|
1
|
Slager CJ, Wentzel JJ, Gijsen FJ,
Schuurbiers JC, van der Wal AC, van der Steen AF and Serruys PW:
The role of shear stress in the generation of rupture-prone
vulnerable plaques. Nat Clin Pract Cardiovasc Med. 2:401–407. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Li YS, Haga JH and Chien S: Molecular
basis of the effects of shear stress on vascular endothelial cells.
J Biomech. 38:1949–1971. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wasserman SM, Mehraban F, Komuves LG, Yang
RB, Tomlinson JE, Zhang Y, Spriggs F and Topper JN: Gene expression
profile of human endothelial cells exposed to sustained fluid shear
stress. Physiol Genomics. 12:13–23. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Cicha I, Beronov K, Ramirez EL, Osterode
K, Goppelt-Struebe M, Raaz D, Yilmaz A, Daniel WG and Garlichs CD:
Shear stress preconditioning modulates endothelial susceptibility
to circulating TNF-alpha and monocytic cell recruitment in a
simplified model of arterial bifurcations. Atherosclerosis.
207:93–102. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Urschel K, Worner A, Daniel WG, Garlichs
CD and Cicha I: Role of shear stress patterns in the TNF-α-induced
atherogenic protein expression and monocytic cell adhesion to
endothelium. Clin Hemorheol Microcirc. 46:203–210. 2010.
|
|
6
|
Pan S: Molecular mechanisms responsible
for the atheropro-tective effects of laminar shear stress. Antioxid
Redox Signal. 11:1669–1682. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Tzima E, Irani-Tehrani M, Kiosses WB,
Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H and Schwartz
MA: A mecha-nosensory complex that mediates the endothelial cell
response to fluid shear stress. Nature. 437:426–431. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Holmes K, Roberts OL, Thomas AM and Cross
MJ: Vascular endothelial growth factor receptor-2: Structure,
function, intracellular signalling and therapeutic inhibition. Cell
Signal. 19:2003–2012. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Shalaby F, Rossant J, Yamaguchi TP,
Gertsenstein M, Wu XF, Breitman ML and Schuh AC: Failure of
blood-island formation and vasculogenesis in Flk-1-deficient mice.
Nature. 376:62–66. 1995. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Fong GH, Rossant J, Gertsenstein M and
Breitman ML: Role of the Flt-1 receptor tyrosine kinase in
regulating the assembly of vascular endothelium. Nature. 376:66–70.
1995. View
Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang Y, Flores L, Lu S, Miao H, Li YS and
Chien S: Shear stress regulates the Flk-1/Cbl/PI3K/NF-κB pathway
via actin and tyrosine kinases. Cell Mol Bioeng. 2:341–350. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Lim HS, Blann AD, Chong AY, Freestone B
and Lip GY: Plasma vascular endothelial growth factor,
angiopoietin-1, and angiopoietin-2 in diabetes: Implications for
cardiovascular risk and effects of multifactorial intervention.
Diabetes Care. 27:2918–2924. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Petrovic D: The role of vascular
endothelial growth factor gene as the genetic marker of
atherothrombotic disorders and in the gene therapy of coronary
artery disease. Cardiovasc Hematol Agents Med Chem. 8:47–54. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Urschel K, Garlichs CD, Daniel WG and
Cicha I: VEGFR2 signalling contributes to increased endothelial
susceptibility to TNF-α under chronic non-uniform shear stress.
Atherosclerosis. 219:499–509. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Howell W, Ali S, Rose-Zerilli M and Ye S:
VEGF polymorphisms and severity of atherosclerosis. J Med Genet.
42:485–490. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhang LJ, Zhang YQ, Han X, Zhang ZT and
Zhang ZQ: Association of VEGFR-2 Gene polymorphisms with
clopidogrel resistance in patients with coronary heart disease. Am
J Ther. 23:e1663–e1670. 2016. View Article : Google Scholar
|
|
17
|
Hermann MM, van Asten F, Muether PS,
Smailhodzic D, Lichtner P, Hoyng CB, Kirchhof B, Grefkes C, den
Hollander AI and Fauser S: Polymorphisms in vascular endothelial
growth factor receptor 2 are associated with better response rates
to ranibizumab treatment in age-related macular degeneration.
