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Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation

  • Authors:
    • Wenyuan Li
    • Lijun Wang
    • Yue Wu
    • Zuyi Yuan
    • Juan Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 401-416
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    Published online on: December 3, 2019
       https://doi.org/10.3892/ijmm.2019.4416
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Abstract

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia and significantly increases the risks of morbidity, mortality and health care expenditure; however, treatment for AF remains unsatisfactory due to the complicated and incompletely understood underlying mechanisms. In the present study, weighted gene co‑expression network analysis (WGCNA) was conducted to identify key modules and hub genes to determine their potential associations with AF. WGCNA was performed in an AF dataset GSE79768 obtained from the Gene Expression Omnibus, which contained data from paired left and right atria in cardiac patients with persistent AF or sinus rhythm. Differentially expressed gene (DEG) analysis was used to supplement and validate the results of WGCNA. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were also performed. Green and magenta modules were identified as the most critical modules associated with AF, from which 6 hub genes, acetyl‑CoA Acetyltransferase 1, death domain‑containing protein CRADD, gypsy retrotransposon integrase 1, FTX transcript, XIST regulator, transcription elongation factor A like 2 and minichromosome maintenance complex component 3 associated protein, were hypothesized to serve key roles in the pathophysiology of AF due to their increased intramodular connectivity. Functional enrichment analysis results demonstrated that the green module was associated with energy metabolism, and the magenta module may be associated with the Hippo pathway and contain multiple interactive pathways associated with apoptosis and inflammation. In addition, the blue module was identified to be an important regulatory module in AF with a higher specificity for the left atria, the genes of which were primarily correlated with complement, coagulation and extracellular matrix formation. These results suggest that may improve understanding of the underlying mechanisms of AF, and assist in identifying biomarkers and potential therapeutic targets for treating patients with AF.
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View References

1 

Zimetbaum P: Atrial Fibrillation. Ann Intern Med. 166:ITC33–ITC48. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Odutayo A, Wong CX, Hsiao AJ, Hopewell S, Altman DG and Emdin CA: Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: Systematic review and meta-analysis. BMJ. 354:i44822016. View Article : Google Scholar : PubMed/NCBI

3 

Ferrari R, Bertini M, Blomstrom-Lundqvist C, Dobrev D, Kirchhof P, Pappone C, Ravens U, Tamargo J, Tavazzi L and Vicedomini GG: An update on atrial fibrillation in 2014: From pathophysiology to treatment. Int J Cardiol. 203:22–29. 2016. View Article : Google Scholar

4 

Liu Y, Shi Q, Ma Y and Liu Q: The role of immune cells in atrial fibrillation. J Mol Cell Cardiol. 123:198–208. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Nattel S: Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation. JACC Clin Electrophysiol. 3:425–435. 2017. View Article : Google Scholar

6 

Qian C, Li H, Chang D, Wei B and Wang Y: Identification of functional lncRNAs in atrial fibrillation by integrative analysis of the lncRNA-mRNA network based on competing endogenous RNAs hypothesis. J Cell Physiol. 234:11620–11630. 2019. View Article : Google Scholar

7 

Prystowsky EN, Padanilam BJ and Fogel RI: Treatment of atrial fibrillation. JAMA. 314:278–288. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Zhang B and Horvath S: A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol. 4:Article172005. View Article : Google Scholar

9 

Liu S, Wang Z, Chen D, Zhang B, Tian RR, Wu J, Zhang Y, Xu K, Yang LM, Cheng C, et al: Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain. Genome Res. 27:1608–1620. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Yin L, Cai Z, Zhu B and Xu C: Identification of key pathways and genes in the dynamic progression of HCC based on WGCNA. Genes (Basel). 9:E922018. View Article : Google Scholar

11 

Zhang X, Feng H, Li Z, Li D, Liu S, Huang H and Li M: Application of weighted gene co-expression network analysis to identify key modules and hub genes in oral squamous cell carcinoma tumorigenesis. OncoTargets Ther. 11:6001–6021. 2018. View Article : Google Scholar

12 

Ahmed M, Lai TH, Zada S, Hwang JS, Pham TM, Yun M and Kim DR: Functional linkage of RKIP to the epithelial to mesenchymal transition and autophagy during the development of prostate cancer. Cancers (Basel). 10:E2732018. View Article : Google Scholar

13 

Radulescu E, Jaffe AE, Straub RE, Chen Q, Shin JH, Hyde TM, Kleinman JE and Weinberger DR: Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain. Mol Psychiatry. Nov 26–2018.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

