Open Access

Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review)

  • Authors:
    • George Mihai Nitulescu
    • Horia Paunescu
    • Sterghios A. Moschos
    • Dimitrios Petrakis
    • Georgiana Nitulescu
    • George Nicolae Daniel Ion
    • Demetrios A. Spandidos
    • Taxiarchis Konstantinos Nikolouzakis
    • Nikolaos Drakoulis
    • Aristidis Tsatsakis
  • View Affiliations

  • Published online on: May 18, 2020     https://doi.org/10.3892/ijmm.2020.4608
  • Pages: 467-488
  • Copyright: © Nitulescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID‑19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID‑19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.
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August-2020
Volume 46 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Nitulescu, G.M., Paunescu, H., Moschos, S.A., Petrakis, D., Nitulescu, G., Ion, G.N. ... Tsatsakis, A. (2020). Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review). International Journal of Molecular Medicine, 46, 467-488. https://doi.org/10.3892/ijmm.2020.4608
MLA
Nitulescu, G. M., Paunescu, H., Moschos, S. A., Petrakis, D., Nitulescu, G., Ion, G. N., Spandidos, D. A., Nikolouzakis, T. K., Drakoulis, N., Tsatsakis, A."Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review)". International Journal of Molecular Medicine 46.2 (2020): 467-488.
Chicago
Nitulescu, G. M., Paunescu, H., Moschos, S. A., Petrakis, D., Nitulescu, G., Ion, G. N., Spandidos, D. A., Nikolouzakis, T. K., Drakoulis, N., Tsatsakis, A."Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review)". International Journal of Molecular Medicine 46, no. 2 (2020): 467-488. https://doi.org/10.3892/ijmm.2020.4608