1
|
Arnett DK, Blumenthal RS, Albert MA,
Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A,
Lloyd-Jones D, McEvoy JW, et al: 2019 ACC/AHA Guideline on the
primary prevention of cardiovascular disease A Report of the
American College of Cardiology/American Heart Association Task
Force on Clinical Practice Guidelines. Circulation. 140. pp.
e596–e646. 2019
|
2
|
Gimbrone MA Jr and García-Cardeña G:
Endothelial cell dysfunction and the pathobiology of
atherosclerosis. Circ Res. 118:620–636. 2016. View Article : Google Scholar : PubMed/NCBI
|
3
|
Bar A, Targosz-Korecka M, Suraj J,
Proniewski B, Jasztal A, Marczyk B, Sternak M, Przybyło M,
Kurpińska A, Walczak M, et al: Degradation of glycocalyx and
multiple manifestations of endothelial dysfunction coincide in the
early phase of endothelial dysfunction before atherosclerotic
plaque development in apolipoprotein E/low-density lipoprotein
receptor-deficient mice. J Am Heart Assoc. 8:e0111712019.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Ference BA, Ginsberg HN, Graham I, Ray KK,
Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H,
et al: Low-density lipoproteins cause atherosclerotic
cardiovascular disease. 1. Evidence from genetic, epidemiologic,
and clinical studies. A consensus statement from the European
Atherosclerosis Society Consensus Panel. Eur Heart J. 38:2459–2472.
2017. View Article : Google Scholar : PubMed/NCBI
|
5
|
Falkenstein KN and Vokes SA:
Transcriptional regulation of graded Hedgehog signaling. Semin Cell
Dev Biol. 33:73–80. 2014. View Article : Google Scholar : PubMed/NCBI
|
6
|
Qi X, Schmiege P, Coutavas E, Wang J and
Li X: Structures of human Patched and its complex with native
palmitoylated sonic hedgehog. Nature. 560:128–132. 2018. View Article : Google Scholar : PubMed/NCBI
|
7
|
Huang P, Zheng S, Wierbowski BM, Kim Y,
Nedelcu D, Aravena L, Liu J, Kruse AC and Salic A: Structural basis
of smoothened activation in hedgehog signaling. Cell. 175:295–297.
2018. View Article : Google Scholar : PubMed/NCBI
|
8
|
Briscoe J and Therond PP: The mechanisms
of Hedgehog signalling and its roles in development and disease.
Nat Rev Mol Cell Biol. 14:416–429. 2013. View Article : Google Scholar : PubMed/NCBI
|
9
|
Lavine KJ, Kovacs A and Ornitz DM:
Hedgehog signaling is critical for maintenance of the adult
coronary vasculature in mice. J Clin Invest. 118:2404–2414.
2008.PubMed/NCBI
|
10
|
Xiao Q, Hou N, Wang YP, He LS, He YH,
Zhang GP, Yi Q, Liu SM, Chen MS and Luo JD: Impaired sonic hedgehog
pathway contributes to cardiac dysfunction in type 1 diabetic mice
with myocardial infarction. Cardiovasc Res. 95:507–516. 2012.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Beckers L, Heeneman S, Wang L, Burkly LC,
Rousch MM, Davidson NO, Gijbels MJ, de Winther MP, Daemen MJ and
Lutgens E: Disruption of hedgehog signalling in ApoE −/− mice
reduces plasma lipid levels, but increases atherosclerosis due to
enhanced lipid uptake by macrophages. J Pathol. 212:420–428. 2007.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Queiroz KC, Bijlsma MF, Tio RA, Zeebregts
CJ, Dunaeva M, Ferreira CV, Fuhler GM, Kuipers EJ, Alves MM, Rezaee
F, et al: Dichotomy in Hedgehog signaling between human healthy
vessel and atherosclerotic plaques. Mol Med. 18:1122–1127. 2012.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Dunaeva M, van Oosterhoud C and
Waltenberger J: Expression of Hedgehog signaling molecules in human
atherosclerotic lesions: An autopsy study. Int J Cardiol.
201:462–464. 2015. View Article : Google Scholar : PubMed/NCBI
|
14
|
Agouni A, Mostefai HA, Porro C, Carusio N,
Favre J, Richard V, Henrion D, Martínez MC and Andriantsitohaina R:
Sonic hedgehog carried by microparticles corrects endothelial
injury through nitric oxide release. FASEB J. 21:2735–2741. 2007.
