Open Access

Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review)

  • Authors:
    • Meryem Alagoz
    • Nasim Kherad
  • View Affiliations

  • Published online on: May 19, 2020     https://doi.org/10.3892/ijmm.2020.4609
  • Pages: 521-534
  • Copyright: © Alagoz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Genome editing techniques are considered to be one of the most challenging yet efficient tools for assisting therapeutic approaches. Several studies have focused on the development of novel methods to improve the efficiency of gene editing, as well as minimise their off‑target effects. Clustered regularly interspaced short palindromic repeats (CRISPR)‑associated protein (Cas9) is a tool that has revolutionised genome editing technologies. New applications of CRISPR/Cas9 in a broad range of diseases have demonstrated its efficiency and have been used in ex vivo models of somatic and pluripotent stem cells, as well as in in vivo animal models, and may eventually be used to correct defective genes. The focus of the present review was the recent applications of CRISPR/Cas9 and its contribution to the treatment of challenging human diseases, such as various types of cancer, neurodegenerative diseases and a broad spectrum of other disorders. CRISPR technology is a novel method for disease treatment, enhancing the effectiveness of drugs and improving the development of personalised medicine.
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August-2020
Volume 46 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos
Alagoz M and Alagoz M: Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review). Int J Mol Med 46: 521-534, 2020
APA
Alagoz, M., & Alagoz, M. (2020). Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review). International Journal of Molecular Medicine, 46, 521-534. https://doi.org/10.3892/ijmm.2020.4609
MLA
Alagoz, M., Kherad, N."Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review)". International Journal of Molecular Medicine 46.2 (2020): 521-534.
Chicago
Alagoz, M., Kherad, N."Advance genome editing technologies in the treatment of human diseases: CRISPR therapy (Review)". International Journal of Molecular Medicine 46, no. 2 (2020): 521-534. https://doi.org/10.3892/ijmm.2020.4609