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Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease

  • Authors:
    • Jian Li
    • Yufan Lu
    • Ning Li
    • Peijun Li
    • Jianqing Su
    • Zhengrong Wang
    • Ting Wang
    • Zhaoyu Yang
    • Yahui Yang
    • Haixia Chen
    • Lu Xiao
    • Hongxia Duan
    • Weibing Wu
    • Xiaodan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Sports Medicine, Shanghai University of Sport, Shanghai 200438, P.R. China, School of Physical Education and Sport Training, Shanghai University of Sport, Shanghai 200438, P.R. China, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1644-1660
    |
    Published online on: March 12, 2020
       https://doi.org/10.3892/ijmm.2020.4537
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Abstract

Decreased diaphragm function is a crucial factor leading to reduced ventilatory efficiency and worsening of quality of life in chronic obstructive pulmonary disease (COPD). Exercise training has been demonstrated to effectively improve the function of the diaphragm. However, the mechanism of this process has not been identified. The emergence of metabolomics has allowed the exploration of new ideas. The present study aimed to analyze the potential biomarkers of exercise‑dependent enhancement of diaphragm function in COPD using metabolomics. Sprague Dawley rats were divided into three groups: COPD + exercise group (CEG); COPD model group (CMG); and control group (CG). The first two groups were exposed to cigarette smoke for 16 weeks to establish a COPD model. Then, the rats in the CEG underwent aerobic exercise training for 9 weeks. Following confirmation that exercise effectively improved the diaphragm function, a gas chromatography tandem time‑of‑flight mass spectrometry analysis system was used to detect the differential metabolites and associated pathways in the diaphragm muscles of the different groups. Following exercise intervention, the pulmonary function and diaphragm contractility of the CEG rats were significantly improved compared with those of the CMG rats. A total of 36 different metabolites were identified in the comparison between the CMG and the CG. Pathway enrichment analysis indicated that these different metabolites were involved in 17 pathways. A total of 29 different metabolites were identified in the comparison between the CMG and the CEG, which are involved in 14 pathways. Candidate biomarkers were selected, and the pathways analysis of these metabolites demonstrated that 2 types of metabolic pathways, the nicotinic acid and nicotinamide metabolism and arginine and proline metabolism pathways, were associated with exercise‑induced pulmonary rehabilitation.
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1 

Horner A, Soriano JB, Puhan MA, Studnicka M, Kaiser B, Vanfleteren LEGW, Gnatiuc L, Burney P, Miravitlles M, García-Rio F, et al: Altitude and COPD prevalence: Analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study. Respir Res. 18:1622017. View Article : Google Scholar : PubMed/NCBI

2 

Mesquita R, Donária L, Genz IC, Pitta F and Probst VS: Respiratory muscle strength during and after hospitalization for COPD exacerbation. Respir Care. 58:2142–2149. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Hodgev VA and Kostianev SS: Maximal inspiratory pressure predicts mortality in patients with chronic obstructive pulmonary disease in a five-year follow-up. Folia Med. 48:36–41. 2006.

4 

Newell SZ, McKenzie DK and Gandevia SC: Inspiratory and skeletal muscle strength and endurance and diaphragmatic activation in patients with chronic airflow limitation. Thorax. 44:903–912. 1989. View Article : Google Scholar : PubMed/NCBI

5 

Fabbri LM and Rabe KF: From COPD to chronic systemic inflammatory syndrome? Lancet. 370:797–799. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Kirkham PA and Barnes PJ: Oxidative stress in COPD. Chest. 144:266–273. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Rochester DF: The diaphragm in COPD. Better than expected, but not good enough. New Engl J Med. 325:961–962. 1991. View Article : Google Scholar : PubMed/NCBI

