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Review Open Access

The association of female and male infertility with telomere length (Review)

  • Authors:
    • Eleni Vasilopoulos
    • Persefoni Fragkiadaki
    • Charikleia Kalliora
    • Domniki Fragou
    • Anca Oana Docea
    • Elena Vakonaki
    • Dimitris Tsoukalas
    • Daniela Calina
    • Ana Maria Buga
    • George Georgiadis
    • Charalampos Mamoulakis
    • Antonios Makrigiannakis
    • Demetrios A. Spandidos
    • Aristidis Tsatsakis
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Temple University, Philadelphia, PA 19122, USA, Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA, Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Obstetrics and Gynecology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece
    Copyright: © Vasilopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 375-389
    |
    Published online on: May 31, 2019
       https://doi.org/10.3892/ijmm.2019.4225
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Abstract

Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negative association between relative TL and different factors of female and male infertility. A systematic search of the PubMed database was conducted. Out of the 206 studies identified, 45 were reviewed as they fulfilled the criteria of validity and relevance. Following an analysis and a comparison of the study outcomes, several clear trends were observed. The majority of female infertility factors were associated with a shorter TL, with the exception of endometriosis, premature ovarian failure and clear cell carcinoma that were associated with a longer TL and polycystic ovary syndrome (PCOS), which revealed conflicting results among several studies, leading to ambiguous conclusions. Male infertility factors were associated with a shorter TL. Although this review can provide an outline of general trends in the association of TL with infertility factors, further epidemiological and original research studies are required to focus on investigating the basis of these varying lengths of telomeres.
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Copy and paste a formatted citation
Spandidos Publications style
Vasilopoulos E, Fragkiadaki P, Kalliora C, Fragou D, Docea AO, Vakonaki E, Tsoukalas D, Calina D, Buga AM, Georgiadis G, Georgiadis G, et al: The association of female and male infertility with telomere length (Review). Int J Mol Med 44: 375-389, 2019.
APA
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A.O., Vakonaki, E. ... Tsatsakis, A. (2019). The association of female and male infertility with telomere length (Review). International Journal of Molecular Medicine, 44, 375-389. https://doi.org/10.3892/ijmm.2019.4225
MLA
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A. O., Vakonaki, E., Tsoukalas, D., Calina, D., Buga, A. M., Georgiadis, G., Mamoulakis, C., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A."The association of female and male infertility with telomere length (Review)". International Journal of Molecular Medicine 44.2 (2019): 375-389.
Chicago
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A. O., Vakonaki, E., Tsoukalas, D., Calina, D., Buga, A. M., Georgiadis, G., Mamoulakis, C., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A."The association of female and male infertility with telomere length (Review)". International Journal of Molecular Medicine 44, no. 2 (2019): 375-389. https://doi.org/10.3892/ijmm.2019.4225
Copy and paste a formatted citation
x
Spandidos Publications style
Vasilopoulos E, Fragkiadaki P, Kalliora C, Fragou D, Docea AO, Vakonaki E, Tsoukalas D, Calina D, Buga AM, Georgiadis G, Georgiadis G, et al: The association of female and male infertility with telomere length (Review). Int J Mol Med 44: 375-389, 2019.
APA
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A.O., Vakonaki, E. ... Tsatsakis, A. (2019). The association of female and male infertility with telomere length (Review). International Journal of Molecular Medicine, 44, 375-389. https://doi.org/10.3892/ijmm.2019.4225
MLA
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A. O., Vakonaki, E., Tsoukalas, D., Calina, D., Buga, A. M., Georgiadis, G., Mamoulakis, C., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A."The association of female and male infertility with telomere length (Review)". International Journal of Molecular Medicine 44.2 (2019): 375-389.
Chicago
Vasilopoulos, E., Fragkiadaki, P., Kalliora, C., Fragou, D., Docea, A. O., Vakonaki, E., Tsoukalas, D., Calina, D., Buga, A. M., Georgiadis, G., Mamoulakis, C., Makrigiannakis, A., Spandidos, D. A., Tsatsakis, A."The association of female and male infertility with telomere length (Review)". International Journal of Molecular Medicine 44, no. 2 (2019): 375-389. https://doi.org/10.3892/ijmm.2019.4225
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