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Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation

  • Authors:
    • Ana Sofía Herrera-Van Oostdam
    • Juan Carlos Toro‑Ortíz
    • Jesús Adrián López
    • Daniel E. Noyola
    • David Alejandro García‑López
    • Noé Valentín Durán‑Figueroa
    • Eduardo Martínez‑Martínez
    • Diana P. Portales‑Pérez
    • Mariana Salgado‑Bustamante
    • Yamilé López‑Hernández
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico, Division of Gynecology and Obstetrics, Hospital Central ‘Dr. Ignacio Morones Prieto’, San Luis Potosí 78290, Mexico, Laboratory of microRNAs and Cancer, Academic Unit of Biological Sciences, Universidad Autónoma de Zacatecas, Zacatecas 98068, Mexico, Department of Microbiology, Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico, Laboratory of Cellular Biology and Neurobiology, Academic Unit of Biological Sciences, Universidad Autónoma de Zacatecas, Zacatecas 98068, Mexico, Interdisciplinary Professional Biotechnology Unit, Instituto Politécnico Nacional, Ciudad de Mexico 07340, Mexico, Laboratory of Cell Communication and Extracellular Vesicles, Instituto Nacional de Medicina Genómica, México City 14610, Mexico, Translational and Molecular Medicine Laboratory, Research Center for Health Sciences and Biomedicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, Mexico, CONACyT, Metabolomics and Proteomics Laboratory, Academic Unit of Biological Sciences, Universidad Autónoma de Zacatecas, Zacatecas 98068, Mexico
    Copyright: © Herrera-Van Oostdam et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 546-560
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    Published online on: June 3, 2020
       https://doi.org/10.3892/ijmm.2020.4626
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Abstract

Placenta‑derived exosomes play an important role in cellular communication both in the mother and the fetus. Their concentration and composition are altered in several pregnancy disorders, such as gestational diabetes mellitus (GDM). The isolation and characterization of placental exosomes from serum, plasma and tissues from patients with GDM have been previously described; however, to the best of our knowledge, to date, there is no study available on placental exosomes isolated from urine of patients with GDM. In the present study, placental exosomes were purified from urine the 1st, 2nd and 3rd trimester of gestation. Placental exosomes were characterized by transmission electron microscopy in cryogenic mode and by western blot analysis, confirming the presence of exosomal vesicles. The expression profile of five microRNAs (miR‑516‑5p, miR‑517‑3p, miR‑518‑5p, miR‑222‑3p and miR‑16‑5p) was determined by RT‑qPCR. In healthy pregnant women, the expression of the miRNAs increased across gestation, apart from miR‑516‑5p, which was not expressed at the 2nd trimester. All the miRNAs examined were downregulated in patients with GDM at the 3rd trimester of gestation. The downregulated miRNAs affected several metabolic pathways closely associated with the pathophysiology of GDM. This provides further evidence of the regulatory role of miRNAs in the GDM. This also suggests that the of urinary exosomes may be an excellent source of biomarkers and therapeutic targets.
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1 

Basina M: Gestational diabetogenesis. J Women's Health Care. 01:e1062012. View Article : Google Scholar

2 

Sáez T, de Vos P, Sobrevia L and Faas MM: Is there a role for exosomes in foetoplacental endothelial dysfunction in gestational diabetes mellitus? Placenta. 61:48–54. 2018. View Article : Google Scholar

3 

Powe CE: Early pregnancy biochemical predictors of gestational diabetes mellitus. Curr Diab Rep. 17:122017. View Article : Google Scholar : PubMed/NCBI

4 

Rodrigo N and Glastras SJ: The emerging role of biomarkers in the diagnosis of gestational diabetes mellitus. J Clin Med. 7:1202018. View Article : Google Scholar :

5 

Akgöl E, Abuşoğlu S, Gün FD and Ünlü A: Prevalence of gestational diabetes mellitus according to the different criterias. Turk J Obstet Gynecol. 14:18–22. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Karcaaltincaba D, Calis P, Ocal N, Ozek A, Altug Inan M and Bayram M: Prevalence of gestational diabetes mellitus evaluated by universal screening with a 75-g,2-h oral glucose tolerance test and IADPSG criteria. Int J Gynecol Obstet. 138:148–151. 2017. View Article : Google Scholar