8 

Scott A, Wang X, Road JD and Reid WD: Increased injury and intramuscular collagen of the diaphragm in COPD: Autopsy observations. Eur Respir J. 27:51–59. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Doucet M, Debigare R, Joanisse DR, Côté C, Leblanc P, Grégoire J, Deslauriers J, Vaillancourt R and Maltais F: Adaptation of the diaphragm and the vastus lateralis in mild-to-moderate COPD. Eur Respir J. 24:971–979. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Haegens A, Schols AM, Gorissen SH, van Essen AL, Snepvangers F, Gray DA, Shoelson SE and Langen RC: NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy. Am J Physiol Lung Cell Mol Physiol. 302:L103–L110. 2012. View Article : Google Scholar

11 

Wijnhoven HJ, Heunks LM, Geraedts MC, Hafmans T, Viña JR and Dekhuijzen PN: Oxidative and nitrosative stress in the diaphragm of patients with COPD. Int J Chron Obstruct Pulmon Dis. 1:173–179. 2006.

12 

Barreiro E and Gea J: Respiratory and limb muscle dysfunction in COPD. COPD. 12:413–426. 2015. View Article : Google Scholar

13 

Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, et al: American thoracic society/European respiratory society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 173:1390–1413. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Ricci C, Terzoni S, Gaeta M, Sorgente A, Destrebecq A and Gigliotti F: Physical training and noninvasive ventilation in COPD patients: A meta-analysis. Respir Care. 59:709–717. 2014. View Article : Google Scholar

15 

Polkey MI, Kyroussis D, Hamnegard CH, Mills GH, Green M and Moxham J: Diaphragm strength in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 154:1310–1317. 1996. View Article : Google Scholar : PubMed/NCBI

16 

Koulmann N and Bigard AX: Interaction between signalling pathways involved in skeletal muscle responses to endurance exercise. Pflugers Arch. 452:125–139. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Rowell LB, Sheriff DD, Wyss CR and Scher AM: The nature of the exercise stimulus. Acta Physiol Scand Suppl. 556:7–14. 1986.PubMed/NCBI

18 

Casado-Vela J, Cebrián A, Gómez del Pulgar MT and Lacal JC: Approaches for the study of cancer: Towards the integration of genomics, proteomics and metabolomics. Clin Transl Oncol. 13:617–628. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Cox J and Mann M: Is proteomics the new genomics? Cell. 130:395–398. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Lindon JC, Holmes E and Nicholson JK: Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res. 23:1075–1088. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Lindon JC, Holmes E, Bollard ME, Stanley EG and Nicholson JK: Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers. 9:1–31. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Wadell K: Water-based exercise is more effective than land-based exercise for people with COPD and physical comorbidities. J Physiother. 60:572014. View Article : Google Scholar : PubMed/NCBI

23 

Wu W, Liu X, Liu J, Li P and Wang Z: Effectiveness of water-based Liuzijue exercise on respiratory muscle strength and peripheral skeletal muscle function in patients with COPD. Int J Chron Obstruct Pulmon Dis. 13:1713–1726. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Carlos SP, Dias AS, Forgiarini Júnior LA, Patricio PD, Graciano T, Nesi RT, Valença S, Chiappa AM, Cipriano G Jr, Souza CT and Chiappa GR: Oxidative damage induced by cigarette smoke exposure in mice: Impact on lung tissue and diaphragm muscle. J Bras Pneumol. 40:411–420. 2014.In English, Portuguese. View Article : Google Scholar : PubMed/NCBI

25 

Vieira Ramos G, Choqueta de Toledo-Arruda A, Maria Pinheiro-Dardis C, Liyoko Suehiro C, Luiz de Russo T, Vieira RP, Arruda Martins M, Salvini TF and Durigan JLQ: Exercise prevents diaphragm wasting induced by cigarette smoke through modulation of antioxidant genes and metalloproteinases. Biomed Res Int. 2018:59090532018. View Article : Google Scholar : PubMed/NCBI

26 

Bowen TS, Aakerøy L, Eisenkolb S, Kunth P, Bakkerud F, Wohlwend M, Ormbostad AM, Fischer T, Wisloff U, Schuler G, et al: Exercise training reverses extrapulmonary impairments in smoke-exposed mice. Med Sci Sports Exerc. 49:879–887. 2017. View Article : Google Scholar

