Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October-2019 Volume 44 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 44 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response

  • Authors:
    • Xiufang Wei
    • Guang Sun
    • Xiaoxue Zhao
    • Qianqian Wu
    • Ling Chen
    • Yichi Xu
    • Xining Pang
    • Guoxian Qi
  • View Affiliations / Copyright

    Affiliations: Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Cardiology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China, Department of Stem Cells and Regenerative Medicine, National Health Commission of China and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang, Liaoning 110122, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1425-1435
    |
    Published online on: July 23, 2019
       https://doi.org/10.3892/ijmm.2019.4286
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Mesenchymal stem cells (MSCs) show immunosuppressive activities and alleviate atherosclerosis (AS) formation in apolipoprotein E‑knockout (apoE‑KO) mice. Human amnion mesenchymal stem cells (hAMSCs), a particular population of mesenchymal stem cells, have been shown to have immunomodulatory abilities. The present study investigated the effects of hAMSCs treatment on early atherosclerotic plaque formation and the progression of established lesion in apoE‑KO mice. In total, 36 mice were fed with a high‑fat diet. Mice were subjected to hAMSCs‑injection treatment simultaneously with high‑fat diet (early treatment) or after 8 weeks of high‑fat diet (delayed treatment). In each treatment, mice were divided into three groups: i) hAMSCs group with hAMSCs treatment; ii) PBS group injected with PBS; and iii) control group without injection. Histological results showed that the plaque area in the aortic arch of mice was significantly reduced after hAMSCs treatment in the early and delayed treatment groups. In addition, immunohistochemical analysis suggested that the accumulation of macrophages was significantly decreased after hAMSCs treatment. Similarly, the release of the pro‑inflammatory cytokine tumor necrosis factor‑α was also decreased, whereas the release of the anti‑inflammatory cytokine interleukin‑10 was increased. In addition, hAMSCs treatment suppressed the phosphorylation of p65 and inhibitor of κB‑α, suggesting that NF‑κB pathway was involved in the hAMSCs‑mediated suppression of immune response. In conclusion, hAMSCs treatment was effective in reducing immune response, which is the one of the major causes of AS, eventually leading to a significant reduction in size of atherosclerotic lesions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, et al: Heart disease and stroke statistics-2015 update: A report from the american heart association. Circulation. 131. pp. e29–e322. 2015

2 

Frostegård J: Immunity, atherosclerosis and cardiovascular disease. BMC Med. 11:1172013. View Article : Google Scholar : PubMed/NCBI

3 

Zhang X, Huang F, Chen Y, Qian X and Zheng SG: Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. Am J Transl Res. 8:4017–4024. 2016.PubMed/NCBI

4 

Wu DJ, Xu JZ, Wu YJ, Jean-Charles L, Xiao B, Gao PJ and Zhu DL: Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice. Atherosclerosis. 207:68–73. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Li Q, Sun W, Wang X, Zhang K, Xi W and Gao P: Skin-derived mesenchymal stem cells alleviate atherosclerosis via modulating macrophage function. Stem Cells Transl Med. 4:1294–1301. 2015. View Article : Google Scholar : PubMed/NCBI

6 

De Jager SC and Pasterkamp G: Crosstalk of lipids and inflammation in atherosclerosis: The PRO of PGRN? Cardiovasc Res. 100:4–6. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Johansson ME, Zhang XY, Edfeldt K, Lundberg AM, Levin MC, Borén J, Li W, Yua XM, Folkersen L, Eriksson P, et al: Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice. Eur J Immunol. 44:3081–3092. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Khan R, Spagnoli V, Tardif JC and L'Allier PL: Novel anti-inflammatory therapies for the treatment of atherosclerosis. Atherosclerosis. 240:497–509. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Mendel I, Yacov N, Harats D and Breitbart E: Therapies targeting innate immunity for fighting inflammation in atherosclerosis. Curr Pharm Des. 21:1185–1195. 2015. View Article : Google Scholar

10 

Asciutto G, Dias NV, Edsfeldt A, Alm R, Fredrikson GN, Gonçalves I and Nilsson J: Low levels of IgG autoantibodies against the apolipoprotein B antigen p210 increases the risk of cardiovascular death after carotid endarterectomy. Atherosclerosis. 239:289–294. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Tedgui A and Mallat Z: Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev. 86:515–581. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Little PJ, Chait A and Bobik A: Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis. Pharmacol Ther. 131:255–268. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Han X and Boisvert WA: Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function. Thromb Haemost. 113:505–512. 2015. View Article : Google Scholar

