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MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism

  • Authors:
    • Wei‑He Qian
    • Yuan‑Yuan Liu
    • Xiang Li
    • Yan Pan
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu 223302, P.R. China, Department of Endocrinology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Clinical Laboratory, Lianshui County People's Hospital, Huai'an, Jiangsu 223400, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 569-581
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    Published online on: May 30, 2019
       https://doi.org/10.3892/ijmm.2019.4221
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Abstract

Alcoholic hepatitis (AH) is a fatal inflammatory syndrome with no effective treatments. Intestinal injury and intestinal endotoxemia (IETM) contribute greatly in the development of AH. MicroRNAs (miRNAs/miRs) have been reported to affect intestinal injury. The present study aims to investigate the role of miR‑141 in intestinal injury and IETM of AH. An AH model was successfully established in mice and they were the injected with a series of miR‑141 mimic, miR‑141 inhibitor or toll like receptor 4 monoclonal antibody (TLR4mAb; an inhibitor of the Toll‑like receptor TLR pathway). After that, the intestinal tissues and intestinal epithelial cells were isolated from differently treated AH mice. The expression of miR‑141 and TLR pathway‑associated genes and the levels of inflammatory factors were determined. Furthermore, a target prediction program and a luciferase reporter assay were employed to examine whether miR‑141 targets TLR4. Finally, MTT and transwell assays were carried out to detect cell viability and cell permeability. Intestinal tissues from AH mice treated with miR‑141 mimic or TLR4mAb exhibited lower levels of inflammatory factors and reduced expression of the TLR pathway‑associated genes, suggesting a decreased inflammatory response as well as inactivation of the TLR pathway by miR‑141. The luciferase reporter assay suggested that miR‑141 negatively regulated TLR4. Intestinal epithelial cells treated with miR‑141 mimic or TLR4mAb demonstrated enhanced viability and reduced permeability. Opposite results were observed in AH mice treated with a miR‑141 inhibitor. Collectively, the results of the present study demonstrated that miR‑141 could ameliorate intestinal injury and repress the progression of IETM through targeting TLR4 and inhibiting the TLR pathway.
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1 

Damgaard Sandahl T: Alcoholic hepatitis. Dan Med J. 61:B47552014.PubMed/NCBI

2 

Kendrick SF, O'Boyle G, Mann J, Zeybel M, Palmer J, Jones DE and Day CP: Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology. 51:1988–1997. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Chayanupatkul M and Liangpunsakul S: Alcoholic hepatitis: A comprehensive review of pathogenesis and treatment. World J Gastroenterol. 20:6279–6286. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Singal AK, Kamath PS, Gores GJ and Shah VH: Alcoholic hepatitis: Current challenges and future directions. Clin Gastroenterol Hepatol. 12:555–564; quiz e31-e32. 2014. View Article : Google Scholar :

5 

Raff E and Singal AK: Optimal management of alcoholic hepatitis. Minerva Gastroenterol Dietol. 60:25–38. 2014.PubMed/NCBI

6 

Torok NJ: Update on alcoholic hepatitis. Biomolecules. 5:2978–2986. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Yan AW and Schnabl B: Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease. World J Hepatol. 4:110–118. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Schnabl B and Brenner DA: Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 146:1513–1524. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Rao R: Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology. 50:638–644. 2009. View Article : Google Scholar : PubMed/NCBI

10 

McDaniel K, Herrera L, Zhou T, Francis H, Han Y, Levine P, Lin E, Glaser S, Alpini G and Meng F: The functional role of microRNAs in alcoholic liver injury. J Cell Mol Med. 18:197–207. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Szabo G and Satishchandran A: MicroRNAs in alcoholic liver disease. Semin Liver Dis. 35:36–42. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Blaya D, Coll M, Rodrigo-Torres D, Vila-Casadesús M, Altamirano J, Llopis M, Graupera I, Perea L, Aguilar-Bravo B, Diaz A, et al: Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation. Gut. 65:1535–1545. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, Alao H, Kodys K and Szabo G: Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology. 56:1946–1957. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Lucas K and Maes M: Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway. Mol Neurobiol. 48:190–204. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Zhou X, Ye F, Yin C, Zhuang Y, Yue G and Zhang G: The interaction between MiR-141 and lncRNA-H19 in regulating cell proliferation and migration in gastric cancer. Cell Physiol Biochem. 36:1440–1452. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Xue J, Niu YF, Huang J, Peng G, Wang LX, Yang YH and Li YQ: miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3. Tumour Biol. 35:12103–12107. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY and Huang XY: Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Sci Rep. 7:54282017. View Article : Google Scholar : PubMed/NCBI

