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Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling

Corrigendum in: /10.3892/ijmm.2020.4663
  • Authors:
    • Huashan Huang
    • Huizhen Yu
    • Liang Lin
    • Junming Chen
    • Pengli Zhu
  • View Affiliations / Copyright

    Affiliations: Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Gynecology and Obstetrics, Fujian Provincial Hospital South Branch, Fuzhou, Fujian 350028, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1864-1874
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    Published online on: March 16, 2020
       https://doi.org/10.3892/ijmm.2020.4542
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Abstract

Sonic hedgehog (Shh) is pivotally important in embryonic and adult blood vessel development and homeostasis. However, whether Shh is involved in atherosclerosis and plays a role in endothelial apoptosis induced by oxidized low‑density lipoprotein (ox‑LDL) has not been reported. The present study used recombinant Shh‑N protein (rShh‑N) and a plasmid encoding the human Shh gene (phShh) to investigate the role of Shh in ox‑LDL‑mediated human umbilical vein endothelial cell (HUVEC) apoptosis. The present study found that ox‑LDL was able to induce apoptosis in HUVECs and that Shh protein expression was downregulated. Furthermore, pretreatment with rShh‑N or transfection with phShh increased anti‑apoptosis protein Bcl‑2 expression and decreased cell apoptosis. These protective effects of rShh‑N could be abolished by cyclopamine, which is a hedgehog signaling inhibitor. Furthermore, a co‑immunoprecipitation assay was performed to demonstrate that Shh interacted with NF‑κB p65 in HUVECs. Additionally, ox‑LDL upregulated the phosphorylation of NF‑κB p65 and inhibitor of NF‑κB‑α (IκBα), and these effects decreased notably following rShh‑N and phShh treatment. Together, the present findings suggested that Shh serves an important protective role in alleviating ox‑LDL‑mediated endothelial apoptosis by inhibiting the NF‑κB signaling pathway phosphorylation and Bcl‑2 mediated mitochondrial signaling.
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View References

1 

Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, et al: 2019 ACC/AHA Guideline on the primary prevention of cardiovascular disease A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 140. pp. e596–e646. 2019

2 

Gimbrone MA Jr and García-Cardeña G: Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 118:620–636. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Bar A, Targosz-Korecka M, Suraj J, Proniewski B, Jasztal A, Marczyk B, Sternak M, Przybyło M, Kurpińska A, Walczak M, et al: Degradation of glycocalyx and multiple manifestations of endothelial dysfunction coincide in the early phase of endothelial dysfunction before atherosclerotic plaque development in apolipoprotein E/low-density lipoprotein receptor-deficient mice. J Am Heart Assoc. 8:e0111712019. View Article : Google Scholar : PubMed/NCBI

4 

Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H, et al: Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 38:2459–2472. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Falkenstein KN and Vokes SA: Transcriptional regulation of graded Hedgehog signaling. Semin Cell Dev Biol. 33:73–80. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Qi X, Schmiege P, Coutavas E, Wang J and Li X: Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature. 560:128–132. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC and Salic A: Structural basis of smoothened activation in hedgehog signaling. Cell. 175:295–297. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Briscoe J and Therond PP: The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 14:416–429. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Lavine KJ, Kovacs A and Ornitz DM: Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest. 118:2404–2414. 2008.PubMed/NCBI

10 

Xiao Q, Hou N, Wang YP, He LS, He YH, Zhang GP, Yi Q, Liu SM, Chen MS and Luo JD: Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction. Cardiovasc Res. 95:507–516. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Beckers L, Heeneman S, Wang L, Burkly LC, Rousch MM, Davidson NO, Gijbels MJ, de Winther MP, Daemen MJ and Lutgens E: Disruption of hedgehog signalling in ApoE −/− mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages. J Pathol. 212:420–428. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Queiroz KC, Bijlsma MF, Tio RA, Zeebregts CJ, Dunaeva M, Ferreira CV, Fuhler GM, Kuipers EJ, Alves MM, Rezaee F, et al: Dichotomy in Hedgehog signaling between human healthy vessel and atherosclerotic plaques. Mol Med. 18:1122–1127. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Dunaeva M, van Oosterhoud C and Waltenberger J: Expression of Hedgehog signaling molecules in human atherosclerotic lesions: An autopsy study. Int J Cardiol. 201:462–464. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Agouni A, Mostefai HA, Porro C, Carusio N, Favre J, Richard V, Henrion D, Martínez MC and Andriantsitohaina R: Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB J. 21:2735–2741. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Chen KY, Cheng CJ and Wang LC: Activation of sonic Hedgehog leads to survival enhancement of astrocytes via the GRP78-dependent pathway in mice infected with angio-strongylus cantonensis. Biomed Res Int. 2015:6743712015.