14 

Tsai FC, Lin YC, Chang SH, Chang GJ, Hsu YJ, Lin YM, Lee YS, Wang CL and Yeh YH: Differential left-to-right atria gene expression ratio in human sinus rhythm and atrial fibrillation: Implications for arrhythmogenesis and thrombogenesis. Int J Cardiol. 222:104–112. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, et al: Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 112:471–481. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Kamel H, Okin PM, Elkind MS and Iadecola C: Atrial fibrillation and mechanisms of stroke: Time for a new model. Stroke. 47:895–900. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Voigt N, Trausch A, Knaut M, Matschke K, Varró A, Van Wagoner DR, Nattel S, Ravens U and Dobrev D: Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol. 3:472–480. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Liao Q, Liu C, Yuan X, Kang S, Miao R, Xiao H, Zhao G, Luo H, Bu D, Zhao H, et al: Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network. Nucleic Acids Res. 39:3864–3878. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y and Liu XS: Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 20:908–913. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Zhang G, Sun H, Zhang Y, Zhao H, Fan W, Li J, Lv Y, Song Q, Li J, Zhang M and Shi H: Characterization of dysregulated lncRNA-mRNA network based on ceRNA hypothesis to reveal the occurrence and recurrence of myocardial infarction. Cell Death Discov. 4:352018. View Article : Google Scholar : PubMed/NCBI

21 

Liao Y, Smyth GK and Shi W: The Subread aligner: Fast, accurate and scalable read mapping by seed-and-vote. Nucleic Acids Res. 41:e1082013. View Article : Google Scholar : PubMed/NCBI

22 

Langfelder P and Horvath S: WGCNA: An R package for weighted correlation network analysis. BMC Bioinformatics. 9:5592008. View Article : Google Scholar : PubMed/NCBI

23 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium Nat Genet. 25:25–29. 2000.

25 

The Gene Ontology Consortium: The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar :

26 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar

27 

Kanehisa M, Sato Y, Furumichi M, Morishima K and Tanabe M: New approach for understanding genome variations in KEGG. Nucleic Acids Res. 47:D590–D595. 2019. View Article : Google Scholar :

28 

Kanehisa M: Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28:1947–1951. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Horvath S and Dong J: Geometric interpretation of gene coexpression network analysis. PLoS Comput Biol. 4:e10001172008. View Article : Google Scholar : PubMed/NCBI

31 

Phipson B, Lee S, Majewski IJ, Alexander WS and Smyth GK: Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression. Ann Appl Stat. 10:946–963. 2016. View Article : Google Scholar

32 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

33 

Lv X, Li J, Hu Y, Wang S, Yang C, Li C and Zhong G: Overexpression of miR-27b-3p targeting Wnt3a regulates the signaling pathway of Wnt/β-catenin and attenuates atrial fibrosis in rats with atrial fibrillation. Oxid Med Cell Longev. 2019:57037642019. View Article : Google Scholar

34 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

35 

Hu YF, Chen YJ, Lin YJ and Chen SA: Inflammation and the pathogenesis of atrial fibrillation. Nat Rev Cardiol. 12:230–243. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Ghezelbash S, Molina CE and Dobrev D: Altered atrial metabolism: An underappreciated contributor to the initiation and progression of atrial fibrillation. J Am Heart Assoc. 4:e0018082015. View Article : Google Scholar : PubMed/NCBI

37 

Lenski M, Schleider G, Kohlhaas M, Adrian L, Adam O, Tian Q, Kaestner L, Lipp P, Lehrke M, Maack C, et al: Arrhythmia causes lipid accumulation and reduced glucose uptake. Basic Res Cardiol. 110:402015. View Article : Google Scholar : PubMed/NCBI

38 

Heijman J and Dobrev D: Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation. Basic Res Cardiol. 110:412015. View Article : Google Scholar : PubMed/NCBI

39 

Mayr M, Yusuf S, Weir G, Chung YL, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, et al: Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol. 51:585–594. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XH and Li N: Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 184:190–197. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Harada M, Melka J, Sobue Y and Nattel S: Metabolic considerations in atrial fibrillation-mechanistic insights and therapeutic opportunities. Circ J. 81:1749–1757. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Zhou Q, Li L, Zhao B and Guan KL: The hippo pathway in heart development, regeneration, and diseases. Circ Res. 116:1431–1447. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Ikeda S and Sadoshima J: Regulation of myocardial cell growth and death by the hippo pathway. Circ J. 80:1511–1519. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Wang J, Liu S, Heallen T and Martin JF: The Hippo pathway in the heart: Pivotal roles in development, disease, and regeneration. Nat Rev Cardiol. 15:672–684. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D and Sadoshima J: Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem. 288:3977–3988. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Leach JP, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill MC, Segura A, Willerson JT and Martin JF: Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 550:260–264. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Rudel LL, Lee RG and Parini P: ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 25:1112–1118. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Fazio S, Dove DE and Linton MF: ACAT inhibition: Bad for macrophages, good for smooth muscle cells? Arterioscler Thromb Vasc Biol. 25:7–9. 2005. View Article : Google Scholar : PubMed/NCBI

49 

da Silva RM: Influence of inflammation and atherosclerosis in atrial fibrillation. Curr Atheroscler Rep. 19:22017. View Article : Google Scholar : PubMed/NCBI

50 

Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T and Alnemri ES: CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 57:615–619. 1997.PubMed/NCBI