14 

Shapiro MD and Fazio S: From lipids to inflammation: New approaches to reducing atherosclerotic risk. Circ Res. 118:732–749. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Hague W, Forder P, Simes J, Hunt D, Tonkin A and Investigators L: Effect of pravastatin on cardiovascular events and mortality in 1516 women with coronary heart disease: Results from the long-term intervention with pravastatin in ischemic disease (LIPID) study. Am Heart J. 145:643–651. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Libby P: The forgotten majority: Unfinished business in cardiovascular risk reduction. J Am Coll Cardiol. 46:1225–1228. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Serban MC, Banach M and Mikhailidis DP: Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options. Expert Opin Pharmacother. 17:369–380. 2016. View Article : Google Scholar

18 

Zhang QZ, Su WR, Shi SH, Wilder-Smith P, Xiang AP, Wong A, Nguyen AL, Kwon CW and Le AD: Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing. Stem Cells. 28:1856–1868. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Chai NL, Zhang XB, Chen SW, Fan KX and Linghu EQ: Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats. World J Gastroenterol. 22:6036–6048. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Tan L, Dai T, Liu D, Chen Z, Wu L, Gao L, Wang Y and Shi C: Contribution of dermal-derived mesenchymal cells during liver repair in two different experimental models. Sci Rep. 6:253142016. View Article : Google Scholar : PubMed/NCBI

21 

Xie Z, Hao H, Tong C, Cheng Y, Liu J, Pang Y, Si Y, Guo Y, Zang L, Mu Y and Han W: Human umbilical cord-derived mesenchymal stem cells elicit macrophages into an anti-inflammatory phenotype to alleviate insulin resistance in type 2 diabetic rats. Stem Cells. 34:627–639. 2016. View Article : Google Scholar

22 

Seebach E, Freischmidt H, Holschbach J, Fellenberg J and Richter W: Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment. Acta Biomater. 10:4730–4741. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Braza F, Dirou S, Forest V, Sauzeau V, Hassoun D, Chesné J, Cheminant-Muller MA, Sagan C, Magnan A and Lemarchand P: Mesenchymal stem cells induce suppressive macrophages-through phagocytosis in a mouse model of asthma. Stem Cells. 34:1836–1845. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Maria ATJ, Toupet K, Maumus M, Fonteneau G, Le Quellec A, Jorgensen C, Guilpain P and Noël D: Human adipose mesenchymal stem cells as potent anti-fibrosis therapy for systemic sclerosis. J Autoimmun. 70:31–39. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Frodermann V, van Duijn J, van Pel M, van Santbrink PJ, Bot I, Kuiper J and de Jager SC: Mesenchymal stem cells reduce murine atherosclerosis development. Sci Rep. 5:155592015. View Article : Google Scholar : PubMed/NCBI

26 

Bobryshev YV, Ivanova EA, Chistiakov DA, Nikiforov NG and Orekhov AN: Macrophages and their role in atherosclerosis: Pathophysiology and transcriptome analysis. Biomed Res Int. 2016:95824302016. View Article : Google Scholar : PubMed/NCBI

27 

Wang ZX, Wang CQ, Li XY, Feng GK, Zhu HL, Ding Y and Jiang XJ: Mesenchymal stem cells alleviate atherosclerosis by elevating number and function of CD4(+)CD25 (+)FOXP3 (+) regulatory T-cells and inhibiting macrophage foam cell formation. Mol Cell Biochem. 400:163–172. 2015. View Article : Google Scholar

28 

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, et al: Macrophage activation and polarization: Nomenclature and experimental guidelines. Immunity. 41:14–20. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Michaeli S, Dakwar V, Weidenfeld K, Granski O, Gilon O, Schif-Zuck S, Mamchur A, Shams I and Barkan D: Soluble mediators produced by pro-resolving macrophages inhibit angiogenesis. Front Immunol. 9:7682018. View Article : Google Scholar : PubMed/NCBI

30 

Triantafyllou E, Woollard KJ, McPhail MJW, Antoniades CG and Possamai LA: The role of monocytes and macrophages in acute and acute-on-chronic liver failure. Front Immunol. 9:29482018. View Article : Google Scholar

