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Article

IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model

  • Authors:
    • Jia‑Long Chen
    • Xue‑Li Niu
    • Ya‑Li Gao
    • Lei Ma
    • Xing‑Hua Gao
    • Hong‑Duo Chen
    • Rui‑Qun Qi
  • View Affiliations / Copyright

    Affiliations: Graduate School, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Dermatology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China
  • Pages: 880-888
    |
    Published online on: June 4, 2020
       https://doi.org/10.3892/ijmm.2020.4630
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Abstract

Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) controls; ii) IL18 knockout (KO) controls; iii) MC903‑treated WT mice; and iv) MC903‑treated KO mice. MC903 (4 nmol in ethanol) was topically applied daily for 15 consecutive days to the exposed skins of mice. AD‑like symptoms and severity were evaluated by the scoring of AD (SCORAD). Serum immunoglobulin E (IgE) and thymic stromal lymphopoietin (TSLP) levels were determined with the use of an enzyme‑linked immunosorbent assay. Immunohistochemistry was used to assess the expression of IL‑1β, signal transducer and activator of transcription (STAT)3 and filaggrin (FLG) in the skin lesions. RT‑qPCR was performed to assess the mRNA levels of IL‑1β, IL‑4, IL‑9, STAT3, corticotropin‑releasing hormone receptor (CRHR)1, CRHR2, TSLP and caspase‑1 in the skin lesions. It was demonstrated that IL‑18 may function as a pleiotropic pro‑inflammatory cytokine in the development of AD‑like lesions. IL‑18 KO reduced aggravated AD‑like lesions induced by MC903, in part by upregulating Th2 cytokines. IL‑18 promoted the expression of FLG in the epidermis and CRHR2 in AD‑like lesions, but downregulated the serum levels of IgE. On the whole, the findings of the present study demonstrate that IL‑18 deficiency alleviates AD‑induced lesions in mice.
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View References

1 

Bolognia J, Schaffer J and Cerroni L: Dermatology. 4th edition. Elsevier Ltd; 2018

2 

Weidinger S, Beck LA, Bieber T, Kabashima K and Irvine AD: Atopic dermatitis. Nat Rev Dis Primers. 4:12018. View Article : Google Scholar : PubMed/NCBI

3 

Lee JH, Cho DH and Park HJ: IL-18 and cutaneous inflammatory diseases. Int J Mol Sci. 16:29357–29369. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al: Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 378:88–91. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Sá DC and Festa CN: Inflammasomes and dermatology. An Bras Dermatol. 91:566–578. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Wild JS, Sigounas A, Sur N, Siddiqui MS, Alam R, Kurimoto M and Sur S: IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. J Immunol. 164:2701–2710. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Hon KL, Tsang KY, Kung JS, Leung TF, Lam CW and Wong CK: Clinical signs, staphylococcus and atopic eczema-related seromarkers. Molecules. 22:2912017. View Article : Google Scholar

8 

Zedan K, Rasheed Z, Farouk Y, Alzolibani AA, Bin Saif G, Ismail HA and Al Robaee AA: Immunoglobulin E, interleukin-18 and interleukin-12 in patients with atopic dermatitis: Correlation with disease activity. J Clin Diagn Res. 9:WC01–WC05. 2015.PubMed/NCBI

9 

Chopra R, Vakharia PP, Sacotte R, Patel N, Immaneni S, White T, Kantor R, Hsu DY and Silverberg JI: Severity strata for eczema area and severity index (EASI), modified EASI, scoring atopic dermatitis (SCORAD), objective SCORAD, atopic dermatitis severity index and body surface area in adolescents and adults with atopic dermatitis. Br J Dermatol. 177:1316–1321. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Ziegler SF and Artis D: Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol. 11:289–293. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Eyerich K and Novak N: Immunology of atopic eczema: Overcoming the Th1/Th2 paradigm. Allergy. 68:974–982. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Moosbrugger-Martinz V, Schmuth M and Dubrac S: A mouse model for atopic dermatitis using topical application of vitamin D3 or of its analog MC903. Methods Mol Biol. 1559:91–106. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Choi J, Kim JR, Kim H, Kim YA, Lee HJ, Kim J and Lee KW: The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 knockout mice. Toxicol Sci. 136:443–449. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Liu XJ, Mu ZL, Zhao Y and Zhang JZ: Topical tetracycline improves MC903-induced atopic dermatitis in mice through inhibition of inflammatory cytokines and thymic stromal lymphopoietin expression. Chin Med J (Engl). 129:1483–1490. 2016. View Article : Google Scholar

15 

Li M, Hener P, Zhang Z, Kato S, Metzger D and Chambon P: Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci USA. 103:11736–11741. 2006. View Article : Google Scholar : PubMed/NCBI

16 

National Research Council (US) Committee for the Update of the Guide for the Care and use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th edition. National Academies Press (US); Washington, DC: 2011

17 

Yu J, Luo Y, Zhu Z, Zhou Y, Sun L, Gao J, Sun J, Wang G, Yao X and Li W: A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor. J Allergy Clin Immunol. 143:2108–2119.e12. 2019. View Article : Google Scholar

18 

Nomura T and Kabashima K: Advances in atopic dermatitis in 2015. J Allergy Clin Immunol. 138:1548–1555. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

20 

Turner MJ, Dasilva-Arnold SC, Yi Q, Mehrotra P, Kaplan MH and Travers JB: Topical application of a vitamin D analogue exacerbates atopic dermatitis and induces the atopic dermatitis-like phenotype in Stat6VT mice. Pediatr Dermatol. 30:574–578. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Irvine AD, McLean WH and Leung DY: Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 365:1315–1327. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Brown SJ and McLean WH: One remarkable molecule: Filaggrin. J Invest Dermatol. 132(3 Pt 2): 751–762. 2012. View Article : Google Scholar :

