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Article

Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells

  • Authors:
    • Ji Hyun Kim
    • Sanghyun Lee
    • Hyun Young Kim
    • Eun Ju Cho
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University, Busan 46241, Republic of Korea, Department of Plant Science and Technology, Chung‑Ang University, Anseong 17546, Republic of Korea, Department of Food Science, Gyeongnam National University of Science and Technology, Jinju 52725, Republic of Korea
  • Pages: 589-596
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    Published online on: December 30, 2019
       https://doi.org/10.3892/ijmm.2019.4448
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Abstract

Acer okamotoanum is reported to have various antioxidant, anti‑inflammatory and beneficial immune system effects. The anti‑adipocyte differentiation effects and mechanisms of the ethyl acetate (EtOAc) fraction of an A. okamotoanum extraction was investigated in 3T3‑L1 adipocyte cells. Treatment with differentiation inducers increased the level of triglycerides (TGs) in 3T3‑L1 adipocyte cells compared with an untreated control. However, the EtOAc fraction of A. okamotoanum significantly decreased TGs. Treatment with 1, 2.5 and 5 µg/ml showed weak activity, but TG production was inhibited at 10 µg/ml compared with the control. In addition, A. okamotoanum caused a significant downregulation of proteins related to adipogenesis, such as γ‑cytidine‑cytidine‑adenosine‑adenosine‑thymidine/enhancer binding protein‑α, ‑β and peroxisome proliferator‑activated receptor‑γ, compared with the untreated control. Furthermore, A. okamotoanum significantly upregulated lipolysis related protein, hormone‑sensitive lipase and the phosphorylation of adenosine monophosphate‑activated protein kinase (AMPK). Therefore, these results indicate that A. okamotoanum suppressed adipogenesis and increased lipolysis and the activation of AMPK, suggesting a protective role in adipocyte differentiation.
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View References

1 

World Health Organization: Media Centre (2017) Obesity and overweight: Key facts. http://www.who.int/mediacentre/fact-sheets/fs311/en/. Accessed February 16, 2018.

2 

Kopelman PG: Obesity as a medical problem. Nature. 404:635–643. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Jo J, Gavrilova O, Pack S, Jou W, Mullen S, Sumner AE, Cushman SW and Periwal V: Hypertrophy and/or hyperplasia: Dynamics of adipose tissue growth. PLoS Comput Biol. 5:e10003242009. View Article : Google Scholar : PubMed/NCBI

4 

Langin D, Dicker A, Tavernier G, Hoffstedt J, Mairal A, Rydén M, Arner E, Sicard A, Jenkins CM, Viguerie N, et al: Adipocyte lipases and defect of lipolysis in human obesity. Diabetes. 54:3190–3197. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Muoio DM, Seefeld K, Witters LA and Coleman RA: AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J. 338:783–791. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Cowherd RM, Lyle RE and McGehee RE Jr: Molecular regulation of adipocyte differentiation. Semin Cell Dev Biol. 10:3–10. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Lane MD, Lin FT, MacDougald OA and Vasseur-Cognet M: Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). Int J Obes Relat Metab Disord. 20(Suppl 3): S91–S96. 1996.PubMed/NCBI

8 

Farmer SR: Regulation of PPARgamma activity during adipo-genesis. Int J Obes (Lond). 29(Suppl 1): S13–S16. 2005. View Article : Google Scholar

9 

Shi Y and Burn P: Lipid metabolic enzymes: Emerging drug targets for the treatment of obesity. Nat Rev Drug Discov. 3:695–710. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R and Lass A: Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 50:3–21. 2009. View Article : Google Scholar

11 

Gao Y, Zhou Y, Xu A and Wu D: Effects of an AMP-activated protein kinase inhibitor, compound C, on adipogenic differentiation of 3T3-L1 cells. Biol Pharm Bull. 31:1716–1722. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Lee HM, Yang G, Ahn TG, Kim MD, Nugroho A, Park HJ, Lee KT, Park W and An HJ: Antiadipogenic effects of aster glehni extract: In vivo and in vitro effects. Evid Based Complement Alternat Med. 2013:8596242013. View Article : Google Scholar : PubMed/NCBI

13 

Gupta A, Kumar A, Kumar D, Nandan S, Shankar K, Varshney S, Rajan S, Srivastava A, Gupta S, Kanojiya S, et al: Ethyl acetate fraction of eclipta alba: A potential phytopharmaceutical targeting adipocyte differentiation. Biomed Pharmacother. 96:572–583. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Feng Z, Hai-ning Y, Xiao-man C, Zun-chen W, Sheng-rong S and Das UN: Effect of yellow capsicum extract on proliferation and differentiation of 3T3-L1 preadipocytes. Nutrition. 30:319–325. 2014. View Article : Google Scholar