Ophthalmology. 121:905–910. 2014. View Article : Google Scholar
|
|
18
|
Jain L, Sissung TM, Danesi R, Kohn EC,
Dahut WL, Kummar S, Venzon D, Liewehr D, English BC, Baum CE, et
al: Hypertension and hand-foot skin reactions related to VEGFR2
genotype and improved clinical outcome following bevacizumab and
sorafenib. J Exp Clin Cancer Res. 29:952010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Kim DH, Xu W, Kamel-Reid S, Liu X, Jung
CW, Kim S and Lipton JH: Clinical relevance of vascular endothelial
growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism
on the treatment outcome following imatinib therapy. Ann Oncol.
21:1179–1188. 2010. View Article : Google Scholar
|
|
20
|
Wang Y, Zheng Y, Zhang W, Yu H, Lou K,
Zhang Y, Qin Q, Zhao B, Yang Y and Hui R: Polymorphisms of KDR gene
are associated with coronary heart disease. J Am Coll Cardiol.
50:760–767. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zhang W, Sun K, Zhen Y, Wang D, Wang Y,
Chen J, Xu J, Hu FB and Hui R: VEGF receptor-2 variants are
associated with susceptibility to stroke and recurrence. Stroke.
40:2720–2726. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kariž S and Petrovič D: Minor association
of kinase insert domain-containing receptor gene polymorphism
(rs2071559) with myocardial infarction in Caucasians with type 2
diabetes mellitus: Case-control cross-sectional study. Clin
Biochem. 47:192–196. 2014. View Article : Google Scholar
|
|
23
|
Yap RW, Shidoji Y, Hon WM and Masaki M:
Association and interaction between dietary pattern and VEGF
receptor-2 (VEGFR2) gene polymorphisms on blood lipids in Chinese
Malaysian and Japanese adults. Asia Pac J Clin Nutr. 21:302–311.
2012.PubMed/NCBI
|
|
24
|
Sahebkar A, Morris DR, Biros E and
Golledge J: Association of single nucleotide polymorphisms in the
gene encoding platelet endothelial cell adhesion molecule-1 with
the risk of myocardial infarction: A systematic review and
meta-analysis. Thromb Res. 132:227–233. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Listi F, Caruso C, Di Carlo D, Falcone C,
Boiocchi C, Cuccia M and Candore G: Association between platelet
endothelial cellular adhesion molecule-1 polymorphisms and
atherosclerosis: Results of a study on patients from northern
Italy. Rejuvenation Res. 13:237–241. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wei YS, Lan Y, Liu YG, Meng LQ, Xu QQ and
Xie HY: Platelet-endothelial cell adhesion molecule-1 gene
polymorphism and its soluble level are associated with ischemic
stroke. DNA Cell Biol. 28:151–158. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Goodman RS, Kirton CM, Oostingh GJ, Schon
MP, Clark MR, Bradley JA and Taylor CJ: PECAM-1 polymorphism
affects monocyte adhesion to endothelial cells. Transplantation.
85:471–477. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Machiela MJ and Chanock SJ: LDlink: A
web-based application for exploring population-specific haplotype
structure and linking correlated alleles of possible functional
variants. Bioinformatics. 31:3555–3557. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Machiela MJ and Chanock SJ: LDassoc: An
online tool for interactively exploring genome-wide association
study results and prioritizing variants for functional
investigation. Bioinformatics. 34:887–889. 2018. View Article : Google Scholar :
|
|
30
|
Fitzpatrick M: Measuring Cell Fluorescence
using ImageJ. Science Tech Blog. 2011, https://theolb.readthedocs.io/en/latest/imaging/measuring-cell-fluorescence-using-imagej.html.
|
|
31
|
Cicha I, Urschel K, Daniel WG and Garlichs
CD: Telmisartan prevents VCAM-1 induction and monocytic cell
adhesion to endothelium exposed to non-uniform shear stress and
TNF-α. Clin Hemorheol Microcirc. 48:65–73. 2011.
|
|
32
|
Hopkins CR, Miller K and Beardmore JM:
Receptor-mediated endocytosis of transferrin and epidermal growth
factor receptors: A comparison of constitutive and ligand-induced
uptake. J Cell Sci Suppl. 3:173–186. 1985. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Goh LK and Sorkin A: Endocytosis of
receptor tyrosine kinases. Cold Spring Harb Perspect Biol.
