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Article

Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice

  • Authors:
    • Shiguang Peng
    • Mei Cao
    • Xiaoying Sun
    • Yaqiong Zhou
    • Chu‑Yen Chen
    • Tian Ma
    • Hongjin Li
    • Bin Li
    • Bo Zhu
    • Xin Li
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Beijing Chao‑yang Hospital, Capital Medical University, Beijing 100020, P.R. China, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, P.R. China, Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, P.R. China, Department of Cancer Immunology and Virology, Dana‑Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
  • Pages: 869-879
    |
    Published online on: May 21, 2020
       https://doi.org/10.3892/ijmm.2020.4612
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Abstract

Psoriasis is a common chronic inflammatory skin disease. Programmed cell death ligand 1 (PD‑L1) and programmed cell death 1 (PD‑1) are expressed on immune cells in a number of chronic inflammatory diseases. However, a limited number of studies have investigated the expression and function of the PD‑L1 and PD‑1 pathway in psoriatic inflammation. The present study used human psoriasis samples and imiquimod‑induced murine psoriasis models to investigate the potential role of PD‑1 in the modulation of psoriatic inflammation. The results demonstrated that inhibition of PD‑1 function with antibodies promoted psoriasis development. PD‑1‑fragment crystallizable (PD‑1‑Fc) treatment inhibited psoriatic inflammation and exhibited additive effects with anti‑tumor necrosis factor α therapy in imiquimod‑induced mouse psoriasis, suggesting that PD‑1‑Fc treatment may serve as a new therapeutic strategy for psoriasis.
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1 

Bowcock AM and Krueger JG: Getting under the skin: The immunogenetics of psoriasis. Nat Rev Immunol. 5:699–711. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Gottlieb AB: Psoriasis: emerging therapeutic strategies. Nat Rev Drug Discov. 4:19–34. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Nickoloff BJ, Bonish B, Huang BB and Porcelli SA: Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system. j Dermatol Sci. 24:212–225. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Chang JC, Smith LR, Froning KJ, Schwabe BJ, Laxer JA, Caralli LL, Kurland HH, Karasek MA, Wilkinson DI, Carlo DJ, et al: CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes. Proc Natl Acad Sci USA. 91:9282–9286. 1994. View Article : Google Scholar

5 

Prinz JC, Vollmer S, Boehncke WH, Menssen A, Laisney I and Trommler P: Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris. Eur J Immunol. 29:3360–3368. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Vollmer S, Menssen A and Prinz JC: Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris. J Invest Dermatol. 117:1296–1301. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Ishida Y, Agata Y, Shibahara K and Honjo T: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11:3887–3895. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Riley JL: PD-1 signaling in primary T cells. Immunol Rev. 229:114–125. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, et al: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 192:1027–1034. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, nunes R, et al: PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2:261–268. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Sun X, Roudi R, Dai T, Chen S, Fan B, Li H, Zhou Y, Zhou M, Zhu B, Yin C, et al: Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: A PRISMA systematic review and meta-analysis. BMC Cancer. 19:5582019. View Article : Google Scholar : PubMed/NCBI

12 

Keir ME, Butte MJ, Freeman GJ and Sharpe AH: PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 26:677–704. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Nishimura H, Agata Y, Kawasaki A, Sato M, Imamura S, Minato N, Yagita H, Nakano T and Honjo T: Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. Int Immunol. 8:773–780. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubata T, Yagita H and Honjo T: expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol. 8:765–772. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Iwai Y, Ishida M, Tanaka Y, okazaki T, Honjo T and Minato N: Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA. 99:12293–12297. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Okazaki T, Chikuma S, Iwai Y, Fagarasan S and Honjo T: A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application. Nat Immunol. 14:1212–1218. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Kuchroo V and Zarour HM: upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med. 207:2175–2186. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Ott PA, Hodi FS and Robert C: CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients. Clin Cancer Res. 19:5300–5309. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. New Engl J Med. 366:2443–2454. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Brahmer JR, Tykodi SS, Chow LG, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, odunsi K, et al: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 366:2455–2465. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Zhang P and Wu MX: A clinical review of phototherapy for psoriasis. Lasers Med Sci. 33:173–180. 2018. View Article : Google Scholar :