27 

Barreiro E, del Puerto-Nevado L, Puig-Vilanova E, Pérez-Rial S, Sánchez F, Martínez-Galán L, Rivera S, Gea J, González-Mangado N and Peces-Barba G: Cigarette smoke-induced oxidative stress in skeletal muscles of mice. Respir Physiol Neurobiol. 182:9–17. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Krüger K, Dischereit G, Seimetz M, Wilhelm J, Weissmann N and Mooren FC: Time course of cigarette smoke-induced changes of systemic inflammation and muscle structure. Am J Physiol Lung Cell Mol Physiol. 309:L119–L128. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Wüst RCI and Degens H: Factors contributing to muscle wasting and dysfunction in COPD patients. Int J Chron Obstruct Pulmon Dis. 2:289–300. 2007.

30 

Nie YC, Wu H, Li PB, Luo YL, Zhang CC, Shen JG and Su WW: Characteristic comparison of three rat models induced by cigarette smoke or combined with LPS: To establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 25:349–356. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Caron MA, Morissette MC, Thériault ME, Nikota JK, Stämpfli MR and Debigaré R: Alterations in skeletal muscle cell homeostasis in a mouse model of cigarette smoke exposure. PLoS One. 8:e664332013. View Article : Google Scholar : PubMed/NCBI

32 

Totou NL, Moura SS, Coelho DB, Oliveira EC, Becker LK and Lima WG: Swimming exercise demonstrates advantages over running exercise in reducing proteinuria and glomerulosclerosis in spontaneously hypertensive rats. Physiol Int. 105:76–85. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Barbosa Neto O, Abate DT, Marocolo Júnior M, Mota GR, Orsatti FL, Rossi e Silva RC, Reis MA and da Silva VJ: Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats. J Sports Sci Med. 12:52–59. 2013.PubMed/NCBI

34 

Egawa T, Tsuda S, Goto A, Ohno Y, Yokoyama S, Goto K and Hayashi T: Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice. Br J Nutr. 117:21–29. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Yao S, Zhang J, Chen H, Sheng Y, Zhang X, Liu Z and Zhang C: Diagnostic value of immunohistochemical staining of GP73, GPC3, DCP, CD34, CD31, and reticulin staining in hepatocellular carcinoma. J Histochem Cytochem. 61:639–648. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Kind T, Wohlgemuth G, Lee DY, Lu Y, Palazoglu M, Shahbaz S and Fiehn O: FiehnLib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal Chem. 81:10038–10048. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Dunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N, Brown M, Knowles JD, Halsall A, Haselden JN, et al: Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc. 6:1060–1083. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Alfakih A, Khandani A and Wolkowicz H: Solving Euclidean distance matrix completion problems via semidefinite programming. Comput Optim Appl. 12:13–30. 1999. View Article : Google Scholar

39 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar

40 

Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44(D1): D457–D462. 2016. View Article : Google Scholar :

41 

Toledo AC, Magalhaes RM, Hizume DC, Vieira RP, Biselli PJ, Moriya HT, Mauad T, Lopes FD and Martins MA: Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke. Eur Respir J. 39:254–264. 2012. View Article : Google Scholar

42 

Ma WL, Cai PC, Xiong XZ and Ye H: Exercise training attenuated chronic cigarette smoking-induced up-regulation of FIZZ1/RELMα in lung of rats. J Huazhong Univ Sci Technolog Med Sci. 33:22–26. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Nishii Y, Kawata S, Fujita N, Tomoda K and Imagita H: Moderate exercise attenuated airway resistance and inflammation induced by cigarette smoke solution and endotoxin in rats. Sport Sci Health. 12:91–97. 2016. View Article : Google Scholar

44 

Eklund BM, Nilsson S, Hedman L and Lindberg I: Why do smokers diagnosed with COPD not quit smoking?-a qualitative study. Tob Induc Dis. 10:172012. View Article : Google Scholar