16 

Yu XH, Zheng XL and Tang CK: Nuclear factor-κB activation as a pathological mechanism of lipid metabolism and atherosclerosis. Adv Clin Chem. 70:1–30. 2015. View Article : Google Scholar

17 

Maziere C, Auclair M, Djavaheri-Mergny M, Packer L and Maziere JC: Oxidized low density lipoprotein induces activation of the transcription factor NF kappa B in fibroblasts, endothelial and smooth muscle cells. Biochem Mol Biol Int. 39:1201–1207. 1996.PubMed/NCBI

18 

Yurdagul A Jr, Sulzmaier FJ, Chen XL, Pattillo CB, Schlaepfer DD and Orr AW: Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression. J Cell Sci. 129:1580–1591. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Cai K, Na W, Guo M, Xu R, Wang X, Qin Y, Wu Y, Jiang J and Huang H: Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 60:772–781. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Lewis LJ, Hoak JC, Maca RD and Fry GL: Replication of human endothelial cells in culture. Science. 181:453–454. 1973. View Article : Google Scholar : PubMed/NCBI

21 

Chen JK: I only have eye for ewe: The discovery of cyclopamine and development of Hedgehog pathway-targeting drugs. Nat Prod Rep. 33:595–601. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Dąbek J, Kułach A and Gąsior Z: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB): A new potential therapeutic target in atherosclerosis? Pharmacol Rep. 62:778–783. 2010. View Article : Google Scholar

23 

Paone S, Baxter AA, Hulett MD and Poon IKH: Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis. Cell Mol Life Sci. 76:1093–1106. 2019. View Article : Google Scholar

24 

Luchetti F, Crinelli R, Cesarini E, Canonico B, Guidi L, Zerbinati C, Di Sario G, Zamai L, Magnani M, Papa S and Iuliano L: Endothelial cells, endoplasmic reticulum stress and oxysterols. Redox Biol. 13:581–587. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Choy JC, Granville DJ, Hunt DW and McManus BM: Endothelial cell apoptosis: Biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol. 33:1673–1690. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R and Sansom MSP: Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and Class F G protein-coupled receptor smoothened. Structure. 27:549–559.e2. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Weiss LE, Milenkovic L, Yoon J, Stearns T and Moerner WE: Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol. Proc Natl Acad Sci USA. 116:5550–5557. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J and Salic A: Cellular cholesterol directly activates smoothened in hedgehog signaling. Cell. 166:1176–1187.e14. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y and Beachy PA: Structural basis for cholesterol transport-like activity of the hedgehog receptor patched. Cell. 175:1352–1364.e1314. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Rajman I, Eacho PI, Chowienczyk PJ and Ritter JM: LDL particle size: An important drug target? Br J Clin Pharmacol. 48:125–133. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Bijlsma MF, Peppelenbosch MP and Spek CA: Hedgehog morphogen in cardiovascular disease. Circulation. 114:1985–1991. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, Iwakura A, Shintani S, Ii M, Asai J, Tkebuchava T, et al: Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. Nat Med. 11:1197–1204. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Xia YP, Dai RL, Li YN, Mao L, Xue YM, He QW, Huang M, Huang Y, Mei YW and Hu B: The protective effect of sonic hedgehog is mediated by the phosphoinositide [corrected] 3-kinase/AKT/Bcl-2 pathway in cultured rat astrocytes under oxidative stress. Neuroscience. 209:1–11. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Marrachelli VG, Mastronardi ML, Sarr M, Soleti R, Leonetti D, Martínez MC and Andriantsitohaina R: Sonic hedgehog carried by microparticles corrects angiotensin II-induced hypertension and endothelial dysfunction in mice. PLoS One. 8:e728612013. View Article : Google Scholar : PubMed/NCBI