7 

Ilekis JV, Tsilou E, Fisher S, Abrahams VM, Soares MJ, Cross JC, Zamudio S, Illsley NP, Myatt L, Colvis C, et al: Placental origins of adverse pregnancy outcomes: Potential molecular targets: An executive workshop summary of the eunice kennedy shriver national institute of child health and human development. Am J Obstet Gynecol. 215(1 Suppl): S1–S46. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Guarino E, Poggi CD, Grieco GE, Cenci V, Ceccarelli E, Crisci I, Sebastiani G and Dotta F: Circulating MicroRNAs as biomarkers of gestational diabetes mellitus: Updates and perspectives. Int J Endocrinol. 2018:63804632018. View Article : Google Scholar : PubMed/NCBI

9 

Kowal J, Tkach M and Théry C: Biogenesis and secretion of exosomes. Curr Opin Cell Biol. 29:116–125. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Cuffe JSM, Holland O, Salomon C, Rice GE and Perkins AV: Review: Placental derived biomarkers of pregnancy disorders. Placenta. 54:104–110. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Fu G, Brkić J, Hayder H and Peng C: MicroRNAs in human placental development and pregnancy complications. Int J Mol Sci. 14:5519–5544. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Ouyang Y, Mouillet JF, Coyne CB and Sadovsky Y: Review: Placenta-specific microRNAs in exosomes-good things come in nano-packages. Placenta. 35(Suppl): S69–S73. 2014. View Article : Google Scholar

13 

Hromadnikova I, Kotlabova K, Ondrackova M, Pirkova P, Kestlerova A, Novotna V, Hympanova L and Krofta L: Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications. DNA Cell Biol. 34:437–457. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zhu Y, Tian F, Li H, Zhou Y, Lu J and Ge Q: Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus. Int J Gynecol Obstet. 130:49–53. 2015. View Article : Google Scholar

15 

Salomon C, Torres MJ, Kobayashi M, Scholz-Romero K, Sobrevia L, Dobierzewska A, Illanes SE, Mitchell MD and Rice GE: A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration. PLoS One. 9:e986672014. View Article : Google Scholar : PubMed/NCBI

16 

Salomon C, Scholz-Romero K, Sarker S, Sweeney E, Kobayashi M, Correa P, Longo S, Duncombe G, Mitchell MD, Rice GE and Illanes SE: Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation. Diabetes. 65:598–609. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy: A world health organization guideline. Diabetes Res Clin Pract. 103:341–363. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Gonzales PA, Zhou H, Pisitkun T, Wang NS, Star RA, Knepper MA and Yuen PS: Isolation and purification of exosomes in urine. Methods Mol Biol. 641:89–99. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Abdalla M: Comprehensive coverage of exosomes purification and exosomal RNA isolation from different types of liquid biopsies. https://www.exosome-rna.com/upcoming-webinar-comprehensive-coverage-of-exosome-purification-and-exosomal-rna-isolation-from-different-types-of-liquid-biopsies/. Accessed April 15, 2019.

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Kwon DN, Chang BS and Kim JH: MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling. Biomed Res Int. 2014:2363852014. View Article : Google Scholar : PubMed/NCBI

22 

Spinetti G, Fortunato O, Caporali A, Shantikumar S, Marchetti M, Meloni M, Descamps B, Floris I, Sangalli E, Vono R, et al: MicroRNA-15a and MicroRNA-16 Impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia. Circ Res. 112:335–346. 2013. View Article : Google Scholar :

23 

Kaddar T, Rouault JP, Chien WW, Chebel A, Gadoux M, Salles G, Ffrench M and Magaud JP: Two new miR-16 targets: Caprin-1 and HMGA1, proteins implicated in cell proliferation. Biol Cell. 101:511–524. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Palmieri D, D'Angelo D, Valentino T, De Martino I, Ferraro A, Wierinckx A, Fedele M, Trouillas J and Fusco A: Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis. Oncogene. 31:3857–3865. 2012. View Article : Google Scholar

