternal infection, and nutrition. J Nutr 145 (Suppl):. 1109S–1115S. 2015. | |
|
Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, Ichinose M, Tatematsu M and Ushijima T: Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 70:1430–1440. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ding W, Mouzaki M, You H, Laird JC, Mato J, Lu SC and Rountree CB: CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology. 49:1277–1286. 2009. View Article : Google Scholar | |
|
Wang YQ, Li YM, Li X, Liu T, Liu XK, Zhang JQ, Guo JW, Guo LY and Qiao L: Hypermethylation of TGF-β1 gene promoter in gastric cancer. World J Gastroenterol. 19:5557–5564. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Boosani CS, Dhar K and Agrawal DK: Down-regulation of hsa-miR-1264 contributes to DNMT1-mediated silencing of SOCS3. Mol Biol Rep. 42:1365–1376. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng C, Huang C, Ma TT, Bian EB, He Y, Zhang L and Li J: SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages. Toxicol Lett. 225:488–497. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kuo PL, Shen KH, Hung SH and Hsu YL: CXCL1/GROα increases cell migration and invasion of prostate cancer by decreasing fibulin-1 expression through NF-κB/HDAC1 epigenetic regulation. Carcinogenesis. 33:2477–2487. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Boosani C and Agrawal DK: Abstract 12818: KPNA4 mediates vitamin D-dependent inhibition of NF-κB activity in swine epicardial preadipocytes. Circulation. 130:A128182014. | |
|
Cao B, Yang Y, Pan Y, Jia Y, Brock MV, Herman JG and Guo M: Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion. Discov Med. 16:137–147. 2013.PubMed/NCBI | |
|
Ramos EA, Grochoski M, Braun-Prado K, Seniski GG, Cavalli IJ, Ribeiro EM, Camargo AA, Costa FF and Klassen G: Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. PLoS One. 6:e294612011. View Article : Google Scholar | |
|
Yasmin R, Siraj S, Hassan A, Khan AR, Abbasi R and Ahmad N: Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies. Mediators Inflamm. 2015.201703:2015. |