22 

Saurat JH, Stingl G, Dubertret L, Papp K, Langley RG, ortonne JP, Unnebrink K, Kaul M and Camez A; CHAMPIon Study Investigators: Efficacy and safety results from the randomized controlled comparative study of adalimumab vs. methotrexate vs placebo in patients with psoriasis (CHAMPIon). Br J Dermatol. 158:558–566. 2008. View Article : Google Scholar

23 

Francisco LM, Sage PT and Sharpe AH: The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 236:219–242. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Imai Y, Ayithan N, Wu X, yuan Y, Wang L and Hwang ST: Cutting edge: PD-1 regulates imiquimod-induced psoriasiform dermatitis through inhibition of IL-17A expression by innate gammadelta-low T cells. J Immunol. 195:421–425. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kim JH, Choi YJ, Lee BH, Song My, Ban CY, Kim J, Park J, Kim Se, Kim TG, Park SH, et al: Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells. J Allergy Clin Immunol. 137:1466–1476.e3. 2016. View Article : Google Scholar

26 

Langley RG and Ellis CN: evaluating psoriasis with psoriasis area and severity index, psoriasis global assessment, and lattice system physician's global assessment. J Am Acad Dermatol. 51:563–569. 2004. View Article : Google Scholar : PubMed/NCBI

27 

van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP and Lubberts E: Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 182:5836–5845. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Zhu B, Zhang M, Williams EM, Keller C, Mansoor A and Davie JK: TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle. Oncogene. 35:4212–4224. 2016. View Article : Google Scholar :

29 

Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'orazio J, Fung CY, Schanbacher CF, Granter SR and Fisher DE: Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 128:853–864. 2007. View Article : Google Scholar : PubMed/NCBI

30 

D'orazio JA, nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, granter SR, Nishimura EK, et al: Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature. 443:340–344. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Works MG, Yin F, Yin CC, Yiu Y, Shew K, Tran TT, Dunlap N, Lam J, Mitchell T, Reader J, et al: Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 193:3278–3287. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Lubrano E, Scriffignano S and Perrotta FM: TNF-alpha inhibitors for the six treatment targets of psoriatic arthritis. Expert Rev Clin Immunol. 15:1303–1312. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Ronholt K and Iversen L: old and new biological therapies for psoriasis. Int J Mol Sci. 18:E22972017. View Article : Google Scholar : PubMed/NCBI

34 

Sibaud V: Dermatologic reactions to immune checkpoint inhibitors: Skin toxicities and immunotherapy. Am J Clin Dermatol. 19:345–361. 2018. View Article : Google Scholar

35 

Muenst S, Soysal SD, Tzankov A and Hoeller S: The PD-1/ PD-L1 pathway: Biological background and clinical relevance of an emerging treatment target in immunotherapy. Expert Opin Ther Targets. 19:201–211. 2015. View Article : Google Scholar

36 

Okazaki T and Honjo T: The PD-1-PD-L pathway in immunological tolerance. Trends Immunol. 27:195–201. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Li X, Xiang Y, Li F, yin C, Li B and Ke X: WnT/β-catenin signaling pathway regulating T cell-inflammation in the tumor microenvironment. Front Immunol. 10:22932019. View Article : Google Scholar

38 

Voudouri D, Nikolaou V, Laschos K, Charpidou A, Soupos N, Triantafyllopoulou I, Panoutsopoulou I, Aravantinos G, Syrigos K and Stratigos A: Anti-PD1/PDL1 induced psoriasis. Curr Probl Cancer. 41:407–412. 2017. View Article : Google Scholar : PubMed/NCBI

39 

De Bock M, Hulstaert E, Kruse V and Brochez L: Psoriasis vulgaris exacerbation during treatment with a PD-1 checkpoint inhibitor: Case report and literature review. Case Rep Dermatol. 10:190–197. 2018. View Article : Google Scholar : PubMed/NCBI

40 

He J, Hu Y, Hu M and Li B: Development of PD-1/PD-L1 pathway in tumor immune microenvironment and treatment for non-small cell lung cancer. Sci Rep. 5:131102015. View Article : Google Scholar : PubMed/NCBI