25 

Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z and Zheng X: MiR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res. 36:5391–5404. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Yin Y, Stephen CW, Luciani MG and Fåhraeus R: p53 stability and activity is regulated by Mdm2-mediated induction of alter-native p53 translation products. Nat Cell Biol. 4:462–467. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Marcel V, Perrier S, Aoubala M, Ageorges S, Groves MJ, Diot A, Fernandes K, Tauro S and Bourdon JC: Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript. FEBS Lett. 584:4463–4468. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Zhu Y, Xia Y, Niu H and Chen Y: MiR-16 induced the suppression of cell apoptosis while promote proliferation in esophageal squamous cell carcinoma. Cell Physiol Biochem. 33:1340–1348. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Parsi S, Smith PY, Goupil C, Dorval V and Hébert SS: Preclinical evaluation of miR-15/107 family members as multifactorial drug targets for Alzheimer's disease. Mol Ther Nucleic Acids. 4:e2562015. View Article : Google Scholar : PubMed/NCBI

30 

Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, Hasan L, Kappeler A, Brunner T and Vassella E: MiR-15a and miR-16 are implicated in cell cycle regulation in a Rb-Dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res. 69:5553–5559. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Bonci D, Coppola V, Musumeci M, Addario A, Giuffrida R, Memeo L, D'Urso L, Pagliuca A, Biffoni M, Labbaye C, et al: The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med. 14:1271–1277. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Lerner M, Harada M, Lovén J, Castro J, Davis Z, Oscier D, Henriksson M, Sangfelt O, Grandér D and Corcoran MM: DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1. Exp Cell Res. 315:2941–2952. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Sebastiani G, Guarino E, Grieco GE, Formichi C, Poggi CD, Ceccarelli E and Dotta F: Circulating microRNA (miRNA) expression profiling in plasma of patients with gestational diabetes mellitus reveals upregulation of miRNA miR-330-3p. Front Endocrinol (Lausanne). 8:3452017. View Article : Google Scholar

34 

Koralewska N, Ciechanowska K, Pokornowska M, Figlerowicz M and Kurzyńska-Kokorniak A: Human ribonuclease Dicer-structure and functions. Postepy Biochem. 65:173–182. 2019.In Polish. View Article : Google Scholar : PubMed/NCBI

35 

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA and McGettrick AF: The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimu-lation. Nat Commun. 3:7072012. View Article : Google Scholar

36 

Füllekrug J, Suganuma T, Tang BL, Hong W, Storrie B and Nilsson T: Localization and recycling of gp27 (hp24gamma3): Complex formation with other p24 family members. Mol Biol Cell. 10:1939–1955. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Wisniewska M, Goettig P, Maskos K, Belouski E, Winters D, Hecht R, Black R and Bode W: Structural determinants of the ADAM inhibition by TIMP-3: Crystal structure of the TACE-N-TIMP-3 complex. J Mol Biol. 381:1307–1319. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Kotronis K, Zafrakas M, Papasozomenou P, Timologou A, Miliaras D, Tarlatzis BC and Grimbizis G: Protein expression pattern of tissue inhibitor of metalloproteinase-3 (TIMP3) in endometriosis and normal endometrium. Gynecol Endocrinol. 35:1103–1106. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Felicetti F, Errico MC, Bottero L, Segnalini P, Stoppacciaro A, Biffoni M, Felli N, Mattia G, Petrini M, Colombo MP, et al: The Promyelocytic leukemia zinc Finger-MicroRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res. 68:2745–2754. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Felicetti F, Errico MC, Segnalini P, Mattia G and Carè A: MicroRNA-221 and -222 pathway controls melanoma progression. Expert Rev Anticancer Ther. 8:1759–1765. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Garofalo M, Quintavalle C, Di Leva G, Zanca C, Romano G, Taccioli C, Liu CG, Croce CM and Condorelli G: MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene. 27:3845–3855. 2008. View Article : Google Scholar : PubMed/NCBI

42 

He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu C G, Franssila K, Suster S, et al: The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA. 102:19075–19080. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Felli N, Fontana L, Pelosi E, Botta R, Bonci D, Facchiano F, Liuzzi F, Lulli V, Morsilli O, Santoro S, et al: MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA. 102:18081–18086. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Gits CM, van Kuijk PF, Jonkers MB, Boersma AW, van Ijcken WF, Wozniak A, Sciot R, Rutkowski P, Schöffski P, Taguchi T, et al: MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours. Br J Cancer. 109:1625–1635. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, et al: Transcriptome-wide identification of RNA-Binding protein and MicroRNA target sites by PAR-CLIP. Cell. 141:129–141. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Elmehdawi F, Wheway G, Szymanska K, Adams M, High AS, Johnson CA and Robinson PA: Human homolog of drosophila ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies. Exp Cell Res. 319:161–172. 2013. View Article : Google Scholar