45 

Taghizadeh N, Vonk JM and Boezen HM: Lifetime smoking history and cause-specific mortality in a cohort study with 43 years of follow-up. PLoS One. 11:e01533102016. View Article : Google Scholar : PubMed/NCBI

46 

Klaude M, Gedik CM and Collins AR: DNA damage and repair after low doses of UV-C radiation; comparable rates of repair in rodent and human cells. Int J Radiat Biol. 67:501–508. 1995. View Article : Google Scholar : PubMed/NCBI

47 

Rees DC, Wood RW and Laties VG: Stimulus control and the development of behavioral tolerance to daily injections of d-amphetamine in the rat. J Pharmacol Exp Ther. 240:65–73. 1987.PubMed/NCBI

48 

Siegel S and Sdao-Jarvie K: Attenuation of ethanol tolerance by a novel stimulus. Psychopharmacology. 88:258–261. 1986. View Article : Google Scholar : PubMed/NCBI

49 

Swanny A, Morton RF and Lee LY: Acute effect of cigarette smoke on breathing is attenuated by chronic smoking in rats. J Appl Physiol (1985). 74:333–338. 1993. View Article : Google Scholar

50 

Thames HD Jr, Withers HR and Peters LJ: Tissue repair capacity and repair kinetics deduced from multifractionated or continuous irradiation regimens with incomplete repair. Br J Cancer Suppl. 6:263–269. 1984.PubMed/NCBI

51 

Rinaldi M, Maes K, De Vleeschauwer S, Thomas D, Verbeken EK, Decramer M, Janssens W and Gayan-Ramirez GN: Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice. Dis Model Mech. 5:333–341. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Berry CE and Wise RA: Interpretation of pulmonary function test: Issues and controversies. Clin Rev Allergy Immunol. 37:173–180. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Cukic V, Lovre V and Ustamujic A: The changes of pulmonary function in COPD during four-year period. Mater Sociomed. 25:88–92. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Wang J, Zhou XM, Yang X, Zhao ST, Ma QL and Wang CZ: A three years longitudinal follow-up study of pulmonary function changes in patients with chronic obstructive pulmonary disease. Chin J Intern Med. 55:302–306. 2016.In Chinese.

55 

Talaminos Barroso A, Márquez Martin E, Roa Romero LM and Ortega Ruiz F: Factors affecting lung function: A review of the literature. Arch Bronconeumol. 54:327–332. 2018.In English, Spanish. View Article : Google Scholar : PubMed/NCBI

56 

Davidson WJ, Verity WS, Traves SL, Leigh R, Ford GT and Eves ND: Effect of incremental exercise on airway and systemic inflammation in patients with COPD. J Appl Physiol (1985). 112:2049–2056. 2012. View Article : Google Scholar

57 

Silva RA, Almeida FM, Olivo CR, Saraiva-Romanholo BM, Martins MA and Carvalho CR: Airway remodeling is reversed by aerobic training in a murine model of chronic asthma. Scand J Med Sci Sports. 25:e258–e266. 2015. View Article : Google Scholar

58 

Vieira RP, Claudino RC, Duarte AC, Santos AB, Perini A, Faria Neto HC, Mauad T, Martins MA, Dolhnikoff M and Carvalho CR: Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice. Am J Respir Crit Care Med. 176:871–877. 2007. View Article : Google Scholar : PubMed/NCBI

59 

Lan CC, Chu WH, Yang MC, Lee CH, Wu YK and Wu CP: Benefits of pulmonary rehabilitation in patients with COPD and normal exercise capacity. Respir Care. 58:1482–1488. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Ambrosino N, Foglio K, Balzano G, Paggiaro PL, Lessi P and Kesten S; Tiotropium Multicentric Italian Study Group: Tiotropium and exercise training in COPD patients: Effects on dyspnea and exercise tolerance. Int J Chron Obstruct Pulmon Dis. 3:771–780. 2008. View Article : Google Scholar : PubMed/NCBI