35 

Qi C, Di Minin G, Vercellino I, Wutz A and Korkhov VM: Structural basis of sterol recognition by human hedgehog receptor PTCH1. Sci Adv. 5:eaaw64902019. View Article : Google Scholar : PubMed/NCBI

36 

Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J and Yan N: Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 361:eaas89352018. View Article : Google Scholar : PubMed/NCBI

37 

Renault MA, Roncalli J, Tongers J, Thorne T, Klyachko Misener S, Volpert OV, Mehta S, Burg A, Luedemann C, et al: Sonic hedgehog induces angiogenesis via Rho kinase-signaling in endothelial cells. J Mol Cell Cardiol. 49:4902010. View Article : Google Scholar : PubMed/NCBI

38 

Chinchilla P, Xiao L, Kazanietz MG and Riobo NA: Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle. 570–579. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Caradu C, Couffinhal T, Chapouly C, Guimbal S, Hollier Ducasse E, Bura-Rivière A, Dubois M and Gadeau Renault MA: Restoring endothelial function by targeting desert Hedgehog downstream of Klf2 improves critical limb ischemia in adults. Circ Res. 123:1053–1065. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Morrow D, Cullen JP, Liu W, Guha S, Sweeney C, Birney Collins N, Walls D, Redmond EM and Cahill PA: Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol. 29:1112–1118. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Jaipersad AS, Lip GY, Silverman S and Shantsila E: The role of monocytes in angiogenesis and atherosclerosis. J Am C Cardiol. 63:1–11. 2014. View Article : Google Scholar

42 

Xu J, Lu X and Shi GP: Vasa vasorum in atherosclerosis and clinical significance. Int J Mol Sci. 16:11574–11608. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Zmysłowski A and Szterk A: Current knowledge on mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols. Lipids Health Dis. 16:1882017. View Article : Google Scholar

44 

Soleti R and Martínez MC: Microparticles harbouring Sonic Hedgehog: Role in angiogenesis regulation. Cell Adh Migr. 293–295. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang H, Yu H, Lin L, Chen J and Zhu P: Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663. Int J Mol Med 45: 1864-1874, 2020.
APA
Huang, H., Yu, H., Lin, L., Chen, J., & Zhu, P. (2020). Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663. International Journal of Molecular Medicine, 45, 1864-1874. https://doi.org/10.3892/ijmm.2020.4542
MLA
Huang, H., Yu, H., Lin, L., Chen, J., Zhu, P."Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663". International Journal of Molecular Medicine 45.6 (2020): 1864-1874.
Chicago
Huang, H., Yu, H., Lin, L., Chen, J., Zhu, P."Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663". International Journal of Molecular Medicine 45, no. 6 (2020): 1864-1874. https://doi.org/10.3892/ijmm.2020.4542
Copy and paste a formatted citation
x
Spandidos Publications style
Huang H, Yu H, Lin L, Chen J and Zhu P: Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663. Int J Mol Med 45: 1864-1874, 2020.
APA
Huang, H., Yu, H., Lin, L., Chen, J., & Zhu, P. (2020). Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663. International Journal of Molecular Medicine, 45, 1864-1874. https://doi.org/10.3892/ijmm.2020.4542
MLA
Huang, H., Yu, H., Lin, L., Chen, J., Zhu, P."Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663". International Journal of Molecular Medicine 45.6 (2020): 1864-1874.
Chicago
Huang, H., Yu, H., Lin, L., Chen, J., Zhu, P."Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling Corrigendum in /10.3892/ijmm.2020.4663". International Journal of Molecular Medicine 45, no. 6 (2020): 1864-1874. https://doi.org/10.3892/ijmm.2020.4542
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