18 

Cai M, Chen S and Hu W: MicroRNA-141 is involved in ulcerative colitis pathogenesis via aiming at CXCL5. J Interferon Cytokine Res. 37:415–420. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Ambade A, Kodys K, Catalano D, Ward DV and Szabo G: Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. PLoS One. 12:e01745442017. View Article : Google Scholar : PubMed/NCBI

20 

Geboes K, Riddell R, Ost A, Jensfelt B, Persson T and Löfberg R: A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut. 47:404–409. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Wang X, Sun L, Wang X, Kang H, Ma X, Wang M, Lin S, Liu M, Dai C and Dai Z: Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression. Cancer Med. 6:788–797. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Li X, Li D, Zhuang Y, Shi Q, Wei W and Ju X: Overexpression of miR-708 and its targets in the childhood common precursor B-cell ALL. Pediatr Blood Cancer. 60:2060–2067. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Ayuk SM, Abrahamse H and Houreld NN: The role of photo-biomodulation on gene expression of cell adhesion molecules in diabetic wounded fibroblasts in vitro. J Photochem Photobiol B. 161:368–374. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Dominguez M, Miquel R, Colmenero J, Moreno M, García-Pagán JC, Bosch J, Arroyo V, Ginès P, Caballeria J and Bataller R: Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis. Gastroenterology. 136:1639–1650. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Boetticher NC, Peine CJ, Kwo P, Abrams GA, Patel T, Aqel B, Boardman L, Gores GJ, Harmsen WS, McClain CJ, et al: A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology. 135:1953–1960. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, Davies NA and Jalan R: Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology. 46:831–840. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Wang XW, Heegaard NH and Orum H: MicroRNAs in liver disease. Gastroenterology. 142:1431–1443. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Saha B, Bruneau JC, Kodys K and Szabo G: Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes. J Immunol. 194:3079–3087. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Nata T, Fujiya M, Ueno N, Moriichi K, Konishi H, Tanabe H, Ohtake T, Ikuta K and Kohgo Y: MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-κB and improving epithelial barrier function. J Gene Med. 15:249–260. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Huang Z, Shi T, Zhou Q, Shi S, Zhao R, Shi H, Dong L, Zhang C, Zeng K, Chen J and Zhang J: miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease. Gut. 63:1247–1257. 2014. View Article : Google Scholar

