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Article

Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk

  • Authors:
    • Gi Suk Nam
    • Kyu‑Shik Lee
    • Kyung‑Soo Nam
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Intractable Disease Research Center, School of Medicine, Dongguk University, Gyeongju, Gyeongsangbuk‑do 38066, Republic of Korea
  • Pages: 658-668
    |
    Published online on: December 10, 2019
       https://doi.org/10.3892/ijmm.2019.4424
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Abstract

Mineral‑balanced deep sea water (MBDSW), an unlimited natural sea source, has been demonstrated to minimize the risk of developing cardiovascular diseases, such as obesity, hypertension, inflammation and hyperlipidemia. This study investigated the effects of MBDSW [magnesium (Mg):calcium (Ca) ratio, 3:1] on platelet activation. MBDSW significantly inhibited the collagen‑ and thrombin‑induced platelet aggregation of human platelets. In collagen‑induced platelets, MBDSW inhibited intracellular calcium mobilization, granule secretion [serotonin, adenosine triphosphate (ATP) and P‑selectin expression] and thromboxane A2 (TXA2) production. Moreover, MBDSW markedly inhibited Akt and extracellular signal‑regulated kinase (ERK) phosphorylation, but not that of c‑Jun N‑terminal kinase (JNK) and p38. Moreover, MBDSW phosphorylated inositol 1,4,5‑triphosphate receptor (IP3R) and vasodilator‑stimulated phosphoprotein (VASP), and it increased the cyclic adenosine monophosphate (cAMP) level in collagen‑induced human platelets. Dipyridamole, a phosphodiesterase (PDE) inhibitor, significantly increased the cAMP level and regulated the Akt, ERK and VASP (Ser157) levels in a manner similar to that of MBDSW. In addition, LY294002, an Akt inhibitor, inhibited the phosphorylation of ERK, and U0126, an ERK inhibitor, inhibited the phosphorylation of Akt. Taken together, the results of the present investigation suggest that the inhibitory effects of MBDSW on platelet aggregation may be associated with the cross‑inhibition of Akt and ERK phosphorylation. These results strongly indicate that MBDSW may have preventive or therapeutic potential for platelet aggregation‑mediated diseases, such as thrombosis, atherosclerosis and myocardial infarction.
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View References

1 

Kuter DJ: The physiology of platelet production. Stem Cells. 14(Suppl 1): S88–S101. 1996. View Article : Google Scholar

2 

Huo Y and Ley KF: Role of platelets in the development of atherosclerosis. Trends Cardiovasc Med. 14:18–22. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Farndale RW, Sixma JJ, Barnes MJ and de Groot PG: The role of collagen in thrombosis and hemostasis. J Thromb Haemost. 2:561–573. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Barnes MJ and Farndale RW: Collagens and atherosclerosis. Exp Gerontol. 34:513–525. 1999. View Article : Google Scholar

5 

Jin J, Quinton TM, Zhang J, Rittenhouse SE and Kunapuli SP: Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors. Blood. 99:193–198. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Flaumenhaft R: Molecular basis of platelet granule secretion. Arterioscler Thromb Vasc Biol. 23:1152–1160. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Hwang HS, Kim HA, Lee SH and Yun JW: Anti-obesity and anti-diabetic effects of deep sea water on ob/ob mice. Mar Biotechnol (NY). 11:531–539. 2016. View Article : Google Scholar

8 

Hataguchi Y, Tai H, Nakajima H and Kimata H: Drinking deep-sea water restores mineral imbalance in atopic eczema/dermatitis syndrome. Eur J Clin Nutr. 59:1093–1096. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Lee KS, Kwon YS, Kim S, Moon DS, Kim HJ and Nam KS: Regulatory mechanism of mineral-balanced deep sea water on hypocholesterolemic effects in HepG2 hepatic cells. Biomed Pharmacother. 86:405–413. 2017. View Article : Google Scholar

10 

Lee KS, Chun SY, Lee MG, Kim S, Jang TJ and Nam KS: The prevention of TNF-α/IFN-γ mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water. Biomed Pharmacother. 97:1331–1340. 2018. View Article : Google Scholar

11 

Sheu MJ, Chou PY, Lin WH, Pan CH, Chien YC, Chung YL, Liu FC and Wu CH: Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: An in vivo study. Mar Drugs. 11:2183–2202. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Lee KS, Shin JS, Kwon YS, Moon DS and Nam KS: Suppression of cancer progression and metastasis in HT-29 human colorectal adenocarcinomas by deep sea water. Biotechnol Bioprocess Eng. 18:194–200. 2013. View Article : Google Scholar