31 

Hu Y, Liao L, Wang Q, Ma L, Ma G, Jiang X and Zhao RC: Isolation and identification of mesenchymal stem cells from human fetal pancreas. J Lab Clin Med. 141:342–349. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Tsai MS, Lee JL, Chang YJ and Hwang SM: Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod. 19:1450–1456. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL and Chen TH: Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood. 103:1669–1675. 2004. View Article : Google Scholar

34 

Kmiecik G, Niklinska W, Kuc P, Pancewicz-Wojtkiewicz J, Fil D, Karwowska A, Karczewski J and Mackiewicz Z: Fetal membranes as a source of stem cells. Adv Med Sci. 58:185–195. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Kim EY, Lee KB and Kim MK: The potential of mesenchymal stem cells derived from amniotic membrane and amniotic fluid for neuronal regenerative therapy. BMB Rep. 47:135–140. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Xiao J: Human amniotic stem cells: Ideal seed cells source for regenerative medicine. J Zunyi Med Univ. 38:439–449. 2015.

37 

Kronsteiner B, Peterbauer-Scherb A, Grillari-Voglauer R, Redl H, Gabriel C, van Griensven M and Wolbank S: Human mesenchymal stem cells and renal tubular epithelial cells differentially influence monocyte-derived dendritic cell differentiation and maturation. Cell Immunol. 267:30–38. 2011. View Article : Google Scholar

38 

Shu J, He X, Zhang L, Li H, Wang P and Huang X: Human amnion mesenchymal cells inhibit lipopolysaccharide-induced TNF-α and IL-1β production in THP-1 cells. Biol Res. 48:692015. View Article : Google Scholar

39 

Shoji M, Oskowitz A, Malone CD, Prockop DJ and Pochampally R: Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flow-restriction by transient suppression of anti-inflammatory cytokines. J Atheroscler Thromb. 18:464–474. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Wu Q, Fang T, Lang H, Chen M, Shi P, Pang X and Qi G: Comparison of the proliferation, migration and angiogenic properties of human amniotic epithelial and mesenchymal stem cells and their effects on endothelial cells. Int J Mol Med. 39:918–926. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Friedewald WT, Levy RI and Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:499–502. 1972.PubMed/NCBI

42 

Frost PH and Havel RJ: Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy. Am J Cardiol. 81:26B–31B. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

44 

Trusler O, Huang Z, Goodwin J and Laslett AL: Cell surface markers for the identification and study of human naive pluripotent stem cells. Stem Cell Res. 26:36–43. 2018. View Article : Google Scholar

45 

Fernandez Vallone VB, Romaniuk MA, Choi H, Labovsky V, Otaegui J and Chasseing NA: Mesenchymal stem cells and their use in therapy: What has been achieved? Differentiation. 85:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Murray RZ and Stow JL: Cytokine secretion in macrophages: SNAREs, Rabs, and membrane trafficking. Front Immunol. 5:5382014. View Article : Google Scholar : PubMed/NCBI

47 

Liu Z, Han Y, Li L, Lu H, Meng G, Li X, Shirhan M, Peh MT, Xie L, Zhou S, et al: The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipo-protein E(−/−) mice. Br J Pharmacol. 169:1795–1809. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Fisher EA: Regression of atherosclerosis: The journey from the liver to the plaque and back. Arterioscler Thromb Vasc Biol. 36:226–235. 2016. View Article : Google Scholar

49 

Lu X: Impact of macrophages in atherosclerosis. Curr Med Chem. 23:1926–1937. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Feig JE, Parathath S, Rong JX, Mick SL, Vengrenyuk Y, Grauer L, Young SG and Fisher EA: Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation. 123:989–998. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Potteaux S, Gautier EL, Hutchison SB, van Rooijen N, Rader DJ, Thomas MJ, Sorci-Thomas MG and Randolph GJ: Suppressed monocyte recruitment drives macrophage removal from athero-sclerotic plaques of Apoe−/− mice during disease regression. J Clin Invest. 121:2025–2036. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Fang SM, Du DY, Li YT, van Rooijen N, Rader DJ, Thomas MJ, Sorci-Thomas MG and Randolph GJ: Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque. Thromb Res. 131:e253–e257. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Yao Y, Huang J, Geng Y, Qian H, Wang F, Liu X, Shang M, Nie S, Liu N, Du X, et al: Paracrine action of mesenchymal stem cells revealed by single cell gene profiling in infarcted murine hearts. PLoS One. 10:e01291642015. View Article : Google Scholar : PubMed/NCBI

