Open Access

Spirulina protein promotes skin wound repair in a mouse model of full-thickness dermal excisional wound

  • Authors:
    • Ping Liu
    • Jeong‑Wook Choi
    • Min‑Kyeong Lee
    • Youn Hee Choi
    • Taek‑Jeong Nam
  • View Affiliations

  • Published online on: April 8, 2020     https://doi.org/10.3892/ijmm.2020.4571
  • Pages: 351-359
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The skin protects body from environmental damage. Skin wounds lead to microbial infection and harmful agent injury. Thus, wound repair is crucial for the recovery of the normal function of skin tissue. The present study investigated the promoting effects of spirulina protein (SPCP) in mice on skin wound repair and also aimed to elucidate the potential underlying mechanisms. The results revealed that SPCP promoted the skin wound repair in a mouse model of full‑thickness excisional wounds. SPCP induced an increase in the expression level of α‑smooth muscle actin (α‑SMA). The activities of superoxide dismutase (SOD) and catalase (CAT) were enhanced by SPCP treatment in the granulation tissue. In addition, SPCP decreased the level of malondialdehyde (MDA) in the granulation tissue. Western blot analysis revealed that SPCP enhanced the phosphorylation and activation of protein kinase B (Akt) and extracellular signal‑regulated kinase (ERK). Moreover, the expression level of transforming growth factor β1 (TGF‑β1) was increased in the SPCP‑treated groups. The phosphorylation level of Smad2 was also increased by treatment of SPCP. Furthermore, SPCP promoted the expression of collagen in the granulation tissue. Taken together, these findings indicate that SPCP exerts a promoting effect on skin wound repair. The Akt, ERK and TGF‑β1 signaling pathways are involved in this process.
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July 2020
Volume 46 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Liu, P., Choi, J., Lee, M., Choi, Y.H., & Nam, T. (2020). Spirulina protein promotes skin wound repair in a mouse model of full-thickness dermal excisional wound. International Journal of Molecular Medicine, 46, 351-359. https://doi.org/10.3892/ijmm.2020.4571
MLA
Liu, P., Choi, J., Lee, M., Choi, Y. H., Nam, T."Spirulina protein promotes skin wound repair in a mouse model of full-thickness dermal excisional wound". International Journal of Molecular Medicine 46.1 (2020): 351-359.
Chicago
Liu, P., Choi, J., Lee, M., Choi, Y. H., Nam, T."Spirulina protein promotes skin wound repair in a mouse model of full-thickness dermal excisional wound". International Journal of Molecular Medicine 46, no. 1 (2020): 351-359. https://doi.org/10.3892/ijmm.2020.4571