41 

Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, et al: Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4(+) T Cell Immunity. Immunity. 45:333–345. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Ellis JS, guloglu FB, Tartar DM, Hoeman CM, Haymaker CL, Cascio JA, Wan X, Dhakal M, VanMorlan A, Yahng SH and Zaghouani H: APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory. J Immunol. 185:3149–3157. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Versteven M, Van den Bergh JMJ, Marcq E, Smits ELJ, Van Tendeloo VFI, Hobo W and Lion E: Dendritic cells and programmed death-1 blockade: A joint venture to combat cancer. Front Immunol. 9:3942018. View Article : Google Scholar : PubMed/NCBI

44 

Ritprajak P and Azuma M: Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. Oral Oncol. 51:221–228. 2015. View Article : Google Scholar

45 

Pulko V, Liu X, Krco CJ, Harris KJ, Frigola X, Kwon ED and Dong H: TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination. J Immunol. 183:3634–3641. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Diskin B, Adam S, Cassini MF, Sanchez G, Liria M, Aykut B, Buttar C, Li E, Sundberg B, Salas RD, et al: PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer. Nat Immunol. 21:442–454. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Balak DM and Hajdarbegovic E: Drug-induced psoriasis: Clinical perspectives. Psoriasis (Auckl). 7:87–94. 2017.

48 

Trafford AM, Parisi R, Kontopantelis E, Griffiths CEM and Ashcroft DM: Association of psoriasis with the risk of developing or dying of cancer: A systematic review and meta-analysis. JAMA Dermatol. 2019.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

49 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

50 

Abrams JR, Lebwohl MG, Guzzo CA, Jegasothy BV, Goldfarb MT, Goffe BS, Menter A, Lowe NJ, Krueger G, Brown MJ, et al: CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest. 103:1243–1252. 1999. View Article : Google Scholar : PubMed/NCBI

51 

El Malki K, Karbach SH, Huppert J, Zayoud M, Reissig S, Schüler R, Nikolaev A, Karram K, Münzel T, Kuhlmann CR, et al: An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol. 133:441–451. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Peng S, Cao M, Sun X, Zhou Y, Chen CY, Ma T, Li H, Li B, Zhu B, Li X, Li X, et al: Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice. Int J Mol Med 46: 869-879, 2020.
APA
Peng, S., Cao, M., Sun, X., Zhou, Y., Chen, C., Ma, T. ... Li, X. (2020). Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice. International Journal of Molecular Medicine, 46, 869-879. https://doi.org/10.3892/ijmm.2020.4612
MLA
Peng, S., Cao, M., Sun, X., Zhou, Y., Chen, C., Ma, T., Li, H., Li, B., Zhu, B., Li, X."Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice". International Journal of Molecular Medicine 46.2 (2020): 869-879.
Chicago
Peng, S., Cao, M., Sun, X., Zhou, Y., Chen, C., Ma, T., Li, H., Li, B., Zhu, B., Li, X."Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice". International Journal of Molecular Medicine 46, no. 2 (2020): 869-879. https://doi.org/10.3892/ijmm.2020.4612
Copy and paste a formatted citation
x
Spandidos Publications style
Peng S, Cao M, Sun X, Zhou Y, Chen CY, Ma T, Li H, Li B, Zhu B, Li X, Li X, et al: Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice. Int J Mol Med 46: 869-879, 2020.
APA
Peng, S., Cao, M., Sun, X., Zhou, Y., Chen, C., Ma, T. ... Li, X. (2020). Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice. International Journal of Molecular Medicine, 46, 869-879. https://doi.org/10.3892/ijmm.2020.4612
MLA
Peng, S., Cao, M., Sun, X., Zhou, Y., Chen, C., Ma, T., Li, H., Li, B., Zhu, B., Li, X."Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice". International Journal of Molecular Medicine 46.2 (2020): 869-879.
Chicago
Peng, S., Cao, M., Sun, X., Zhou, Y., Chen, C., Ma, T., Li, H., Li, B., Zhu, B., Li, X."Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice". International Journal of Molecular Medicine 46, no. 2 (2020): 869-879. https://doi.org/10.3892/ijmm.2020.4612
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