13 

Miyamura M, Yoshioka S, Hamada A, Takuma D, Yokota J, Kusunose M, Kyotani S, Kawakita H, Odani K, Tsutsui Y and Nishioka Y: Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis. Biol Pharm Bull. 27:1784–1787. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Lee KS, Chun SY, Kwon YS, Kim S and Nam KS: Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression. Mol Med Rep. 15:2814–2822. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Chun SY, Kim S and Nam KS: The inhibitory effects of deep-sea water on doxorubicin-induced epithelial-mesenchymal transition. Oncol Rep. 38:1163–1171. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Chen J, De S, Damron DS, Chen WS, Hay N and Byzova TV: Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood. 104:1703–1710. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Stojanovic A, Marjanovic JA, Brovkovych VM, Peng X, Hay N, Skidgel RA and Du X: A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. J Biol Chem. 281:16333–16339. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Flevaris P, Li Z, Zhang G, Zheng Y, Liu J and Du X: Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood. 113:893–901. 2009. View Article : Google Scholar :

19 

Heemskerk JW, Bevers EM and Lindhout T: Platelet activation and blood coagulation. Thromb Haemost. 88:186–193. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Rittenhouse-Simmons S and Deykin D: Isolation of membranes from normal and thrombin treated gel-filtered platelets using a lectin marker. Biochim Biophys Acta. 426:688–696. 1976. View Article : Google Scholar : PubMed/NCBI

21 

Schaeffer J and Blaustein MP: Platelet free calcium concentrations measured with fura-2 are influenced by the transmembrane sodium gradient. Cell Calcium. 10:101–113. 1989. View Article : Google Scholar : PubMed/NCBI

22 

Nesbitt WS, Giuliano S, Kulkarni S, Dopheide SM, Harper IS and Jackson SP: Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol. 160:1151–1161. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Shattil SJ and Newman PJ: Integrins: Dynamic scaffolds for adhesion and signaling in platelets. Blood. 104:1606–1615. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Reinhard M, Jarchau T and Walter U: Actin-based motility: Stop and go with Ena/VASP proteins. Trends Biochem Sci. 26:243–249. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Gambaryan S, Kobsar A, Rukoyatkina N, Herterich S, Geiger J, Smolenski A, Lohmann SM and Walter U: Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J Biol Chem. 285:18352–18363. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Paul BZ, Jin J and Kunapuli SP: Molecular mechanism of throm-boxane A(2)-induced platelet aggregation Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem. 274:29108–29114. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Mathur RK: Role of diabetes, hypertension, and cigarette smoking on atherosclerosis. J Cardiovasc Dis Res. 1:64–68. 2010. View Article : Google Scholar : PubMed/NCBI

28 

O'Donnell CJ and Elosua R: Cardiovascular risk factors. Insights from Framingham Heart Study. Rev Esp Cardiol. 61:299–310. 2008.In Spanish. View Article : Google Scholar : PubMed/NCBI

29 

Willoughby S, Holmes A and Loscalzo J: Platelets and cardiovascular disease. Eur J Cardiovasc Nurs. 1:273–288. 2002. View Article : Google Scholar

30 

Ha BG, Shin EJ, Park JE and Shon YH: Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice. Mar Drugs. 11:4193–4212. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Katsuda S, Yasukawa T, Nakagawa K, Miyake M, Yamasaki M, Katahira K, Mohri M, Shimizu T and Hazama A: Deep-sea water improves cardiovascular hemodynamics in kurosawa and kusanagi-hypercholesterolemic (KHC) rabbits. Biol Pharm Bull. 31:38–44. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Yoshioka S, Hamada A, Cui T, Yokota J, Yamamoto S, Kusunose M, Miyamura M, Kyotani S, Kaneda R, Tsutsui Y, et al: Pharmacological activity of deep-sea water: Examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 26:1552–1559. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Borissoff JI, Spronk HM, Heeneman S and ten Cate H: Is thrombin a key player in the 'coagulation-atherogenesis' maze? Cardiovasc Res. 82:392–403. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Gawaz M, Ott I, Reininger AJ and Neumann FJ: Effects of magnesium on platelet aggregation and adhesion Magnesium modulates surface expression of glycoproteins on platelets in vitro and ex vivo. Thromb Haemost. 72:912–918. 1994. View Article : Google Scholar : PubMed/NCBI

35 

Gow IF, Padfield PL, Reid M, Stewart SE, Edwards CR and Williams BC: High sodium intake increases platelet aggregation in normal females. J Hypertens. (Suppl 5)–S246. 1987.