47 

von Stechow L, Typas D, Carreras Puigvert J, Oort L, Siddappa R, Pines A, Vrieling H, van de Water B, Mullenders LH and Danen EH: The E3 Ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-Mediated mRNA translation arrest. Mol Cell Biol. 35:1254–1268. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Kishore S, Jaskiewicz L, Burger L, Hausser J, Khorshid M and Zavolan M: A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 8:559–564. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, et al: Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 11:4992020. View Article : Google Scholar :

50 

Shen N, Liu Y, Zhang K, Lyu Y, Gao M, Ma J, Xu L and Gai Z: Analysis of RPS6KA3 gene mutation in a Chinese pedigree affected with coffinlowry syndrome. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 36:798–800. 2019.In Chinese. PubMed/NCBI

51 

Zhang J, Yang M, Li D, Zhu S, Zou J, Xu S, Wang Y, Shi J and Li Y: Homeobox C8 is a transcriptional repressor of E-cadherin gene expression in non-small cell lung cancer. Int J Biochem Cell Biol. 114:1055572019. View Article : Google Scholar : PubMed/NCBI

52 

Gong C, Zou J, Zhang M, Zhang J, Xu S, Zhu S, Yang M, Li D, Wang Y, Shi J and Li Y: Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple-negative breast cancer. Mol Carcinog. 58:1863–1875. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Fang X and Yan R: MiR-152 inhibits the proliferation and invasion of chordoma cells by targeting HOXC8. J Int Med Res. 47:5185–5193. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Gottwein E, Corcoran DL, Mukherjee N, Skalsky RL, Hafner M, Nusbaum JD, Shamulailatpam P, Love CL, Dave SS, Tuschl T, et al: Viral MicroRNA targetome of KSHV-Infected primary effusion lymphoma cell lines. Cell Host Microbe. 10:515–526. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene Ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

56 

The Gene Ontology Consortium: The gene ontology resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar :

57 

Cheng X, Veverka V, Radhakrishnan A, Waters LC, Muskett FW, Morgan SH, Huo J, Yu C, Evans EJ, Leslie AJ, et al: Structure and interactions of the human programmed cell death 1 receptor. J Biol Chem. 288:11771–11785. 2013. View Article : Google Scholar : PubMed/NCBI

58 

He PX, Ma ZL, Han H, Zhang XY, Niu SH, Du LN, Zheng YC and Liu HM: Expression of programmed death ligand 1 (PD-L1) is associated with metastasis and differentiation in gastric cancer. Life Sci. 242:1172472020. View Article : Google Scholar : PubMed/NCBI

59 

Whisnant AW, Bogerd HP, Flores O, Ho P, Powers JG, Sharova N, Stevenson M, Chen CH and Cullen BR: In-Depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms. MBio. 4:e0001932013. View Article : Google Scholar : PubMed/NCBI

60 

Racapé M, Duong Van Huyen JP, Danger R, Giral M, Bleicher F, Foucher Y, Pallier A, Pilet P, Tafelmeyer P, Ashton-Chess J, et al: The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. PLoS One. 6:e193212011. View Article : Google Scholar : PubMed/NCBI

61 

Gan H, Lin L, Hu N, Yang Y, Gao Y, Pei Y, Chen K and Sun B: KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p. Cell Biochem Funct. 37:424–431. 2019. View Article : Google Scholar : PubMed/NCBI

62 

McHugh T, Zou J, Volkov VA, Aurélie Bertin A, Talapatra SK, Rappsilber J, Dogterom M and Welburn JPI: The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation. J Cell Sci. 132:jcs2283532019. View Article : Google Scholar :

63 

Nečasová I, Janoušková E, Klumpler T and Hofr C: Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it. Nucleic Acids Res. 45:12170–12180. 2017. View Article : Google Scholar

64 

Karginov FV and Hannon GJ: Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes Dev. 27:1624–1632. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Moldovan L, Batte KE, Trgovcich J, Wisler J, Marsh CB and Piper M: Methodological challenges in utilizing miRNAs as circulating biomarkers. Version 2 J Cell Mol Med. 18:371–390. 2014. View Article : Google Scholar