61 

Leelarungrayub J, Pinkaew D, Puntumetakul R and Klaphajone J: Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: A preliminary study. Int J Chron Obstruct Pulmon Dis. 12:1415–1425. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Armbruster C, Dassow C, Gamerdinger K, Guttmann J, Schneider M and Schumann S: In vitro muscle contraction force measurements on isolated and entire rat diaphragms. Critical Care. 14:P2042010. View Article : Google Scholar :

63 

Gea J, Agusti A and Roca J: Pathophysiology of muscle dysfunction in COPD. J Appl Physiol (1985). 114:1222–1234. 2013. View Article : Google Scholar

64 

Levine S, Bashir MH, Clanton TL, Powers SK and Singhal S: COPD elicits remodeling of the diaphragm and vastus lateralis muscles in humans. J Appl Physiol (1985). 114:1235–1245. 2013. View Article : Google Scholar

65 

Gayan-Ramirez G and Decramer M: Mechanisms of striated muscle dysfunction during acute exacerbations of COPD. J Appl Physiol (1985). 114:1291–1299. 2013. View Article : Google Scholar

66 

Levine S, Kaiser L, Leferovich J and Tikunov B: Cellular adaptations in the diaphragm in chronic obstructive pulmonary disease. N Engl J Med. 337:1799–1806. 1997. View Article : Google Scholar : PubMed/NCBI

67 

Marin-Corral J, Minguella J, Ramirez-Sarmiento AL, Hussain SN, Gea J and Barreiro E: Oxidised proteins and superoxide anion production in the diaphragm of severe COPD patients. Eur Respir J. 33:1309–1319. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Spruit MA, Gosselink R, Troosters T, De Paepe K and Decramer M: Resistance versus endurance training in patients with COPD and peripheral muscle weakness. Eur Respir J. 19:1072–1078. 2002. View Article : Google Scholar : PubMed/NCBI

69 

Franssen FM, Broekhuizen R, Janssen PP, Wouters EF and Schols AM: Effects of whole-body exercise training on body composition and functional capacity in normal-weight patients with COPD. Chest. 125:2021–2028. 2004. View Article : Google Scholar : PubMed/NCBI

70 

Cortopassi F, Castro AA, Porto EF, Colucci M, Fonseca G, Torre-Bouscoulet L, Iamonti V and Jardim JR: Comprehensive exercise training improves ventilatory muscle function and reduces dyspnea perception in patients with COPD. Monaldi Arch Chest Dis. 71:106–112. 2009.PubMed/NCBI

71 

Wada JT, Borges-Santos E, Porras DC, Paisani DM, Cukier A, Lunardi AC and Carvalho CR: Effects of aerobic training combined with respiratory muscle stretching on the functional exercise capacity and thoracoabdominal kinematics in patients with COPD: A randomized and controlled trial. Int J Chron Obstruct Pulmon Dis. 11:2691–2700. 2016. View Article : Google Scholar : PubMed/NCBI

72 

Ries AL, Bauldoff GS, Carlin BW, Casaburi R, Emery CF, Mahler DA, Make B, Rochester CL, Zuwallack R and Herrerias C: Pulmonary rehabilitation: Joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest. 131(5 Suppl): 4S–42S. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Wanke T, Formanek D, Lahrmann H, Brath H, Wild M, Wagner C and Zwick H: Effects of combined inspiratory muscle and cycle ergometer training on exercise performance in patients with COPD. Eur Respir J. 7:2205–2211. 1994. View Article : Google Scholar : PubMed/NCBI

74 

de Souto Araujo ZT, de Miranda Silva Nogueira PA, Cabral EE, de Paula Dos Santos L, da Silva IS and Ferreira GM: Effectiveness of low-intensity aquatic exercise on COPD: A randomized clinical trial. Respir Med. 106:1535–1543. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Wackerhage H and Ratkevicius A: Signal transduction pathways that regulate muscle growth. Essays Biochem. 44:99–108. 2008. View Article : Google Scholar : PubMed/NCBI