36 

Togna G, Gallozzi S and Caprino L: Influence of strontium chloride on blood platelet function. Arch Toxicol. 63:366–369. 1989. View Article : Google Scholar

37 

Komalavilas P and Lincoln TM: Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J Biol Chem. 269:8701–8707. 1994.PubMed/NCBI

38 

Supattapone S, Danoff SK, Theibert A, Joseph SK, Steiner J and Snyder SH: Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium. Proc Natl Acad Sci USA. 85:8747–8750. 1988. View Article : Google Scholar : PubMed/NCBI

39 

Nishikawa M, Tanaka T and Hidaka H: Ca2+-calmodulin- dependent phosphorylation and platelet secretion. Nature. 287:863–865. 1980. View Article : Google Scholar : PubMed/NCBI

40 

Reed GL, Fitzgerald ML and Polgár J: Molecular mechanisms of platelet exocytosis: Insights into the 'secrete' life of thrombocytes. Blood. 96:3334–3342. 2000.PubMed/NCBI

41 

Payrastre B, Missy K, Trumel C, Bodin S, Plantavid M and Chap H: The integrin alpha IIb/ beta 3 in human platelet signal transduction. Biochem Pharmacol. 60:1069–1074. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Smolenski A: Novel roles of cAMP/cGMP-dependent signaling in platelets. J Thromb Haemost. 10:167–176. 2012. View Article : Google Scholar

43 

Kim S, Jee K, Kim D, Koh H and Chung J: Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J Biol Chem. 276:12864–12870. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Lin LL, Wartmann M, Lin AY, Knopf JL, Seth A and Davis RJ: cPLA2 is phosphorylated and activated by MAP kinase. Cell. 72:269–278. 1993. View Article : Google Scholar : PubMed/NCBI

45 

Birk AV, Broekman MJ, Gladek EM, Robertson HD, Drosopoulos JH, Marcus AJ and Szeto HH: Role of extracellular ATP metabolism in regulation of platelet reactivity. J Lab Clin Med. 140:166–175. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Cerrito F, Lazzaro MP, Gaudio E, Arminio P and Aloisi G: 5HT2-receptors and serotonin release: Their role in human platelet aggregation. Life Sci. 53:209–215. 1993. View Article : Google Scholar : PubMed/NCBI

47 

Bröijersén A, Hamsten A, Eriksson M, Angelin B and Hjemdahl P: Platelet activity in vivo in hyperlipoproteinemia-importance of combined hyperlipidemia. Thromb Haemost. 79:268–275. 1998. View Article : Google Scholar

48 

Nityanand S, Pande I, Bajpai VK, Singh L, Chandra M and Singh BN: Platelets in essential hypertension. Thromb Res. 72:447–454. 1993. View Article : Google Scholar : PubMed/NCBI

49 

Nowak J, Murray JJ, Oates JA and FitzGerald GA: Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes. Circulation. 76:6–14. 1987. View Article : Google Scholar : PubMed/NCBI

50 

Manduteanu I, Calb M, Lupu C, Simionescu N and Simionescu M: Increased adhesion of human diabetic platelets to cultured valvular endothelial cells. J Submicrosc Cytol Pathol. 24:539–547. 1992.PubMed/NCBI

51 

Eikelboom JW, Hirsh J, Spencer FA, Baglin TP and Weitz JI: Antiplatelet drugs: Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice Guidelines. Chest. 141(2 Suppl): e89S–e119S. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nam GS, Lee KS and Nam KS: Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk. Int J Mol Med 45: 658-668, 2020.
APA
Nam, G.S., Lee, K., & Nam, K. (2020). Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk. International Journal of Molecular Medicine, 45, 658-668. https://doi.org/10.3892/ijmm.2019.4424
MLA
Nam, G. S., Lee, K., Nam, K."Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk". International Journal of Molecular Medicine 45.2 (2020): 658-668.
Chicago
Nam, G. S., Lee, K., Nam, K."Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk". International Journal of Molecular Medicine 45, no. 2 (2020): 658-668. https://doi.org/10.3892/ijmm.2019.4424
Copy and paste a formatted citation
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Spandidos Publications style
Nam GS, Lee KS and Nam KS: Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk. Int J Mol Med 45: 658-668, 2020.
APA
Nam, G.S., Lee, K., & Nam, K. (2020). Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk. International Journal of Molecular Medicine, 45, 658-668. https://doi.org/10.3892/ijmm.2019.4424
MLA
Nam, G. S., Lee, K., Nam, K."Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk". International Journal of Molecular Medicine 45.2 (2020): 658-668.
Chicago
Nam, G. S., Lee, K., Nam, K."Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk". International Journal of Molecular Medicine 45, no. 2 (2020): 658-668. https://doi.org/10.3892/ijmm.2019.4424
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