15 

Jin W, Thuong PT, Su ND, Min BS, Son KH, Chang HW, Kim HP, Kang SS, Sok DE and Bae K: Antioxidant activity of cleomiscosins A and C isolated from Acer okamotoanum. Arch Pharm Res. 30:275–281. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Lee J, Lee DG, Rodriguez JP, Park JY, Cho EJ, Jacinto SD and Lee S: Determination of flavonoids in Acer okamotoanum and their aldose reductase inhibitory activities. Hortic Environ Biotechnol. 59:131–137. 2018. View Article : Google Scholar

17 

Yoo YM, Jung EM, Kang HY, Choi IG, Choi KC and Jeung EB: The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats. Int J Mol Med. 28:489–495. 2011.PubMed/NCBI

18 

An BS, Kang JH, Yang H, Yang MP and Jeung EB: Effects of Acer okamotoanum sap on the function of polymorphonuclear neutrophilic leukocytes in vitro and in vivo. Mol Med Rep. 7:654–658. 2013. View Article : Google Scholar

19 

Yang H, Hwang I, Koo TH, Ahn HJ, Kim S, Park MJ, Choi WS, Kang HY, Choi IG, Choi KC and Jeung EB: Beneficial effects of Acer okamotoanum sap on L-NAME-induced hypertension-like symptoms in a rat model. Mol Med Rep. 5:427–431. 2012.

20 

Choi SY, Kim JH, Lee J, Lee S and Cho EJ: Protective effect of Acer okamotoanum from oxidative stress in C6 glial cells. J Appl Biol Chem. 60:141–147. 2017. View Article : Google Scholar

21 

Choi SY, Lee J, Lee DG, Lee S and Cho EJ: Acer okamotoanum improves cognition and memory function in Aβ25-35-induced Alzheimer's mice model. Appl Biol Chem. 60:1–9. 2017. View Article : Google Scholar

22 

Kim EJ, Kang MJ, Seo YB, Nam SW and Kim GD: Acer okamotoanum nakai leaf extract inhibits adipogenesis via suppressing expression of PPARγ and C/EBPα in 3T3-L1 cells. J Microbiol Biotechnol. 28:1645–1653. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. 65:55–63. 1983. View Article : Google Scholar : PubMed/NCBI

24 

Ramírez-Zacarías JL, Castro-Muñozledo F and Kuri-Harcuch W: Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with oil red O. Histochemistry. 97:493–497. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Zebisch K, Voigt V, Wabitsch M and Brandsch M: Protocol for effective differentiation of 3T3-L1 cells to adipocytes. Anal Biochem. 425:88–90. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Tang QQ, Otto TC and Lane MD: CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci USA. 100:850–855. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Moseti D, Regassa A and Kim WK: Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules. Int J Mol Sci. 17:E1242016. View Article : Google Scholar : PubMed/NCBI

28 

Ntambi JM and Young-Cheul K: Adipocyte differentiation and gene expression. J Nutr. 130:3122S–3126S. 2000. View Article : Google Scholar

29 

Abdali D, Samson SE and Grover AK: How effective are antioxidant supplements in obesity and diabetes? Med Princ Pract. 24:201–215. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Schmid B, Rippmann JF, Tadayyon M and Hamilton BS: Inhibition of fatty acid synthase prevents preadipocyte differentiation. Biochem Biophys Res Commun. 328:1073–1082. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Gregoire FM, Smas CM and Sul HS: Understanding adipocyte differentiation. Physiol Rev. 78:783–809. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Ma X, Zhang H, Yuan L, Jing H, Thacker P and Li D: CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipo-cytes. Biochem J. 439:27–38. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Hernandez R, Teruel T and Lorenzo M: Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes: Synergistic effect through CCAAT/enhancer-binding protein alpha. Biochem J. 372:617–624. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Shen WJ, Patel S, Miyoshi H, Greenberg AS and Kraemer FB: Functional interaction of hormone sensitive lipase and perilipin in lipolysis. J Lipid Res. 50:2306–2313. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Sztalryd C and Kraemer FB: Regulation of hormone-sensitive lipase in streptozotocin-induced diabetic rats. Metabolism. 44:1391–1396. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A and Zechner R: Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 306:1383–1386. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Yang X, Zhang X, Heckmann BL, Lu X and Liu J: Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-α (TNF-α)-induced lipolysis in adipocytes. J Biol Chem. 286:40477–40485. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Lim CT, Kola B and Korbonits M: AMPK as a mediator of hormonal signalling. J Mol Endocrinol. 44:87–97. 2010. View Article : Google Scholar