76 

Chaouloff F, Kennett GA, Serrurrier B, Merino D and Curzon G: Amino acid analysis demonstrates that increased plasma free tryptophan causes the increase of brain tryptophan during exercise in the rat. J Neurochem. 46:1647–1650. 1986. View Article : Google Scholar : PubMed/NCBI

77 

Inuzuka M, Hayakawa M and Ingi T: Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. J Biol Chem. 280:35776–35783. 2005. View Article : Google Scholar : PubMed/NCBI

78 

Pantaleo A, Ferru E, Carta F, Mannu F, Giribaldi G, Vono R, Lepedda AJ, Pippia P and Turrini F: Analysis of changes in tyro-sine and serine phosphorylation of red cell membrane proteins induced by P. falciparum growth. Proteomics. 10:3469–3479. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Hu SI, Katz M, Chin S, Qi X, Cruz J, Ibebunjo C, Zhao S, Chen A and Glass DJ: MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle. Sci Signal. 5:ra142012. View Article : Google Scholar : PubMed/NCBI

80 

Talanian JL, Tunstall RJ, Watt MJ, Duong M, Perry CG, Steinberg GR, Kemp BE, Heigenhauser GJ and Spriet LL: Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise. Am J Physiol Regul Integr Comp Physiol. 291:R1094–R1099. 2006. View Article : Google Scholar : PubMed/NCBI

81 

Li F, Chong ZZ and Maiese K: Cell life versus cell longevity: The mysteries surrounding the NAD+ precursor nicotinamide. Curr Med Chem. 13:883–895. 2006. View Article : Google Scholar : PubMed/NCBI

82 

Ungerstedt JS, Blömback M and Söderström T: Nicotinamide is a potent inhibitor of proinflammatory cytokines. Clin Exp Immunol. 131:48–52. 2003. View Article : Google Scholar : PubMed/NCBI

83 

Traister A, Breitman I, Bar-Lev E, Zvibel I, Harel A, Halpern Z and Oren R: Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells. Scand J Gastroenterol. 40:1226–1234. 2005. View Article : Google Scholar : PubMed/NCBI

84 

Chlopicki S, Swies J, Mogielnicki A, Buczko W, Bartus M, Lomnicka M, Adamus J and Gebicki J: 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. Br J Pharmacol. 152:230–239. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Surenkok O, Kin-Isler A, Aytar A and Gültekin Z: Effect of trunk-muscle fatigue and lactic acid accumulation on balance in healthy subjects. J Sport Rehabil. 17:380–386. 2008. View Article : Google Scholar

86 

Robergs RA, Ghiasvand F and Parker D: Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol. 287:R502–R516. 2004. View Article : Google Scholar : PubMed/NCBI

87 

Gladden LB: Lactate metabolism: A new paradigm for the third millennium. J Physiol. 558:5–30. 2004. View Article : Google Scholar : PubMed/NCBI

88 

Lewis SF and Haller RG: The pathophysiology of McArdle's disease: Clues to regulation in exercise and fatigue. J Appl Physiol (1985). 61:391–401. 1986. View Article : Google Scholar

89 

Hunt TK, Aslam R, Hussain Z and Beckert S: Lactate, with oxygen, incites angiogenesis. Adv Exp Med Biol. 614:73–80. 2008. View Article : Google Scholar : PubMed/NCBI

90 

Groussard C, Morel I, Chevanne M, Monnier M, Cillard J and Delamarche A: Free radical scavenging and antioxidant effects of lactate ion: An in vitro study. J Appl Physiol (1985). 89:169–175. 2000. View Article : Google Scholar

91 

Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, et al: A community-driven global reconstruction of human metabolism. Nat Biotechnol. 31:419–425. 2013. View Article : Google Scholar : PubMed/NCBI

92 

Stoltz JF and Nicolas A: Study of amino groups of the human platelet membrane. Acta Haematol. 60:304–309. 1978. View Article : Google Scholar : PubMed/NCBI

93 

Menon R, Tolbert D and Cefali E: The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet. Biopharm Drug Dispos. 28:297–306. 2007. View Article : Google Scholar : PubMed/NCBI

