Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2020 Volume 45 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2020 Volume 45 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Osteoking improves OP rat by enhancing HSP90‑β expression

  • Authors:
    • Yan Sun
    • Ran Chen
    • Di Zhu
    • Zhi‑Qiang Shen
    • Hong‑Bin Zhao
    • Wen‑Hui Lee
  • View Affiliations / Copyright

    Affiliations: Pharmaceutical College and Key Laboratory of Pharmacology for Natural Products of Yunnan Province, Kunming Medical University, Kunming, Yunnan 650500, P.R. China, The Clinical Laboratory Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, P.R. China, The Emergency Department, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, P.R. China, Key Laboratory of Bio‑active Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, 650032, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1543-1553
    |
    Published online on: March 6, 2020
       https://doi.org/10.3892/ijmm.2020.4529
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoporosis (OP) is a chronic bone disease that affects individuals worldwide. Osteoporosis is primarily asymptomatic, and patients with OP suffer from pain, inconvenience, economic pressure and osteoporotic fracture (OPF). Osteoking, a Traditional Chinese Medicine compound that originates from the Yi ethnic group, has been used for a number of years to treat fractures. In our previous study, osteoking exhibited therapeutic effects on rats with OPF by promoting calcium deposition. Based on bioinformatics and network pharmacology analyses of a component‑target‑disease database, heat shock protein HSP 90‑β (HSP90‑β), also known as HSP90‑β, was identified to be a key target of osteoking in OP. High HSP90‑β expression levels were observed in osteoporotic rats and rat bone mesenchymal stem cells (rBMSCs) following osteoking treatment. After 12 weeks of administration in vivo, there was increased bone mineral density (BMD) (P<0.05), increased bone alkaline phosphatase (P<0.05), and improved bone microstructure in the osteoking group compared with those of the negative control group. In vitro, increased calcium deposition in rBMSCs was observed after 4 weeks of osteoking treatment. These results suggest that the mechanisms of osteoking are closely associated with HSP90‑β and activate the bone morphogenetic protein (BMP) signalling pathway, primarily through BMP‑2. Osteoking treatment improves OP in rats by enhancing HSP90‑β expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Dunnewind T, Dvortsin EP, Smeets HM, Konijn RM, Bos JHJ, de Boer PT, van den Bergh JP and Postma MJ: Economic consequences and potentially preventable costs related to osteoporosis in the Netherlands. Value Health. 20:762–768. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Ensrud KE and Crandall CJ: Osteoporosis. Ann Intern Med. 168:306–307. 2018. View Article : Google Scholar : PubMed/NCBI

3 

McClung MR: Denosumab for the treatment of osteoporosis. Osteoporos Sarcopenia. 3:8–17. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Fukumoto S and Matsumoto T: Recent advances in the management of osteoporosis. F1000Res. 6:6252017. View Article : Google Scholar : PubMed/NCBI

5 

Qaseem A, Forciea MA, McLean RM and Denberg TD; Clinical Guidelines Committee of the American College of Physicians. Treatment of low bone density or osteoporosis to prevent fractures in men and women: A clinical practice guideline update from the American college of physicians. Ann Intern Med. 166:818–839. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B and Kanis JA: Osteoporosis in the European Union: Medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 8:1362013. View Article : Google Scholar : PubMed/NCBI

7 

Ramírez J, Nieto-González JC, Curbelo Rodríguez R, Castañeda S and Carmona L: Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. 48:44–52. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Tawaratsumida H, Setoguchi T, Arishima Y, Ohtsubo H, Akimoto M, Ishidou Y, Nagano S, Taketomi E, Sunahara N and Komiya S: Risk factors for bone loss in patients with rheumatoid arthritis treated with biologic disease-modifying anti-rheumatic drugs. BMC Res Notes. 10:7652017. View Article : Google Scholar : PubMed/NCBI

9 

Minisola S, Cipriani C, Occhiuto M and Pepe J: New anabolic therapies for osteoporosis. Intern Emerg Med. 12:915–921. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Rossini M, Adami S, Bertoldo F, Diacinti D, Gatti D, Giannini S, Giusti A, Malavolta N, Minisola S, Osella G, et al: Guidelines for the diagnosis, prevention and management of osteoporosis. Reumatismo. 68:1–39. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Kanis JA, Cooper C, Rizzoli R and Reginster JY; Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 30:3–44. 2019. View Article : Google Scholar

12 

Management of osteoporosis in postmenopausal women: 2010 position statement of the North American Menopause Society. Menopause. 17:25–54; quiz 55–26. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Dai L, Wu H, Yu S, Zhao H, Xue L, Xu M, Shen Z and Hu M: Effects of OsteoKing on osteoporotic rabbits. Mol Med Rep. 12:1066–1074. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Fan L, Ma J, Chen Y and Chen X: Antioxidant and antimicrobial phenolic compounds from Setaria viridis. Chem Nat Compounds. 50:433–437. 2014. View Article : Google Scholar

15 

Hu M, Zhao HB, Qian CY, et al: Ultrastructural evaluation of the SANFH rabbit animal models intervened by Osteoking. Chin J Tradit Chin Med Pharm. 26:486–489. 2011.(In Chinese).

