Open Access

Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells

  • Authors:
    • Yun Zhang
    • Linlin Guo
    • Betty Yuen‑Kwan Law
    • Xiaobo Liang
    • Ning Ma
    • Guofeng Xu
    • Xiaoyun Wang
    • Xiefang Yuan
    • Hongmei Tang
    • Qi Chen
    • Vincent Kam‑Wai Wong
    • Xing Wang
  • View Affiliations

  • Published online on: March 16, 2020     https://doi.org/10.3892/ijmm.2020.4539
  • Pages: 1673-1684
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

One of the major risk factors for asthma development is exposure to environmental allergens. House dust mites (HDM) can induce DNA damage, resulting in asthma. Resveratrol (RES) produced by several plants, has anti‑apoptotic properties and may affect a variety of biological processes. The aim of the present study was to investigate the protective role of RES against apoptosis in bronchial epithelial cells. C57BL/6J mice treated with HDM exhibited high levels of cell apoptosis, while RES significantly reversed this process. Induced DNA damage was more severe in the HDM group vs. the HDM combined with RES group. This result was confirmed by immunostaining and western blot analysis of the protein expression of the DNA damage‑related gene γH2AX, which was highly induced by HDM. In addition, treatment with RES protected bronchial epithelial cells exposed to HDM from DNA damage. RES decreases reactive oxygen species levels to inhibit oxidative DNA damage in bronchial epithelial cells. Furthermore, compared with the HDM group, induced cell apoptosis could be attenuated by RES in the group of combined treatment with RES and HDM. A DNA repair inhibitor augmented DNA damage and apoptosis in bronchial epithelial cells, whereas RES significantly attenuated cell apoptosis through inhibiting DNA damage.
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June-2020
Volume 45 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhang Y, Guo L, Law BY, Liang X, Ma N, Xu G, Wang X, Yuan X, Tang H, Chen Q, Chen Q, et al: Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells. Int J Mol Med 45: 1673-1684, 2020
APA
Zhang, Y., Guo, L., Law, B.Y., Liang, X., Ma, N., Xu, G. ... Wang, X. (2020). Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells. International Journal of Molecular Medicine, 45, 1673-1684. https://doi.org/10.3892/ijmm.2020.4539
MLA
Zhang, Y., Guo, L., Law, B. Y., Liang, X., Ma, N., Xu, G., Wang, X., Yuan, X., Tang, H., Chen, Q., Wong, V. K., Wang, X."Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells". International Journal of Molecular Medicine 45.6 (2020): 1673-1684.
Chicago
Zhang, Y., Guo, L., Law, B. Y., Liang, X., Ma, N., Xu, G., Wang, X., Yuan, X., Tang, H., Chen, Q., Wong, V. K., Wang, X."Resveratrol decreases cell apoptosis through inhibiting DNA damage in bronchial epithelial cells". International Journal of Molecular Medicine 45, no. 6 (2020): 1673-1684. https://doi.org/10.3892/ijmm.2020.4539