94 

Shibata K, Matsumoto K, Fushiki T and Sugimoto E: Effects of exercise on the metabolism of NAD in rats. Biosci Biotech Bioch. 58:1763–1766. 1994. View Article : Google Scholar

95 

White AT and Schenk S: NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise. Am J Physiol Endocrinol Metab. 303:E308–E321. 2012. View Article : Google Scholar : PubMed/NCBI

96 

Wu G and Morris SM Jr: Arginine metabolism: Nitric oxide and beyond. Biochem J. 336:1–17. 1998. View Article : Google Scholar : PubMed/NCBI

97 

Barton ER, Morris L, Kawana M, Bish LT and Toursel T: Systemic administration of L-arginine benefits mdx skeletal muscle function. Muscle nerve. 32:751–760. 2005. View Article : Google Scholar : PubMed/NCBI

98 

Wu G, Bazer FW, Datta S, Johnson GA, Li P, Satterfield MC and Spencer TE: Proline metabolism in the conceptus: Implications for fetal growth and development. Amino Acids. 35:691–702. 2008. View Article : Google Scholar : PubMed/NCBI

99 

Ruzsics I, Nagy L, Keki S, Sarosi V, Illes B, Illes Z, Horvath I, Bogar L and Molnar T: L-arginine pathway in COPD patients with acute exacerbation: A new potential biomarker. COPD. 13:139–145. 2016. View Article : Google Scholar

100 

Dohm GL, Beecher GR, Warren RQ and Williams RT: Influence of exercise on free amino acid concentrations in rat tissues. J Appl Physiol Respir Environ Exerc Physiol. 50:41–44. 1981.PubMed/NCBI

101 

Parmaksız ET, Inal A, Salepci B, Comert S, Fidan A, Kiral N, Doǧan C and Caglayan B: Relationship of asymmetric dimethylarginine levels with disease severity and pulmonary hypertension in chronic obstructive pulmonary disease. Lung India. 35:199–203. 2018. View Article : Google Scholar

102 

van den Berg MP, Meurs H and Gosens R: Targeting arginase and nitric oxide metabolism in chronic airway diseases and their comorbidities. Curr Opin Pharmacol. 40:126–133. 2018. View Article : Google Scholar : PubMed/NCBI

103 

Hörster I, Weigt-Usinger K, Carmann C, Chobanyan-Jürgens K, Köhler C, Schara U, Kayacelebi AA, Beckmann B, Tsikas D and Lücke T: The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids. Amino Acids. 47:1853–1863. 2015. View Article : Google Scholar : PubMed/NCBI

104 

Wang W, Wu Z, Dai Z, Yang Y, Wang J and Wu G: Glycine metabolism in animals and humans: Implications for nutrition and health. Amino Acids. 45:463–477. 2013. View Article : Google Scholar : PubMed/NCBI

105 

Bruno A, Chanez P, Chiappara G, Siena L, Giammanco S, Gjomarkaj M, Bonsignore G, Bousquet J and Vignola AM: Does leptin play a cytokine-like role within the airways of COPD patients? Eur Respir J. 26:398–405. 2005. View Article : Google Scholar : PubMed/NCBI

106 

Bianco A, Mazzarella G, Turchiarelli V, Nigro E, Corbi G, Scudiero O, Sofia M and Daniele A: Adiponectin: An attractive marker for metabolic disorders in chronic obstructive pulmonary disease (COPD). Nutrients. 5:4115–4125. 2013. View Article : Google Scholar : PubMed/NCBI

107 

Al Mutairi SS, Mojiminiyi OA, Shihab-Eldeen A, Al Rammah T and Abdella N: Putative roles of circulating resistin in patients with asthma, COPD and cigarette smokers. Dis Markers. 31:1–7. 2011. View Article : Google Scholar : PubMed/NCBI