16 

Zhao HB, Hu M and Liang HS: Experimental study on osteoking in promoting gene expression of core binding factor alpha 1 in necrotic femoral head of rabbits. Zhongguo Zhong Xi Yi Jie He Za Zhi. 26:1003–1006. 2006.(In Chinese). PubMed/NCBI

17 

Zhao H, Hu M, Wang W and Li L: Effects of the VEGF gene expressions of Osteoking in the treatment of femoral head necrosis. China J Orthop Traumatol. 20:757–759. 2007.

18 

Zhao HB, Hu M, Zheng HY, Liang HS and Zhu XS: Clinical study on effect of Osteoking in preventing postoperational deep venous thrombosis in patients with intertrochanteric fracture. Chin J Integr Med. 22:297–299. 2005.

19 

Yan S: The effect of Osteoking on ovariectomized female rat model of Osteoporosis in Chinese. Chin J Osteoporosis. 12:21–24. 2016.

20 

Hu M, Zhao HB, Wang B, Liang HS, Zhang CQ, Zheng HY and Zhao XL: Clinical observation on promoting effect of henggu gushang union agent on post-operational healing of Gosselin’s fracture. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2:160–161. 2005.(In Chinese).

21 

Hasan S, Bonde BK, Buchan NS and Hall MD: Network analysis has diverse roles in drug discovery. Drug Discov Today. 17:869–874. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, et al: Predicting new molecular targets for known drugs. Nature. 462:175–181. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Qin D, Zhang H, Zhang H, Sun T, Zhao H and Lee WH: Anti-osteoporosis effects of osteoking via reducing reactive oxygen species. J Ethnopharmacol. 244:1120452019. View Article : Google Scholar : PubMed/NCBI

24 

Jones-Bolin S: Guidelines for the care and use of laboratory animals in biomedical research. Curr Protoc Pharmacol. Appendix 4: Appendix 4B. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Ahlquist RP: Experimental methods in pharmacology. J Pharm Sci. 59:7282010. View Article : Google Scholar

26 

Morgan SL and Prater GL: Quality in dual-energy X-ray absorptiometry scans. Bone. 104:13–28. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Clough E and Barrett T: The gene expression omnibus database. Methods Mol Biol. 1418:93–110. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Gage GJ, Kipke DR and Shain W: Whole animal perfusion fixation for rodents. J Vis Exp. 35642012.PubMed/NCBI

29 

Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ and Müller R: Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 25:1468–1486. 2010. View Article : Google Scholar : PubMed/NCBI

30 

The UniProt Consortium. The universal protein knowledgebase. Nucleic Acids Res. 45:D158–D169. 2017. View Article : Google Scholar

31 

NCBI Resource Coordinators. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 46:D8–D13. 2018. View Article : Google Scholar :

32 

Kibbe WA: OligoCalc: An online oligonucleotide properties calculator. Nucleic Acids Res. 35(Web Server issue): W43–W46. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

34 

Guo XL, Liu LZ, Wang QQ, Liang JY, Lee WH, Xiang Y, Li SA and Zhang Y: Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation. Commun Biol. 2:592019. View Article : Google Scholar : PubMed/NCBI

35 

Zuehlke AD, Moses MA and Neckers L: Heat shock protein 90: Its inhibition and function. Philos Trans R Soc Lond B Biol Sci. 373:201605272018. View Article : Google Scholar

36 

Yan X, Hui Y, Hua Y, Huang L, Wang L, Peng F, Tang C, Liu D, Song J and Wang F: EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway. Biomed Pharmacother. 109:762–769. 2019. View Article : Google Scholar

37 

Saryeddine L, Zibara K, Kassem N, Badran B and El-Zein N: EGF-induced VEGF exerts a PI3K-dependent positive feedback on ERK and AKT through VEGFR2 in hematological in vitro models. PLoS One. 11:e01658762016. View Article : Google Scholar : PubMed/NCBI

38 

Yasui H, Hideshima T, Ikeda H, Jin J, Ocio EM, Kiziltepe T, Okawa Y, Vallet S, Podar K, Ishitsuka K, et al: BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth. Br J Haematol. 136:414–423. 2007. View Article : Google Scholar