View Article : Google Scholar : PubMed/NCBI
|
15
|
Chen KY, Cheng CJ and Wang LC: Activation
of sonic Hedgehog leads to survival enhancement of astrocytes via
the GRP78-dependent pathway in mice infected with angio-strongylus
cantonensis. Biomed Res Int. 2015:6743712015.
|
16
|
Yu XH, Zheng XL and Tang CK: Nuclear
factor-κB activation as a pathological mechanism of lipid
metabolism and atherosclerosis. Adv Clin Chem. 70:1–30. 2015.
View Article : Google Scholar
|
17
|
Maziere C, Auclair M, Djavaheri-Mergny M,
Packer L and Maziere JC: Oxidized low density lipoprotein induces
activation of the transcription factor NF kappa B in fibroblasts,
endothelial and smooth muscle cells. Biochem Mol Biol Int.
39:1201–1207. 1996.PubMed/NCBI
|
18
|
Yurdagul A Jr, Sulzmaier FJ, Chen XL,
Pattillo CB, Schlaepfer DD and Orr AW: Oxidized LDL induces
FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1
expression. J Cell Sci. 129:1580–1591. 2016. View Article : Google Scholar : PubMed/NCBI
|
19
|
Cai K, Na W, Guo M, Xu R, Wang X, Qin Y,
Wu Y, Jiang J and Huang H: Targeting the cross-talk between the
hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk
Lymphoma. 60:772–781. 2019. View Article : Google Scholar : PubMed/NCBI
|
20
|
Lewis LJ, Hoak JC, Maca RD and Fry GL:
Replication of human endothelial cells in culture. Science.
181:453–454. 1973. View Article : Google Scholar : PubMed/NCBI
|
21
|
Chen JK: I only have eye for ewe: The
discovery of cyclopamine and development of Hedgehog
pathway-targeting drugs. Nat Prod Rep. 33:595–601. 2016. View Article : Google Scholar : PubMed/NCBI
|
22
|
Dąbek J, Kułach A and Gąsior Z: Nuclear
factor kappa-light-chain-enhancer of activated B cells (NF-κB): A
new potential therapeutic target in atherosclerosis? Pharmacol Rep.
62:778–783. 2010. View Article : Google Scholar
|
23
|
Paone S, Baxter AA, Hulett MD and Poon
IKH: Endothelial cell apoptosis and the role of endothelial
cell-derived extracellular vesicles in the progression of
atherosclerosis. Cell Mol Life Sci. 76:1093–1106. 2019. View Article : Google Scholar
|
24
|
Luchetti F, Crinelli R, Cesarini E,
Canonico B, Guidi L, Zerbinati C, Di Sario G, Zamai L, Magnani M,
Papa S and Iuliano L: Endothelial cells, endoplasmic reticulum
stress and oxysterols. Redox Biol. 13:581–587. 2017. View Article : Google Scholar : PubMed/NCBI
|
25
|
Choy JC, Granville DJ, Hunt DW and McManus
BM: Endothelial cell apoptosis: Biochemical characteristics and
potential implications for atherosclerosis. J Mol Cell Cardiol.
33:1673–1690. 2001. View Article : Google Scholar : PubMed/NCBI
|
26
|
Hedger G, Koldsø H, Chavent M, Siebold C,
Rohatgi R and Sansom MSP: Cholesterol interaction sites on the
transmembrane domain of the hedgehog signal transducer and Class F
G protein-coupled receptor smoothened. Structure. 27:549–559.e2.
2019. View Article : Google Scholar : PubMed/NCBI
|
27
|
Weiss LE, Milenkovic L, Yoon J, Stearns T
and Moerner WE: Motional dynamics of single Patched1 molecules in
cilia are controlled by Hedgehog and cholesterol. Proc Natl Acad
Sci USA. 116:5550–5557. 2019. View Article : Google Scholar : PubMed/NCBI
|
28
|
Huang P, Nedelcu D, Watanabe M, Jao C, Kim
Y, Liu J and Salic A: Cellular cholesterol directly activates
smoothened in hedgehog signaling. Cell. 166:1176–1187.e14. 2016.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Zhang Y, Bulkley DP, Xin Y, Roberts KJ,
Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y and Beachy PA:
Structural basis for cholesterol transport-like activity of the
hedgehog receptor patched. Cell. 175:1352–1364.e1314. 2018.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Rajman I, Eacho PI, Chowienczyk PJ and
Ritter JM: LDL particle size: An important drug target? Br J Clin
Pharmacol. 48:125–133. 1999. View Article : Google Scholar : PubMed/NCBI
|
31
|
Bijlsma MF, Peppelenbosch MP and Spek CA:
Hedgehog morphogen in cardiovascular disease. Circulation.