108 

Tomaki M, Sugiura H, Koarai A, Komaki Y, Akita T, Matsumoto T, Nakanishi A, Ogawa H, Hattori T and Ichinose M: Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. Pulm Pharmacol Ther. 20:596–605. 2007. View Article : Google Scholar

109 

Tilg H and Moschen AR: Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 6:772–783. 2006. View Article : Google Scholar : PubMed/NCBI

110 

Horowitz JF and Klein S: Lipid metabolism during endurance exercise. Am J Clin Nutr. 72(2 Suppl): 558S–563S. 2000. View Article : Google Scholar : PubMed/NCBI

111 

Gill JM, Frayn KN, Wootton SA, Miller GJ and Hardman AE: Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity. Clin Sci (Lond). 100:517–527. 2001. View Article : Google Scholar

112 

de Batlle J, Sauleda J, Balcells E, Gómez FP, Méndez M, Rodriguez E, Barreiro E, Ferrer JJ, Romieu I, Gea J, et al: Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. J Nutr Biochem. 23:817–821. 2012. View Article : Google Scholar

113 

Warnakulasuriya SN, Ziaullah and Rupasinghe HP: Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts. Eur J Pharmacol. 781:128–138. 2016. View Article : Google Scholar : PubMed/NCBI

114 

Garrod R, Ansley P, Canavan J and Jewell A: Exercise and the inflammatory response in chronic obstructive pulmonary disease (COPD)-Does training confer anti-inflammatory prop-erties in COPD? Med Hypotheses. 68:291–298. 2007. View Article : Google Scholar

115 

Spurzem JR and Rennard SI: Pathogenesis of COPD. Semin Respir Crit Care Med. 26:142–153. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Lu Y, Li N, Li P, Su J, Wang Z, Wang T, Yang Z, Yang Y, Chen H, Chen H, et al: Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease. Int J Mol Med 45: 1644-1660, 2020.
APA
Li, J., Lu, Y., Li, N., Li, P., Su, J., Wang, Z. ... Liu, X. (2020). Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease. International Journal of Molecular Medicine, 45, 1644-1660. https://doi.org/10.3892/ijmm.2020.4537
MLA
Li, J., Lu, Y., Li, N., Li, P., Su, J., Wang, Z., Wang, T., Yang, Z., Yang, Y., Chen, H., Xiao, L., Duan, H., Wu, W., Liu, X."Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease". International Journal of Molecular Medicine 45.6 (2020): 1644-1660.
Chicago
Li, J., Lu, Y., Li, N., Li, P., Su, J., Wang, Z., Wang, T., Yang, Z., Yang, Y., Chen, H., Xiao, L., Duan, H., Wu, W., Liu, X."Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease". International Journal of Molecular Medicine 45, no. 6 (2020): 1644-1660. https://doi.org/10.3892/ijmm.2020.4537
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Lu Y, Li N, Li P, Su J, Wang Z, Wang T, Yang Z, Yang Y, Chen H, Chen H, et al: Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease. Int J Mol Med 45: 1644-1660, 2020.
APA
Li, J., Lu, Y., Li, N., Li, P., Su, J., Wang, Z. ... Liu, X. (2020). Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease. International Journal of Molecular Medicine, 45, 1644-1660. https://doi.org/10.3892/ijmm.2020.4537
MLA
Li, J., Lu, Y., Li, N., Li, P., Su, J., Wang, Z., Wang, T., Yang, Z., Yang, Y., Chen, H., Xiao, L., Duan, H., Wu, W., Liu, X."Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease". International Journal of Molecular Medicine 45.6 (2020): 1644-1660.
Chicago
Li, J., Lu, Y., Li, N., Li, P., Su, J., Wang, Z., Wang, T., Yang, Z., Yang, Y., Chen, H., Xiao, L., Duan, H., Wu, W., Liu, X."Muscle metabolomics analysis reveals potential biomarkers of exercise‑dependent improvement of the diaphragm function in chronic obstructive pulmonary disease". International Journal of Molecular Medicine 45, no. 6 (2020): 1644-1660. https://doi.org/10.3892/ijmm.2020.4537
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