5:a0174592013. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Sorkin A and von Zastrow M: Endocytosis
and signalling: Intertwining molecular networks. Nat Rev Mol Cell
Biol. 10:609–622. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Murdaca J, Treins C, Monthouel-Kartmann
MN, Pontier-Bres R, Kumar S, Van Obberghen E and Giorgetti-Peraldi
S: Grb10 prevents Nedd4-mediated vascular endothelial growth factor
receptor-2 degradation. J Biol Chem. 279:26754–26761. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Sigismund S, Confalonieri S, Ciliberto A,
Polo S, Scita G and Di Fiore PP: Endocytosis and signaling: Cell
logistics shape the eukaryotic cell plan. Physiol Rev. 92:273–366.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Gampel A, Moss L, Jones MC, Brunton V,
Norman JC and Mellor H: VEGF regulates the mobilization of
VEGFR2/KDR from an intracellular endothelial storage compartment.
Blood. 108:2624–2631. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Basagiannis D and Christoforidis S:
Constitutive endocytosis of VEGFR2 protects the receptor against
shedding. J Biol Chem. 291:16892–16903. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Zhang Y, Pillai G, Gatter K, Blazquez C,
Turley H, Pezzella F and Watt SM: Expression and cellular
localization of vascular endothelial growth factor A and its
receptors in acute and chronic leukemias: An immunohistochemical
study. Hum Pathol. 36:797–805. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Blazquez C, Cook N, Micklem K, Harris AL,
Gatter KC and Pezzella F: Phosphorylated KDR can be located in the
nucleus of neoplastic cells. Cell Res. 16:93–98. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Stewart M, Turley H, Cook N, Pezzella F,
Pillai G, Ogilvie D, Cartlidge S, Paterson D, Copley C, Kendrew J,
et al: The angiogenic receptor KDR is widely distributed in human
tissues and tumours and relocates intracellularly on
phosphorylation. An immunohistochemical study Histopathology.
43:33–39. 2003.
|
|
42
|
Domingues I, Rino J, Demmers JA, de
Lanerolle P and Santos SC: VEGFR2 translocates to the nucleus to
regulate its own transcription. PLoS One. 6:e256682011. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Conway D and Schwartz MA: Lessons from the
endothelial junctional mechanosensory complex. F1000 Biol Rep.
4:12012.PubMed/NCBI
|
|
44
|
Shay-Salit A, Shushy M, Wolfovitz E, Yahav
H, Breviario F, Dejana E and Resnick N: VEGF receptor 2 and the
adherens junction as a mechanical transducer in vascular
endothelial cells. Proc Natl Acad Sci USA. 99:9462–9467. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Wang Y, Chang J, Li YC, Li YS, Shyy JY and
Chien S: Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt
signaling pathway. Am J Physiol Heart Circ Physiol. 286:H685–H692.
2004. View Article : Google Scholar
|
|
46
|
Jin ZG, Ueba H, Tanimoto T, Lungu AO,
Frame MD and Berk BC: Ligand-independent activation of vascular
endothelial growth factor receptor 2 by fluid shear stress
regulates activation of endothelial nitric oxide synthase. Circ
Res. 93:354–363. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Li L, Pan Y, Dai L, Liu B and Zhang D:
Association of genetic polymorphisms on vascular endothelial growth
factor and its receptor genes with susceptibility to coronary heart
disease. Med Sci Monit. 22:31–40. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Liu D, Song J, Ji X, Liu Z, Cong M and Hu
B: Association of genetic polymorphisms on VEGFA and VEGFR2 with
risk of coronary heart disease. Medicine (Baltimore). 95:e34132016.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Medicine USNLo: SNP Database. https://www.ncbi.nlm.nih.gov/snp.
|
|
50
|
Zhang H, Zhai Q, Zhang Z, Cai B, Cai H,
Zhou S, Sun L, Xie Y, Kong D, Xu Z, et al: Association of
GWAS-Supported Variants rs556621 on Chromosome 6p21.1 with large
artery atherosclerotic stroke in a Southern Chinese Han Population.
Neuromolecular Med. 19:94–100. 2017. View Article : Google Scholar
|