66 

Munaut C, Tebache L, Blacher S, Noël A, Nisolle M and Chantraine F: Dysregulated circulating miRNAs in preeclampsia. Biomed Rep. 5:686–692. 2016. View Article : Google Scholar

67 

Li D and Li J: Association of miR-34a3p/5p, miR-1413p/5p, and miR-24 in decidual natural killer cells with unexplained recurrent spontaneous abortion. Med Sci Monit. 22:922–929. 2016. View Article : Google Scholar : PubMed/NCBI

68 

Song GY, Song WW, Han Y, Wang D and Na Q: Characterization of the role of microRNA-517a expression in low birth weight infants. J Dev Orig Health Dis. 4:522–526. 2013. View Article : Google Scholar

69 

Li J, Chen L, Tang Q, Wu W, Gu H, Liu L, Wu J, Jiang H, Ding H, Xia Y, et al: The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia. Sci Rep. 5:172122015. View Article : Google Scholar : PubMed/NCBI

70 

Cai M, Kolluru GK and Ahmed A: Small molecule, big prospects: MicroRNA in pregnancy and its complications. J Pregnancy. 2017:69727322017. View Article : Google Scholar : PubMed/NCBI

71 

Cao YL, Jia YJ, Xing BH, Shi DD and Dong XJ: Plasma microRNA-16-5p-17-5p and -20a-5p: Novel diagnostic biomarkers for gestational diabetes mellitus. J Obstet Gynaecol Res. 43:974–981. 2017. View Article : Google Scholar : PubMed/NCBI

72 

Geng Y, Ju Y, Ren F, Qiu Y, Tomita Y, Tomoeda M, Kishida M, Wang Y, Jin L, Su F, et al: Insulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2. J Biol Chem. 289:11230–11241. 2014. View Article : Google Scholar : PubMed/NCBI

73 

Ortega FJ, Mercader JM, Moreno-Navarrete JM, Rovira O, Guerra E, Esteve E, Xifra G, Martínez C, Ricart W, Rieusset J, et al: Profiling of circulating MicroRNAs reveals common micrornas linked to type 2 diabetes that change with insulin sensitization. Diabetes Care. 37:1375–1383. 2014. View Article : Google Scholar : PubMed/NCBI

74 

Demirsoy İH, Ertural DY, Balci Ş, Çınkır Ü, Sezer K, Tamer L and Aras N: Profiles of circulating MiRNAs following metformin treatment in patients with type 2 diabetes. J Med Biochem. 37:499–506. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Collares CV, Evangelista AF, Xavier DJ, Rassi DM, Arns T, Foss-Freitas MC, Foss MC, Puthier D, Sakamoto-Hojo ET, Passos GA, et al: Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients. BMC Res Notes. 6:4912013. View Article : Google Scholar : PubMed/NCBI

76 

Zhao C, Dong J, Jiang T, Shi Z, Yu B, Zhu Y, Chen D, Xu J, Huo R, Dai J, et al: Early second-trimester serum MiRNA profiling predicts gestational diabetes mellitus. PLoS One. 6:e239252011. View Article : Google Scholar : PubMed/NCBI

77 

Pheiffer C, Dias S, Rheeder P and Adam S: Decreased expression of circulating miR-20a-5p in South African women with gestational diabetes mellitus. Mol Diagn Ther. 22:345–352. 2018. View Article : Google Scholar : PubMed/NCBI

78 

Shi Z, Zhao C, Guo X, Ding H, Cui Y, Shen R and Liu J: Differential expression of microRNAs in omental adipose tissue from gestational diabetes mellitus subjects reveals miR-222 as a regulator of Erα expression in estrogen-induced insulin resistance. Endocrinology. 155:1982–1990. 2014. View Article : Google Scholar : PubMed/NCBI

79 

López-Hernández Y, Herrera-Van Oostdam A, Toro-Ortiz JC, López JA, Salgado-Bustamante M, Murgu M and Torres-Torres LM: Urinary metabolites altered during the third trimester in pregnancies complicated by gestational diabetes mellitus: Relationship with potential upcoming metabolic disorders. Int J Mol Sci. 20:11862019. View Article : Google Scholar :

80 

Ibarra A, Vega-Guedes B, Brito-Casillas Y and Wägner AM: Diabetes in pregnancy and MicroRNAs: Promises and limitations in their clinical application. Noncoding RNA. 4:322018.