31 

Wang LL, Huang YH, Yan CY, Wei XD, Hou JQ, Pu JX and Lv JX: N-acetylcysteine ameliorates prostatitis via miR-141 regulating keap1/Nrf2 signaling. Inflammation. 39:938–947. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Piccinini AM and Midwood KS: Endogenous control of immunity against infection: Tenascin-C regulates TLR4-mediated inflammation via microRNA-155. Cell Rep. 2:914–926. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Von Hahn T, Halangk J, Witt H, Neumann K, Müller T, Puhl G, Neuhaus P, Nickel R, Beuers U, Wiedenmann B and Berg T: Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. Scand J Gastroenterol. 43:584–592. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Zhai Y, Shen XD, O'Connell R, Gao F, Lassman C, Busuttil RW, Cheng G and Kupiec-Weglinski JW: Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol. 173:7115–7119. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Affò S, Morales-Ibanez O, Rodrigo-Torres D, Altamirano J, Blaya D, Dapito DH, Millán C, Coll M, Caviglia JM, Arroyo V, et al: CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut. 63:1782–1792. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Sugiura Y, Kamdar K, Khakpour S, Young G, Karpus WJ and DePaolo RW: TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. Mucosal Immunol. 6:1101–1109. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Tada A, Zelaya H, Clua P, Salva S, Alvarez S, Kitazawa H and Villena J: Immunobiotic Lactobacillus strains reduce small intestinal injury induced by intraepithelial lymphocytes after Toll-like receptor 3 activation. Inflamm Res. 65:771–783. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Tatum PM Jr, Harmon CM, Lorenz RG and Dimmitt RA: Toll-like receptor 4 is protective against neonatal murine ischemia-reperfusion intestinal injury. J Pediatr Surg. 45:1246–1255. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Choi BM, Lee SH, An SM, Park DY, Lee GW and Noh GJ: The time-course and RNA interference of TNF-α, IL-6, and IL-1β expression on neuropathic pain induced by L5 spinal nerve transection in rats. Korean J Anesthesiol. 68:159–169. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Peng Y, French BA, Tillman B, Morgan TR and French SW: The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation. Exp Mol Pathol. 97:305–313. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Shen WS, Xu XQ, Zhai NN, Zhou ZS, Shao J and Yu YH: Potential mechanisms of microRNA-141-3p to alleviate chronic inflammatory pain by downregulation of downstream target gene HMGB1: In vitro and in vivo studies. Gene Ther. 24:353–360. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Akira S and Takeda K: Toll-like receptor signalling. Nat Rev Immunol. 4:499–511. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Chen Q, Wang H, Liu Y, Song Y, Lai L, Han Q, Cao X and Wang Q: Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT3. PLoS One. 7:e429712012. View Article : Google Scholar

44 

Grimaldi D, Guivarch E, Neveux N, Fichet J, Pène F, Marx JS, Chiche JD, Cynober L, Mira JP and Cariou A: Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients. Resuscitation. 84:60–65. 2013. View Article : Google Scholar

45 

Sonnier DI, Bailey SR, Schuster RM, Gangidine MM, Lentsch AB and Pritts TA: Proinflammatory chemokines in the intestinal lumen contribute to intestinal dysfunction during endotoxemia. Shock. 37:63–69. 2012. View Article : Google Scholar

46 

Nahid MA, Satoh M and Chan EK: Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol. 186:1723–1734. 2011. View Article : Google Scholar

47 

Liu Y, Chen Q, Song Y, Lai L, Wang J, Yu H, Cao X and Wang Q: MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett. 585:1963–1968. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Bafica A, Feng CG, Santiago HC, Aliberti J, Cheever A, Thomas KE, Taylor GA, Vogel SN and Sher A: The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. J Immunol. 179:5514–5522. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qian WH, Liu YY, Li X and Pan Y: MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism. Int J Mol Med 44: 569-581, 2019.
APA
Qian, W., Liu, Y., Li, X., & Pan, Y. (2019). MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism. International Journal of Molecular Medicine, 44, 569-581. https://doi.org/10.3892/ijmm.2019.4221
MLA
Qian, W., Liu, Y., Li, X., Pan, Y."MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism". International Journal of Molecular Medicine 44.2 (2019): 569-581.
Chicago
Qian, W., Liu, Y., Li, X., Pan, Y."MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism". International Journal of Molecular Medicine 44, no. 2 (2019): 569-581. https://doi.org/10.3892/ijmm.2019.4221
Copy and paste a formatted citation
x
Spandidos Publications style
Qian WH, Liu YY, Li X and Pan Y: MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism. Int J Mol Med 44: 569-581, 2019.
APA
Qian, W., Liu, Y., Li, X., & Pan, Y. (2019). MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism. International Journal of Molecular Medicine, 44, 569-581. https://doi.org/10.3892/ijmm.2019.4221
MLA
Qian, W., Liu, Y., Li, X., Pan, Y."MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism". International Journal of Molecular Medicine 44.2 (2019): 569-581.
Chicago
Qian, W., Liu, Y., Li, X., Pan, Y."MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism". International Journal of Molecular Medicine 44, no. 2 (2019): 569-581. https://doi.org/10.3892/ijmm.2019.4221
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