51 

Long B, Li N, Xu XX, Li XX, Xu XJ, Guo D, Zhang D, Wu ZH and Zhang SY: Long noncoding RNA FTX regulates cardiomyocyte apoptosis by targeting miR-29b-1-5p and Bcl2l2. Biochem Biophys Res Commun. 495:312–318. 2018. View Article : Google Scholar

52 

Harada M, Van Wagoner DR and Nattel S: Role of inflammation in atrial fibrillation pathophysiology and management. Circ J. 79:495–502. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Takei Y, Assenberg M, Tsujimoto G and Laskey R: The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3. J Biol Chem. 277:43121–43125. 2002. View Article : Google Scholar : PubMed/NCBI

54 

Kim YS, Hwan JD, Bae S, Bae DH and Shick WA: Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma. BMC Cancer. 10:5762010. View Article : Google Scholar : PubMed/NCBI

55 

Lloréns C and Marín I: A mammalian gene evolved from the integrase domain of an LTR retrotransposon. Mol Biol Evol. 18:1597–1600. 2001. View Article : Google Scholar : PubMed/NCBI

56 

Kirmanoglou K, Hannekum A and Schafler AE: Expression of mortalin in patients with chronic atrial fibrillation. Basic Res Cardiol. 99:404–408. 2004. View Article : Google Scholar : PubMed/NCBI

57 

García A, Eiras S, Parguiña AF, Alonso J, Rosa I, Salgado- Somoza A, Rico TY, Teijeira-Fernández E and González-Juanatey JR: High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation. Int J Cardiol. 150:283–290. 2011. View Article : Google Scholar

58 

Lip GY, Lip PL, Zarifis J, Watson RD, Bareford D, Lowe GD and Beevers DG: Fibrin D-dimer and beta-thromboglobulin as markers of thrombogenesis and platelet activation in atrial fibrillation. Effects of introducing ultra-low-dose warfarin and aspirin. Circulation. 94:425–431. 1996. View Article : Google Scholar : PubMed/NCBI

59 

Hijazi Z, Oldgren J, Siegbahn A, Granger CB and Wallentin L: Biomarkers in atrial fibrillation: A clinical review. Eur Heart J. 34:1475–1480. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Lappegård KT, Garred P, Jonasson L, Espevik T, Aukrust P, Yndestad A, Mollnes TE and Hovland A: A vital role for complement in heart disease. Mol Immunol. 61:126–134. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Kornej J, Büttner P, Hammer E, Engelmann B, Dinov B, Sommer P, Husser D, Hindricks G, Völker U and Bollmann A: Circulating proteomic patterns in AF related left atrial remod-eling indicate involvement of coagulation and complement cascade. PLoS One. 13:e01984612018. View Article : Google Scholar

62 

Lin CS and Pan CH: Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation. Cell Mol Life Sci. 65:1489–1508. 2008. View Article : Google Scholar : PubMed/NCBI

63 

Zhu H, Zhang W, Zhong M, Zhang G and Zhang Y: Differential gene expression during atrial structural remodeling in human left and right atrial appendages in atrial fibrillation. Acta Biochim Biophys Sin (Shanghai). 43:535–541. 2011. View Article : Google Scholar

64 

Gialeli C, Gungor B and Blom AM: Novel potential inhibitors of complement system and their roles in complement regulation and beyond. Mol Immunol. 102:73–83. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li W, Wang L, Wu Y, Yuan Z and Zhou J: Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation. Int J Mol Med 45: 401-416, 2020.
APA
Li, W., Wang, L., Wu, Y., Yuan, Z., & Zhou, J. (2020). Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation. International Journal of Molecular Medicine, 45, 401-416. https://doi.org/10.3892/ijmm.2019.4416
MLA
Li, W., Wang, L., Wu, Y., Yuan, Z., Zhou, J."Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation". International Journal of Molecular Medicine 45.2 (2020): 401-416.
Chicago
Li, W., Wang, L., Wu, Y., Yuan, Z., Zhou, J."Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation". International Journal of Molecular Medicine 45, no. 2 (2020): 401-416. https://doi.org/10.3892/ijmm.2019.4416
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Wang L, Wu Y, Yuan Z and Zhou J: Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation. Int J Mol Med 45: 401-416, 2020.
APA
Li, W., Wang, L., Wu, Y., Yuan, Z., & Zhou, J. (2020). Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation. International Journal of Molecular Medicine, 45, 401-416. https://doi.org/10.3892/ijmm.2019.4416
MLA
Li, W., Wang, L., Wu, Y., Yuan, Z., Zhou, J."Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation". International Journal of Molecular Medicine 45.2 (2020): 401-416.
Chicago
Li, W., Wang, L., Wu, Y., Yuan, Z., Zhou, J."Weighted gene co‑expression network analysis to identify key modules and hub genes associated with atrial fibrillation". International Journal of Molecular Medicine 45, no. 2 (2020): 401-416. https://doi.org/10.3892/ijmm.2019.4416
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