39 

Daval M, Foufelle F and Ferré P: Functions of AMP-activated protein kinase in adipose tissue. J Physiol. 574:55–62. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Gaidhu MP, Fediuc S, Anthony NM, So M, Mirpourian M, Perry RL and Ceddia RB: Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: Novel mechanisms integrating HSL and ATGL. J Lipid Res. 50:704–715. 2009. View Article : Google Scholar :

41 

Chen S, Li Z, Li W, Shan Z and Zhu W: Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Can J Physiol Pharmacol. 89:793–799. 2011.PubMed/NCBI

42 

Kang SW, Kang SI, Shin HS, Yoon SA, Kim JH, Ko HC and Kim SJ: Sasa quelpaertensis nakai extract and its constituent p-coumaric acid inhibit adipogenesis in 3T3-L1 cells through activation of the AMPK pathway. Food Chem Toxicol. 59:380–385. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Kang K, Liu W, Albright KJ, Park Y and Pariza MW: Trans-10, cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPAR gamma expression. Biochem Biophys Res Commun. 303:795–779. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Moon HS, Lee HG, Seo JH, Chung CS, Kim TG, Kim IY, Lim KW, Seo SJ, Choi YJ and Cho CS: Downregulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis. Arch Biochem Biophys. 456:19–29. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Jiang S, Chen H, Wang Z, Riethoven JJ, Xia Y, Miner J and Fromm M: Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. J Nutr Biochem. 22:656–664. 2011. View Article : Google Scholar

46 

Bi W, Gao Y, Shen J, He C, Liu H, Peng Y, Zhang C and Xiao P: Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): A review. J Ethnopharmacol. 189:31–60. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Zhao WH, Gao LF, Gao W, Yuan YS, Gao CC, Cao LG, Hu ZZ, Guo JQ and Zhang YX: Weight-reducing effect of Acer truncatum bunge may be related to the inhibition of fatty acid synthase. Nat Prod Res. 25:422–431. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Gao L, Cao L, Tian M and Chen Z: Study on the weight-reducing effect of Acer truncatum leave extract in alimentary obesity rat. Wei Sheng Yan Jiu. 41:609–611. 2012.In Chinese.

49 

Lee CW, Seo JY, Lee J, Choi JW, Cho S, Bae JY, Sohng JK, Kim SO, Kim J and Park YI: 3-O-Glucosylation of quercetin enhances inhibitory effects on the adipocyte differentiation and lipogenesis. Biomed Pharmacother. 95:589–598. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Nabavi SF, Russo GL, Daglia M and Nabavi SM: Role of quer-cetin as an alternative for obesity treatment: You are what you eat! Food Chem. 179:305–310. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Chen S, Jiang H, Wu X and Fang J: Therapeutic effects of quer-cetin on inflammation, obesity, and type 2 diabetes. Mediators Inflamm. 2016:93406372016. View Article : Google Scholar

52 

Lee YJ, Choi HS, Seo MJ, Jeon HJ, Kim KJ and Lee BY: Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish. Food Funct. 6:2824–2833. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim JH, Lee S, Kim HY and Cho EJ: Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells. Int J Mol Med 45: 589-596, 2020.
APA
Kim, J.H., Lee, S., Kim, H.Y., & Cho, E.J. (2020). Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells. International Journal of Molecular Medicine, 45, 589-596. https://doi.org/10.3892/ijmm.2019.4448
MLA
Kim, J. H., Lee, S., Kim, H. Y., Cho, E. J."Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells". International Journal of Molecular Medicine 45.2 (2020): 589-596.
Chicago
Kim, J. H., Lee, S., Kim, H. Y., Cho, E. J."Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells". International Journal of Molecular Medicine 45, no. 2 (2020): 589-596. https://doi.org/10.3892/ijmm.2019.4448
Copy and paste a formatted citation
x
Spandidos Publications style
Kim JH, Lee S, Kim HY and Cho EJ: Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells. Int J Mol Med 45: 589-596, 2020.
APA
Kim, J.H., Lee, S., Kim, H.Y., & Cho, E.J. (2020). Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells. International Journal of Molecular Medicine, 45, 589-596. https://doi.org/10.3892/ijmm.2019.4448
MLA
Kim, J. H., Lee, S., Kim, H. Y., Cho, E. J."Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells". International Journal of Molecular Medicine 45.2 (2020): 589-596.
Chicago
Kim, J. H., Lee, S., Kim, H. Y., Cho, E. J."Acer okamotoanum inhibits adipocyte differentiation by the regulation of adipogenesis and lipolysis in 3T3‑L1 cells". International Journal of Molecular Medicine 45, no. 2 (2020): 589-596. https://doi.org/10.3892/ijmm.2019.4448
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