81 

Sadovsky Y, Mouillet JF, Ouyang Y, Bayer A and Coyne CB: The function of trophomirs and other micrornas in the human placenta. Cold Spring Harb Perspect Med. 5:a0230362015. View Article : Google Scholar : PubMed/NCBI

82 

Hromadnikova I, Kotlabova K, Ivankova K and Krofta L: First trimester screening of circulating C19MC microRNAs and the evaluation of their potential to predict the onset of preeclampsia and IUGR. PLoS One. 12:e01717562017. View Article : Google Scholar : PubMed/NCBI

83 

Hromadnikova I, Dvorakova L, Kotlabova K and Krofta L: The prediction of gestational hypertension, preeclampsia and fetal growth restriction via the first trimester screening of plasma exosomal C19MC microRNAs. Int J Mol Sci. 20:29722019. View Article : Google Scholar :

84 

Esteves JV, Enguita FJ and Machado UF: MicroRNAs-Mediated regulation of skeletal muscle GLUT4 expression and translocation in insulin resistance. J Diabetes Res. 2017:72679102017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Herrera-Van Oostdam AS, Toro‑Ortíz JC, López JA, Noyola DE, García‑López DA, Durán‑Figueroa NV, Martínez‑Martínez E, Portales‑Pérez DP, Salgado‑Bustamante M, López‑Hernández Y, López‑Hernández Y, et al: Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. Int J Mol Med 46: 546-560, 2020.
APA
Herrera-Van Oostdam, A.S., Toro‑Ortíz, J.C., López, J.A., Noyola, D.E., García‑López, D.A., Durán‑Figueroa, N.V. ... López‑Hernández, Y. (2020). Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. International Journal of Molecular Medicine, 46, 546-560. https://doi.org/10.3892/ijmm.2020.4626
MLA
Herrera-Van Oostdam, A. S., Toro‑Ortíz, J. C., López, J. A., Noyola, D. E., García‑López, D. A., Durán‑Figueroa, N. V., Martínez‑Martínez, E., Portales‑Pérez, D. P., Salgado‑Bustamante, M., López‑Hernández, Y."Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation". International Journal of Molecular Medicine 46.2 (2020): 546-560.
Chicago
Herrera-Van Oostdam, A. S., Toro‑Ortíz, J. C., López, J. A., Noyola, D. E., García‑López, D. A., Durán‑Figueroa, N. V., Martínez‑Martínez, E., Portales‑Pérez, D. P., Salgado‑Bustamante, M., López‑Hernández, Y."Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation". International Journal of Molecular Medicine 46, no. 2 (2020): 546-560. https://doi.org/10.3892/ijmm.2020.4626
Copy and paste a formatted citation
x
Spandidos Publications style
Herrera-Van Oostdam AS, Toro‑Ortíz JC, López JA, Noyola DE, García‑López DA, Durán‑Figueroa NV, Martínez‑Martínez E, Portales‑Pérez DP, Salgado‑Bustamante M, López‑Hernández Y, López‑Hernández Y, et al: Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. Int J Mol Med 46: 546-560, 2020.
APA
Herrera-Van Oostdam, A.S., Toro‑Ortíz, J.C., López, J.A., Noyola, D.E., García‑López, D.A., Durán‑Figueroa, N.V. ... López‑Hernández, Y. (2020). Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation. International Journal of Molecular Medicine, 46, 546-560. https://doi.org/10.3892/ijmm.2020.4626
MLA
Herrera-Van Oostdam, A. S., Toro‑Ortíz, J. C., López, J. A., Noyola, D. E., García‑López, D. A., Durán‑Figueroa, N. V., Martínez‑Martínez, E., Portales‑Pérez, D. P., Salgado‑Bustamante, M., López‑Hernández, Y."Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation". International Journal of Molecular Medicine 46.2 (2020): 546-560.
Chicago
Herrera-Van Oostdam, A. S., Toro‑Ortíz, J. C., López, J. A., Noyola, D. E., García‑López, D. A., Durán‑Figueroa, N. V., Martínez‑Martínez, E., Portales‑Pérez, D. P., Salgado‑Bustamante, M., López‑Hernández, Y."Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation". International Journal of Molecular Medicine 46, no. 2 (2020): 546-560. https://doi.org/10.3892/ijmm.2020.4626
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