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Article Open Access

Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways

  • Authors:
    • Wen‑Yong Fei
    • Qiang Huo
    • Pei‑Qing Zhao
    • Long‑Juan Qin
    • Tao Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Center of Translational Medicine, Central Hospital of Zibo, Shandong University, Zibo, Shandong 255036, P.R. China, Orthopedic Basic and Translational Research Center, Jiangyin, Jiangsu 214400, P.R. China
    Copyright: © Fei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1669-1678
    |
    Published online on: February 18, 2019
       https://doi.org/10.3892/ijmm.2019.4099
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Abstract

Magnolol is the active component of the traditional Chinese medicine Magnolia officinalis, and has antioxidant, anti‑inflammatory and anticancer activities, as well as an effect on bone metabolism in vitro. In the present study, it is reported that magnolol suppresses osteoclastogenesis in vivo and in vitro. Magnolol prevented ovariectomy‑induced bone loss and osteoclastogenesis in vivo, and decreased the serum levels of C‑terminal telopeptide of type 1 collagen, interleukin‑6, tumor necrosis factor (TNF)‑α and tartrate‑resistant acid phosphatase 5B. In vitro, magnolol inhibited the osteoclastogenesis induced by the receptor activator for nuclear factor‑κB ligand, and impaired the osteoclast function in bone marrow monocytes and RAW264.7 cells in a dose‑dependent manner. Furthermore, magnolol suppressed the expression levels of the osteoclastogenesis markers cathepsin K, calcitonin receptor, matrix metalloproteinase 9, TNF receptor‑associated factor 6 and tartrate‑resistant acid phosphatase by inhibiting the nuclear factor‑κB and mitogen‑activated protein kinase pathways. Therefore, magnolol is a promising agent for the treatment of osteoporosis and associated disorders.
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Copy and paste a formatted citation
Spandidos Publications style
Fei WY, Huo Q, Zhao PQ, Qin LJ and Li T: Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways . Int J Mol Med 43: 1669-1678, 2019.
APA
Fei, W., Huo, Q., Zhao, P., Qin, L., & Li, T. (2019). Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways . International Journal of Molecular Medicine, 43, 1669-1678. https://doi.org/10.3892/ijmm.2019.4099
MLA
Fei, W., Huo, Q., Zhao, P., Qin, L., Li, T."Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways ". International Journal of Molecular Medicine 43.4 (2019): 1669-1678.
Chicago
Fei, W., Huo, Q., Zhao, P., Qin, L., Li, T."Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways ". International Journal of Molecular Medicine 43, no. 4 (2019): 1669-1678. https://doi.org/10.3892/ijmm.2019.4099
Copy and paste a formatted citation
x
Spandidos Publications style
Fei WY, Huo Q, Zhao PQ, Qin LJ and Li T: Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways . Int J Mol Med 43: 1669-1678, 2019.
APA
Fei, W., Huo, Q., Zhao, P., Qin, L., & Li, T. (2019). Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways . International Journal of Molecular Medicine, 43, 1669-1678. https://doi.org/10.3892/ijmm.2019.4099
MLA
Fei, W., Huo, Q., Zhao, P., Qin, L., Li, T."Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways ". International Journal of Molecular Medicine 43.4 (2019): 1669-1678.
Chicago
Fei, W., Huo, Q., Zhao, P., Qin, L., Li, T."Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways ". International Journal of Molecular Medicine 43, no. 4 (2019): 1669-1678. https://doi.org/10.3892/ijmm.2019.4099
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