Open Access

SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells

  • Authors:
    • Xue‑Qing Wan
    • Jia‑Yu Cai
    • Yue Zhu
    • Qiu‑Xia Wang
    • Hai‑Tao Zhu
    • Hui‑Min Ju
    • Hong‑Yan Lu
  • View Affiliations

  • Published online on: October 29, 2018     https://doi.org/10.3892/ijmm.2018.3964
  • Pages: 371-381
  • Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Post‑translational modification via small ubiquitin‑like modifier (SUMO) is involved in the regulation of various important cellular processes. SUMO modification can be regulated at the level of conjugation, and can also be reversed by the SUMO‑specific proteases (SENPs). However, current studies of the regulation and function of SENP in lung development remain limited. In this study, the expression levels of SENP1 and SUMO1 were assessed during lung development in rats. SUMO1 modification occurred during lung development and changes in SENP1 expression were consistent with the changes in the presence of free SUMO1. In order to investigate the function of SENP1, alveolar type (AT) 2 cells were transfected with SENP1‑targeting small interfering RNA, and the proliferation, apoptosis and differentiation function of AT2 cells was subsequently evaluated. Marked upregulation of conjugated SUMO1 was observed following SENP1 inhibition. Furthermore, depletion of SENP1 resulted in increased apoptosis, decreased proliferation and impaired differentiation status of AT2 cells. Thus, the results support that SENP1 is an essential regulator of the balance between SUMOylation and deSUMOylation during lung development, specifically affecting the proliferation and differentiation status of AT2 cells.
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January 2019
Volume 43 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Wan, X., Cai, J., Zhu, Y., Wang, Q., Zhu, H., Ju, H., & Lu, H. (2019). SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells. International Journal of Molecular Medicine, 43, 371-381. https://doi.org/10.3892/ijmm.2018.3964
MLA
Wan, X., Cai, J., Zhu, Y., Wang, Q., Zhu, H., Ju, H., Lu, H."SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells". International Journal of Molecular Medicine 43.1 (2019): 371-381.
Chicago
Wan, X., Cai, J., Zhu, Y., Wang, Q., Zhu, H., Ju, H., Lu, H."SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells". International Journal of Molecular Medicine 43, no. 1 (2019): 371-381. https://doi.org/10.3892/ijmm.2018.3964