39 

Khong T and Spencer A: Targeting HSP90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma. Mol Cancer Ther. 10:1909–1917. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Miyasaka M, Nakata H, Hao J, Kim YK, Kasugai S and Kuroda S: Low-intensity pulsed ultrasound stimulation enhances heat-shock protein 90 and mineralized nodule formation in mouse calvaria-derived osteoblasts. Tissue Eng Part A. 21:2829–2839. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Tash JS, Chakrasali R, Jakkaraj SR, Hughes J, Smith SK, Hornbaker K, Heckert LL, Ozturk SB, Hadden MK, Kinzy TG, et al: Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells. Biol Reprod. 78:1139–1152. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Yao Y, Watson AD, Ji S and Bostrom KI: Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. Circ Res. 105:575–584. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Zhang Z, Ma Y, Guo S, He Y, Bai G and Zhang W: Low-intensity pulsed ultrasound stimulation facilitates in vitro osteogenic differentiation of human adipose-derived stem cells via up-regulation of heat shock protein (HSP)70, HSP90, and bone morphogenetic protein (BMP) signaling pathway. Biosci Rep. 38:BSR201800872018. View Article : Google Scholar :

44 

Chung E, Sampson AC and Rylander MN: Influence of heating and cyclic tension on the induction of heat shock proteins and bone-related proteins by MC3T3-E1 cells. Biomed Res Int. 2014:354260. 2014. View Article : Google Scholar

45 

Graner MW: HSP90 and immune modulation in cancer. Adv Cancer Res. 129:191–224. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Vázquez-Carrera M: HSP90 inhibitors as a future therapeutic strategy in diabetes-driven atherosclerosis. Clin Investig Arterioscler. 29:67–68. 2017.(In English, Spanish). PubMed/NCBI

47 

Yu C, Dai L, Ma Z, Zhao H, Yuan Y, Zhang Y, Bao P, Su Y, Ma D, Liu C, et al: Effect of Osteoking on the osteogenic and adipogenic differentiation potential of rat bone marrow mesenchymal stem cells in vitro. BMC Complement Altern Med. 19:362019. View Article : Google Scholar : PubMed/NCBI

48 

Huang K, Wu G, Zou J and Peng S: Combination therapy with BMP-2 and psoralen enhances fracture healing in ovariectomized mice. Exp Ther Med. 16:1655–1662. 2018.PubMed/NCBI

49 

Griffith JF, Wang YX, Zhou H, Kwong WH, Wong WT, Sun YL, Huang Y, Yeung DK, Qin L and Ahuja AT: Reduced bone perfusion in osteoporosis: Likely causes in an ovariectomy rat model. Radiology. 254:739–746. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Ding WG, Wei ZX and Liu JB: Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice. Connect Tissue Res. 52:25–29. 2011. View Article : Google Scholar

51 

Peng J, Lai ZG, Fang ZL, Xing S, Hui K, Hao C, Jin Q, Qi Z, Shen WJ, Dong QN, et al: Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis. PLoS One. 9:e1127442014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Chen R, Zhu D, Shen ZQ, Zhao HB and Lee WH: Osteoking improves OP rat by enhancing HSP90‑β expression. Int J Mol Med 45: 1543-1553, 2020.
APA
Sun, Y., Chen, R., Zhu, D., Shen, Z., Zhao, H., & Lee, W. (2020). Osteoking improves OP rat by enhancing HSP90‑β expression. International Journal of Molecular Medicine, 45, 1543-1553. https://doi.org/10.3892/ijmm.2020.4529
MLA
Sun, Y., Chen, R., Zhu, D., Shen, Z., Zhao, H., Lee, W."Osteoking improves OP rat by enhancing HSP90‑β expression". International Journal of Molecular Medicine 45.5 (2020): 1543-1553.
Chicago
Sun, Y., Chen, R., Zhu, D., Shen, Z., Zhao, H., Lee, W."Osteoking improves OP rat by enhancing HSP90‑β expression". International Journal of Molecular Medicine 45, no. 5 (2020): 1543-1553. https://doi.org/10.3892/ijmm.2020.4529
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Chen R, Zhu D, Shen ZQ, Zhao HB and Lee WH: Osteoking improves OP rat by enhancing HSP90‑β expression. Int J Mol Med 45: 1543-1553, 2020.
APA
Sun, Y., Chen, R., Zhu, D., Shen, Z., Zhao, H., & Lee, W. (2020). Osteoking improves OP rat by enhancing HSP90‑β expression. International Journal of Molecular Medicine, 45, 1543-1553. https://doi.org/10.3892/ijmm.2020.4529
MLA
Sun, Y., Chen, R., Zhu, D., Shen, Z., Zhao, H., Lee, W."Osteoking improves OP rat by enhancing HSP90‑β expression". International Journal of Molecular Medicine 45.5 (2020): 1543-1553.
Chicago
Sun, Y., Chen, R., Zhu, D., Shen, Z., Zhao, H., Lee, W."Osteoking improves OP rat by enhancing HSP90‑β expression". International Journal of Molecular Medicine 45, no. 5 (2020): 1543-1553. https://doi.org/10.3892/ijmm.2020.4529
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team