23 

Kelly-Welch AE, Hanson EM, Boothby MR and Keegan AD: Interleukin-4 and interleukin-13 signaling connections maps. Science. 300:1527–1528. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, et al: Sensory neurons Co-opt classical immune signaling pathways to mediate chronic itch. Cell. 171:217–228.e13. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Morales JK, Falanga YT, Depcrynski A, Fernando J and Ryan JJ: Mast cell homeostasis and the JAK-STAT pathway. Genes Immun. 11:599–608. 2010. View Article : Google Scholar : PubMed/NCBI

26 

El-Darawish Y, Li W, Yamanishi K, Pencheva M, Oka N, Yamanishi H, Matsuyama T, Tanaka Y, Minato N and Okamura H: Frontline science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy. J Leukoc Biol. 104:253–264. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Alboni S, Montanari C, Benatti C, Sanchez-Alavez M, Rigillo G, Blom JM, Brunello N, Conti B, Pariante MC and Tascedda F: Interleukin 18 activates MAPKs and STAT3 but not NF-κB in hippocampal HT-22 cells. Brain Behav Immun. 40:85–94. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Stritesky GL, Muthukrishnan R, Sehra S, Goswami R, Pham D, Travers J, Nguyen ET, Levy DE and Kaplan MH: The transcription factor STAT3 is required for T helper 2 cell development. Immunity. 34:39–49. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Lyu Y, Zhu L, Qi R, Xu J, Di Z, Chen H and Gao X: Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitis. Chin Med J (Engl). 127:2389–2391. 2014.

30 

Siegel AM, Stone KD, Cruse G, Lawrence MG, Olivera A, Jung MY, Barber JS, Freeman AF, Holland SM, O'Brien M, et al: Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol. 132:1388–1396. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R, Webster E and Chrousos G: Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology. 139:403–413. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Crompton R, Clifton VL, Bisits AT, Read MA, Smith R and Wright IM: Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways. J Clin Endocrinol Metab. 88:5427–5432. 2033. View Article : Google Scholar

33 

Ganceviciene R, Graziene V, Fimmel S and Zouboulis CC: Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. Br J Dermatol. 160:345–352. 2009. View Article : Google Scholar

34 

Singh LK, Boucher W, Pang X, Letourneau R, Seretakis D, Green M and Theoharides TC: Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J Pharmacol Exp Ther. 288:1349–1356. 1999.PubMed/NCBI

35 

Clifton VL, Read MA, Leitch IM, Giles WB, Boura AL, Robinson PJ and Smith R: Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: Involvement of the nitric oxide-cyclic guanosine 3′,5′-monophosphate-mediated pathway. J Clin Endocrinol Metab. 80:2888–2893. 1995.PubMed/NCBI

36 

Vasiadi M, Therianou A, Sideri K, Smyrnioti M, Sismanopoulos N, Delivanis DA, Asadi S, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, et al: Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis. J Allergy Clin Immunol. 129:1410–1413. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Sakai T, Hatano Y, Zhang W, Fujiwara S and Nishiyori R: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1α, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes. J Dermatol Sci. 80:158–160. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Holmes J, Fairclough LC and Todd I: Atopic dermatitis and autoimmunity: The occurrence of autoantibodies and their association with disease severity. Arch Dermatol Res. 311:141–162. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Jin JJ, Zou YX and Zeng SW: Risk factors for and expression of immune and inflammatory factors in atopic dermatitis in Chinese population: A birth cohort study. Mol Cell Probes. 30:168–173. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Kabashima-Kubo R, Nakamura M, Sakabe J, Sugita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, et al: A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type. J Dermatol Sci. 67:37–43. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, et al: Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med. 12:650–656. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen JL, Niu XL, Gao YL, Ma L, Gao XH, Chen HD and Qi RQ: IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model. Int J Mol Med 46: 880-888, 2020.
APA
Chen, J., Niu, X., Gao, Y., Ma, L., Gao, X., Chen, H., & Qi, R. (2020). IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model. International Journal of Molecular Medicine, 46, 880-888. https://doi.org/10.3892/ijmm.2020.4630
MLA
Chen, J., Niu, X., Gao, Y., Ma, L., Gao, X., Chen, H., Qi, R."IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model". International Journal of Molecular Medicine 46.2 (2020): 880-888.
Chicago
Chen, J., Niu, X., Gao, Y., Ma, L., Gao, X., Chen, H., Qi, R."IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model". International Journal of Molecular Medicine 46, no. 2 (2020): 880-888. https://doi.org/10.3892/ijmm.2020.4630
Copy and paste a formatted citation
x
Spandidos Publications style
Chen JL, Niu XL, Gao YL, Ma L, Gao XH, Chen HD and Qi RQ: IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model. Int J Mol Med 46: 880-888, 2020.
APA
Chen, J., Niu, X., Gao, Y., Ma, L., Gao, X., Chen, H., & Qi, R. (2020). IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model. International Journal of Molecular Medicine, 46, 880-888. https://doi.org/10.3892/ijmm.2020.4630
MLA
Chen, J., Niu, X., Gao, Y., Ma, L., Gao, X., Chen, H., Qi, R."IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model". International Journal of Molecular Medicine 46.2 (2020): 880-888.
Chicago
Chen, J., Niu, X., Gao, Y., Ma, L., Gao, X., Chen, H., Qi, R."IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model". International Journal of Molecular Medicine 46, no. 2 (2020): 880-888. https://doi.org/10.3892/ijmm.2020.4630
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