114:1985–1991. 2006. View Article : Google Scholar : PubMed/NCBI
|
32
|
Kusano KF, Pola R, Murayama T, Curry C,
Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, et
al: Sonic hedgehog myocardial gene therapy: Tissue repair through
transient reconstitution of embryonic signaling. Nat Med.
11:1197–1204. 2005. View
Article : Google Scholar : PubMed/NCBI
|
33
|
Xia YP, Dai RL, Li YN, Mao L, Xue YM, He
QW, Huang M, Huang Y, Mei YW and Hu B: The protective effect of
sonic hedgehog is mediated by the phosphoinositide [corrected]
3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under
oxidative stress. Neuroscience. 209:1–11. 2012. View Article : Google Scholar : PubMed/NCBI
|
34
|
Marrachelli VG, Mastronardi ML, Sarr M,
Soleti R, Leonetti D, Martínez MC and Andriantsitohaina R: Sonic
hedgehog carried by microparticles corrects angiotensin II-induced
hypertension and endothelial dysfunction in mice. PLoS One.
8:e728612013. View Article : Google Scholar : PubMed/NCBI
|
35
|
Qi C, Di Minin G, Vercellino I, Wutz A and
Korkhov VM: Structural basis of sterol recognition by human
hedgehog receptor PTCH1. Sci Adv. 5:eaaw64902019. View Article : Google Scholar : PubMed/NCBI
|
36
|
Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei
J and Yan N: Structural basis for the recognition of Sonic Hedgehog
by human Patched1. Science. 361:eaas89352018. View Article : Google Scholar : PubMed/NCBI
|
37
|
Renault MA, Roncalli J, Tongers J, Thorne
T, Klyachko Misener S, Volpert OV, Mehta S, Burg A, Luedemann C, et
al: Sonic hedgehog induces angiogenesis via Rho kinase-signaling in
endothelial cells. J Mol Cell Cardiol. 49:4902010. View Article : Google Scholar : PubMed/NCBI
|
38
|
Chinchilla P, Xiao L, Kazanietz MG and
Riobo NA: Hedgehog proteins activate pro-angiogenic responses in
endothelial cells through non-canonical signaling pathways. Cell
Cycle. 570–579. 2010. View Article : Google Scholar : PubMed/NCBI
|
39
|
Caradu C, Couffinhal T, Chapouly C,
Guimbal S, Hollier Ducasse E, Bura-Rivière A, Dubois M and Gadeau
Renault MA: Restoring endothelial function by targeting desert
Hedgehog downstream of Klf2 improves critical limb ischemia in
adults. Circ Res. 123:1053–1065. 2018. View Article : Google Scholar : PubMed/NCBI
|
40
|
Morrow D, Cullen JP, Liu W, Guha S,
Sweeney C, Birney Collins N, Walls D, Redmond EM and Cahill PA:
Sonic Hedgehog induces Notch target gene expression in vascular
smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol.
29:1112–1118. 2009. View Article : Google Scholar : PubMed/NCBI
|
41
|
Jaipersad AS, Lip GY, Silverman S and
Shantsila E: The role of monocytes in angiogenesis and
atherosclerosis. J Am C Cardiol. 63:1–11. 2014. View Article : Google Scholar
|
42
|
Xu J, Lu X and Shi GP: Vasa vasorum in
atherosclerosis and clinical significance. Int J Mol Sci.
16:11574–11608. 2015. View Article : Google Scholar : PubMed/NCBI
|
43
|
Zmysłowski A and Szterk A: Current
knowledge on mechanism of atherosclerosis and pro-atherosclerotic
properties of oxysterols. Lipids Health Dis. 16:1882017. View Article : Google Scholar
|
44
|
Soleti R and Martínez MC: Microparticles
harbouring Sonic Hedgehog: Role in angiogenesis regulation. Cell
Adh Migr. 293–295. 2009. View Article : Google Scholar : PubMed/NCBI
|