54 

Togel F, Weiss K, Yang Y, Hu Z, Zhang P and Westenfelder C: Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol. 292:F1626–F1635. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Perek B, Kowalska K, Kempisty B, Nowicki A, Jankowski M, Nawrocki MJ and Malińska A: Role of macrophages in the pathogenesis of atherosclerosis and aortocoronary graft disease. J Biol Regul Homeost Agents. 32:1055–1059. 2018.PubMed/NCBI

56 

Ding Y, Huang L, Xian X, Yuhanna IS, Wasser CR, Frotscher M, Mineo C, Shaul PW and Herz J: Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation. Sci Signal. 9:ra292016. View Article : Google Scholar : PubMed/NCBI

57 

Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, et al: CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer. Nat Immunol. 11:155–161. 2010. View Article : Google Scholar :

58 

Okabe Y and Medzhitov R: Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell. 157:832–844. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Yamamoto Y and Gaynor RB: IkappaB kinases: Key regulators of the NF-kappaB pathway. Trends Biochem Sci. 29:72–79. 2004. View Article : Google Scholar : PubMed/NCBI

60 

Putra A, Ridwan FB, Putridewi AI, Kustiyah AR, Wirastuti K, Sadyah NAC, Rosdiana I and Munir D: The role of TNF-α induced MSCs on suppressive inflammation by increasing TGF-β and IL-10. Open Access Maced J Med Sci. 6:1779–1783. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Maiti P, Peruzzaro S, Kolli N, Andrews M, Al-Gharaibeh A, Rossignol J and Dunbar GL: Transplantation of mesenchymal stem cells overexpressing interleukin-10 induces autophagy response and promotes neuroprotection in a rat model of TBI. J Cell Mol Med. Jun 4;2019(Epub ahead of print). http://doi.org/10.1111/jcmm.14396urisimpledoi.org/10.1111/jcmm.14396.

62 

Nemeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, et al: Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med. 15:42–49. 2009. View Article : Google Scholar

63 

Anderson LC: Institutional and IACUC responsibilities for animal care and use education and training programs. ILAR J. 48:90–95. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wei X, Sun G, Zhao X, Wu Q, Chen L, Xu Y, Pang X and Qi G: Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response. Int J Mol Med 44: 1425-1435, 2019.
APA
Wei, X., Sun, G., Zhao, X., Wu, Q., Chen, L., Xu, Y. ... Qi, G. (2019). Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response. International Journal of Molecular Medicine, 44, 1425-1435. https://doi.org/10.3892/ijmm.2019.4286
MLA
Wei, X., Sun, G., Zhao, X., Wu, Q., Chen, L., Xu, Y., Pang, X., Qi, G."Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response". International Journal of Molecular Medicine 44.4 (2019): 1425-1435.
Chicago
Wei, X., Sun, G., Zhao, X., Wu, Q., Chen, L., Xu, Y., Pang, X., Qi, G."Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response". International Journal of Molecular Medicine 44, no. 4 (2019): 1425-1435. https://doi.org/10.3892/ijmm.2019.4286
Copy and paste a formatted citation
x
Spandidos Publications style
Wei X, Sun G, Zhao X, Wu Q, Chen L, Xu Y, Pang X and Qi G: Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response. Int J Mol Med 44: 1425-1435, 2019.
APA
Wei, X., Sun, G., Zhao, X., Wu, Q., Chen, L., Xu, Y. ... Qi, G. (2019). Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response. International Journal of Molecular Medicine, 44, 1425-1435. https://doi.org/10.3892/ijmm.2019.4286
MLA
Wei, X., Sun, G., Zhao, X., Wu, Q., Chen, L., Xu, Y., Pang, X., Qi, G."Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response". International Journal of Molecular Medicine 44.4 (2019): 1425-1435.
Chicago
Wei, X., Sun, G., Zhao, X., Wu, Q., Chen, L., Xu, Y., Pang, X., Qi, G."Human amnion mesenchymal stem cells attenuate atherosclerosis by modulating macrophage function to reduce immune response". International Journal of Molecular Medicine 44, no. 4 (2019): 1425-1435. https://doi.org/10.3892/ijmm.2019.4286
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team